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Search Results: 1 - 10 of 14887 matches for " Enrico Di Stasio "
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Additive value of blood neutrophil gelatinase-associated lipocalin to clinical judgement in acute kidney injury diagnosis and mortality prediction in patients hospitalized from the emergency department
Salvatore Di Somma, Laura Magrini, Benedetta De Berardinis, Rossella Marino, Enrico Ferri, Paolo Moscatelli, Paola Ballarino, Giuseppe Carpenteri, Paola Noto, Biancamaria Gliozzo, Lorenzo Palladino, Enrico Di Stasio
Critical Care , 2013, DOI: 10.1186/cc12510
Abstract: This is a multicenter Italian prospective emergency department (ED) cohort study in which we enrolled 665 patients admitted to hospital from the ED.Blood NGAL and serum creatinine (sCr) where determined at ED presentation (T0), and at: 6 (T6), 12 (T12), 24 (T24) and 72 (T72) hours after hospitalization. A preliminary assessment of AKI by the treating ED physician occurred in 218 of 665 patients (33%), while RIFLE AKI by expert nephrologists was confirmed in 49 of 665 patients (7%). ED physician's initial judgement lacked sensitivity and specificity, over predicting the diagnosis of AKI in 27% of the cohort, while missing 20% of those with AKI final diagnosis. The area under the receiver operating characteristic curve (AUC), obtained at T0, for blood NGAL alone in the AKI group was 0.80. When NGAL at T0 was added to the ED physician's initial clinical judgment the AUC was increased to 0.90, significantly greater when compared to the AUC of the T0 estimated glomerular filtration rate (eGFR) obtained either by modification of diet in renal disease (MDRD) equation (0.78) or Cockroft-Gault (0.78) formula (p=0.022 and p=0.020 respectively). The model obtained by combining NGAL with ED physician's initial clinical judgement compared to the model combining sCr with the ED physician's initial clinical judgement, resulted in a net reclassification index of 32.4 percentage points. Serial assessment of T0 and T6 hours NGAL provided a high negative predictive value (NPV) (98%) in ruling out the diagnosis of AKI within 6 hours of patients' ED arrival. NGAL (T0) showed the strongest predictive value for in-hospital patient's mortality at a cut-off of 400 ng/ml.Our study demonstrated that assessment of a patient's initial blood NGAL when admitted to hospital from the ED improved the initial clinical diagnosis of AKI and predicted in-hospital mortality. Blood NGAL assessment coupled with ED physician's clinical judgment may provide utility in deciding the appropriate strategies for
Placer, razón, imaginación o estética indeterminada en la comprensión de la experiencia socioestética
Iazzetta Di Stasio,Esteban;
Argos , 2010,
Abstract: facing the need of discussing about actual aesthetics experience emerges the purpose to establish the reference point to build socio-aesthetics experience interpretation framed in a determined time and space. a position is generated from a documental study, based on a rational approach, since arts as aesthetics value about aesthetics experience and its relationship with culture industry in order to form the basis of interpretation of undetermined aesthetics experience based on sensations. it is a referential critical position to comprehend the socio-aesthetics in the world of sensitiveness of who experiment it with the object-public space. it is understood as the integration of architecture and the relationship of the body with space through social practices; conditioned space by image created through form, technique, fashion and the interesting stuff.
Study on milk proteins loci in some decreasing Italian cattle breeds
P Merlin, Liliana Di Stasio
Genetics Selection Evolution , 1982, DOI: 10.1186/1297-9686-14-1-17
Práctica y crítica teórica de un enfoque epistemológico para analizar la experiencia socioestética en frentes de agua
Iazzetta Di Stasio,Esteban Pedro;
Revista de Ciencias Sociales , 2010,
Abstract: the epistemological approach to socio-aesthetic experience analysis is based on integrating experience and practice to build a theory about socio-aesthetics on waterfronts. experience and practice are based on previous, sensitive and rational knowledge about la vereda, a park located on the waterfront of maracaibo, the second-largest venezuelan city and capital of the state of zulia. the epistemological approach is based on social practices and a theoretical-critical position regarding action: relation of the body with space, culture and the space-time concept (bourdieu, hall and lotman). the study tries to explain the social reality of the socio-aesthetic experience manifested in waterfronts (bourdieu, gadamer, lyotard) through symbolic comprehension and subjectivity of the social and cultural world, all in hermeneutic language. thus, the epistemological approach considers phenomenology as the philosophy of intuition, systematizes and generates a method that integrates and relates forms of building knowledge: analytical-synthetic, hermeneutic-symbolic, as well as the analysis of practice. it also considers principles based truly on human nature itself between the symbolic and biological, and on fluctuating, dynamic and changing historical knowledge where laws are uncertain and emerging.
Variability of some genes of the somatotropic axis in the Piemontese cattle breed
L. Di Stasio,S. Sartore
Italian Journal of Animal Science , 2011, DOI: 10.4081/ijas.2003.s1.118
Abstract: Growth hormone (GH) is a major participant in the control of several complex physiological processes, including growth and metabolism. The growth promoting aspects are generally mediated by the insulin-like growth factor 1 (IGF-1), produced primarily in the liver in response to GH, while the metabolic effects are mainly the result of the GH direct binding to its receptors (GHR) on target cells. The production of GH is modulated by growth hormone releasing hormone (GHRH) and somatostatin (SST); the former stimulates both the synthesis and the secretion of GH, the latter inhibits the GH release (Frohman and Jansson, 1986; Bonneau, 1991; Buyse and Decuypere, 1999; Duclos et al., 1999; Sodhi and Rajput, 2001). Due to the several effects of GH, the genes coding for GH and other hormones and factors involved in growth have been suggested.........
Variability of μ-Calpain and Calpastatin genes in cattle
Claudio Lisa,Liliana Di Stasio
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2009.s2.99
Abstract: A preliminary analysis on the variability of μ-Calpain (CAPN1) and Calpastatin (CAST) genes in six cattle breeds was carried out, focusing the attention on CAPN1 g.5709C>G, CAPN1 g.6545C>T, and CAST g.282C>G SNPs, which have been suggested to affect beef tenderness in cattle. The results indicate that the two genes are polymorphic in all the analysed breeds, with significant between-breed differences. On the basis of their variability, only CAPN1 g.6545C>T and CAST g.282C>G SNPs seem appropriate to be considered as potential markers for beef tenderness.
MC1R gene analysis applied to breed traceability of beef
Andrea Rolando,Liliana Di Stasio
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2006.87
Abstract: Since the breed of origin highly affects the beef price, reliable methods are needed to detect incorrect declarations. As most breeds are standardised for coat colour, the Melanocortin 1 Receptor gene (MC1R), involved in the regulation of eu/pheomelanins synthesis, has been suggested as marker for breed traceability of products of animal origin. The aim of this investigation is to characterise the main breeds reared in the Piedmont Region by MC1R locus and to apply the analysis of the locus to breed traceability of beef cuts purchased in different outlets of the Region. A total of 168 DNA samples of four cattle breeds (Piemontese, Blonde d’Aquitaine, Italian Friesian and Aosta Red Pied) were analysed for MC1R locus by PCR-RFLP. In addition, 28 DNA samples from beef with breed indication were tested. Piemontese and Blonde d’Aquitaine were monomorphic for the E+and eallele, respectively. In the Friesian breed the EdEd genotype was the most frequent, but Edewas also observed (2%). Aosta Red Pied was the most variable breed, with the presence of the three alleles and five genotypes out of six. The comparison of the genotypic distribution in the four breeds clearly indicates that it is possible to distinguish among Piemontese, Blonde d’Aquitaine and Friesian breeds, but the same is not true for Aosta Red Pied, which has genotypes in common with the other breeds. The results on beef samples revealed a high percentage of mislabelling (about 18%), which concerned Friesian breed and crossbreds. These results indicate that MC1R locus is an effective marker in breed traceability of beef, when the involved breeds are characterised by different genotypes. Moreover, compared to other genetic markers, it has the great advantage of not requiring DNA reference sam- ples. This survey, though limited, has revealed a high percentage of incompatibilities. Therefore, the analysis of MC1R locus is recommended in the framework of product certification, at least for random controls within a system aimed at preventing fraud.
Connection between low energy effective Hamiltonians and energy level statistics
M. Di Stasio,X. Zotos
Physics , 1994, DOI: 10.1103/PhysRevLett.74.2050
Abstract: We study the level statistics of a non-integrable one dimensional interacting fermionic system characterized by the GOE distribution. We calculate numerically on a finite size system the level spacing distribution $P(s)$ and the Dyson-Mehta $\Delta_3$ correlation. We observe that its low energy spectrum follows rather the Poisson distribution, characteristic of an integrable system, consistent with the fact that the low energy excitations of this system are described by the Luttinger model. We propose this Random Matrix Theory analysis as a probe for the existence and integrability of low energy effective Hamiltonians for strongly correlated systems.
Variability of Leptin gene promoter in cattle
C. Lisa,S. Sartore,L. Di Stasio
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2007.1s.150
Abstract: A preliminary analysis on the variability of Leptin gene promoter in seven cattle breeds was carried out, focusing the attention on the SNP at nt 1759, which has been suggested to affect some quantitative traits in cattle. In addition, the linkage disequilibrium with the C305T mutation in exon 2 of Leptin gene was tested. The results indicate that the Leptin gene promoter is polymorphic in all the analysed breeds, with significant betweenbreed differences. Pairwise comparison of genotypes at the two considered SNPs revealed a significant linkage disequilibrium, with the presence of the haplotypes 1759C - 305T and 1759G - 305C.
Genetic characterization of the Bardigiano horse using microsatellite markers
Liliana Di Stasio,Giovanna Perrotta,Michele Blasi,Claudio Lisa
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2008.243
Abstract: The study was aimed at investigating the genetic structure of the Bardigiano horse and its relationships with the Haflinger, Maremmano and Arabian breeds using 11 microsatellite markers. A total of 94 alleles were detected across the breeds, with a mean of 8.5 alleles per locus and a mean observed heterozygosity of 0.69. Compared to the other breeds, the Bardigiano horse showed quite a high genetic variability, as indicated by the mean number of alleles (7.0 vs 6.1÷7.6) and by the observed heterozygosity (0.72 vs 0.66÷0.71). Moreover, the genotype distributions in the Bardigiano groups of different sex and age were not significantly different. The overall FST value showed that the genetic differences among breeds accounted for 7.8% (P=0.001) of the total variation, and the pairwise FST values were all significant. The assignment test allocated between 96.8 and 98.9% of the individuals to the population they were collected from, with a mean probability of assignment of about 97% for all breeds, except for the Arabian, where it approached 100%. The results have highlighted that the Bardigiano breed has a high within and between breed variability, which is considerably more than could be expected by looking at its evolution history. This justifies the need for the development of additional breeding strategies to preserve the existing genetic variability.
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