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is an acute illness due to Epstein Barr virus infection, which occurs commonly
in young adults. Liver involvement in acute EBV infection occurs in up to 95%
of patients between the 6th and 15th day of illness and is usually mild .
Here we report on a 7-year-old girl treated by Gastroenterology, Hepatology,
and Nutrition Unit of Al-Adan Hospital pediatric Department, presented with
prolonged fever, lymphadenopathy, generalized edema, hyperbilurubi- nemia and
elevated liver enzymes secondary to EBV infection. This case represents a rare
presentation of common viral infection in pediatric population.
Pseudotumor (IPT) forms a group of etiologically, histologically, and
biologically heterogeneous tumefactive lesions that are histologically
characterized by prominent inflammatory infiltrates. It has been described in
various organs including the lungs, bladder, liver, spleen, heart, and others.
It may mimic a malignant tumor clinically and radiologically. Splenic IPT are
most frequently detected incidentally. We report a case of 38-year-old women
admitted for recurrent abdominal pain. Physical examination was unremarkable.
Contrast enhanced CT showed a well hypodense, circumscribed lesion, measuring 5
× 3.5 cm. A differential diagnosis of lymphoma, teratomas, angioma or
angiosarcoma was considered. The patient underwent splenectomy. Histologically,
the tumor consisted of an inflammatory infiltrate composed predominantly of
diffusely lymphoplasmocytic cells and stromal fibroblasts. Epstein-Barr virus
was detected on in situ hybridization
exclusively in the epitheloid and spindles cells. The optimal management of
this tumor and eventually in asymptomatic patients is still controversial. IPT
of the spleen should be remembered when evaluating single or multiple nodules
in spleens. The clinical and pathological features of previously reported cases
are reviewed in this paper.