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Search Results: 1 - 10 of 124 matches for " Eszter Pankotai "
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Mesenchymal stem cells rescue cardiomyoblasts from cell death in an in vitro ischemia model via direct cell-to-cell connections
Attila Cselenyák, Eszter Pankotai, Eszter M Horváth, Levente Kiss, Zsombor Lacza
BMC Cell Biology , 2010, DOI: 10.1186/1471-2121-11-29
Abstract: Our model revealed that adding normal MSCs to the ischemic cell population significantly decreased the ratio of dead H9c2 cells (H9c2 only: 0.85 ± 0.086 vs. H9c2+MSCs: 0.16 ± 0.035). This effect was dependent on direct cell-to-cell contact since co-cultivation with MSCs cultured in cell inserts did not exert the same beneficial effect (ratio of dead H9c2 cells: 0.90 ± 0.055). Confocal microscopy revealed that cardiomyoblasts and MSCs frequently formed 200-500 nm wide intercellular connections and cell fusion rarely occurred between these cells.Based on these results we hypothesize that mesenchymal stem cells may reduce the number of dead cardiomyoblasts after ischemic damage via direct cell-to-cell interactions and intercellular tubular connections may play an important role in these processes.Cardiovascular diseases represent an enormous medical and social burden [1,2] and the pathophysiology of most of these diseases, such as myocardial infarction or heart failure, involves death of cardiac myocytes leading to a loss of functional tissue. Cell based therapies are commonly believed to be the next generation of therapies for replacing such lost tissue [3-5]. Several in vivo animal and human studies have found that implantation of various cell types, typically bone marrow derived stem cells, into damaged myocardium improved cardiac performance. Also where the experimental protocol allowed, surviving grafted cells were detected in the myocardium [6,7], suggesting that grafting is an effective treatment of acute myocardial infarction [8]. However, the extent of the beneficial effect, the optimal cell type and number, the best method of administration, and the mechanism of action need to be further evaluated [9].One important issue is the exact mechanism of action, in other words, the interaction between graft and host. Paracrine factors, transdifferentiation and cell fusion are the three generally accepted hypotheses explaining the beneficial effects of stem cell graft
In Vivo Evaluation of an Injectable Premixed Radiopaque Calcium Phosphate Cement
Jonas berg,Eszter Pankotai,Gry Hulsart Billstr m,Miklós Weszl,Sune Larsson,Csaba Forster-Horváth,Zsombor Lacza,H kan Engqvist
International Journal of Biomaterials , 2011, DOI: 10.1155/2011/232574
Abstract: In this work a radiopaque premixed calcium phosphate cement (pCPC) has been developed and evaluated in vivo. Radiopacity was obtained by adding 0–40 % zirconia to the cement paste. The effects of zirconia on setting time, strength and radiopacity were evaluated. In the in vivo study a 2 by 3.5 mm cylindrical defect in a rat vertebrae was filled with either the pCPC, PMMA or bone chips. Nano-SPECT CT analysis was used to monitor osteoblast activity during bone regeneration. The study showed that by adding zirconia to the cement the setting time becomes longer and the compressive strength is reduced. All materials evaluated in the in vivo study filled the bone defect and there was a strong osteoblast activity at the injury site. In spite of the osteoblast activity, PMMA blocked bone healing and the bone chips group showed minimal new bone formation. At 12 weeks the pCPC was partially resorbed and replaced by new bone with good bone ingrowth. The radiopaque pCPC may be considered to be used for minimal invasive treatment of vertebral fractures since it has good handling, radiopacity and allows healing of cancellous bone in parallel with the resorption of the cement.
Cytoprotective and anti-inflammatory effects of hydrogen sulfide in macrophages and mice
C Szabo, L Kiss, E Pankotai
Critical Care , 2007, DOI: 10.1186/cc5162
Abstract:
The Threat of Otherness in Bram Stocker's Dracula
Eszter Muskovits
Trans : Revue de Littérature Générale et Comparée , 2010,
Abstract: La deuxième moitié du XIXe siècle a constitué un tournant dans la conceptualisation des pratiques et comportements sexuels dans les sociétés occidentales. L’hétéro-normativité monogame a commencé à être contestée, et c’est probablement le roman gothique qui a offert le médium le plus adapté pour renverser le concept traditionnel de la sexualité. L’objectif de cet article est d’explorer le caractère ambigu du vampire dans le Dracula de Bram Stoker (1897), un agencement possible de ce que le système sexuel normatif patriarcal a marginalisé comme autre . The second half of the nineteenth century was a turning point in conceptualizing sexual practices and behaviour in Western societies. Monogamous heteronormativity was beginning to be challenged, and it was probably the gothic novel that offered the most flexible medium for subverting the traditional concept of sexuality. The purpose of this paper is to explore the ambiguous character of the vampire in Bram Stoker’s Dracula (1897); a possible agency of what the normative patriarchal gender system marginalized as ‘other.’
Save the Children of War! Thoughts on Child Recruitment
Eszter Kirs
Acta Societatis Martensis , 2006,
Abstract: The article addresses the problematic and urgent questions arising from the phenomenon of child soldiering. Children are cheap, obedient and easy to engage in fearless killing. These characteristics compel the leaders of armed groups to choose children for improving their armed forces. Fighting, lack of family and all the abuse which child-soldiers suffer cause — beyond the physical damage — very serious psycho-social problems. Reintegration is extremely difficult because of the way their personality has changed as a consequence of war. Therefore, prevention of child recruitment has a great significance which shall be ensured by proper legal regulation also in the field of international law.
Simultaneous observability of networks of beams and strings
Eszter Sikolya
Boletim da Sociedade Paranaense de Matemática , 2003,
Abstract: In this paper we investigate a nite system of vibrating beams andstrings. We obtain results on simultaneous observability by observing a common endpoint.
Notes on the characterization of derivations
Eszter Gselmann
Mathematics , 2013,
Abstract: Although the characterization of ring derivations has an extensive literature, up to now, all of the characterizations have had the following form: additivity and another property imply that the function in question is a derivation. The aim of this note is to point out that derivations can be described via a single equation.
Recent results on the stability of the parametric fundamental equation of information
Eszter Gselmann
Mathematics , 2013,
Abstract: The purpose of this paper is to summarize the recent results on the stability of the parametric fundamental equation of information. Furthermore, by the help of a modification of a method we used in \cite{GM08} we shall give a unified proof for the Hyers--Ulam stability of the equation in question, assuming that the parameter does not equal to 1. As a corollary of the main result, a system of equations, that defines the recursive and semi--symmetric information measures is also discussed.
On the modified entropy equation
Eszter Gselmann
Mathematics , 2013,
Abstract: The object of this paper is to solve the so--called modified entropy equation \[ f=f+ \muf<\mathbf{0}, \frac{y}{y+z}, \frac{z}{y+z}>, \] on the positive cone of $\R^{k}$, where $\mu$ is a given multiplicative function on this cone. After that the regular solutions of this equation are determined. Furthermore we investigate its connection between the entropy equation and other equations, as well.
On the stability of the modified entropy equation
Eszter Gselmann
Mathematics , 2013, DOI: 10.1007/s00025-010-0053-1
Abstract: The aim of this paper is to prove that under some conditions the modified entropy equation is stable on its one-dimensional domain.
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