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Search Results: 1 - 10 of 483529 matches for " Elza Márcia T.;Valério "
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Clinical and eeg analysis of mesial and lateral temporal lobe seizures
DANTAS, FáBIO GALV?O;YACUBIAN, ELZA MáRCIA T.;JORGE, CARMEN L.;PEDREIRA, CHRISTIANE C.;BUENO, JOAQUIM F.;VALéRIO, ROSA M. F.;
Arquivos de Neuro-Psiquiatria , 1998, DOI: 10.1590/S0004-282X1998000300001
Abstract: the analysis of the temporal lobe seizures through video-eeg systems shows that they often consist of a sequence of clinical and eeg features which may suggest the localization and the lateralization of the epileptogenic lobe. we analyzed clinical and eeg features of 50 temporal lobe seizures which were separated in group 1 with 25 patients (related to mesial temporal sclerosis) and group 2 with 25 patients (other neocortical temporal lesions). among the auras, the epigastric type was the most frequent and predominated in group 1. there were differences between the two groups, considering dystonic and tonic posturing and versive head and eye movements. dystonic posturing was always contralateral to the ictal onset and was considered the most useful lateralizing clinical feature. ictal speech, spitting and blinking automatisms, prolonged disorientation for place and a greatest percentage of postictal language preservation occurred in right temporal seizures. postictal aphasia and global disorientation predominated in left temporal seizures. eeg was important for lateralizing the epileptogenic lobe, specially considering rhythmic ictal activity and postictal findings.
Manifesta??es clínicas de crises parciais complexas do lobo temporal: um estudo vídeo-eletrencefalográfico
Yacubian, Elza Márcia T.;Valério, Rosa Maria F.;Jorge, Carmem Lisa;Fiore, Lia A.;Cukiert, Arthur;Assis, Luís Marques De;
Arquivos de Neuro-Psiquiatria , 1994, DOI: 10.1590/S0004-282X1994000200001
Abstract: we analysed 27 complex partial seizures arising from the temporal lobes recorded on videotape simultaneously with the eeg emphasizing the motor manifestations specially dystonic posturing, ictal paresis and head and eye forced deviation (version). the temporal lobe origin of the seizures was based on the agreement of many scalp-sphenoidal or zygomatic interictal and ictal eeg recordings, ct and mri findings, interictal and, in some patients, ictal spect studies. 8 patients had surgery. in 5 from 7 patients who had temporal lobectomy, mesial temporal sclerosis was the anatomopathological finding and in one patient who had selective amigdalohippocampectomy,.hemosiderosis and gliosis probably due to bleeding of a posterior cerebral artery giant aneurysm was found. all patients have been seizure free after surgery. while dystonic posturing and ictal paresis, present in 18 seizures(66.6%), were excellent as lateralizing seizure signs, since they were always contralateral to the ictal onset, contralateral and ipsilateral versive head and eye movements were observed.
Tomografia por emiss?o de fóton único em epilepsia temporal: estudos intercríticos e críticos com análise visual e semi quantitativa
Yacubian, Elza Márcia T.;Yamaga, Lilian Y.I.;Valério, Rosa Maria F.;Fiore, Lia A.;Jorge, Carmen Lisa;Buchpiguel, Carlos A.;
Arquivos de Neuro-Psiquiatria , 1995, DOI: 10.1590/S0004-282X1995000300002
Abstract: single photon emission tomography (spect) was performed in 27 patients with refractory complex partial seizures from the temporal lobes due to mesial temporal sclerosis. independent blinded observers assessed the 28 interictal studies and 9 ictal/postictal studies. visual analysis of interictal studies detected hypoperfusion in 22, ipsilateral to the epileptogenic zone in 19 (67%) and contralateral in 3 (10.7%). quantified temporal lobe asymmetry, greater than a previously derived normal range, correctly identified the epileptogenic zone in 16 (61.5%) with false lateralization in 4 (15.3%). in all 9 cases in which they were performed, ictal/postictal studies showed hypoperfusion at the region of epileptic focus. in 3 patients with complex partial seizures followed by symmetric generalized tonic-clonic seizures, hyperperfusion restricted to the temporal lobe was demonstrated. in 5 of these patients the interictal studies were unable to demonstrate localized changes. there were no significant correlations between spect findings and clinical parameters or eeg slowing in the temporal lobes.
Bradicardia como manifesta??o epiléptica em epilepsia temporal: relato de caso
JORGE, CARMEN L.;VALéRIO, ROSA M. F.;YACUBIAN, ELZA M. T.;
Arquivos de Neuro-Psiquiatria , 2000, DOI: 10.1590/S0004-282X2000000500022
Abstract: we describe a patient who had cardiac arrhythmia as epileptic manifestation. in a 34-year-old woman who had many episodes of loss of consciousness, the simultaneous ecg and video-eeg monitoring recorded bradycardia with a short episode of asystolia (4 seconds) and left temporal rhythmic teta activity on eeg. mri showed a small mass lesion in the left parahippocampal gyrus. alterations in cardiac rhythm have been reported in epileptic seizures and taquycardia is the most common finding associated with them; bradyarrhythmia during seizures was uncommon. many interconnections among insular cortex, limbic system and hypothalamus, may be responsible for vegetative manifestations in temporal lobe epilepsy.
Bradicardia como manifesta o epiléptica em epilepsia temporal: relato de caso
JORGE CARMEN L.,VALéRIO ROSA M. F.,YACUBIAN ELZA M. T.
Arquivos de Neuro-Psiquiatria , 2000,
Abstract: Descrevemos um caso de arritmia cardíaca como manifesta o epiléptica. A monitoriza o video-eletrencefalográfica de uma paciente com 34 anos de idade que apresentava episódios de perda de consciência permitiu a detec o de períodos de assistolia como principal manifesta o clínica, exigindo a implanta o de marca-passo. O registro eletrencefalográfico concomitante mostrou atividade rítmica a 6-7 Hz de proje o na regi o temporal esquerda. A ressonancia magnética mostrou les o expansiva no giro para-hipocampal esquerdo. Altera es do ritmo cardíaco como taquicardia sinusal s o frequentes em crises epilépticas. A descri o de bradicardia e/ou assistolia é rara. As conex es das estruturas mesiais temporais com estruturas profundas como o hipotálamo devem ser responsáveis pelas manifesta es vegetativas durante crises epilépticas temporais.
Medicamentos genéricos no tratamento das epilepsias: uma reflex?o
Yacubian, Elza Márcia T.;
Journal of Epilepsy and Clinical Neurophysiology , 2007, DOI: 10.1590/S1676-26492007000300007
Abstract: objective: we discuss some controversial aspects with prescription of generic drugs (gd) and the problems concerning bioequivalence in the treatment of epilepsy. some antiepileptic drugs (aed) are poorly soluble in water, have nonlinear kinetics and a narrow therapeutic range, implying that problems with bioequivalence are likely to occur. there are clearly advantages (cost saving) and disadvantages (loss of seizure control or drug toxicity) in prescribing generics aed. methods: review of literature. results and conclusion: the main information is about classical aed (phenytoin, carbamazepine and valproate). regarding the new aed we found only one poster presentation related to lamotrigine substitution. the level of evidence is, generally, weak, based on case-series and expert opinion without explicit critical appraisal (except in phenytoin with level of evidence moderate, based on some analytical studies). we may allow the use of generics for epilepsy treatment. however, this opens the possibility of successive substitution of different formulations which may even be life threatening.
Clinical characteristics and surgical outcome of patients with temporal lobe tumors and epilepsy
JORGE, CARMEN LISA;NAGAHASHI-MARIE, SUELY K.;PEDREIRA, CHRISTIANE C.;ROSEMBERG, SéRGIO;VALéRIO, ROSA M.F.;VALENTE, KETTE D.R.;YACUBIAN, ELZA M.T.;
Arquivos de Neuro-Psiquiatria , 2000, DOI: 10.1590/S0004-282X2000000600004
Abstract: this is a retrospective study of 21 surgically treated patients with temporal lobe tumors and epilepsy. evaluation included clinical data, eeg findings, structural scans, pathological diagnosis and post-surgical follow-up. there were 9 cases of ganglioglioma, 5 pilocytic astrocytoma, 3 ganglioneuroma, 2 dysembryoplastic neuroepithelial tumor, 1 pleomorphic xantoastrocytoma, and 1 meningioangiomatosis. mean follow-up time was 22 months and outcome was evaluated according to engel's classification; 76.2% were classified in class i and 23.8% in ii and iii. all patients classes ii and iii had been submitted to mesial and neocortical resections. there were no differences related to clinical characteristics, pathological diagnosis or duration of follow-up in patients seizure-free or not. all patients had abnormal mri and ten of these had normal ct; the mri characteristics were compared to pathological diagnosis and specific histological characteristics of the tumors were not discernible by mri. we concluded that mri was essential for the diagnosis and precise location of tl tumors. ganglioglioma was the most frequent tumor and lesionectomy associated to mesial resection doesn't guarantee a better prognosis.
Porcine Circovirus 2: Immunopathogenesis and Recent Developments in Vaccines  [PDF]
Abelardo Silva Júnior, Otávio Valério de Carvalho, Luiz Henrique Silva Bulos, Juliana Lopes Rangel Fietto, Mauro Pires Moraes, Márcia Rogéria de Almeida
World Journal of Vaccines (WJV) , 2012, DOI: 10.4236/wjv.2012.22013
Abstract: Porcine circovirus 2 (PCV2) is currently considered an important etiologic agent of swine and its infection has potentially serious economic impact on the swine industry worldwide. This virus is frequently associated with postweaning multisystemic wasting syndrome (PMWS), and also with other clinical conditions such as porcine dermatitis and nephropathy syndrome (PDNS), late-term abortions, reproductive failure in sows, proliferative and necrotizing pneumonia and congenital tremors. The term porcine circovirus-associated disease (PCVAD) is currently used to refer to any of these diseases when they are associated with PCV2 infection. The PCV2 was recognized as a pathogen in 1997, and many questions regarding its biology and pathogenesis remain unanswered. Currently, some studies have shown the production of new vaccine candidates and field efficacy testing of commercial vaccines. This review discusses some major points concerned with immunopathogenesis and vaccines for PCV2 infection.
Consenso terminológico da associa??o brasileira de epilepsia
Guilhoto, Laura M. F. Ferreira;Muszkat, Regina S.;Yacubian, Elza Márcia T.;
Journal of Epilepsy and Clinical Neurophysiology , 2006, DOI: 10.1590/S1676-26492006000500011
Abstract: the objective of this paper is to review the terminology about epilepsy used in brazil, in order to unify terms for lay people and health professionals, hence there is no consensus. because of the heterogeneity of epilepsy, the term disorder seems to be the more complete regarding scientific and social aspects. the associa??o brasileira de epilepsia proposes the following definition based on ilae definition (2005): "epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures and by the neurobiologic, cognitive, psychological, and social consequences of this condition. the definition of epilepsy requires the occurrence of at least one epileptic seizure". the abe considers that the terms disease, carrier, epileptic must be outlawed and epilepsy should be considered a disorder, and the individuals that present it, people with epilepsy.
Clinical and eeg analysis of mesial and lateral temporal lobe seizures
DANTAS FáBIO GALV?O,YACUBIAN ELZA MáRCIA T.,JORGE CARMEN L.,PEDREIRA CHRISTIANE C.
Arquivos de Neuro-Psiquiatria , 1998,
Abstract: The analysis of the temporal lobe seizures through video-EEG systems shows that they often consist of a sequence of clinical and EEG features which may suggest the localization and the lateralization of the epileptogenic lobe. We analyzed clinical and EEG features of 50 temporal lobe seizures which were separated in group 1 with 25 patients (related to mesial temporal sclerosis) and group 2 with 25 patients (other neocortical temporal lesions). Among the auras, the epigastric type was the most frequent and predominated in group 1. There were differences between the two groups, considering dystonic and tonic posturing and versive head and eye movements. Dystonic posturing was always contralateral to the ictal onset and was considered the most useful lateralizing clinical feature. Ictal speech, spitting and blinking automatisms, prolonged disorientation for place and a greatest percentage of postictal language preservation occurred in right temporal seizures. Postictal aphasia and global disorientation predominated in left temporal seizures. EEG was important for lateralizing the epileptogenic lobe, specially considering rhythmic ictal activity and postictal findings.
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