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Search Results: 1 - 10 of 911 matches for " Erikka Carr "
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Microarray Data Reveal Relationship between Jag1 and Ddr1 in Mouse Liver
Lara A. Underkoffler, Erikka Carr, Anthony Nelson, Matthew J. Ryan, Reiner Schultz, Kathleen M. Loomes
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084383
Abstract: Alagille syndrome is an autosomal dominant disorder involving bile duct paucity and cholestasis in addition to cardiac, skeletal, ophthalmologic, renal and vascular manifestations. Mutations in JAG1, encoding a ligand in the Notch signaling pathway, are found in 95% of patients meeting clinical criteria for Alagille syndrome. In order to define the role of Jag1 in the bile duct developmental abnormalities seen in ALGS, we previously created a Jag1 conditional knockout mouse model. Mice heterozygous for the Jag1 conditional and null alleles demonstrate abnormalities in postnatal bile duct growth and remodeling, with portal expansion and increased numbers of malformed bile ducts. In this study we report the results of microarray analysis and identify genes and pathways differentially expressed in the Jag1 conditional/null livers as compared with littermate controls. In the initial microarray analysis, we found that many of the genes up-regulated in the Jag1 conditional/null mutant livers were related to extracellular matrix (ECM) interactions, cell adhesion and cell migration. One of the most highly up-regulated genes was Ddr1, encoding a receptor tyrosine kinase (RTK) belonging to a large RTK family. We have found extensive co-localization of Jag1 and Ddr1 in bile ducts and blood vessels in postnatal liver. In addition, co-immunoprecipitation data provide evidence for a novel protein interaction between Jag1 and Ddr1. Further studies will be required to define the nature of this interaction and its functional consequences, which may have significant implications for bile duct remodeling and repair of liver injury.
Prospective Teachers’ Perceptions of Science Theories: An Action Research Study  [PDF]
James P. Concannon, Patrick L. Brown, Erikka Brown
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.41011
Abstract: This study investigates prospective teachers’ conceptions of science theories before and after instruction. Instruction focused specifically on prospective teachers’ misconceptions that theories are not used to predict, that laws are more important than theories, and that theories are simply hunches. The action research investigation was successful in helping students accommodate new information presented in the lesson and facilitated their understanding towards the accepted explanation of what a theory in science means; however, the vernacular misconception that “theories are hunches” persisted.
A Pilot Study on the New USDA Meal Pattern for School Breakfast in a Sample of First-Grade Students  [PDF]
Noelle Carr, Sibylle Kranz
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.39175
Abstract: Background: The United States Department of Agriculture (USDA) recently modified the school breakfast program (SBP) to improve children’s nutrition. Based on the new patterns, schools must offer larger amounts of fruits, grains, and proteins/meats to children; the amounts of fluid foods (milk and juice) remained the same. This study examined the effect of the new food pattern on student’s consumption and food cost. Methods: The amounts and cost of foods served and wasted for one week in first grade students attending two elementary schools (n = 812) were measured. One school received the current SBP pattern (control breakfast, average number of students attending breakfast n = 81), the other school’s breakfast reflected the proposed changes (test breakfast, n = 82). To test the hypothesis that the test breakfast leads to significantly increased food cost and food waste compared to the control breakfast, the weekly average amount of the served solid and fluid foods (grams and milliliters) as well as their waste were compared between the two groups using paired student’s t-test in STATA 11 (significance at p-value < 0.05). Results: Data confirmed the hypothesis in that the test breakfast was associated with significantly higher food cost (by approximately $100/week) and solid food waste but there was no change in milk and juice consumption. Conclusions: This exploratory study indicates that a significant portion of the additional foods served to first-graders to improve their nutritional status were not consumed but wasted. Further studies in larger samples and including students from all grades are needed to examine this issue fully.
Weather extremes from anthropogenic global warming  [PDF]
Paul H. Carr
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.51A020
Abstract:

Although sea levels are predicted to rise 1 to 2 meters by 2100, the more immediate effects of global warming are weather extremes. The number of natural disasters since 1996 costing $1 billion or more doubled compared with the previous 15-year period. Extreme summer heat anomalies now cover about 10% of land area, up from 0.2% in 1950-1980. The human influence on global warming is evident from climate data and physical modeling. Since the beginning of the industrial era, carbon dioxide (CO2) increases correlate with those of temperature. Carbon dating shows that the CO2 increase is from burning ancient fossil fuels. Increasing CO2 and other greenhouse gases blanket and warm the earth’s surface, allowing less heat to reach the stratosphere, which is cooling. This is consistent with satellite measurements showing that solar irradiance is not changing. The present CO2 rate increase of 2 ppm/year is 300 times higher than the rate at which the earth recovered from the ice age 18,000 years ago. Without the radiative forcing of noncondensing persistent CO2, the terrestrial greenhouse would collapse, plunging the global climate into an icebound earth state. Will new technologies lower our carbon emissions in time to prevent more weather extremes? Electric cars now get the equivalent of 100 miles per gallon. The cost of electricity from solar photovoltaic cells has reached grid parity.

GIOTTO
Carrà, Carlo;
ARS (S?o Paulo) , 2009, DOI: 10.1590/S1678-53202009000100013
Abstract: while commenting giotto's art, carrà enhances qualities as "freshness", "spontaneity", and a "rough plastic grace". he points out the differences between his position and those of other critics or commentators, such as the adherents of "certain pseudo primitivisms" or of "the theory derived from xvi century's platonism"; ruskin; marcel raymond; mason perkins. he states that, in order to apprehend the "humanity" of giotto's art, "instead of any aesthetic theory", a "pictorial sensibility" would be necessary. finally, carrà examines the decoration of the scrovegni chapel (padova, 1305), "where giotto's genius achieves its maximum splendor".
The Banco Central do Brasil's institutional framework after ten years
Carré, Emmanuel;
Revista de Economia Política , 2011, DOI: 10.1590/S0101-31572011000400006
Abstract: the banco central do brazil (bacen) adopted inflation targeting in 1999. this monetary policy regime originates in institutional design which remains crucial today for the expectations management, and is in permanent evolution. after 10 years, the bacen institutional framework is assessed, asking if there is still room for improvement. various institutional procedures are analysed, and lessons are drawn from the international experience of a panel of sixteen countries. some proposals for the bacen institutional framework are made.
Notes on the zoogeography of the Atlantic sea turtles of the genus Lepidochelys
Carr,Archie;
Revista de Biología Tropical , 2002,
Abstract: the sea turtle lepidochelys kempi has an extensive range in coastal waters of the united states, and in parts of florida is abundant as a seasonal resident. all known populations are sexually immature, and the breeding area of the species is not known. the present paper suggests the necessity of assuming a distant origin for the north american population, examines fragmentary evidence bearing on the coronary assumption of migratory movement, and somewhat hesitantly proposes the coast of northwestern africa as a possible site of nesting. spreading into american waters may occur via the gulf stream system. new records extend the range of the genus to northern mauretania and into the mediterranean
Using Technology and Innovative Designs to Build Complex Architectural Envelopes
Emily Carr
Techne : Journal of Technology for Architecture and Environment , 2011,
Abstract: Permasteelisa Group is a manufacturer of curtain walls specialized worldwide in the creation of personalized architectural envelopes. The Group’s mission is to use innovative design methods and advanced technologies to construct architecturally significant fa ades. In order to meet project budget and timing requirements 3D modelling, personalized applications and automated production processes have been implemented company-wide. Together with the new technologies, the new design methods developed within the company, such as cold-formed units of curtain walls and toleran- ce compensation units, have given designers the ability to break classic design rules.
A Review of 'Women and Gaming: The Sims and 21st Century Learning'. Authors: James Paul Gee and Elizabeth R. Hayes
Marian Carr
International Journal of Gender, Science and Technology , 2011,
Abstract:
The Map of Watchful Architecture
Garrett Carr
EchoGéo , 2011,
Abstract: The international border between Northern Ireland and the South (the Republic of Ireland) came into beingin 1922, but there are many important historical antecedents to the notion and expression of spatial separation in this borderland. The author identifies historical precedents and links them to recent defensive features in order to generate a 'map of watchful architecture' that includes recent and much older elements.
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