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Search Results: 1 - 10 of 4248 matches for " Emmanuel Abidemi Omonisi "
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Pattern of Upper Gastrointestinal Malignancies as Seen at Endoscopy in Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria  [PDF]
Akande Oladimeji Ajayi, Ebenezer Adekunle Ajayi, Olusoji Abidemi Solomon, Emmanuel Abidemi Omonisi, Samuel Ayokunle Dada
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102731
Abstract:
Aims and Objective: Gastrointestinal malignancies are among the most lethal of all malignancies and are equally notorious for rapidly progressing to advanced stages even in the absence of serious symptoms, thus leading to delayed diagnoses and dismal prognoses. The aim of this study was to determine the prevalence, type, pattern and the histologic characteristics of upper gastrointestinal tumors seen in patients who underwent upper gastrointestinal endoscopy at the Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria. Materials and Methods: This was a three year cross-sectional study involving 78 patients with suspected upper gastrointestinal tumor referred for upper gastrointestinal endoscopy. The study was conducted from January 2011 to December 2013 at the Ekiti State University Teaching Hospital (EKSUTH), Ado-Ekiti, Nigeria. Relevant clinical information such as age, gender, clinical presentations, smoking history, alcohol use, spices, and consumption of opiates were obtained from the patients. Tissue biopsies were taken from the suspected lesions for histological confirmation and characterization. An ethical clearance for this study was obtained from the EKSUTH Ethical and Research committee and all the patients gave written consent for the study. SPSS version 15.0 (SPSS, Inc., Chicago, Illinois, USA) was applied for statistical analysis using the t-test for quantitative variables and χ2 test for qualitative variables. Differences were considered to be statistically significant if P value was less than 0.05. Results: Seventy eight patients were enrolled into this study comprising 22 females and 56 males. The mean age of the population was 55.75 ± 7.20 years. The presenting symptoms were; abdominal mass in 30.8%, abdominal pain in 29.5%, weight loss in 20.5%, dysphagia in 6.4%, haematemesis in 5.1%, melaena in 5.1% and anaemia in 2.6% of the patients. The risk factors identified in the study included; tobacco use or smoking in 25.6%, alcohol in 19.2%, spices in 14.1%, opiates in 3.8% and combination of the above risk factors in 37.2%. 67.9% of the tumors were located in the stomach, 16.7% in the oesophagus and 15.4% in the first part of the duodenum. Of those located in the stomach, 62.3% were in the antrum while 37.7% were in the corpus. Of the oesophageal tumors, 61.5% were in the mid oesophagus, 30.8% were in the lower oesophagus and 7.8% in the upper oesophagus. Tissue histology showed 70.5% were adenocarcinoma, 26.9% were squamous cell carcinoma, 1.3% lymphoma and 1.3% malignant polyp. This was statistically significant p =< 0.05. Conclusion: In view of the fact that upper GI tumors can rapidly progress to advanced stages in the absence of serious symptoms, gastroduodenoscopy is advocated in patients with signs and symptoms of dyspepsia to avoid delayed diagnosis and improve the disease outcome.
Clinico-Pathologic Study of Salivary Gland Disorders at a Sub-Urban Nigerian Tertiary Hospital: A 5 Year Retrospective Review  [PDF]
Obitade S. Obimakinde, Olabamiji A. Olajuyin, Waheed A. Adegbiji, Abidemi E. Omonisi, Christopher O. Ibidun
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2019, DOI: 10.4236/ijohns.2019.83012
Abstract: Background: The spectrum of salivary gland lesions is wide and the relative incidence of neoplastic and non-neoplastic lesions is variable in different studies. Despite the relatively common nature of salivary gland disorders, there is dearth of literature on these lesions, especially in sub-Saharan Africa. We therefore embarked on this study to analyze the differential diagnosis of salivary gland lesions seen and managed at our institution. Methods: A retrospective review of salivary gland disorders that presented at our facility from January 2012 to December 2016 was done. Information on patients’ demographic details, type and location of salivary gland lesion, histologic diagnosis and treatment were retrieved and analyzed with SPSS version 20. Result: A total of 65 patients were treated for salivary gland lesions of various types during the study period. The age of the patients ranged from 3 months to 68 years [mean 33.8 ± 12.3]. Neoplastic lesions [n = 39, 60.0%] were the commonest followed by sialolithiasis [n = 14, 21.5%] while mucous retention/extravasation cysts accounted for 13.9% of the cases. Pleomorphic adenoma was the predominant tumor in this series [87.2%] and the commonest site was the parotid gland [58.8%]. On the contrary submandibular gland appeared to be the commonest site for sialolithiasis [57.1%]. The majority of mucous retention/extravasation cysts occurred in the sublingual gland [55.5%]. Conclusion: Neoplastic lesions remain the commonest salivary gland disorder and pleomorphic adenoma was the most prevalent. Sialolithiasis and mucous cysts are salivary gland lesions with equally wide disease spectrum.
Levels of Pb, Fe, Cd and Co in Soils of Automobile Workshop in Osun State, Nigeria
OO Abidemi
Journal of Applied Sciences and Environmental Management , 2011,
Abstract: The disposal of waste of all kinds in auto-repair workshop areas in Nigeria is becoming alarming. The study looks into the contribution of different sections in auto-repair workshop to heavy metal pollution in soil .Thirty –two soil samples were collected at an auto-repair workshop in Osogbo, Ikirun, Iragbiji and Iree in Osun State for their cobalt, iron , lead and cadmium level at different sections namely: auto-mechanic unit, auto welding unit, auto electrician unit and auto painting unit using atomic absorption spectrophotometer.The highest cobalt concentration was obtained in Iree at the auto welding unit, (17.25± 1.10mg/kg), iron had its highest level in Ikirun at the auto-mechanic unit (43937± 35mg/kg) , lead had its highest concentration in Iree at the auto welding unit (2460±16 mg/kg) and cadmium with the highest in Iree at the auto welding unit as well (2.02 ±1.01 mg/kg).Sites studied had higher levels of heavy metals compared to control areas. The general trend of dispersion of metal contamination within the soil profile is iron>> lead>> cobalt>cadmium. Statistical analysis reveals correlation between lead/iron (r = 0.636) at p<0.01. This work reveals the individual contribution of various allied artisans to soil pollution in automobile workshop. The research serves as an important contribution to the database on the baseline qualities of Nigerian soil.
Analysis of Inflation and its Determinants in Nigeria
Odusanya Ibrahim Abidemi,Atanda Akinwande Abdul Maliq
Pakistan Journal of Social Sciences , 2012, DOI: 10.3923/pjssci.2010.97.100
Abstract: The study critically analyzed the dynamic and simultaneous inter-relationship between inflation and its determinants in Nigeria between 1970 and 2007. The time series variables properties were examined using the Augmented Dickey Fuller (ADF) unit root test and the result reveals that inflation rate, growth rate of real output and money supply and real share of Fiscal deficit are stationary at levels while other incorporated variables in the empirical analysis; real share of Import, Exchange rate and Interest rate are stationary at first difference. The long-run and short-run mechanism of interaction between inflation and its determinants were examined usig the Augmented Engle-Granger (AEG) cointegration test and Error Correction Mechanism (ECM) model, respectively.
Anxiolytic and sedative properties of hydroethanolic extract of Telfairia occidentalis leaves in mice
Mutiu Y. Ajao,Abidemi J. Akindele
Revista Brasileira de Farmacognosia , 2013,
Abstract: Telfairia occidentalis Hook. f., Cucurbitaceae, is a leafy vegetable used in soup and folk medicine in southern Nigeria. This study was conducted to investigate the anxiolytic and sedative activities of the hydroethanolic extract of the leaves of T. occidentalis in mice. The hole-board, elevated plus maze, open-field, light-dark, and social interaction tests were used in this study. T. occidentalis (50-400 mg/kg) and diazepam (1 mg/kg) were administered p.o. to different groups of mice and appropriate observations were made. T. occidentalis increased the number of sectional crossings (p<0.01) and duration of head dips (p<0.05) at doses of 50 and 100 mg/kg respectively; increased number of entries into open arms (p<0.01) at the dose of 100 mg/kg; increased number of central squares crossed (p<0.01) at the dose of 50 mg/kg; and increased number of social interactions (p<0.001) at doses of 50 and 100 mg/kg. At the dose of 400 mg/kg, T. occidentalis reduced number of head dips and sectional crossings (p<0.01); reduced time spent in open arms and increased time spent in closed arms (p<0.01, 0.001) at doses of 200 and 400 mg/kg; reduced number of assisted rearings (p<0.001) at doses of 200 and 400 mg/kg; increased latency of entry into and time spent in dark box (p<0.01, 0.001) at doses of 200 and 400 mg/kg; and reduced number of social interactions (p<0.001) at the dose of 400 mg/kg. The findings in this study suggest that T. occidentalis possess anxiolytic property at doses of 50 and 100 mg/kg, and sedative activity at doses of 200 and 400 mg/kg.
Anxiolytic and sedative properties of hydroethanolic extract of Telfairia occidentalis leaves in mice
Mutiu Y. Ajao,Abidemi J. Akindele
Revista Brasileira de Farmacognosia , 2012, DOI: 10.1590/s0102-695x2012005000138
Abstract: Telfairia occidentalis Hook. f., Cucurbitaceae, is a leafy vegetable used in soup and folk medicine in southern Nigeria. This study was conducted to investigate the anxiolytic and sedative activities of the hydroethanolic extract of the leaves of T. occidentalis in mice. The hole-board, elevated plus maze, open-field, light-dark, and social interaction tests were used in this study. T. occidentalis (50-400 mg/kg) and diazepam (1 mg/kg) were administered p.o. to different groups of mice and appropriate observations were made. T. occidentalis increased the number of sectional crossings (p<0.01) and duration of head dips (p<0.05) at doses of 50 and 100 mg/kg respectively; increased number of entries into open arms (p<0.01) at the dose of 100 mg/kg; increased number of central squares crossed (p<0.01) at the dose of 50 mg/kg; and increased number of social interactions (p<0.001) at doses of 50 and 100 mg/kg. At the dose of 400 mg/kg, T. occidentalis reduced number of head dips and sectional crossings (p<0.01); reduced time spent in open arms and increased time spent in closed arms (p<0.01, 0.001) at doses of 200 and 400 mg/kg; reduced number of assisted rearings (p<0.001) at doses of 200 and 400 mg/kg; increased latency of entry into and time spent in dark box (p<0.01, 0.001) at doses of 200 and 400 mg/kg; and reduced number of social interactions (p<0.001) at the dose of 400 mg/kg. The findings in this study suggest that T. occidentalis possess anxiolytic property at doses of 50 and 100 mg/kg, and sedative activity at doses of 200 and 400 mg/kg.
Acute rheumatic fever: a public health concern in resource-poor settings
Olusegun Busari,George Opadijo,Abidemi Fasae
Arsiv Kaynak Tarama Dergisi , 2013,
Abstract: Acute rheumatic fever remains a public health concern in developing countries as well as in poorer communities and among indigenous populations in some developed nations. It poses serious economic problem at individual, communal and national levels through direct and indirect health care costs. The objective of this article is to review acute rheumatic fever in the global context with some emphasis on the continuing burden of this disease in the developing settings. The Cochrane Database of Systematic Reviews, PubMed, EMBASE and AJOL were searched with focus on epidemiology, pathogenesis, diagnosis and treatment, and control of acute rheumatic fever. The review shows that acute rheumatic fever still occurs under conditions of impoverished overcrowding and poor sanitation and where access to healthcare services is limited. Since acute rheumatic fever is a preventable disease, improved housing and sanitation, access to effective healthcare services, early diagnosis, registration of cases and follow up remain the bedrock of the control of this disease [Archives Medical Review Journal 2013; 22(2.000): 153-169]
Nutritional, Microbiological and Sensory Characteristics of Malted Soy-Kunu Zaki: An Improved Traditional Beverage  [PDF]
Aminat O. Adelekan, Adediran E. Alamu, Ngozi U. Arisa, Yetunde O. Adebayo, Abidemi S. Dosa
Advances in Microbiology (AiM) , 2013, DOI: 10.4236/aim.2013.34053
Abstract:

The nutritional, microbiological and sensory characteristics of improved kunu-zaki produced from malted cereals enriched with malted soymilk at different substitution levels (0% - 30%) were investigated. Enrichment with soymilk and malting increased the protein, amino acid, ash and moisture content of the improved kunu-zaki. Malting resulted in a decrease in carbohydrate and fat content. The protein content of the malted samples ranged between 2.79% and 3.82% while that of unmalted was 2.36%. There was decrease in the concentration of phytic acid and trypsin inhibitor after malting but the concentration increased as soymilk was added. Microbiological analyses showed that microbial load of samples increased with the addition of soymilk. There was a significant difference (p < 0.05) in the sensory attributes, acceptability decrease with increase in soymilk addition because of the beany flavor.

Dose and time-dependent sub-chronic toxicity study of hydroethanolic leaf extract of Flabellaria paniculata Cav. (Malpighiaceae) in rodents
Abidemi J. Akindele,Adejuwon A. Adeneye
Frontiers in Pharmacology , 2014, DOI: 10.3389/fphar.2014.00078
Abstract: Flabellaria paniculata Cav. (Malpighiaceae) is a climbing shrub, the preparations of which are used in the treatment of wounds and ulcers in Nigeria and Ghana. This study investigated the sub-chronic toxicity profile of the hydroethanolic leaf extract of Flabellaria paniculata (HLE-FP). HLE-FP was administered p.o. (20, 100 and 500 mg/kg) for 30 and 60 days to different groups of rats. Control animals received 10 ml/kg distilled water. In the group of animals for reversibility study, HLE-FP administration ceased on the 60th day and animals were monitored for a further 15 days. Results showed that oral treatment with HLE-FP for 30 days caused significant (p< 0.05) reductions in weight gain pattern compared to control. These changes were sustained with 60 days treatment. However, no significant (p>0.05) differences in relative organ weights between control and treatment groups were observed. HLE-FP-treated rats showed significant (p< 0.05) increases in Hb, PCV and RBC on day 30 and significant (p< 0.05) increases in MCV and MCH indices on day 60 compared to control. There were significant (p< 0.05) elevations in serum K+, urea and creatinine compared to control. The liver function tests showed slightly but non-significant alterations when compared to control. Biochemical findings were supported by histopathological observations of vital organs including the kidney and liver. Toxicities observed in respect of kidney function were irreversible at 15 days of stoppage of treatment. In the acute toxicity study, HLE-FP given p.o. caused no lethality at 5000 mg/kg but behavioural manifestations like restlessness, generalized body tremor, feed and water refusal were observed. The i.p. LD50 was estimated to be 2951.2 mg/kg. Findings in this study showed that HLE-FP is relatively non-toxic on acute exposure and generally safe on sub-chronic administration, but could be deleterious on the kidneys on prolonged oral exposure at a high dose. Thus, caution should be exercised with i
Occurrence and Levels of Chlorinated Pesticides Residues in Cow Milk: A Human Health Risk Assessment  [PDF]
Olayinka Abidemi Ibigbami, Ademola Festus Aiyesanmi, Adeolu Jonathan Adesina, Olugbenga Kayode Popoola
Journal of Agricultural Chemistry and Environment (JACEN) , 2019, DOI: 10.4236/jacen.2019.81005
Abstract: Background: The study determined the presence and concentration of persistent organochlorine pesticides (OCPs) residues in cow milk from Ekiti State University Agricultural farm in Ado-Ekiti, Nigeria. The study was investigated in order to monitor consumer’s exposure to these chemicals pesticides. Methods: Qualitative identification and quantification evaluation of the extracted pesticides after clean-up on silica gel were done with a Gas Chromatography coupled with an Electron Capture Detector (GC-ECD). Results: The results revealed the presence of 11 OCPs residues in the milk samples, with concentration range of 0.001 - 0.189 mg/l, while α-BHC, endrin, endrin aldehyde, endosulfan II, endosulfan sulphate and methoxychlor were not detected. The analysis of variance revealed no significant variation in the levels of all the analysed pesticides except dieldrin. Conclusion: The hazard indices (HIs) were significantly lower than 1 with the range of 0.00063 - 0.107, indicating no potential health risk.
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