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Search Results: 1 - 10 of 2385 matches for " Emily Chew "
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Application of Random Forests Methods to Diabetic Retinopathy Classification Analyses
Ramon Casanova, Santiago Saldana, Emily Y. Chew, Ronald P. Danis, Craig M. Greven, Walter T. Ambrosius
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0098587
Abstract: Background Diabetic retinopathy (DR) is one of the leading causes of blindness in the United States and world-wide. DR is a silent disease that may go unnoticed until it is too late for effective treatment. Therefore, early detection could improve the chances of therapeutic interventions that would alleviate its effects. Methodology Graded fundus photography and systemic data from 3443 ACCORD-Eye Study participants were used to estimate Random Forest (RF) and logistic regression classifiers. We studied the impact of sample size on classifier performance and the possibility of using RF generated class conditional probabilities as metrics describing DR risk. RF measures of variable importance are used to detect factors that affect classification performance. Principal Findings Both types of data were informative when discriminating participants with or without DR. RF based models produced much higher classification accuracy than those based on logistic regression. Combining both types of data did not increase accuracy but did increase statistical discrimination of healthy participants who subsequently did or did not have DR events during four years of follow-up. RF variable importance criteria revealed that microaneurysms counts in both eyes seemed to play the most important role in discrimination among the graded fundus variables, while the number of medicines and diabetes duration were the most relevant among the systemic variables. Conclusions and Significance We have introduced RF methods to DR classification analyses based on fundus photography data. In addition, we propose an approach to DR risk assessment based on metrics derived from graded fundus photography and systemic data. Our results suggest that RF methods could be a valuable tool to diagnose DR diagnosis and evaluate its progression.
Reducing Stigma Barriers to Help-Seeking Behaviors among College Students  [PDF]
Emily Reichert
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.310134
Abstract: College students suffer disproportionately from depression, an illness with significant consequences that, untreated, escalates in severity. A review of literature reveals that seeking help for this health issue is often stigmatized, reducing the likelihood of treatment. While the literature identifies the types of stigma, less is known about the communicative processes involved in stigma coping. This paper applies Meisenbach’s (2010) Theory of Stigma Management Communication (SMC) to this issue, suggested strategies researching depression stigma coping as well as new and promising intervention strategies to increase help seeking rates among college students.
Do You Know where Your Money Is? Product Disclosure Statements for Discretionary Investment Services  [PDF]
Emily Lou
Beijing Law Review (BLR) , 2013, DOI: 10.4236/blr.2013.41006

New Zealand capital markets currently do not serve retail investors well, creating investor skepticism regarding participation. A recent Reader’s Digest survey rated financial advisers among the least trustworthy of professions. This article maps the legal implications of the new measures introduced by the Financial Markets Conduct Bill 2011 to guard investor interests in relation to financial products and services. The paper provides a useful critique of the proposed reforms, in particular, whether the “Product Disclosure Statement” (PDS) and the new licensing of fund managers will give retail investors confidence in investing through financial intermediaries. The paper concluded with recommendation for New Zealand regulator to obtain inspiration from overseas model.

DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ω-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways
John Paul SanGiovanni, Jing Chen, Przemyslaw Sapieha, Christopher M. Aderman, Andreas Stahl, Traci E. Clemons, Emily Y. Chew, Lois E. H. Smith
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053155
Abstract: Background Increased intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) and use of peroxisome proliferator activator receptor (PPAR)-activating drugs are associated with attenuation of pathologic retinal angiogenesis. ω-3 LCPUFAs are endogenous agonists of PPARs. We postulated that DNA sequence variation in PPAR gamma (PPARG) co-activator 1 alpha (PPARGC1A), a gene encoding a co-activator of the LCPUFA-sensing PPARG-retinoid X receptor (RXR) transcription complex, may influence neovascularization (NV) in age-related macular degeneration (AMD). Methods We applied exact testing methods to examine distributions of DNA sequence variants in PPARGC1A for association with NV AMD and interaction of AMD-associated loci in genes of complement, lipid metabolism, and VEGF signaling systems. Our sample contained 1858 people from 3 elderly cohorts of western European ancestry. We concurrently investigated retinal gene expression profiles in 17-day-old neonatal mice on a 2% LCPUFA feeding paradigm to identify LCPUFA-regulated genes both associated with pathologic retinal angiogenesis and known to interact with PPARs or PPARGC1A. Results A DNA coding variant (rs3736265) and a 3'UTR-resident regulatory variant (rs3774923) in PPARGC1A were independently associated with NV AMD (exact P = 0.003, both SNPs). SNP-SNP interactions existed for NV AMD (P<0.005) with rs3736265 and a AMD-associated variant in complement factor B (CFB, rs512559). PPARGC1A influences activation of the AMD-associated complement component 3 (C3) promoter fragment and CFB influences activation and proteolysis of C3. We observed interaction (P≤0.003) of rs3736265 with a variant in vascular endothelial growth factor A (VEGFA, rs3025033), a key molecule in retinal angiogenesis. Another PPARGC1A coding variant (rs8192678) showed statistical interaction with a SNP in the VEGFA receptor fms-related tyrosine kinase 1 (FLT1, rs10507386; P≤0.003). C3 expression was down-regulated 2-fold in retinas of ω-3 LCPUFA-fed mice – these animals also showed 70% reduction in retinal NV (P≤0.001). Conclusion Ligands and co-activators of the ω-3 LCPUFA sensing PPAR-RXR axis may influence retinal angiogenesis in NV AMD via the complement and VEGF signaling systems. We have linked the co-activator of a lipid-sensing transcription factor (PPARG co-activator 1 alpha, PPARGC1A) to age-related macular degeneration (AMD) and AMD-associated genes.
Clinical breast cancer and estrogen
HK Chew
Breast Cancer Research , 2003, DOI: 10.1186/bcr677
Malaysian Family Physician , 2008,
Abstract: The massive 2008 Sichuan earthquake brought unprecedented international humanitarian aid to China. The monstrous damages and casualties aroused all human’s sympathy. I took the opportunity to join a Malaysian voluntary medical relief team to Sichuan in June 2008. This essay recounts the immediate events post-earthquake and reports on my experience during the mission.
Malaysian Family Physician , 2010,
Abstract: This case reports a 57-year-old lady presented with cough of two months duration despite repeated treatments from multiple general practitioners. It took her another two months to know her diagnoses and a further couple of months to be relieved of her cough and became asymptomatic. Chronic cough management in primary care often needs an empiric integrative approach and requires good doctor-patient rapport with informed follow ups and continuity of care to be successful.
Milne Quantum-Universe Redshift-Luminosity Correlation
Geoffrey Chew
Physics , 2011,
Abstract: Milne`s classical homogeneous-universe cosmology predicts a product of Hubble constant with luminosity distance that equals z + z2/2, where z is redshift. Supernova-data are consistent with this relation, supporting quantum-theoretic considerations that reveal Milne`s universe as "non-empty".
Encouraging the Innovative Use of Geometer’s Sketchpad through Lesson Study  [PDF]
Chew Cheng Meng, Lim Chap Sam
Creative Education (CE) , 2011, DOI: 10.4236/ce.2011.23032
Abstract: The purpose of this study was to encourage the innovative use of Geometer’s Sketchpad (GSP) in the teaching and learning of mathematics among secondary school teachers in Malaysia through Lesson Study (LS). Three LS groups were set up in three secondary schools. Qualitative data were collected through written lesson plans, video-taped teaching and individual interviews with the participants. Findings of the study show positive changes in the participants’ knowledge and skills of using GSP to teach the topics of “Lines and Planes in Three Dimensions,” “Loci in Two Dimensions” and “Plans and Elevations.” These are evidenced in their mathematics lesson plans, GSP sketches, worksheets and videotaped teaching observations. Analysis of their interview transcripts also reveals positive acceptance and encouraging feedback about LS that promotes peer support and collaboration. Thus, the participants have more confidence in using GSP innovatively to teach mathematics at the secondary school level after the LS collaboration.
Airway Foreign Body in Children  [PDF]
Hui Sing Chew, Henry Kun Kiaang Tan
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.37117

Introduction: Foreign body aspiration is not uncommon in children. It can be associated with significant morbidity and mortality. This study aims to determine and analyze the characteristics of local pediatrics airway foreign body (FB) aspiration. Methods: A retrospective study of medical records from KK hospital (1997-2010) is done. Patient demographics, clinical/investigative findings, duration of hospitalization and complications are analyzed. Results: The sample consisted of 26 patients (eight months - 13 years of age), who underwent rigid bronchoscopy for FB removal over the last 13 years. Seventy-seven percent were three years of age or younger. Peak incidence (61.6%) was at one to two years of age. Nineteen were males and seven were females. The top three clinical presentations were: cough (61.5%), choking (46.2%) and wheezing (42.3%). Decreased air entry (34.6%), tachypnea (26.9%) and no significant findings (23.1%) were the most common features on physical examination. The most common radiographic findings were consolidation (30.8%), presence of a foreign body (23.1%) and no abnormality (23.1%). Aspiration was primarily into the right main bronchus (38.5%), and 61.5% of the FB was organic in nature [principally peanuts (38.5%)]. Mean hospitalization duration was three days. Delayed diagnose in three cases were secondary to mis-diagnoses as croup (n = two) and respiratory tract infection (n = one). Complications were noted in eight cases (30.8%). There was no mortality. Conclusion: High index of suspicion is required in diagnosing airway FB. Physician’s diagnostic acumen is vital in prompt successful treatment. Heightening public’s awareness is the key to prevention of pediatrics FB aspiration.

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