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Search Results: 1 - 10 of 1230 matches for " Erin Moshier "
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Pancreatic polypeptide secreting tumors – an ins- titutional experience and review of the literature
Angela Tatiana Alistar,Michelle Kang Kim,Richard Warner,Erin Moshier
Journal of Solid Tumors , 2012, DOI: 10.5430/jst.v2n4p11
Abstract: Objectives: We present a retrospective analysis of patients with pancreatic neuroendocrine tumors (PNETs) who have had Pancreatic Polypeptide testing in an attempt to better define Pancreatic Polypeptide producing tumors as an entity and the role of Pancreatic Polypeptide (PP) as a biomarker. To our knowledge, this is the first single center comprehensive review of Pancreatic Polypeptide producing tumors. Methods: A retrospective study of patients with pancreatic neuroendocrine tumors seen at our institution from 1980 to 2011. All patients that have had PP concentrations measured at least once were evaluated. Data relating to diagnosis, pathology, surgery, liver directed therapies, chemotherapy and survival outcome were noted. Results: 71 patients with PNETs fulfilled the inclusion criteria (8 PPomas, 22 PP producing tumors and 41 non -PP producing tumors). We identified a trend towards better survival for patients with PP producing tumors vs. non- PP producing tumors (p=0.19). There was no correlation between survival and a diagnosis of PPoma in relation to other PP producing tumors or non-PP producing tumors. There was a borderline significant positive correlation of PP in association with Chromogranin A in a postoperative setting (p=0.061). Conclusions: Pancreatic Polypeptide is a biomarker that is worth prospective investigation and a standardized assay. Our analysis investigating Pancreatic Polypeptide as a prognostic and or predictive biomarker reveals a trend towards showing these characteristics. Using a standardized test and investigating this biomarker prospectively could lead to the validation of Pancreatic Polypeptide as a biomarker.
Gender and respiratory findings in workers occupationally exposed to organic aerosols: A meta analysis of 12 cross-sectional studies
E Neil Schachter, Eugenija Zuskin, Erin L Moshier, James Godbold, Jadranka Mustajbegovic, Jasna Pucarin-Cvetkovic, Angelo Chiarelli
Environmental Health , 2009, DOI: 10.1186/1476-069x-8-1
Abstract: Three thousand and eleven (3011) workers employed in "organic dust" industries (1379 female and 1632 male) were studied. A control group of 806 workers not exposed to any kind of dust were also investigated (male = 419, female = 387). Acute and chronic respiratory symptoms and lung function were measured. The weighted average method and the Mantel-Haentszel method were used to calculate the odds ratios of symptoms. Hedge's unbiased estimations were used to measure lung function differences between men and women.There were high prevalences of acute and chronic respiratory symptoms in all the "dusty" studied groups compared to controls. Significantly less chronic cough, chronic phlegm as well as chronic bronchitis were found among women than among men after the adjustments for smoking, age and duration of employment. Upper respiratory tract symptoms by contrast were more frequent in women than in men in these groups. Significant gender related lung function differences occurred in the textile industry but not in the food processing industry or among farmers.The results of this study suggest that in industries processing organic compounds there are gender differences in respiratory symptoms and lung function in exposed workers. Whether these findings represent true physiologic gender differences, gender specific workplace exposures or other undefined gender variables not defined in this study cannot be determined. These data do not suggest that special limitations for women are warranted for respiratory health reasons in these industries, but the issue of upper respiratory irritation and disease warrants further study.Our studies as well as those of others demonstrate the adverse respiratory effects of exposure to organic dusts in the workplace. We have studied workers in the textile industry (cotton, flax, wool, jute, sisal and hemp) food processing industry (i.e. green and roasted coffee, tea, spices, dried fruits, cocoa, flour, soy) as well as in farming [1-12]. The
Trajectories in Glycemic Control over Time Are Associated with Cognitive Performance in Elderly Subjects with Type 2 Diabetes
Ramit Ravona-Springer, Anthony Heymann, James Schmeidler, Erin Moshier, James Godbold, Mary Sano, Derek Leroith, Sterling Johnson, Rachel Preiss, Keren Koifman, Hadas Hoffman, Jeremy M. Silverman, Michal Schnaider Beeri
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097384
Abstract: Objective To study the relationships of long-term trajectories of glycemic control with cognitive performance in cognitively normal elderly with type 2 diabetes (T2D). Methods Subjects (n = 835) pertain to a diabetes registry (DR) established in 1998 with an average of 18 HbA1c measurements per subject, permitting identification of distinctive trajectory groups of HbA1c and examining their association with cognitive function in five domains: episodic memory, semantic categorization, attention/working memory, executive function, and overall cognition. Analyses of covariance compared cognitive function among the trajectory groups adjusting for sociodemographic, cardiovascular, diabetes-related covariates and depression. Results Subjects averaged 72.8 years of age. Six trajectories of HbA1c were identified, characterized by HbA1c level at entry into the DR (Higher/Lower), and trend over time (Stable/Decreasing/Increasing). Both groups with a trajectory of decreasing HbA1c levels had high HbA1c levels at entry into the DR (9.2%, 10.7%), and high, though decreasing, HbA1c levels over time. They had the worst cognitive performance, particularly in overall cognition (p<0.02) and semantic categorization (p<0.01), followed by that of subjects whose HbA1c at entry into the DR was relatively high (7.2%, 7.8%) and increased over time. Subjects with stable HbA1c over time had the lowest HbA1c levels at entry (6.0%, 6.8%) and performed best in cognitive tests. Conclusion Glycemic control trajectories, which better reflect chronicity of T2D than a single HbA1c measurement, predict cognitive performance. A trajectory of stable HbA1c levels over time is associated with better cognitive function.
Squares from D(–4) and D(20) Triples  [PDF]
Zvonko ?erin
Advances in Pure Mathematics (APM) , 2011, DOI: 10.4236/apm.2011.15052
Abstract: We study the eight infinite sequences of triples of natural numbers A=(F2n+1,4F2n+3,F2n+7), B=(F2n+1,4F2n+5,F2n+7), C=(F2n+1,5F2n+1,F2n+3), D=(F2n+3,4F2n+1,F2n+3) and A=(L2n+1,4L2n+3,L2n+7), B=(L2n+1,4L2n+5,L2n+7), C=(L2n+1,5L2n+1,L2n+3), D=(L2n+3,4L2n+1,L2n+3. The sequences A,B,C and D are built from the Fibonacci numbers Fn while the sequences A, B, C and D from the Lucas numbers Ln. Each triple in the sequences A,B,C and D has the property D(-4) (i. e., adding -4 to the product of any two different components of them is a square). Similarly, each triple in the sequences A, B, C and D has the property D(20). We show some interesting properties of these sequences that give various methods how to get squares from them.
Identification of a 12-Gene Signature for Lung Cancer Prognosis through Machine Learning  [PDF]
Erin Bard, Wei Hu
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.22017
Abstract: Personalized medicine is critical for lung cancer treatment. Different gene signatures that can classify lung cancer patients as high- or low-risk for cancer recurrence have been found. The aim of this study is to identify a novel gene signature that has higher recurrence risk prediction accuracy for non-small cell lung cancer patients than previous re-search, which can clearly differentiate the high- and low-risk groups. To accomplish this we employed an ensemble of feature selection algorithms, an ensemble of classification algorithms, and a genetic algorithm, an evolutionary search algorithm. Compared to one previous study, our 12-gene signature more accurately classifies the patients in the training set (n = 256), 57.32% compared to 50.78%, as well as in the two test sets (n = 104 and n = 82), 67.07% compared to 54.9% and 57.32% compared to 54.8%; where the prediction accuracy was determined by the average of the four classifiers. Through Kaplan-Meier analysis on high- and low-risk patients our 12-gene signature revealed statistically significant risk differentiation in each data set: the training set had a p-value less than 0.001 (log-rank) and the two test sets had (log-rank) p-values less than 0.05. Analysis of the posterior probabilities revealed strong correlation between 5-year survival and the 12-gene signature. Also, functional pathway analysis uncovered associations between the 12-gene signature and cancer causing genes in the literature.
Ethical and Regulatory Issues with Residual Newborn Screening Dried Bloodspots  [PDF]
Erin Rothwell, Jeffrey R. Botkin
Open Journal of Preventive Medicine (OJPM) , 2015, DOI: 10.4236/ojpm.2015.510045
Abstract: After newborn screening is completed, most states retain leftover dried bloodspots. These dried bloodspots are stored for varying lengths of time among different state newborn screening programs. Dried bloodspots are a unique and valuable resource for the development of new newborn screening tests, quality assurance and biomedical research. Recent changes to the 2014 Newborn Screening Reauthorization Saves Lives Act require explicit parental consent for the retention and use of dried bloodspots in federally funded research. This has raised several ethical and regulatory issues and highlighted the challenges of respecting individual autonomy and public health goals. This article provides an overview of these issues and discusses methods for obtaining parental consent. These issues may be applicable to consent for the storage and use of biospecimens among other settings according to proposed changes to the Common Rule.
Mitochondrial Uptake of Thiamin Pyrophosphate: Physiological and Cell Biological Aspects
Veedamali S. Subramanian, Svetlana M. Nabokina, Yaping Lin-Moshier, Jonathan S. Marchant, Hamid M. Said
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073503
Abstract: Mammalian cells obtain vitamin B1 (thiamin) from their surrounding environment and convert it to thiamin pyrophosphate (TPP) in the cytoplasm. Most of TPP is then transported into the mitochondria via a carrier-mediated process that involves the mitochondrial thiamin pyrophosphate transporter (MTPPT). Knowledge about the physiological parameters of the MTPP-mediated uptake process, MTPPT targeting and the impact of clinical mutations in MTPPT in patients with Amish lethal microcephaly and neuropathy and bilateral striatal necrosis are not fully elucidated, and thus, were addressed in this study using custom-made 3H-TPP as a substrate and mitochondria isolated from mouse liver and human-derived liver HepG2 cells. Results showed 3H-TPP uptake by mouse liver mitochondria to be pH-independent, saturable (Km = 6.79±0.53 μM), and specific for TPP. MTPPT protein was expressed in mouse liver and HepG2 cells, and confocal images showed a human (h)MTPPT-GFP construct to be targeted to mitochondria of HepG2 cells. A serial truncation analysis revealed that all three modules of hMTPPT protein cooperated (although at different levels of efficiency) in mitochondrial targeting rather than acting autonomously as independent targeting module. Finally, the hMTPPT clinical mutants (G125S and G177A) showed proper mitochondrial targeting but displayed significant inhibition in 3H-TPP uptake and a decrease in level of expression of the MTPPT protein. These findings advance our knowledge of the physiology and cell biology of the mitochondrial TPP uptake process. The results also show that clinical mutations in the hMTPPT system impair its functionality via affecting its level of expression with no effect on its targeting to mitochondria.
Antipoda. Revista de Antropología y Arqueología , 2007,
Abstract: this article examines contemporary artwork in south africa in orderto understand its role within the larger process of transitional justice taking place in the country. how has contemporary art contributed to and/or shaped the construction of a 'collective memory' about apartheid? how has this art interacted with the truth and reconciliation commission (trc)? the author argues that south african artists have played a significant role in the overall social transformation of the country, undertaking projects which continue to negotiate the legacies of apartheid.
Proper shape invariants: Tameness and movability
Zvonko ?erin
International Journal of Mathematics and Mathematical Sciences , 1996, DOI: 10.1155/s0161171296000403
Abstract: We study geometric properties of topological spaces called proper NC ¢ -tameness, proper PC ¢ -tameness, and proper N ¢ -movability, where ¢ and C denote classes of spaces. They are related to proper MC ¢ -tameness and proper M ¢ -movability from [5] and could be regarded as their dual forms. All three are invariants of a recently invented author's proper shape theory and are described by the use of proper multi-valued functions. We explore their basic properties and prove several results on their preservation under proper maps.
Anti-Bardolatry Through the Ages - or, Why Voltaire, Tolstoy, Shaw and Wittgenstein Didn't Like Shakespeare
Erin Sullivan
Opticon1826 , 2007, DOI: 10.5334/opt.020708
Abstract: Long before today’s debates about English literary heritage, compulsory school readings, and whether or not England’s national poet, William Shakespeare, should remain safe from the national curriculum’s axe, members of the European public passionately debated the value of Shakespeare’s plays and their place in an increasingly modern world. Indeed, more than one hundred and fifty years before Harold Bloom declared that Shakespeare invented the human, the poet Samuel Taylor Coleridge similarly promised in him a ‘wisdom deeper even than our consciousness’ and characterised his talents as god-like. In his public lectures, Coleridge assured his audiences that Shakespeare’s art was of such majesty that every line was instantly recognisable – ‘not a sentence could be read without its being discovered if it were Shakespeare’ – and, furthermore, that it was so noble as to be morally impeccable, ‘keeping at all times the high road of life’ and making its ‘readers better as well as wiser’. Notes from Coleridge’s lectures, writings, and conversations reveal his unequivocal devotion to Shakespeare, expressed to its full extent in his discussion of the playwright’s rhythm: ‘He goes on kindling like a meteor through the dark atmosphere; yet, when the creation in its outline is once perfect, then he seems to rest from his labour, and to smile upon his work, and tell himself that it is very good’.1 In his version of Genesis, Coleridge envisioned Shakespeare as a divine Creator, shaping form out of chaos as he dashed off a few hundred lines of his sublime iambic pentameter. The effort was minimal, the result ‘very good’, and the appropriate response on the part of the reader humble veneration.
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