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Search Results: 1 - 10 of 6945 matches for " Epstein Barr Virus "
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A Case Report of Pediatric Epstein Barr Virus (EBV) Related Cholestasis from Al-Adan Hospital, Kuwait  [PDF]
Fawaz Al-Refaee, Sarah Al-Enezi, Enamul Hoque, Assad Albadrawi
Open Journal of Pediatrics (OJPed) , 2015, DOI: 10.4236/ojped.2015.51005

Infectious mononucleosis is an acute illness due to Epstein Barr virus infection, which occurs commonly in young adults. Liver involvement in acute EBV infection occurs in up to 95% of patients between the 6th and 15th day of illness and is usually mild [1]. Here we report on a 7-year-old girl treated by Gastroenterology, Hepatology, and Nutrition Unit of Al-Adan Hospital pediatric Department, presented with prolonged fever, lymphadenopathy, generalized edema, hyperbilurubi- nemia and elevated liver enzymes secondary to EBV infection. This case represents a rare presentation of common viral infection in pediatric population.

Epstein Barr Virus—The Cause of Multiple Sclerosis  [PDF]
Katarina Baruk?i?, Ilija Baruk?i?
Journal of Applied Mathematics and Physics (JAMP) , 2016, DOI: 10.4236/jamp.2016.46109
Abstract: Although many studies have found a kind of a relationship between an Epstein-Barr Virus (EBV) and the development of Multiple Sclerosis (MS), a fundamental aspect of this relationship remains uncertain. What is the cause of Multiple Sclerosis (MS)? In this study, we re-analysed the data as published by Wandinger et al. and were able to establish a new insight: without an Epstein-Barr Virus (EBV) infection no development of Multiple Sclerosis (MS). Furthermore, we determined a highly significant causal relationship between Epstein-Barr Virus (EBV) and multiple sclerosis. Altogether, Epstein-Barr Virus (EBV) is the cause of multiple sclerosis (p-value 0.0004251570).
Kikuchi-Fujimoto Disease Associated to the Epstein-Barr Virus. A Type of Rare Necrotizing Lymphadenitis and Its Differential Diagnosis  [PDF]
Mónica Belinda Romero Guadarrama, Oscar Daniel Guzmán-Aguilar, Adriana Carolina López-Ugalde, José Samuel Almeida Navarro, Humberto Cruz-Ortíz
Open Journal of Pathology (OJPathology) , 2013, DOI: 10.4236/ojpathology.2013.34034
Abstract: Introduction: Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a specific and self-limited disease; its etiology is unknown. Some causal microorganisms have been proposed. The objective of the present article is to emphasize the clinicopathological characteristics of this disease that has been associated to the Epstein-Barr virus and to compare the histological changes with other types of necrotizing lymphadenopathies. Material and Methods: We studied 32 patients of the Surgical Pathology Service with necrotizing lymphadenitis, diagnosed in the years from 2004 to 2012 to found more cases of this rare disease in our Institution. Patients were 18 women and 14 men with an average age of 37 years. Results: The lymph nodes were cervical and axillary ones, some were associated to autoimmune diseases and no cause was identified in others. One of the cases, was diagnosed as KFD, presented morphological changes characteristic of this disease, such as subcapsular lymphoid follicles, zones with cell debris, epithelioid macrophages, clear-cytoplasm histiocytes, and immunoblast-reactive lymphocytes. Immunohistochemical markers were determined, such as CD20, CD2, CD4, CD8, CD68, lysozyme, CD56, granzyme B and EBER, which demonstrated the presence of B, T lymphocytes, histiocytes and cells positive to EBER. Histological changes in KFD occurred in three stages: proliferative stage, necrotizing, and xanthomatous. It is important to identify the histological stages of the disease because a differential diagnosis must be performed in regard to lymphadenopathies with necrosis and diverse types of lymphomas. Conclusion: We present a case of necrotizing lymphadenitis (KFD) associated to the Epstein-Barr virus and in some cases it is not possible to render a specific diagnosis based on morphologic findings, alone, and a diagnosis of necrotizing lymphadenitis may be used.


Presence of Epstein- Barr Virus in Oral Lichen Planus and Normal Oral Mucosa
M Sahebjamee,M Eslami,I Jahanzad,M Babaee
Iranian Journal of Public Health , 2007,
Abstract: Background: Oral lichen planus (OLP) is a chronic immunologic disease. The etiology of OLP is unknown, viral antigens (for example Epstein-Bar virus) have been proposed as etiologic agents. OLP may get transformation to malignancy so re search on the presence of EBV in OLP lesions seems to be necessary. The aim of this study was to ascertain if EBV acted as etiologic factor in pathogenesis of OLP. Methods: Tissue specimens of 22 patients with clinical diagnosis and histopathological confirmation of OLP were used as case group. And that of 22 persons without OLP served as control group. Polymerase Chain Reaction (PCR) method was used. Each sample was tested twice. Results: All biopsy specimens from patients and controls were negative for EBV presence. Conclusions: In spite of the fact that the presence of EBV in OLP in these two small groups of Iranian population was not confirmed with PCR method, but due to different ideas and reports in this field, proving or disproving of presence or etio logical role of EBV in OLP is continuously a question and needs to be examined in further studies.
Ebstein-Barr virus as a rare cause of acute hepatitis: Case report
?zcan Karaman,?hsan Uslan,Mehmet ??lbay,Gürsel Acartürk
Medical Journal of Bakirk?y , 2007,
Abstract: Most common cause of acute hepatitis are viral agents. Hepatotropic virus constitute more than 95% of this group. A rare cause of acute hepatitis is Epstein Barr virus (EBV). The main disease caused by EBV is Infectious mononucleosis characterized by sore throat, fever, and adenopathy triad. Gastrointestinal manifestations are frequently present (80%), but often unrecognized. These manifestations include mild elevation (3-5 fold) in liver function tests in 5-10% cases, abdominal pain, and hepatosplenomegaly. However, little number of cases with serious hepatitis, fulminant liver failure, and splenic rupture related with EBV were also reported. We report here 25 years old patient with fever, sore throat, and 12-15 fold elevation in liver function tests and EBV was determined as the cause of viral hepatitis.
Chronological changes in Epstein-Barr virus genome and subsets of peripheral mononuclear cells in a case of HLH  [PDF]
Yukayo Ukeba-Terashita, Yoshinori Saita, Yoshinori Ito, Hirokazu Kanegane, Hiroshi Kimura, Ichiro Kobayashi
Open Journal of Pediatrics (OJPed) , 2011, DOI: 10.4236/ojped.2011.13008
Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder characterized by high grade fever, heaptos-plenomegaly, lymphadenopathy and cytopenia in association with hypercytokinemia and macrophage activation. Epstein-Barr virus (EBV) is a common cause of HLH particularly in Asian countries. Although EBV usually infects B cells and causes infectious mononucleosis, it is detected predominantly in CD8+ T cells in EBV-associated HLH. In the present study we found the EBV genome in various lineages of the lymphoid cells including T, B, and natural killer cells in a 14-month-old boy with mild EBV-associated HLH. Furthermore, chronological changes in the copy number of EBV-DNA in each lineage are reported. Profound decrease in the number of peripheral natural killer cells at the early stage could be involved in the development of HLH.
Epstein-Barr Virus Positive Inflammatory Pseudotumor of the Spleen: Case Report and Review of the Literature  [PDF]
Slim Jarboui, Abelwaheb Hlel, Med Ali Bekkay, Habib BelHaadj Khalifa, Moncef Mokni
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.38098

Inflammatory Pseudotumor (IPT) forms a group of etiologically, histologically, and biologically heterogeneous tumefactive lesions that are histologically characterized by prominent inflammatory infiltrates. It has been described in various organs including the lungs, bladder, liver, spleen, heart, and others. It may mimic a malignant tumor clinically and radiologically. Splenic IPT are most frequently detected incidentally. We report a case of 38-year-old women admitted for recurrent abdominal pain. Physical examination was unremarkable. Contrast enhanced CT showed a well hypodense, circumscribed lesion, measuring 5 × 3.5 cm. A differential diagnosis of lymphoma, teratomas, angioma or angiosarcoma was considered. The patient underwent splenectomy. Histologically, the tumor consisted of an inflammatory infiltrate composed predominantly of diffusely lymphoplasmocytic cells and stromal fibroblasts. Epstein-Barr virus was detected on in situ hybridization exclusively in the epitheloid and spindles cells. The optimal management of this tumor and eventually in asymptomatic patients is still controversial. IPT of the spleen should be remembered when evaluating single or multiple nodules in spleens. The clinical and pathological features of previously reported cases are reviewed in this paper.

Lymphomatoid Granulomatosis as a Debut of Common Variable Immunodeficiency: A Case Report and Review of Literature  [PDF]
Magdalena Fernández-García, Tetyana Zhuravetska, Jose Luis Rodríguez, Elsa Ots
Journal of Biosciences and Medicines (JBM) , 2014, DOI: 10.4236/jbm.2014.28002
Abstract: Lymphomatoid granulomatosis, currently called as extranodal angiocentric and angiodestructive immunoproliferative disorder, is a rare entity of unclear etiology. It involves most frequently lungs, central nervous system and skin. The clinical course is variable, but mortality is high. Today, it represents a diagnostic challenge because it can emulate autoimmunity, infection, and malignancy processes. Optimal therapy scheme is still unknown. We report the case of a 20 year-old man presenting with fever, weight loss, sweating, multiple bilateral lung nodules on the chest X-ray and cutaneous involvement.
Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response  [PDF]
Taryn G. Aubrecht, Zachary M. Weil, Bachir Abi Salloum, Maria Eugenia Ariza, Marshall Williams, Brenda Reader, Ronald Glaser, John Sheridan, Randy J. Nelson
Journal of Behavioral and Brain Science (JBBS) , 2015, DOI: 10.4236/jbbs.2015.511049
Abstract: Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome. Stress is known to influence the immune system and can exacerbate the sickness response. Although a role for psychological stress in the sickness response, particularly in combination with EBV-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) has been established, and the role of physical stressors in these interactions remains unspecified. In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection. We hypothesize that a chronic physical stressor will exacerbate the sickness response following EBV-encoded dUTPase injection. To test this hypothesis mice receive daily injections of EBV-encoded dUTPase or vehicle and are subjected to 15 min of swim stress each day for 14 days or left unmanipulated. On the final evening of injections mice undergo behavioral testing. EBV-encoded dUTPase injection alone produces some sickness behaviors. The physical swimming stress does not alter the sickness response.
Acute Kidney Injury with Epstein Barr Virus-Associated Hemophagocytic Syndrome  [PDF]
Ryo Ishida, Kazumi Komaki, Tetsuro Kusaba, Tsuneyuki Nakanouchi
Case Reports in Clinical Medicine (CRCM) , 2016, DOI: 10.4236/crcm.2016.57042
Abstract: A 59-year-old man, who was treated for schizophrenia and psoriasis vulgaris with risperidone and cyclosporine, presented with high fever and myalgia. Those did not respond to treatment for neuroleptic malignant syndrome for two weeks, and multiple organ dysfunction developed, so he was admitted to our hospital, but died two days later. Autopsy detected the hemophagocytosis, Epstein Barr Virus (EBV)-reactivated cells, and the absence of glomerulonephritis and interstitial tubulitis. We considered that hemophagocytic syndrome (HPS) and myalgia were caused by reactivated EBV and the viremia under immunosuppression, and renal failure was caused by sepsis-like state by cytokine storm of HPS.
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