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Search Results: 1 - 10 of 464800 matches for " Ernesto A.;Marcolin "
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Antiretroviral therapy during pregnancy and early neonatal life: consequences for HIV-exposed, uninfected children
El Beitune, Patrícia;Duarte, Geraldo;Quintana, Silvana Maria;Figueiró-Filho, Ernesto A.;Marcolin, Alessandra Cristina;Abduch, Renata;
Brazilian Journal of Infectious Diseases , 2004, DOI: 10.1590/S1413-86702004000200004
Abstract: women have emerged as the fastest growing human immunodeficiency virus (hiv) infected population worldwide, mainly because of the increasing occurrence of heterosexual transmission. most infected women are of reproductive age and one of the greatest concerns for both women and their physicians is that more than 1,600 infants become infected with hiv each day. almost all infections are a result of mother-to-child transmission of hiv. with the advent of combination antiretroviral therapies, transmission rates lower than 2% have been achieved in clinical studies. antiretroviral compounds differ from most other new pharmaceutical agents in that they have become widely prescribed in pregnancy in the absence of proof of safety. we reviewed antiretroviral agents used in pregnant women infected with human immunodeficiency virus, mother-to-child transmission, and their consequences for infants.
Fausto A. Panizzolo,Giuseppe Marcolin,Nicola Petrone
Journal of Sports Science and Medicine , 2013,
Abstract: The aims of this study were to examine two ski simulators, Skimagic and Skier's Edge, and to evaluate their efficacy as functional training devices for skiers. Vertical ground reaction forces, knee flexion angle kinematics and muscles activity were recorded on these devices and compared with those measured in similar condition while skiing on snow. Five ski instructors performed three randomized testing sessions (snow, Skimagic and Skier's Edge). During the testing sessions, vertical ground reaction forces were recorded by means of pressure insoles in synchronisation with a portable data logger that collected values of knee flexion-extension and EMG activation of rectus femoris and vastus medialis. EMG activations and ground reaction forces measured while skiing on simulators were lower than on snow. Although less overall EMG activation was present on the simulators, the pattern of EMG activity was closer to real snow on Skimagic than on Skiers' Edge. Results of the present study suggested that the two devices are not effectively applicable for strength training. However, based on the recorded EMG patterns, the Skimagic treadmill is potentially suitable to act as a functional training device for recreational skiers provided that an increase of speed and slope on Skimagic could induce a closer matching of the studied biomechanical parameters with the snow skiing conditions.
Efeito diabetogênico das drogas anti-retrovirais em ratas Wistar prenhes
Figueiró-Filho, Ernesto Antonio;Duarte, Geraldo;El Beitune, Patrícia;Quintana, Silvana Maria;Marcolin, Alessandra Cristina;
Revista Brasileira de Ginecologia e Obstetrícia , 2004, DOI: 10.1590/S0100-72032004000100005
Abstract: purpose: to experimentally evaluate the diabetogenic effects of antiretroviral drugs on pregnant wistar rats and the perinatal effects on the offspring. methods: adult female pregnant wistar rats weighing 200-230 g were used. the antiretroviral drugs zidovudine (zdv), lamivudine (3tc) and nelfinavir (nfv) were used alone and in association at daily doses of ten times the dose normally used in pregnant women, proportionally to the animal's body weight. seven groups were studied, including the control. the experiment started on day 0 of pregnancy and the pregnant animals were sacrificed on day 21. the fetuses were counted and weighed. blood determinations of glucose, insulin, glucagon and lactate were performed on day 21. the retroperitoneal adipose tissue was weighed. data were analyzed statistically by student's t-test. results: the groups treated with 3tc, zdv + 3tc and zdv + 3tc + nfv showed decreasing values of maternal daily body weight gain, retroperitoneal adipose tissue weight and weight of fetuses (control group: 6.2 g; 3tc group variation: 4.1-5.6 g). the serum lactate levels were also decreased when compared to the control in these groups (control group: 5.8 mmol/ml; 3tc group variations: 3.2-3.7 mmol/ml). all antiretroviral-treated groups showed a decreasing number of fetuses when compared to the control (control group: 14.7; drug group variation: 11.1-12.7). all treated groups also showed decreasing serum values of insulin (control group: 6.2 μiu/ml; drug group variation: 2.1 to 2.7 μiu/ml) and increasing serum levels of glucagon when compared to the control (control group: 88.2 pg/ml; drug group variation: 99.7 to 120.7 pg/ml). there was no statistical significance of glucose levels when comparing treated groups to the control. conclusions: the antiretroviral drugs interfered in carbohydrate metabolism of pregnant rats and reduced the number of fetuses. 3tc caused less maternal body weight gain, decreased fetus weight and lactate and insulin levels and
O uso de anti-retrovirais em gestantes modifica o perfil lipídico?
El Beitune, Patrícia;Duarte, Geraldo;Santos, José Ernesto dos;Quintana, Silvana Maria;Figueiró-Filho, Ernesto Antonio;Marcolin, Alessandra Cristina;
Revista Brasileira de Ginecologia e Obstetrícia , 2003, DOI: 10.1590/S0100-72032003000800008
Abstract: purpose: to investigate the effect of antiretroviral drugs on the lipid metabolism in hiv-infected pregnant women. methods: a prospective study was conducted on 57 pregnant women. the women were divided into three groups: zdv group, consisting of 20 hiv-infected women taking zdv; tt group, consisting of 25 hiv-1-infected women on triple antiretroviral treatment (zdv + 3tc + nfv), and control group, consisting of 12 pregnant women considered to be normal from a clinical and laboratory viewpoint. demographic and anthropometric data were homogeneous. patients with a personal and family history of hyperlipidemia were excluded. blood samples were obtained for the determination of fasting lipids (total cholesterol, ldl and hdl, and triglycerides) at four periods during pregnancy (1st = 14-20 weeks; 2nd = 21-26 weeks; 3rd = 27-32 weeks and 4th = 33-38 weeks). data were analyzed statistically using the nonparametric c2, friedman and kruskal-wallis tests . results: the use of antiretroviral drugs during pregnancy induced no difference in total or hdl cholesterol but caused an increase from 76.5 and 84 mg/dl to 96 and 105 mg/dl in the concentration of the ldl fraction along gestation in zdv and tt groups, respectively (p<0.01). a positive significant association was observed between triglycerides and viral burden in the zdv group (r: 0.534; p=0.015). conclusion: antiretroviral agents during pregnancy increase serum ldl-colesterol levels. the risk of pregnancy regarding potentiation of long-term antiretroviral effects on lipid metabolism, remains to be established.
Trazodona: farmacologia e intera??es medicamentosas
Cantarelli, Maria da Gra?a;Marcolin, Marco Antonio;
Revista de Psiquiatria Clínica , 2006, DOI: 10.1590/S0101-60832006000600006
Abstract: background: trazodone is an atypical antidepressant with further therapeutic effects on anxiety and sleep disorders. objective: to review the pharmacokinetic and pharmacodynamic properties of trazodone in order to better understand the potential of adverse events related to drug interactions. methods: electronic search of medline and high wire press databases using the keywords: "trazodone", "adverse drug reaction", and "drug interaction". additional references were obtained from pharmacology textbooks. results: a comprehensive data set on the pharmacological profile of trazodone was obtained. conclusion: trazodone is being increasedly prescribed no only to depressive and sleep disorders, but also in certain sexual dysfunctions. the risk of adverse events due to drug interactions is acceptable and manageable, rendering trazodone a useful tool in the treatment of psychiatric and related disorders.
Efeitos das drogas anti-retrovirais sobre o metabolismo glicídico e células de Langerhans de pancreas de ratas Wistar prenhes
Figueiró-Filho, Ernesto Antonio;El Beitune, Patrícia;Rudge, Marilza Cunha Vieira;Quintana, Silvana Maria;Marcolin, Alessandra Cristina;Duarte, Geraldo;
Revista Brasileira de Ginecologia e Obstetrícia , 2004, DOI: 10.1590/S0100-72032004000500005
Abstract: objective: to assess the action of antiretroviral drugs on glycid metabolism and on the pancreas of pregnant wistar rats. methods: adult pregnant wistar rats weighing 200-230g were used. azidothymidine, lamivudine and nelfinavir were administered to the animals at doses 10 times higher than those administered to pregnant women. the animals were divided into seven groups of 10 animals, including a control group. the animals were sacrificed on the 21st day of pregnancy and glycemia, insulinemia, glucagonemia, free fatty acids (ffa) and hepatic glycogen were measured. direct counts of the number of immunohistochemically labeled insulin- and glucagon-producing cells were used to determine pancreatic damage. data were analyzed statistically by the student's t-test comparing each treated group with the control group. results: increased serum glucagon (control group: 88.2 pg/ml; treated groups: 99.7-120.7 pg/ml) and reduced insulin (control group: 6.2 miu/ml; treated groups: 2.1-2.7 miu/ml) were observed in all groups treated with antiretroviral drugs after 21 days of pregnancy. there was no significant difference between the experimental groups and the control in glycemia, plasma ffa or hepatic glycogen. also, there was no significant difference in number of insulin- and glucagon-producing cells between the treated groups and the control. conclusion: treatment of noninfected rats with antiretroviral drugs during pregnancy altered maternal glycid metabolism causing insulin decrease and glucagon elevation, with normal glycemia and unchanged number of pancreatic cells.
Encuentros: entre la palabra y la imagen
Marina Marcolin
álabe , 2012,
World Soybean Trade: Growth and Sustainability  [PDF]
Ian McFarlane, Ernesto A. O’Connor
Modern Economy (ME) , 2014, DOI: 10.4236/me.2014.55054

Soybeans can be consumed directly as food, and in China they are the major ingredient in food products such as tofu and soy milk, but direct consumption is small relative to their wider use in animal feed, and it is the requirement for livestock feed that drives international trade. Rapid growth of economies and population, especially in Asia, has led to increased demand for animal protein and cooking oil. This paper analyses the recent growth in supply of soybeans from North and South America to China, and considers the factors that may affect this trade in future; a contrast is made with supply from North and South America to Europe, which has not been increasing. The constraints preventing an increase in supply of soybeans to Europe are reviewed. The paper concludes with brief discussion of the factors which will affect world markets for soybeans and soybean products in future.

Controle de polidramnio recorrente em gestante portadora do HIV-1: relato de caso
Duarte, Geraldo;Figueiró-Filho, Ernesto Antonio;El Beitune, Patrícia;Quintana, Silvana Maria;Marcolin, Alessandra Cristina;Yano, Rafael Kioshi;Cavalli, Ricardo de Carvalho;
Revista Brasileira de Ginecologia e Obstetrícia , 2004, DOI: 10.1590/S0100-72032004000300011
Abstract: the reduction of mother-to-child transmission (mtct) of the hiv-1 using zidovudine (zdv) represents a cornerstone in the prenatal and obstetrical care to these patients. the invasive fetal and obstetric procedures are proscribed in hiv-1 infected pregnant patients, to avoid the increased risk of mtct of this virus. the authors present a case of an hiv-1 infected woman with recurrent polyhydramnios. four ultrasound-guided amniotic punctures were performed in the 23rd, 26th, 27th and 29th weeks of gestation, each one draining the respective volumes of 1,800, 1,450, 1,700 and 1,960 ml of clear amniotic fluid. the patient started preterm labor with 30 weeks and 5 days resulting in vaginal delivery of a male neonate weighing 1,690g and measuring 43cm. the baby presented a post natal diagnosis of a sodium-losing nephropathy and was submitted to three negative polymerase chain reaction tests for hiv-1. the authors point out that the option to manage cases of hiv-1 infected pregnancies that could need invasive obstetric procedures should be to give the patient 2 mg//kg of zdv endovenously before the procedure, in order to avoid mtct of hiv-1, as it has demonstrated good results in this case.
Intolerancia glicêmica e o prognóstico perinatal em gestantes utilizando anti-retrovirais
El Beitune, Patrícia;Duarte, Geraldo;Quintana, Silvana Maria;Foss, Milton César;Mussi-Pinhata, Marisa Márcia;Figueiró-Filho, Ernesto Antonio;Marcolin, Alessandra Cristina;
Revista Brasileira de Ginecologia e Obstetrícia , 2003, DOI: 10.1590/S0100-72032003000700002
Abstract: purpose: to investigate the effect of antiretroviral drugs on carbohydrate metabolism in hiv-infected pregnant women and on fetal and neonatal prognosis. methods: a prospective study was conducted on 57 pregnant women. the women were divided into three groups: zdv group, taking zidovudine (n=20), tt group, taking zidovudine + lamivudine + nelfinavir (n=25), and control group (n=12). blood samples were obtained for the determination of the area under the curve (auc) after a 75-g oral glucose test at four periods during pregnancy (1st=14-20 weeks, 2nd= 21-26 weeks, 3rd=27-32 weeks and 4th=33-38 weeks). perinatal prognosis was based on prematurity rates, intrauterine growth restriction (iugr), low birth weight, perinatal mortality, and vertical hiv-1 transmission. data were analyzed statistically using the nonparametric c2 test, friedman test and kruskal-wallis test. results: the median values of the auc were 11.685 mg/dl for the control group, 13.477 mg/dl for the zdv group, and 13.650 mg/dl for the tt group (p=0.049). the antiretroviral agents had no deleterious effects on prematurity, low birth weight, iugr rates or on apgar score. there was no case of vertical transmission of hiv-1. conclusions: an association was detected between the use of triple therapy and the development of carbohydrate intolerance during pregnancy. this association was not shown with zdv alone. the antiretroviral agents had no deleterious effects on perinatal prognosis.
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