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Search Results: 1 - 10 of 136472 matches for " Eszter Angéla Tóth "
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TGFβ Activated Kinase 1 (TAK1) at the Crossroad of B Cell Receptor and Toll-Like Receptor 9 Signaling Pathways in Human B Cells
Dániel Szili, Zsuzsanna Bankó, Eszter Angéla Tóth, Gy?rgy Nagy, Bernadette Rojkovich, Tamás Gáti, Melinda Simon, Zoltán Hérincs, Gabriella Sármay
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096381
Abstract: B cell development and activation are regulated by combined signals mediated by the B cell receptor (BCR), receptors for the B-cell activating factor of the tumor necrosis factor family (BAFF-R) and the innate receptor, Toll-like receptor 9 (TLR9). However, the underlying mechanisms by which these signals cooperate in human B cells remain unclear. Our aim was to elucidate the key signaling molecules at the crossroads of BCR, BAFF-R and TLR9 mediated pathways and to follow the functional consequences of costimulation.Therefore we stimulated purified human B cells by combinations of anti-Ig, B-cell activating factor of the tumor necrosis factor family (BAFF) and the TLR9 agonist, CpG oligodeoxynucleotide. Phosphorylation status of various signaling molecules, B cell proliferation, cytokine secretion, plasma blast generation and the frequency of IgG producing cells were investigated. We have found that BCR induced signals cooperate with BAFF-R- and TLR9-mediated signals at different levels of cell activation. BCR and BAFF- as well as TLR9 and BAFF-mediated signals cooperate at NFκB activation, while BCR and TLR9 synergistically costimulate mitogen activated protein kinases (MAPKs), ERK, JNK and p38. We show here for the first time that the MAP3K7 (TGF beta activated kinase, TAK1) is responsible for the synergistic costimulation of B cells by BCR and TLR9, resulting in an enhanced cell proliferation, plasma blast generation, cytokine and antibody production. Specific inhibitor of TAK1 as well as knocking down TAK1 by siRNA abrogates the synergistic signals. We conclude that TAK1 is a key regulator of receptor crosstalk between BCR and TLR9, thus plays a critical role in B cell development and activation.
A comperative clinical study of mucotomy and KTP laser treatment of the inferior turbinate in allergic and non-allergic subjects  [PDF]
ágnes Patzkó, Eszter Tóth, Krisztina Somogyvári, Imre Gerlinger
Health (Health) , 2010, DOI: 10.4236/health.2010.211191
Abstract: Mucotomy is one of the most frequently applied surgical techniques for the management of inferior turbinate hyperplasia. Mucotomy guarantees patent airway, however, it might lead to the emergence of sicca syndrome. In contrast, KTP (potassium titanyl phosphate) laser treatment spares the medial part of the inferior turbinate mucosa, contributing to maintenance of physiological nasal function. A retrospective comparative clinical study was performed to reveal the advantages and side-effects of both surgical methods in medium- and long-term in allergic rhinitis and non-allergic patients. Furthermore, we wished to determine the exact indications of the up-to-date laser treatment. Ninety-one of the 117 patients who underwent bilateral turbinate surgery during an 8-year period (2000-2007) responded to our questionnaire focusing on subjective postoperative changes. Patients were separated into 6 groups, based on the type of operation they underwent, the length of the follow-up and whether they suffered from allergies. The major complaint, nasal obstruction, improved in all 6 groups, which reached significance (p ? 0.05) in 4 groups. The most pronounced improvement was observed in the group of non-allergic patients with medium-term follow-up who underwent mucotomy. Nevertheless, a serious side- effect: crusting also increased significantly (p ? 0.05) in the latter group, while it was absent in allergic patients with medium-term follow-up, who underwent mucotomy. These results lead us to propose the following protocol for the treatment of inferior turbinate hyperplasia: 1) after unsuccessful conservative treatment, laser treatment is suggested for non-allergic patients; 2) following unsuccessful conservative and even repeated laser treatment in the allergic group, mucotomy or turbinoplasty should be attempted.
Chemical and Colloidal Stability of Carboxylated Core-Shell Magnetite Nanoparticles Designed for Biomedical Applications
Márta Szekeres,Ildikó Y. Tóth,Erzsébet Illés,Angéla Hajdú,István Zupkó,Katalin Farkas,Gábor Oszlánczi,László Tiszlavicz,Etelka Tombácz
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140714550
Abstract: Despite the large efforts to prepare super paramagnetic iron oxide nanoparticles (MNPs) for biomedical applications, the number of FDA or EMA approved formulations is few. It is not known commonly that the approved formulations in many instances have already been withdrawn or discontinued by the producers; at present, hardly any approved formulations are produced and marketed. Literature survey reveals that there is a lack for a commonly accepted physicochemical practice in designing and qualifying formulations before they enter in vitro and in vivo biological testing. Such a standard procedure would exclude inadequate formulations from clinical trials thus improving their outcome. Here we present a straightforward route to assess eligibility of carboxylated MNPs for biomedical tests applied for a series of our core-shell products, i.e., citric acid, gallic acid, poly(acrylic acid) and poly(acrylic acid- co-maleic acid) coated MNPs. The discussion is based on physicochemical studies (carboxylate adsorption/desorption, FTIR-ATR, iron dissolution, zeta potential, particle size, coagulation kinetics and magnetization measurements) and involves in vitro and in vivo tests. Our procedure can serve as an example to construct adequate physico-chemical selection strategies for preparation of other types of core-shell nanoparticles as well.
Elementary proof techniques for the maximum number of islands
János Barát,Péter Hajnal,Eszter K. Horváth
Mathematics , 2009,
Abstract: Islands are combinatorial objects that can be intuitively defined on a board consisting of a finite number of cells. Based on the neighbor relation of the cells, it is a fundamental property that two islands are either containing or disjoint. Recently, numerous extremal questions have been answered using different methods. We show elementary techniques unifying these approaches. Our building parts are based on rooted binary trees and discrete geometry. Among other things, we show the maximum cardinality of islands on a toroidal board and in a hypercube. We also strengthen a previous result by rarefying the neighborhood relation.
THE FORMATION OF THE PRECIPITATION BASED ON THE LONG TIME SERIES OF THE METEOROLOGICAL OBSERVATION OF KESZTHELY
Tímea KOCSIS,Angéla ANDA
Journal of Central European Agriculture , 2007,
Abstract: Almost all of the meteorological elements have influence on the success of the agricultural cultivation, but in Hungary among all of these elements precipitation is the most capricious one. The aim of our research is to detect the changes in the 130-year-long time series of precipitation. The precipitation at Keszthely shows a not significant decreasing trend of 42 mm less rainfall in a 100 year long period. The seasonal amounts of rainfall -except for winter- are decreasing. The significantly reduced amount of spring is an unfavorable factor for agriculture. The usual secondary maximum of the yearly precipitation in the autumn at Keszthely seems to vanish. Our farmers must count on at least one period of more than 15 days without rainfall, or two dry periods of 10-14 days length in a vegetation period.
Coexistence of the Hypersecretion of Catecholamine, Adrenal Cortical Nodular Hyperplasia, and Nephrotic-Range Proteinuria of Focal Segmental Scleronephrosis: Is It Fat-Induced Hypertension?  [PDF]
Khanh Vinh Qu?c Luong, Lan Th? Hòang Nguy?n, S? V?n Nguy?n, Ninh T Nguy?n
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.23034
Abstract: Two patients had a long history of hypertension and one of them also had a nephrotic-range proteinuria secondary to focal segmental scleronephrosis which had been diagnosed by kidney biopsy. They presented with uncontrolled hypertension. Laboratory examination suggested hypersecretion of catecholamines by the left adrenal glands in both patients and primary aldosteronism in one of them. A computed tomography scan revealed small nodules on left adrenal gland in both patients. Patients underwent laparoscopic left adrenalectomy. After surgery, blood pressure was normalized and proteinuria was resolved. Most interestingly, prominent adipocytes infiltrated were detected in the adrenal cortex and were associated with the presence of lymphocytes, which suggested that adipocytes might have a role in the pathogenesis of these diseases in our patients.
Restriction Enzyme Body Doubles and PCR Cloning: On the General Use of Type IIS Restriction Enzymes for Cloning
Eszter Tóth, Krisztina Huszár, Petra Bencsura, Péter István Kulcsár, Barbara Vodicska, Antal Nyeste, Zsombor Welker, Szilvia Tóth, Ervin Welker
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090896
Abstract: The procedure described here allows the cloning of PCR fragments containing a recognition site of the restriction endonuclease (Type IIP) used for cloning in the sequence of the insert. A Type IIS endonuclease - a Body Double of the Type IIP enzyme - is used to generate the same protruding palindrome. Thus, the insert can be cloned to the Type IIP site of the vector without digesting the PCR product with the same Type IIP enzyme. We achieve this by incorporating the recognition site of a Type IIS restriction enzyme that cleaves the DNA outside of its recognition site in the PCR primer in such a way that the cutting positions straddle the desired overhang sequence. Digestion of the PCR product by the Body Double generates the required overhang. Hitherto the use of Type IIS restriction enzymes in cloning reactions has only been used for special applications, the approach presented here makes Type IIS enzymes as useful as Type IIP enzymes for general cloning purposes. To assist in finding Body Double enzymes, we summarised the available Type IIS enzymes which are potentially useful for Body Double cloning and created an online program (http://group.szbk.u-szeged.hu/welkergr/b?ody_double/index.html) for the selection of suitable Body Double enzymes and the design of the appropriate primers.
Mesenchymal stem cells rescue cardiomyoblasts from cell death in an in vitro ischemia model via direct cell-to-cell connections
Attila Cselenyák, Eszter Pankotai, Eszter M Horváth, Levente Kiss, Zsombor Lacza
BMC Cell Biology , 2010, DOI: 10.1186/1471-2121-11-29
Abstract: Our model revealed that adding normal MSCs to the ischemic cell population significantly decreased the ratio of dead H9c2 cells (H9c2 only: 0.85 ± 0.086 vs. H9c2+MSCs: 0.16 ± 0.035). This effect was dependent on direct cell-to-cell contact since co-cultivation with MSCs cultured in cell inserts did not exert the same beneficial effect (ratio of dead H9c2 cells: 0.90 ± 0.055). Confocal microscopy revealed that cardiomyoblasts and MSCs frequently formed 200-500 nm wide intercellular connections and cell fusion rarely occurred between these cells.Based on these results we hypothesize that mesenchymal stem cells may reduce the number of dead cardiomyoblasts after ischemic damage via direct cell-to-cell interactions and intercellular tubular connections may play an important role in these processes.Cardiovascular diseases represent an enormous medical and social burden [1,2] and the pathophysiology of most of these diseases, such as myocardial infarction or heart failure, involves death of cardiac myocytes leading to a loss of functional tissue. Cell based therapies are commonly believed to be the next generation of therapies for replacing such lost tissue [3-5]. Several in vivo animal and human studies have found that implantation of various cell types, typically bone marrow derived stem cells, into damaged myocardium improved cardiac performance. Also where the experimental protocol allowed, surviving grafted cells were detected in the myocardium [6,7], suggesting that grafting is an effective treatment of acute myocardial infarction [8]. However, the extent of the beneficial effect, the optimal cell type and number, the best method of administration, and the mechanism of action need to be further evaluated [9].One important issue is the exact mechanism of action, in other words, the interaction between graft and host. Paracrine factors, transdifferentiation and cell fusion are the three generally accepted hypotheses explaining the beneficial effects of stem cell graft
Lattice induced threshold functions and Boolean functions
Eszter K. Horváth,Branimir Seselja,Andreja Tepavcevic
Mathematics , 2013,
Abstract: Lattice induced threshold function is a Boolean function determined by a particular linear combination of lattice elements. We prove that every isotone Boolean function is a lattice induced threshold function and vice versa. We also represent lattice valued up-sets on a finite Boolean lattice in the framework of cuts and lattice induced threshold functions. In terms of closure systems we present necessary and sufficient conditions for a representation of lattice valued up-sets on a finite Boolean lattice by linear combinations of elements of the co-domain lattice.
Rothmund-thomson syndrome and cutan T-cell lymphoma in childhood  [PDF]
Katalin Bartyik, K. Míta Gábor,la Iványi, István Németh, Eszter Karg
Open Journal of Pediatrics (OJPed) , 2013, DOI: 10.4236/ojped.2013.33047
Abstract:

We report a 3-year-old girl suffering from RothmundThomson Syndrome (RTS). The patient at birth had multiplex anomalies: poikilodermatous rash, sceletal abnormalities: palatoschisis, micrognathi, aplasia radii, hypoplastic right and left thenar and thumbs, pesequinus on both site, ectopy renis. The patient in the later ages was detected dental malformation, facial dysmorfism. At the age 3, she had lasion in her muscle. After biopsy, histological examination showed cutan T-cell lymphoma. The patient is the first case who had cutan T-cell lymphoma associated with RTS in this young age.

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