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Imbuing Education with Brain Research Can Improve Teaching and Enhance Productive Learning  [PDF]
Isaac A. Friedman, Etty Grobgeld, Ariela Teichman-Weinberg
Psychology (PSYCH) , 2019, DOI: 10.4236/psych.2019.102010
Abstract: The article presents an experimental three-year Neuropedagogy Adaptation Project (NAP) that exposed practicing teachers to neuroscientific concepts and research findings in order to merge them with their teaching and classroom management practice. The project addressed two basic issues. First, selecting pertinent neuroscientific content areas that are best applicable to teaching and learning. Second, establishing a methodology and practice to infuse education with neuroscientific knowhow. The article gives an account of the project’s guidelines, and participants’ applications of neuroscientific concepts to classroom practices, and teacher student relationships. Based on the conclusions derived from the project, we argue that the time is ripe for establishing a new educational discipline—Neuropedagogy that is a blend of neuroscience, neurocognitive psychology and education.
Hubungan Corporate Governance, Corporate Social Responsibilities dan Corporate Financial Performance Dalam Satu Continuum
Etty Murwaningsari
Jurnal Akuntansi dan Keuangan , 2009,
Abstract: This research aims to identify the influence of Good Corporate Governance, represented by institutional ownership and managerial ownership, on Corporate Social Responsibility and Corporate Financial Performance, and also to observe the possible influence of Corporate Social Responsibility on Corporate Financial Performance. This research examines 126 manufacturing companies which are listed in Indonesian Stock Exchange (ISX) and have issued an audited financial statement for 2006. The statistical method used to test the hypothesis is Path Analysis. The result suggests that Good Corporate Governance influences both the disclosure of Corporate Social Responsibility and Corporate Financial Performance and that Corporate Social Responsibility significantly influences Corporate Financial Performance. The result also suggests that CEO Tenure, the controlling variable, holds a significant influence on the disclosure of Corporate Social Responsibility. Yet, there is no strong evidence to support the type of industries as an influencing factor of Corporate Social Responsibility. Furthermore, we found that the latter condition would also apply when we analyze the influence of Corporate Secretary and Nomination and Remuneration Committee on Corporate Financial Performance. Abstract in Bahasa Indonesia: Penelitian ini bertujuan untuk mengidentifikasi pengaruh antara struktur Coorporate Governance yang diproksikan sebagai kepemilikan institusional, kepemilikan manajerial terhadap corporate social responsibility dan corporate social responsibility terhadap corporate financial performance. Penelitian menggunakan data sekunder dari laporan tahunan 2006 perusahaan publik yang terdapat di Pusat Referensi Pasar Modal (PRPM) Bursa Efek Indonesia (BEI). Sampel dalam penelitian ini sebanyak 126 perusahaan. Melalui pendekatan analisa jalur (path analysis) menunjukkan Good Corporate Governance yaitu kepemilikan managerial dan institusional mempunyai pengaruh terhadap kinerja perusahaan Good Corporate Governance yang diamati melalui kepemilikan managerial dan institusional, mempunyai pengaruh terhadap pengungkapan tanggung jawab sosial perusahaan (CSR). Pengujian variabel control, yaitu CEO Tenure mempunyai pengaruh terhadap pengungkapan tanggung jawab sosial perusahaan (CSR). Sedangkan jenis Industri tidak mempunyai pengaruh terhadap CSR. Untuk Corporate Secretary dan Komite Nominasi dan Remunerasi juga tidak mempunyai pengaruh terhadap kinerja perusahaan. Kata kunci: corporate governance, corporate social responsibility, corporate financial performance, kepemilikan institusio
Isolation, Characterization, and Molecular Identification of Phosphate Solubilizing Bacteria from Several Tropical Soils
Fahrizal Hazra,Etty Pratiwi
Jurnal Tanah Tropika , 2013,
Abstract: The objectives of the research were: (i) to isolate and characterize of phosphate solubilizing bacteria (PSB) and (ii) to identify PSB based on molecular amplification of 16S rRNA gene. Soil samples were collected from rhizosphere in Bogor, West Nusa Tenggara, and East Nusa Tenggara. Several stages in this research were: (i) isolation PSB in Pikovskaya agar, (ii) morphological and biochemical characterization of PSB, (iii) measurement of phosphatase enzymes, and (iv) measurement of secreting indole acetic acid phytohormone. As many as 29 isolates of PSB have been collected and three isolates of them, namely: P 3.5 (East Nusa Tenggara), P 6.2 (West Nusa Tenggara), and P 10.1 (Citeureup, West Java) were chosen for further study. There were many characteristics of isolate P 10.1: (i) it had capable to solubilize P with the value of highest solubilization index (1.80), (ii) it had the highest phosphatase enzyme (120.40 mg kg-1), and (iii) it had the highest pH decrease at each observation for six days. Isolates P 3.5 and P 10.1 were the Gram-negative bacteria with coccus shapes and isolate P 6.2 was a Gram-negative bacteria with bacillus shape. Deoxiribonucleat Acid (DNA) amplification of these bacteria employing 16S rRNA primers generated the 1,300bp-PCR product. The results of the analysis of 16S rRNA gene sequences showed that isolates P 3.5 and P 10.1 has 98% similarity with Gluconacetobacter sp. strains Rg1-MS-CO and isolate P 6.2 has 97% similarity with Enterobacter sp. pp9c strains.
Anti-Malaria Study of Nigella sativa L. Seed Water Extract in Mus musculus Mice Balb C Strain In Vivo
Tunru Insan Sosiawan,Weni Linda,Widyantia Etty
Makara Seri Sains , 2012,
Abstract: Nigella sativa L. has been reported to exhibit many pharmacological effects, including anti-parasitic properties. This study investigated the anti-malarial effects of a water extract of N. sativa seed in Mus muculus mice infected with the Plasmodium berghei NK65 parasite. The method used was to take a blood parasitaemia count, following the use of Giemsa dye, determining the level of nitric oxide in mice that were infected with P. berghei malaria, using the spectrophotometric method, and determining their survival rate after 20 days of being infected with P. berghei malaria. The results showed that the decrease in the number of parasitaemia and the level of nitric oxide in subjects treated with doses of N. sativa was significant (p < 0.05). Further results showed that P. berghei-infected mice that were given 100 μg/kg of body weight had a better chance of survival. The conclusion is that the provision of N. sativa may reduce the number of malaria parasites and reduce levels of NO. The decrease in the number of parasites may be caused by an immune mechanism, through the regulation of NO levels (lower levels of NO), due to the influence of the anti-oxidant effects of N. sativa. Survival rates of the mice did not show significant results with reduced levels of parasitaemia and NO. This is likely to be because the levels of NO in this group were below the threshold levels at which NO can function as an anti-parasitic. It is alleged that, while NO can function as an anti-parasitic at certain levels, at lower levels its function as an antiparasitic is not optimal. On the other hand, if the levels are too high, damage will result, because of the nature of free-radicals.
Matrix metalloproteinase-2 is elevated in midtrimester amniotic fluid prior to the development of preeclampsia
Michal Lavee, Shlomit Goldman, Etty Daniel-Spiegel, Eliezer Shalev
Reproductive Biology and Endocrinology , 2009, DOI: 10.1186/1477-7827-7-85
Abstract: Amniotic fluid was obtained from 133 women undergoing genetic second trimester amniocentesis. Zymography was performed for MMP characterization and an MMP-2 ELISA kit was used to determine MMP-2 levels. TIMP-2 expression was evaluated using western blot.Mean amniotic fluid MMP-2 and TIMP-2 levels were significantly higher in women who developed a hypertensive disorder compared to normotensive women (P < 0.0004 and P < 0.01, respectively). When subdivided into subgroups, amniotic fluid from women who eventually developed preeclampsia or superimposed preeclampsia showed significantly higher MMP-2 levels than normotensive women (P < 0.05). However, no statistical difference in MMP-2 levels was found between patients with gestational hypertension and normotensive patients.Higher amniotic fluid MMP-2 and TIMP-2 levels are found in women who eventually develop preeclampsia.Preeclampsia is a multi-system disorder of pregnancy characterized by hypertension, proteinuria and generalized systemic vasoconstriction. The disorder is diagnosed in the latter half of pregnancy, effects about 5% of pregnancies and accounts for considerable mortality and morbidity [1].Several models have been proposed for the pathogenesis of preeclampsia. [2-4]. Prevailing evidence suggest insufficient trophoblast invasion of the maternal spiral arteries as the main pathogenesis of the disease. Whereas in normal pregnancy the luminal diameter of the spiral arteries is greatly increased and the vascular smooth muscle is replaced by trophoblast cells, in preeclamptic pregnancies this process is deficient. The resulting under-perfused placenta attempts to compensate by promoting the secretion of factors into the maternal circulation causing systemic alterations in endothelial cell function, accounting for the clinical syndrome of preeclampsia. Although this hypothesis is widely accepted, the molecular mechanisms that regulate this pathological process are still controversial.The role of matrix metallopro
The Use of Selected Biomarkers, Phagocytic and Cholinesterase Activity to Detect the Effects of Dimethoate on Marine Mussel (Mytilus edulis)
HAYATI Journal of Biosciences , 2008,
Abstract: Effects of organophosphorous pesticide, dimethoate on blue mussels, Mytilus edulis using selected biomarkers have been studied. Mussels were exposed to serial dilutions of dimethoate, 7.88, 15.75, 31.35, and 63.00 μg/l including positive and negative controls for 14 days. The suppression effects of dimethoate on phagocytic activity significantly occurred at two lowest concentrations of dimethoate (7.88 and 15.75 μg/l), but stimulation effects significantly emerged at the following highest concentrations (31.35 and 63.00 μg/l). The declining tendency of the cholinesterase (ChE) activity (23% lower than the control) appeared when mussels exposed to 7.88 and 15.75 μg/l dimethoate. Moreover, the significant inhibition of the ChE activity occurred at 31.35 μg/l dimethoate exposure. This study suggested that the phagocytic and the ChE activity are useful biomarkers for assessing the affects of organophosporous pesticide, dimethoate on neuro-immune system of blue mussels, M. edulis.
Identification and Phylogenetic Analysis of Bacterial Isolates from Litopenaeus vannamei Shrimp Culture System and Gut Environment Based on 16SrRNA Gene Sequence Data
Microbiology Indonesia , 2009,
Abstract: Selected bacterial isolates from a Litopenaeus vannamei shrimp culture system and gut environment were assessed using 16S rRNA gene sequencing method to identify their identity and to construct their phylogenetic relationship. In a preliminary study, a total of 19 isolates were selected as probiotics. These isolates were prepared using freeze and heat-shock method to obtain the DNA template. PCR amplification of 16S ribosomal RNA gene of isolates was carried out using bacterial universal primers 9F and 1510R and was sequenced using an automated DNA sequencer. These gene sequences were compared with other gene sequences in the GenBank database (NCBI) using a BLAST search to find closely related sequences. Alignment of these sequences with sequences available from GenBank database was carried out to construct a phylogenetic tree for these bacteria. Most of the isolates obtained, i.e. 17 out of the 19 isolates, belonged to different species of Bacillus, sharing 95 to 99% 16S ribosomal RNA identity with the respective type-strain, whereas the remaining 2 isolates belonged to Micrococcus sp. and Micrococcus luteus with 97 to 99% 16S rRNA homology, consecutively.
BIOTROPIA : the Southeast Asian Journal of Tropical Biology , 2010,
Abstract: Disqualified tiger prawn broodstock has undergone ablation after two breeding periods, which causes high production cost, pollution of environment and difficulties in providing the broodstock continuously with enough quantity at an exact time. The purpose of this study was to find the proper dosage of dopamine to improve the quality for breeding of the disqualified tiger prawn, because dopamine inhibits maturation, so there will be enough time for maturation and improvement of the eggs quality.This experiment used 15 pairs of the twice breeding tiger prawn, which was collected from -9Perigi (Central Java). The samples were treated with different dosages of dopamine (dosage 10 , -8 -7 -6 10 , 10 , 10 moll and control/injected with aquabidest). The parameters identified in this experiment were duration (days) for eggs maturation, fecundity, fertilizing rate, hatching rate, egg diameter and phototaxis response of the nauplii.The research concluded that the average duration for eggs maturation on the broodstock -9 -8 -7 -6that were injected with dopamine, dosage 10 , 10 , 10 , 10 moll and control, were 14, 12, 4, 2, 5 days, respectively. Fecundities were 561.489, 503.000, 384.205, 230.850 and 150.034. Fertilizing rates were 89.8%, 82.1%, 56.0%, 46.3%, and 23.2%. Hatching rates were 79.53%, 72.53%, 47.75%, 12.27%, and 36.6%. Diameters were 0.29; 0.29; 0.29; 0.27; and 0.27 mm. The nauplii -9 -8 -7produced by injecting broodstock with dopamine dosages of 10 , 10 , 10 , have positive -6phototaxis response, while for dosage 10 and control the responses were weak.
Suwari Suwari,Etty Riani,Bambang Pramudya,Ita Djuwita
Bumi Lestari , 2011,
Abstract: The Surabaya River plays an important role as water supply of the Surabaya PDAM, irrigation, industry, transportation, and means of recreation. However, domestic, industrial, and agricultural waste that were discharged into the river stream polluted the Surabaya River and decreased the carrying capacity and assimilative capacity. Therefore, effort to monitor and control the Surabaya River water pollution need to be well organized and implemented. The aim of the research is to develop a model of water pollution control on Surabaya River region. The research was carried out based on field survey, in situ and laboratory sample examination, questionnaire, and expert judgment. Pollution control model developed in this study was built into three sub-models, namely: (1) ecology sub-model, (2) social sub-model, and (3) economy sub-model using powersim constructor 2.5 version. Pollution control scenarios were developed using prospective analysis. The results of water pollution parameters such as TSS, DO, BOD, COD, N-NO2, and the level of mercury (Hg) were higher than the allowable class 1 standard. The sources of Surabaya River pollution mainly are domestic and industrial waste with total load of BOD, COD, and TSS are 55.49, 132.58, and 210.13 ton/day, respectively. According to water quality status, the Surabaya River is categorized as heavy polluted and the loading pollution need to be decreased. By using prospective analysis, there were five important factors that affect the future of the Surabaya River water pollution control, i.e.: (1) population growth and community awareness, (2) community perception, (3) implementation of regulations, (4) commitment/local government support, and (5) system and institutional capacity. There are three development scenarios, that are pessimistic, moderate and optimistic. The moderate and optimistic scenario are the realistic scenarios that occur in the future for Surabaya River water pollution control in considering of ecology, social and economy aspects.
Protective Role of STAT3 in NMDA and Glutamate-Induced Neuronal Death: Negative Regulatory Effect of SOCS3
Keun W. Park, Susan E. Nozell, Etty N. Benveniste
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0050874
Abstract: The present study investigates the involvement of the IL-6 family of cytokines, activation of the transcription factor Signal Transducer and Activator of Transcription-3 (STAT3), and the role of Suppressor Of Cytokine Signaling-3 (SOCS3) in regulating excitotoxic neuronal death in vitro. Biochemical evidence demonstrates that in primary cortical neurons and SH-SY5Y neuroblastoma cells, IL-6 cytokine family members, OSM and IL-6 plus the soluble IL-6R (IL-6/R), prevent NMDA and glutamate-induced neuronal toxicity. As well, OSM and IL-6/R induce tyrosine and serine phosphorylation of STAT3 in primary cortical neurons and SH-SY5Y cells. Studies using Pyridine 6 (P6), a pan-JAK inhibitor, demonstrate that the protective effect of OSM and IL-6/R on neuronal death is mediated by the JAK/STAT3 signaling pathway. In parallel to STAT3 phosphorylation, OSM and IL-6/R induce SOCS3 expression at the mRNA and protein level. P6 treatment inhibits SOCS3 expression, indicating that STAT3 is required for OSM and IL-6/R-induced SOCS3 expression. Lentiviral delivery of SOCS3, an inhibitor of STAT3 signaling, into primary neurons and SH-SY5Y cells inhibits OSM and IL-6/R-induced phosphorylation of STAT3, and also reverses the protective effect of OSM and IL-6/R on NMDA and glutamate-induced neurotoxicity in primary cortical neurons. In addition, treatment with IL-6 cytokines increases expression of the anti-apoptotic protein Bcl-xL and induces activation of the Akt signaling pathway, which are also negatively regulated by SOCS3 expression. Thus, IL-6/R and OSM-induced SOCS3 expression may be an important factor limiting the neuroprotective effects of activated STAT3 against NMDA and glutamate-induced neurotoxicity.
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