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Search Results: 1 - 10 of 297 matches for " Enji Okuda "
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The Relationship between Experiences of Athletic and Daily Life and Personality in Senior High School Students  [PDF]
Daisuke Horii, Enji Okuda
Psychology (PSYCH) , 2019, DOI: 10.4236/psych.2019.103020
Abstract: No single factor has yet emerged to date in the literature on personality, and it is unlikely that one will ever be found given the diversity of traits subsumed under the category of personality. We hypothesized that experiences of crisis, exploration, and commitment in athletic and daily life events affect personality. This study examined the relationship between experiences of athletic and daily life and personality in Japanese senior high school students by using multiple regression analysis. We had senior high school students (189 males and 118 females) complete a questionnaire assessing their experiences of crisis, exploration, and commitment on four issues (Teammates, Authority Figures, Competition Results, Contest Continuation) in the athletic domain, and on six issues (Study, Future Courses, Values, Family, Opposite Sex Friends, Same Sex Friends) in the daily life domain. Our results reveal that, there are significant models for factors of Extraversion and Neuroticism in males with less than 10 years of experience; for males with over 10 years of experience, there were significant models for factors of Neuroticism. Moreover, for males with less than 10 years of experience, there were significant relationships between personality with regards to exploration in the athletic domain and daily life domain; for males with over 10 years of experience, there were significant relationships between personality with regards to commitment in the athletic domain, crisis, and commitment in the daily life domain. For females with less than 10 years of experience, there was no significant difference; for females with over 10 years of experience, there were significant relationships between personality with regards to crisis in the athletic domain. Thus, there was a more significant relationship between various experiences and personality in males than females. Similar to previous research examining personality, this study highlights the importance of including experiences of crisis, exploration, and commitment when taking part in sports activity.
Albanian legal framework on Factoring contract
Anjeza Li?enji,Kestrin Katro
Academicus : International Scientific Journal , 2013, DOI: 10.7336/academicus.2013.08.10
Abstract: Factoring contract is a new phenomenon, compared to earlier forms of commerce in juridical circulation. Factoring is a method used by a firm to obtain cash when available cash balance, held by the firm, is insufficient to meet current obligations, and accommodate its other cash needs, such as new orders or contracts. The use of factoring to obtain the cash, needed to accommodate the firm’s immediate cash needs, will allow the firm to maintain a smaller ongoing cash balance. By reducing the size of its cash balances, more money becomes available for investment in the firm’s growth. A company sells its invoices at discount to their face value when it calculates that it will be better off proceeding to bolster its own growth than it would be by effectively functioning as its “customer’s bank”. Many businesses have cash flow that varies. A business might have a relatively large cash flow in one period, as well as a relatively small cash flow in another period. Because of this, firms find it necessary to both keep a cash balance on hand, and use such methods as factoring, in order to enable them to cover their short term cash needs in those periods in which these needs exceed cash flow.
Multidrug Delivery Systems with Single Formulation——Current status and Future Perspective  [PDF]
Tatsuya Okuda, Satoru Kidoaki
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.31007
Abstract: Development of new way and system for multidrug delivery has recently attracted much attention and became one of major issue in drug delivery research. Although this research field is still immature compared to the single drug delivery system, intensive efforts have recently been devoted by researchers in order to realize more efficient, functional, and safe combination therapy using multiple drugs or agents. In this review article, we outline several targets in terms of application for biochemical modulation together with various concrete attempts of simultaneous and sequential delivery of multiple drugs or agents with single formulation. Finally, we will also summarize the possible contribution of biomaterial sciences and nanobiotechnology for improvement of future multidrug delivery system.
Distinct Transforming Activity of ABL Family Tyrosine Kinase Oncogenes Is Induced by Their C-Terminal Domain*  [PDF]
Keiko Okuda, Hideyo Hirai
Open Journal of Blood Diseases (OJBD) , 2013, DOI: 10.4236/ojbd.2013.33A005
Abstract: The TEL/ARG oncogene is similar in structure to the TEL/ABL fusion found in human leukemia, however, we have demonstrated previously that the expression of TEL/ARG in Ba/F3 cells does not sustain strong activity of proliferation, whereas, that of TEL/ABL appeared to induce immediate cell proliferation. To study the molecular basis of the difference in the transforming activity of TEL/ARG and TEL/ABL, TEL/ARG mutants that swapped the kinase domain or C-terminus of ARG with the corresponding domain in ABL were generated, and each mutant was expressed in Ba/F3 cells. A TEL/ARG mutant containing the ABL kinase domain was similar to TEL/ARG in this study, but replacing the ARG C-terminal domain with that of ABL resulted in accelerated proliferation that was similar to that of TEL/ABL. When expressed in primary mouse bone marrow cells by retroviral transduction, spontaneous colony formation in methylcellulose culture was observed, in a fashion dependent on the C-terminal portion of ABL. These results indicate that distinct bio-phenotypes associated with these oncogenes are likely to be regulated by their C-termini, and the C-terminus of ARG contains a functional subdomain that impairs the growth signal induced by ABL family tyrosine kinase.
Review of tocilizumab in the treatment of rheumatoid arthritis
Yasuaki Okuda
Biologics: Targets and Therapy , 2008,
Abstract: Yasuaki OkudaDepartment of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, Matsuyama-city, Ehime, JapanAbstract: Constitutively overproduced in proliferating synovial tissues, interleukin-6 (IL-6) is deeply involved in the pathology of rheumatoid arthritis (RA). Tocilizumab is a humanized anti-human IL-6 receptor antibody that binds to soluble and membrane-bound IL-6 receptor, and at detectable levels in blood, tocilizumab is capable of almost completely blocking the transmembrane signaling of IL-6. In clinical trials for patients with RA in Japan, tocilizumab monotherapy has shown clinical efficacy equaling that of tumor necrosis factor (TNF) inhibitor in combination with methotrexate, and in an extension study in patients who responded to tocilizumab, almost no patients showed a decrease in the efficacy of tocilizumab. Evidence obtained in a phase III study in Japan demonstrated that tocilizumab monotherapy had a significant inhibitory effect on the progression of structural joint damage compared with that of conventional disease modifying antirheumatic drugs (DMARDs). Furthermore it has been shown that tocilizumab has an excellent ability to suppress serum amyloid A levels and could therefore be an important therapeutic strategy in amyloid A amyloidosis secondary to rheumatic diseases. The safety profile of tocilizumab appears to be satisfactory. However, several serious infections were also reported, and careful monitoring is therefore important during use.Keywords: tocilizumab, rheumatoid arthritis, interleukin-6, treatment, amyloidosis, biologics
The Equality of Solutions in Vacuum String Field Theory
Takuya Okuda
Physics , 2002, DOI: 10.1016/S0550-3213(02)00615-6
Abstract: We analytically prove that the matter solution of vacuum string field theory constructed by Kostelecky and Potting is the matter sliver state. We also give an analytical proof that the ghost solution by Hata and Kawano is the sliver state in the twisted ghost CFT. It is also proved that the candidate state for the tachyon proposed by Hata and Kawano can be identified with the state constructed by Rastelli, Sen and Zwiebach using CFT. Our proofs are based on the techniques recently developed by Okuyama.
Recent results from Telescope Array
Takeshi Okuda
Physics , 2014,
Abstract: The Telescope Array (TA) observatory, located in midwest Utah, USA, is designed to detect ultra high energy cosmic rays whose energy is greater than 1 EeV. TA mainly consists of two types of detector. The first type is the atmospheric Fluorescence Detector (FD). TA's three FDs have been in operation since Fall 2007. The other type of detector is a ground-covering Surface Detector (SD), which has been operating at TA since Spring 2008. In addition, the TA-Rader (TARA) and EUSO-TA associated experiments are co-located with TA, and the TA Low Energy (TALE) extension recently started partial operation. I report some recent general results from TA, and describe our future plans.
Low angular momentum flow model II for Sgr A*
Toru Okuda
Physics , 2014, DOI: 10.1093/mnras/stu738
Abstract: We examine 1D two-temperature accretion flows around a supermassive black hole, adopting the specific angular momentum \lambda, the total specific energy \epsilon and the input accretion rate \dot M_{input} = 4.0x10^{-6} solar mass/yr estimated in the recent analysis of stellar wind of nearby stars around Sgr A*. The two-temperature flow is almost adiabatic even if we take account of the heating of electrons by ions, the bremsstrahlung cooling and the synchrotron cooling, as long as the ratio \beta of the magnetic energy density to the thermal energy density is taken to be as \beta < 1. The different temperatures of ions and electrons are caused by the different adiabatic indices of ions and electrons which depend on their temperature states under the relativistic regime. The total luminosity increases with increasing \beta and results in - 10^{35} - 10^{36} erg/s for \beta=10^{-3} - 1. Furthermore, from 2D time-dependent hydrodynamical calculations of the above flow, we find that the irregularly oscillating shocks are formed in the inner region and that the luminosity and the mass-outflow rate vary by a factor of 2 -- 3 and 1.5 -- 4, respectively. The time variability may be relevant to the flare activity of Sgr A*.
Super-Eddington Black-Hole Models for SS 433
Toru Okuda
Physics , 2002, DOI: 10.1093/pasj/54.2.253
Abstract: We examine highly super-Eddington black-hole models for SS 433, based on two-dimensional hydrodynamical calculations coupled with radiation transport. The super-Eddington accretion flow with a small viscosity parameter, $\alpha = 10^{-3}$, results in a geometrically and optically thick disk with a large opening angle of $\sim 60^{\circ}$ to the equatorial plane and a very rarefied, hot, and optically thin high-velocity jets region around the disk. The thick accretion flow consists of two different zones: an inner advection-dominated zone and an outer convection-dominated zone. The high-velocity region around the disk is divided into two characteristic regions, a very rarefied funnel region along the rotational axis and a moderately rarefied high-velocity region outside of the disk. The temperatures of $\sim 10^7$ K and the densities of $\sim 10^{-7}$ g cm$^{-3}$ in the upper disk vary sharply to $\sim 10^8$ K and $10^{-8}$ g cm$^{-3}$, respectively, across the disk boundary between the disk and the high-velocity region. The X-ray emission of iron lines would be generated only in a confined region between the funnel wall and the photospheric disk boundary, where flows are accelerated to relativistic velocities of $\sim$ 0.2 $c$ due to the dominant radiation-pressure force. The results are discussed regarding the collimation angle of the jets, the large mass-outflow rate obserevd in SS 433, and the ADAFs and the CDAFs models.
Classification of semisimple symmetric spaces with proper SL(2,R)-actions
Takayuki Okuda
Mathematics , 2012,
Abstract: We give a complete classification of irreducible symmetric spaces for which there exist proper SL(2,R)-actions as isometries, using the criterion for proper actions by T. Kobayashi [Math. Ann. '89] and combinatorial techniques of nilpotent orbits. In particular, we classify irreducible symmetric spaces that admit surface groups as discontinuous groups, combining this with Benoist's theorem [Ann. Math. '96].
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