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Search Results: 1 - 10 of 68671 matches for " Er-Qing Wei "
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Nicotinamide Phosphoribosyltransferase May Be Involved in Age-Related Brain Diseases
Li-Ying Liu, Feng Wang, Xia-Yan Zhang, Peng Huang, Yun-Bi Lu, Er-Qing Wei, Wei-Ping Zhang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044933
Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme for nicotinamide adenine dinucleotide (NAD) biosynthesis, and can be found either intracellularly (iNAMPT) or extracellularly (eNAMPT). Studies have shown that both iNAMPT and eNAMPT are implicated in aging and age-related diseases/disorders in the peripheral system. However, their functional roles in aged brain remain to be established. Here we showed that upon aging, NAMPT level increased in serum but decreased in brain, decreased in cortex and hippocampus but remained unchanged in cerebellum and striatum in brain, and increased in microglia but likely decreased in neuron. Accordingly, total NAD (tNAD) level significantly decreased in hippocampus, cerebellum and striatum in aged brain. Application of recombinant NAMPT, mimicking the elevated serum NAMPT level, enhanced the susceptibility of cerebral endothelial cells to ischemic injury, while inhibition of iNAMPT by FK866, a specific inhibitor, reduced intracellular NAD level and induced neuronal death. Taken together, we have revealed a region- and cell-specific change of NAMPT level in brain and serum upon aging, deduced its potential consequences, which suggests that NAMPT is a regulatory factor in aging and age-related brain diseases.
Structure and photoluminescence properties of Er3+-doped TiO2-SiO2 powders prepared by sol-gel method

Zhao Jian-Guo,Zhang Wei-Ying,Ma Zi-Wei,Xie Er-Qing,Zhao A-Ke,Liu Zhao-Jun,

中国物理 B , 2011,
Research on the Development of Beijing Biotechnology Industry

CAO Wei,LEI Er-qing,WANG Lei,LEI Ting,WU Le-shan,

中国生物工程杂志 , 2006,
Abstract: 生物技术及其相关产业是北京重点发展的高新技术领域之一.“九五”以来北京在该领域取得了稳步发展,具有研发、人才和临床优势.概述了近年来北京生物技术领域在研究、产业、政策等领域的发展现状,提出了目前北京在该领域发展面临的主要问题,并以此为基础为北京市该领域未来发展提出了相关建议.
Transarterial Onyx embolization of sagittal sinus dural arteriovenous fistulae
Chai Er-qing,Wang Jianlin
Neurology India , 2011,
Abstract: We report four patients (1 woman and 3 men) with sagittal sinus dural arteriovenous fistulae (DAVF) treated by Onyx embolizations via the middle meningeal artery. Anatomic cure and clinical cure were achieved in all the patients. The fistulae were located in the middle and posterior parts of the sagittal sinus. By Cognard classification the fistulae were: type I - one, type IIb - one, and type IV -two. All these four patients underwent a clinical and angiography follow-up, which confirmed complete cure. Based on this experience, we hypothesize that sagittal sinus DAVFs can be cured using a transarterial endovascular approach.
Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1
Xue-Qin Huang, Xia-Yan Zhang, Xiao-Rong Wang, Shu-Ying Yu, San-Hua Fang, Yun-Bi Lu, Wei-Ping Zhang, Er-Qing Wei
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-145
Abstract: In primary cultures of rat astrocytes, the effects of TGF-β1 and CysLT receptor agonists on migration and proliferation were assayed, and the expression of 5-LOX, CysLT receptors and TGF-β1 was detected. 5-LOX activation was analyzed by measuring its products (CysLTs) and applying its inhibitor. The role of CysLT1R was investigated by applying CysLT receptor antagonists and CysLT1R knockdown by small interfering RNA (siRNA). TGF-β1 release was assayed as well.TGF-β1-induced astrocyte migration was potentiated by LTD4, but attenuated by the 5-LOX inhibitor zileuton and the CysLT1R antagonist montelukast. The non-selective agonist LTD4 at 0.1 to 10 nM also induced a mild migration; however, the selective agonist N-methyl-LTC4 and the selective antagonist Bay cysLT2 for CysLT2R had no effects. Moreover, CysLT1R siRNA inhibited TGF-β1- and LTD4-induced astrocyte migration by down-regulating the expression of this receptor. However, TGF-β1 and LTD4 at various concentrations did not affect astrocyte proliferation 24?h after exposure. On the other hand, TGF-β1 increased 5-LOX expression and the production of CysLTs, and up-regulated CysLT1R (not CysLT2R), while LTD4 and N-methyl-LTC4 did not affect TGF-β1 expression and release.TGF-β1-induced astrocyte migration is, at least in part, mediated by enhanced endogenous CysLTs through activating CysLT1R. These findings indicate that the interaction between the cytokine TGF-β1 and the pro-inflammatory mediators CysLTs in the regulation of astrocyte function is relevant to glial scar formation.
Cerebral Ischemia Is Exacerbated by Extracellular Nicotinamide Phosphoribosyltransferase via a Non-Enzymatic Mechanism
Bing Zhao, Meng Zhang, Xue Han, Xia-Yan Zhang, Qiong Xing, Xu Dong, Qiao-Juan Shi, Peng Huang, Yun-Bi Lu, Er-Qing Wei, Qiang Xia, Wei-Ping Zhang, Chun Tang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0085403
Abstract: Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) in neuron has been known as a protective factor against cerebral ischemia through its enzymatic activity, but the role of central extracellular NAMPT (eNAMPT) is not clear. Here we show that eNAMPT protein level was elevated in the ischemic rat brain after middle-cerebral-artery occlusion (MCAO) and reperfusion, which can be traced to at least in part from blood circulation. Administration of recombinant NAMPT protein exacerbated MCAO-induced neuronal injury in rat brain, while exacerbated oxygen-glucose-deprivation (OGD) induced neuronal injury only in neuron-glial mixed culture, but not in neuron culture. In the mixed culture, NAMPT protein promoted TNF-α release in a time- and concentration-dependent fashion, while TNF-α neutralizing antibody protected OGD-induced, NAMPT-enhanced neuronal injury. Importantly, H247A mutant of NAMPT with essentially no enzymatic activity exerted similar effects on ischemic neuronal injury and TNF-α release as the wild type protein. Thus, eNAMPT is an injurious and inflammatory factor in cerebral ischemia and aggravates ischemic neuronal injury by triggering TNF-α release from glia cells, via a mechanism not related to NAMPT enzymatic activity.
Study of 3C-SiC and 4H-SiC films deposited using RF sputtering method

Lin Hong-Feng,Xie Er-Qing,Ma Zi-Wei,Zhang Jun,Peng Ai-Hua,He De-Yan,
,谢二庆,马紫微,张 军,彭爱华,贺德衍

物理学报 , 2004,
Abstract: 利用射频溅射法在Si衬底上制备了SiC薄膜 ,并利用x射线衍射 (XRD)和红外 (IR)吸收谱对薄膜的结构、成分及化学键合状态进行了分析 .XRD结果表明 ,低温制备的SiC薄膜为非晶相 ,而在高温下 (>80 0℃ ) ,薄膜呈现 4H SiC和 3C SiC结晶相 .IR谱显示 ,溅射制备薄膜的吸收特性主要为Si—C键的吸收 .此外 ,还利用原子力显微镜对薄膜的表面形貌进行了研究 ,并研究了样品的场发射特性
Electrical and optical properties of Cu-Al-O thin films sputtered using non-stoichiometric target

Pan Jia-Qi,Zhu Chen-Quan,Li Yu-Ren,Lan Wei,Su Qing,Liu Xue-Qin,Xie Er-Qing,

物理学报 , 2011,
Abstract: 考虑到铜铝溅射速率的差别,使用铜铝比例为0.9 ∶1的多晶CuAlO2靶材,用射频磁控溅射法制备Cu-Al-O薄膜.研究不同衬底温度对薄膜光学电学性能的影响.在衬底温度500 ℃附近,薄膜在可见光范围内具有很好的透光性,达到70%,计算拟合得到直接帯隙为3.52 eV,与CuAlO2相的理论值符合较好.在室温附近,薄膜导电符合半导体热激活机理,在衬底温度为500 ℃附近薄膜电导率达到2.48×10-3 S·cm-1.
The fabrication and properties of InAs/GaAs columnal islands

Zhu Tian-Wei,Xu Bo,He Jun,Zhao Feng-Ai,Zhang Chun-Ling,Xie Er-Qing,Liu Feng-Qi,Wang Zhan-Guo,

物理学报 , 2004,
Abstract: 利用固源分子束外延(MBE)的方法经SK模式自组装生长由多层InAs/GaAs量子点组成的柱形岛.具体分析了GaAs间隔层厚度,生长停顿时间以及InAs淀积量对发光峰波长的影响.原子力显微镜(AFM)结果显示柱形岛表面的形状和尺寸都比较均匀;室温下不同高度的柱形岛样品的发光波长分别达到1.32和1.4μm,而单层量子点的发光波长仅为1.1μm,充分说明了量子点高度对发光波长的决定性影响,这为调节量子点发光波长提供了一种直观且行之有效的方法.
A Novel Model of the H Radical in Hot-Filament Chemical Vapor Deposition

GUO Xiao-Song,BAO Zhong,ZHANG Shan-Shan,XIE Er-Qing,

中国物理快报 , 2011,
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