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Search Results: 1 - 10 of 863 matches for " Esraa Abdallah Abdelkariem Gadallah "
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Efficacy of Nilotinib versus Imatinib in Philadelphia Positive Patients with Chronic Myeloid Leukemia in Early Chronic Phase Who Have a Warning Molecular Response to Imatinib  [PDF]
Amen Hamdy Zaky Aly, Ahmed EL Sayed Mohammed Khalifa, Esraa Abdallah Abdelkariem Gadallah
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.911073
Abstract: Background and Objectives: Chronic myeloid leukemia (CML) accounts for approximately 15% of newly diagnosed cases of leukemia in adults. In this study, the efficacy of nilotinib at 400 mg BID is compared with imatinib at 400 mg BID in CML patients with suboptimal molecular response after at least 12 months of daily dose 400 mg of imatinib therapy. Patients and Methods: This study included a total number of 50 patients, divided into two groups (25 patients each). The first group (Group I): Patients received imatinib at 400 mg BID, second group (Group II): Patients had a suboptimal molecular response to imatinib and received nilotinib at 400 mg BID in early chronic phase. During the two years period of data collection, the primary end included median survival. The secondary end included response rate, type of response, duration of response and progression free survival. Also side effects were recorded. Patients were followed up every month by complete and differential blood counts, liver function test, renal function test and (PCR) every three months for two year. Results: Nilotinib group had significantly higher frequency of major molecular response (MMR) where 23 (92%) patients achieved it while only 16 (64%) patients in Imatinib group achieved MMR (P = 0.01). Nilotinib had better toxicities profile than Imatinib. Conclusion: Both Nilotinib and high dose Imatinib achieved response in CML patients with suboptimal response with rapid and deeper molecular response, better survival outcomes and less side effects in nilotinib.
An Adaptive OFDMA-Based MAC Protocol for Underwater Acoustic Wireless Sensor Networks
Issa M. Khalil,Yasser Gadallah,Mohammad Hayajneh,Abdallah Khreishah
Sensors , 2012, DOI: 10.3390/s120708782
Abstract: Underwater acoustic wireless sensor networks (UAWSNs) have many applications across various civilian and military domains. However, they suffer from the limited available bandwidth of acoustic signals and harsh underwater conditions. In this work, we present an Orthogonal Frequency Division Multiple Access (OFDMA)-based Media Access Control (MAC) protocol that is configurable to suit the operating requirements of the underwater sensor network. The protocol has three modes of operation, namely random, equal opportunity and energy-conscious modes of operation. Our MAC design approach exploits the multi-path characteristics of a fading acoustic channel to convert it into parallel independent acoustic sub-channels that undergo flat fading. Communication between node pairs within the network is done using subsets of these sub-channels, depending on the configurations of the active mode of operation. Thus, the available limited bandwidth gets fully utilized while completely avoiding interference. We derive the mathematical model for optimal power loading and subcarrier selection, which is used as basis for all modes of operation of the protocol. We also conduct many simulation experiments to evaluate and compare our protocol with other Code Division Multiple Access (CDMA)-based MAC protocols.
Rheological, Organoleptical and Quality Characteristics of Gluten-Free Rice Cakes Formulated with Sorghum and Germinated Chickpea Flours  [PDF]
Mohamed G. E. Gadallah
Food and Nutrition Sciences (FNS) , 2017, DOI: 10.4236/fns.2017.85037
Abstract: Gluten-free bakery products are produced for people suffering from celiac disease due to sensitivity to gluten. So, the aim of this work was to study the effect of partial substitution of rice flour at 20%, 30% and 40% with sorghum and germinated chickpea flours on rheological, physical, sensory properties and staling rate of prepared gluten-free cake. Obtained results showed that germinated chickpea flour had the highest contents of crude protein (23.62%), lipids (4.89%) and crude fibers (5.76%) as compared to other grain flours. Gradual increase in gelatinization temperature and decrease in maximum viscosity and setback were fond of cake batters with increasing the substituting levels of rice flour from 20% to 40% with sorghum or germinated chickpea flours in comparison to rice flour batter. No significant difference was observed in specific volume between rice cake and cake containing 20% of germinated chickpea and sorghum flours which given 2.71, 2.62 and 2.56 cm3/g, respectively. Data also revealed that gluten-free cake lightness (L*) and total intensity significantly increased with 40% of sorghum flour followed by 30 and 20% of sorghum flour. Substitution of 40% rice flour with germinated chickpea flour resulted in significant high in redness (a*), yellowness (b*) and chroma of gluten-free cake being 11.95, 33.72 and 35.77, respectively followed by substituted levels 30% and 20% which attributed to their natural yellow pigments compared with other investigated samples. Overall acceptability of gluten-free cakes was improved after adding 20, 30% of sorghum flour and 20% of germinated chickpea flour which being 90.7, 88.6 and 87.5, respectively compared to rice flour cake (88.4). Rice flour cake was more freshness than wheat flour cake and other treatments during storage duration. After 6 days, rice cake had significant high freshness (306.2%) followed by gluten-free cake samples with 20% of sorghum or germinated chickpea flours which given 294.5% and 289.4%, respectively. Generally, it could be concluded that the quality and nutritional properties of gluten-free
Silica Gel Supported Hydrophobic Ionic Liquid for Selective Extraction and Determination of Coumarin  [PDF]
Hadi M. Marwani, Esraa M. Bakhsh
American Journal of Analytical Chemistry (AJAC) , 2013, DOI: 10.4236/ajac.2013.41002

In this study, a modified silica gel surface with a hydrophobic ionic liquid (SG-1,10-PhenanNTf2) was used as an adsorbent for a selective extraction of coumarin prior to its determination by use of high performance liquid chromatography. Results demonstrated that SG-1,10-PhenanNTf2 phase had a good adsorption capacity up to 85.29 mg?g?1, high selectivity, good site accessibility and fast binding kinetics toward coumarin. The adsorption capacity for coumarin was improved by 62.33% with the SG-1,10-PhenanNTf2 phase as compared to activated silica gel. Adsorption isotherm data displayed that the adsorption process was mainly monolayer on a homogeneous adsorbent surface, confirming the validity of Langmuir adsorption isotherm model. The adsorption of coumarin on the SG-1,10-PhenanNTf2 phase was accomplished after only 60 min contact time. Results of kinetic models showed that the adsorption of coumarin on the SG-1,10-PhenanNTf2 phase obeyed a pseudo second-order kinetic model. Finally, the efficiency of this methodology was confirmed by applying it to real water samples.

Value Addition on Nutritional and Sensory Properties of Biscuit Using Desert Truffle (Terfezia claveryi) Powder  [PDF]
Mohamed G. E. Gadallah, Ihab S. Ashoush
Food and Nutrition Sciences (FNS) , 2016, DOI: 10.4236/fns.2016.712109
Abstract: Desert truffle is popular nutritious food that shows high content of protein, fibers, phenolic compounds and health promoting bioactive compounds. The aim of present study is to produce fortified functional biscuits by incorporated Dessert Truffle Powder (DTP). The effect of replacing 0 (control), 5%, 10% and 15% of wheat flour with DTP on chemical composition, antioxidant activity, physical properties and sensory characteristics of biscuits was investigated. The results revealed that the crude protein, ash and crude fiber content of prepared biscuits improved with the incorporation of DTP. Phenolic contents of fortified biscuits were increased gradually with increasing the level of DTP addition. Furthermore, all the selected levels of DTP incorporated in prepared biscuits showed a good ability in radical scavenging activity which ranged from 21.52% to 42.11%, compared to 2.08% in case of control biscuit. Data also indicated that replacing 5% and 10% of wheat flour with DTP in biscuit preparation resulted in high significance of spread ratio 8.78 and 8.59, respectively when compared to control biscuit which given 7.53. The lightness (L) and total intensity of biscuits were decreased from 71.19 to 60.31 and from 76.09 to 66.87 with increasing the substitution level of DTP in biscuits from 5% to 15%, respectively. Biscuits incorporated with DTP at up to 10% had the acceptable mean scores by panelists for all sensory attributes. There was no significant difference in overall acceptability of biscuits incorporated with 5% and 10% of DTP which recorded 7.4 and 7.5 and control biscuit 8.2, respectively. Thus, the present study concluded that replacing up to 10% of wheat flour with DTP enhanced the nutritional quality and antioxidant activity with acceptable sensory characteristics of biscuits. So, our study recommends encouraging the bakery products producers to incorporated DTP at 10% in biscuits production.
Simultaneous Determination of Amlodipine and Valsartan
Nashwah Gadallah Mohamed
Analytical Chemistry Insights , 2012, DOI: 10.4137/ACI.S7282
Abstract: A spectrophotometric method was developed for simultaneous determination of amlodipine (Aml) and valsartan (Val) without previous separation. In this method amlodipine in methanolic solution was determined using zero order UV spectrophotometry by measuring its absorbency at 360.5 nm without any interference from valsartan. Valsartan spectrum in zero order is totally overlapped with that of amlodipine. First, second and third derivative could not resolve the overlapped peaks. The first derivative of the ratio spectra technique was applied for the measurement of valsartan. The ratio spectrum was obtained by dividing the absorption spectrum of the mixture by that of amlodipine, so that the concentration of valsartan could be determined from the first derivative of the ratio spectrum at 290 nm. Quantification limits of amlodipine and valsartan were 10–80 μg/ml and 20–180 μg/ml respectively. The method was successfully applied for the quantitative determination of both drugs in bulk powder and pharmaceutical formulation.
Optimization Formulation Based on Limited Data and RSM: An Approximation
Mohamed H. Gadallah
Lecture Notes in Engineering and Computer Science , 2009,
Computer Simulation-based Optimization: Hybrid Branch & Bound and Orthogonal Array based Enumeration Algorithm
Mohamed H. Gadallah
Lecture Notes in Engineering and Computer Science , 2009,
Simultaneous Determination of Amlodipine and Valsartan
Nashwah Gadallah Mohamed
Analytical Chemistry Insights , 2011,
How Ideas Turn into an Active Force in Society  [PDF]
Abdallah Hidri
Advances in Journalism and Communication (AJC) , 2019, DOI: 10.4236/ajc.2019.71001
Abstract: The Most prominent feature of social media and personal blogging websites is that, with their advanced and flexible nature, they are now media under the management of social individuals all involved in the sensmaking and reality shaping processes and remain thanks to their design of the communicative environment with the greatest influence on the techno-social activities of society. Given the fact that this environment was distinctive from its early days with a strong flavor of individualism—through language mostly—it actually brought back the romanticism of the 18th century that swept across the fields literature, arts and philosophy and dragged it right to the center of the media focus declaring a veritable revolution against the ways of the classic institutionalized media ruled by the standards and the ethics of media. Social media are now considered the effective drive of crisis management and the true vehicle of the public opinion as it would appear form social and political events fa?ades, as it would be—for instance—in the case of the Arab Spring, or the events of July 2016 Turkish failed coup d’état. But how again? How social media could be the media environment on which ideas could turn into an active force of society?
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