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Search Results: 1 - 10 of 1501 matches for " Elvira Mohr "
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Involvement of the epidermal growth factor receptor in the modulation of multidrug resistance in human hepatocellular carcinoma cells in vitro
Katrin Hoffmann, Zhi Xiao, Clemens Franz, Elvira Mohr, Susanne Serba, Markus W Büchler, Peter Schemmer
Cancer Cell International , 2011, DOI: 10.1186/1475-2867-11-40
Abstract: Chemotherapeutic treatment induces multidrug resistance and significantly increases ABC-transport protein expression and function in a time- and dose-dependent manner in HCC cells. Furthermore, cytostatic treatment increases the mRNA expression of tyrosine kinases and induces the phosphorylation of ERK. EGF activation of the tyrosine kinase pathway up-regulated the ABC-transport protein mRNA expression and enhanced the survival of resistant HCC cells. Consistent with these effects, inhibition of the EGFR using siRNA decreased the ABC-transport protein mRNA expression and inhibited the proliferation of resistant cells. Additional treatment with Gefitinib, a clinically approved EGFR inhibitor, caused a dose-dependent reversal of resistance to conventional chemotherapy.The present study demonstrates that the multidrug resistance of HCC is modulated through the EGF-activated tyrosine kinase cascade. Consequentially, the restoration of chemosensitivity by EGFR inhibition may lead towards new tailored therapies in patients with highly resistant tumors.Hepatocellular carcinoma (HCC) is a major health problem worldwide. Its incidence is increasing continuously in the Western world. In the United States and Europe the diagnosis of HCC has almost doubled during the last two decades [1]. Despite recent improvements in surveillance programs and diagnostic tools, only 30-40% of HCC patients are eligible for liver resection or transplantation, the only curative treatment options to date [2]. The tyrosine kinase inhibitor sorafenib is the current standard of care for palliative treatment; the partial response rate, however, is only about 10% [3]. Conventional systemic chemotherapy has shown only minor effectiveness with response rates far below 10% [4]. A substantial resistance against structurally and functionally unrelated cytostatic drugs develops through the destruction of vulnerable and negative chemoresistant tumor cell populations during hepatocarcinogenesis. An increased c
MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma
Shibo Lin, Katrin Hoffmann, Zhi Xiao, Nan Jin, Uwe Galli, Elvira Mohr, Markus W Büchler, Peter Schemmer
Cancer Cell International , 2013, DOI: 10.1186/1475-2867-13-3
Abstract: The Raf1 kinase inhibitor (GW5074) and different MEK inhibitors (U0126 and AZD6244) were used to treat HCC cells to identify their effects on HCC cell growth and ABC proteins expression in vitro. Cell viability tests were performed after the treatment of MAPK pathway inhibitors and in combination with gemcitabine or doxorubicin. Western blot was applied to assess the changes of MAPK pathway and protein expression of MRP1 and MRP3. Flow cytometry was used to measure intracellular doxorubicin accumulation after the treatment of MEK inhibitors.Both Raf1 inhibitor (GW5074) and MEK inhibitors (U0126 and AZD6244) suppressed HCC cell growth in a dose dependent manner. Pre-treatment of MEK inhibitor U0126 or AZD6244 sensitized HCC cells to gemcitabine or doxorubicin based chemotherapy. Raf1 inhibitor GW5074 had no effect on MRP1 and MRP3 protein expression. Treatment of gemcitabine or doxorubicin activated phosphorylated ERK and induced the upregulation of MRP1 and MRP3. MEK inhibitors U0126 and AZD6244 deactivated phosphorylated ERK, decreased endogenous MRP1 expression, reversed gemcitabine or doxorubicin induced MRP1 and MRP3 upregulation, and increased the intracellular doxorubicin accumulation.This study provides evidence that MEK inhibitors sensitize HCC cells to chemotherapy by increasing intracellular chemodrug accumulation. MEK inhibirors U0126 and AZD6244 reduced MRP1 as well as MRP3 expression, and may contribute partially to the sensitization. The combination of MEK inhibitor and conventional chemotherapy may offer new therapeutic option for the treatment of resistant HCC.Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality and causes more than half a million deaths annually worldwide [1,2]. The number of new cases of primary liver cancer increases globally and HCC accounts for 70% to 85% of them [3]. Potentially curative treatment, including liver resection, transplantation and local ablation, could provide promising 5-year-survival
Effects of a Preconditioning Oral Nutritional Supplement on Pig Livers after Warm Ischemia
Arash Nickkholgh,Zhanqing Li,Xue Yi,Elvira Mohr,Rui Liang,Saulius Mikalauskas,Marie-Luise Gross,Markus Zorn,Steffen Benzing,Heinz Schneider,Markus W. Büchler,Peter Schemmer
HPB Surgery , 2012, DOI: 10.1155/2012/783479
Abstract: Background. Several approaches have been proposed to pharmacologically ameliorate hepatic ischemia/reperfusion injury (IRI). This study was designed to evaluate the effects of a preconditioning oral nutritional supplement (pONS) containing glutamine, antioxidants, and green tea extract on hepatic warm IRI in pigs. Methods. pONS (70?g per serving, Fresenius Kabi, Germany) was dissolved in 250?mL tap water and given to pigs 24, 12, and 2?hrs before warm ischemia of the liver. A fourth dose was given 3?hrs after reperfusion. Controls were given the same amount of cellulose with the same volume of water. Two hours after the third dose of pONS, both the portal vein and the hepatic artery were clamped for 40?min. 0.5, 3, 6, and 8?hrs after reperfusion, heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), portal venous flow (PVF), hepatic arterial flow (HAF), bile flow, and transaminases were measured. Liver tissue was taken 8?hrs after reperfusion for histology and immunohistochemistry. Results. HR, MAP, CVP, HAF, and PVF were comparable between the two groups. pONS significantly increased bile flow 8?hrs after reperfusion. ALT and AST were significantly lower after pONS. Histology showed significantly more severe necrosis and neutrophil infiltration in controls. pONS significantly decreased the index of immunohistochemical expression for TNF-α, MPO, and cleaved caspase-3 ( ). Conclusion. Administration of pONS before and after tissue damage protects the liver from warm IRI via mechanisms including decreasing oxidative stress, lipid peroxidation, apoptosis, and necrosis. 1. Introduction During liver surgery, the inflow occlusion maneuver to prevent blood loss as well as the liver manipulation itself have been shown to induce a cascade of molecular events, referred to as ischemia-reperfusion injury (IRI). IRI leads to the activation of Kupffer cells (KCs), the release of reactive oxygen species (ROS) and proinflammatory cytokines, microcirculatory disturbances, and eventually liver dysfunction and failure [1–10]. Different strategies have been proposed to prevent or ameliorate IRI. Among others, pharmacological preconditioning has been shown to be effective via mechanisms including, but not limited to, the direct neutralization of ROS, upregulation of anti-inflammatory, and downregulation of proinflammatory signaling pathways [11–27]. During IRI, intestinal endotoxins (LPS) leak through the altered gut membrane into the portal circulation and enhance the phagocytosis in hepatic KCs [28–35]. This interrelation between intestinal LPS and
Development and Application of an Inter-Organizational PPP Knowledge Transfer Effectiveness Model for Knowledge Sourced in Public Sector Organizations  [PDF]
Geoffrey Aerts, Elvira Haezendonck
American Journal of Industrial and Business Management (AJIBM) , 2017, DOI: 10.4236/ajibm.2017.75050
Abstract: The research aim is to develop and apply the conceptual inter-organizational knowledge transfer effectiveness (IOKTE) model to the inter-organizational transfer of Public-Private Partnership (PPP) related knowledge between public sector organizations in Flanders. The model assumes a relationship between an individual’s ability to make PPP-related decisions and the extent to which knowledge is sought after, applied and shared in an inter-organisational manner within the public sector. The inter-organizational transfer of knowledge studied in this article is specific to PPP in Flanders and studied for public sector actors active at diverse policy levels. The aim is to uncover the extent to which the current system of inter-organizational knowledge transfer fits the user’s satisfaction, expressed as the extent to which the use of the system improves the perceived decision-making on PPPs. The results indicate that searching for, sharing and using PPP-related knowledge sourced in public sector organizations improve the perceived decision-making ability. The research establishes that the current public sector PPP knowledge transfer system is perceived as being effective, yet for the assessment of its efficiency, insufficient data is found. Issues that stand to be improved are the fragmentation of the knowledge assets and the access across policy levels.
Integration of Spirituality and Religion in the Care of Patients with Severe Mental Disorders
Sylvia Mohr
Religions , 2011, DOI: 10.3390/rel2040549
Abstract: Spirituality and religiousness (S/R) are resources for finding meaning and hope in suffering and have been identified as key components in the process of psychological recovery. However, religion may also be associated with psycho-pathology, suffering and non-adherence with psychiatric treatment. Based on a literature review, this paper examines how S/R can be integrated in the treatment of patients with serious mental illness. We implemented a pilot “Spirituality and Recovery Group” designed to (1) help patients to resort to S/R as a means of recovery; (2) work on resolving conflicts between S/R and life issues and treatment; and (3) provide information on S/R in the context of psychosis. Preliminary results are presented.
Análise do conteúdo de 'saúde' em livros didáticos
Mohr, Adriana;
Ciência & Educa??o (Bauru) , 2000, DOI: 10.1590/S1516-73132000000200002
Abstract: the article proposes a set of criteria to be adopted in the analysis of textbooks used by students from the four initial years of elementary school in brazil. the health notions identified in three collections are here analysed.
α-Cluster States in Intermediate Mass Nuclei
Peter Mohr
The Open Nuclear & Particle Physics Journal , 2008, DOI: 10.2174/1874415000902010001]
Abstract: Properties of intermediate mass nuclei have been investigated within the framework of the α-cluster model in combination with systematic double-folding potentials. Previously, this ??-cluster model has been widely applied to light nuclei, in particular to 8Be = α α, 20Ne = 16O ?? α, and 44Ti = 40Ca ?? α, and to heavy nuclei, in particular to 212Po = 208Pb ?? α. In the present work a wide range of nuclei is investigated with the magic neutron number N = 50 in the mass range around A ?? 80 - 100: (A+4,N=52) = (A,N=50) ?? α. It is found that excitation energies, decay properties, and transition strengths can be described successfully within this model. The smooth and small variation of the underlying parameters of the α-nucleus potential may be used for extrapolations to predict experimentally unknown properties in the nuclei under study.
The chemistry of gold-fluoro compounds: A continuing challenge for gold chemists
Fabian Mohr
Gold Bulletin , 2004, DOI: 10.1007/BF03215208
Abstract: This article gives a brief overview of the chemistry of gold-fluoro compounds known to date. The synthesis, structures, reactivity and computational results of gold fluorides are reviewed, discussed according to the gold oxidation state. The literature up to (and including) 2003 has been covered.
Local court reforms and ‘global’ law
Richard Mohr
Utrecht Law Review , 2007,
Abstract: This study considers court reform programmes sponsored by the IMF and World Bank in Indonesia and Venezuela. It aims to broaden the frame of reference of ‘globalisation’ in law beyond the two traditional sites of human rights and trade. Drawing on a tradition of legal pluralism, it investigates the various sources of ‘global’ or universalising pressures on the law. The sources and impacts of these efforts may derive from and benefit or disadvantage specific groups in various locations. They will also promote or inhibit particular political, social or economic projects. The study concludes that various constituencies and impulses to reform refer to different versions of the ‘universal’ for their conception of right and legitimacy. These are neither inherently local nor unambiguously global. Local religious or egalitarian movements may refer to universal religious or political values just as interests in fair commercial dealing can call on international legal norms. In contrast to the local sites where law is performed, these universal sites exist in a multitude of indigenous, religious, political and legal imagined communities, each of which may be invoked in attempts to reform local practice.
Resultados del estudio SYNTAX desde el punto de vista del cirujano
Friedrich Mohr
Revista Argentina de Cardiología , 2009,
Abstract: El estudio SYNTAX (SYNergia entre ICP con TAXus y cirugía cardíaca) se enfocó en pacientesportadores de enfermedad coronaria de tres vasos o enfermedad del tronco de lacoronaria izquierda no tratados previamente. Se aleatorizaron 1.800 pacientes, 1:1 en cadarama, respectivamente, a ICP o bypass. El primer punto final combinado estuvo compuestopor mortalidad, eventos cardíacos y cerebrovasculares y necesidad de nueva revascularización(MACCE = major adverse cardiac and cerebrovascular event). Se demostró una superioridadsignificativa de la cirugía sobre la ICP. La frecuencia de MACCE al a o fue del 17,8%para ICP en comparación con el 12,1% en la rama bypass (p = 0,0015). Esta situación seincrementó a los 2 a os con los grupos de mayor riesgo. En pacientes de riesgo alto, la tasade MACCE fue del 15,4% versus el 28,2% para el grupo ICP (p < 0,001). En este contexto, lamortalidad por todas las causas fue del 5,9% para el grupo ICP y del 3,3% para el CABG (p< 0,008). La frecuencia de eventos cardiovasculares fue a favor de la ICP. Es importanteesperar las conclusiones a los 5 a os.REV ARGENT CARDIOL 2009;77:518-520.
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