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Search Results: 1 - 10 of 483191 matches for " Elvira M.M.;Maranh?o "
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Irregularidade do ciclo menstrual no menacme como marcador para fatores de risco cardiovasculares na pós-menopausa
Azevedo, George D.;Duarte, Jo?o-Marcelo B.P.;Souza, Maxwell O.;Costa-e-Silva, Thiago D.N.;Soares, Elvira M.M.;Maranho, Técia M.O.;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2006, DOI: 10.1590/S0004-27302006000500008
Abstract: to evaluate the association between cardiovascular risk factors (cvrf) during postmenopausal years and previous menstrual irregularity during reproductive years, we performed a case-control study in 414 postmenopausal women (mean age 60.4 ± 5.5 years; bmi 25.3 ± 4.7 kg/m2). the variables assessed were: menstrual cycle characteristics at age 20-35y (independent) and records of arterial hypertension, dyslipidemia, diabetes mellitus, and coronary heart disease (dependent). statistical analysis used the chi-square test and logistic regression, adjusting for potential confounders for cardiovascular risk, with significance set at 5%. women reporting previous menstrual irregularity were associated with increased risk for some cvrf [adjusted odds ratio (or) 2.14; ci-95%= 1.02-4.48], when compared with those reporting regular menstrual cycles. stratified analysis demonstrated significant associations of previous menstrual irregularity with: arterial hypertension [or= 2.74; ci-95%= 1.39-5.41), hypercholesterolemia (or= 2.32; ci-95%= 1.17-4.59), hypertriglyceridemia (or= 2.09; ci-95%=1.10-4.33), and coronary angioplasty (or= 6.82; ci-95%= 1.44-32.18). these data suggest that a prior history of menstrual irregularity, as indicative of polycystic ovary syndrome, may be related to increased risk for cvd during postmenopausal years.
Expression of anti-Z-DNA single chain antibody variable fragment on the filamentous phage surface
Maranho, A.Q.;Brígido, M.M.;
Brazilian Journal of Medical and Biological Research , 2000, DOI: 10.1590/S0100-879X2000000500012
Abstract: we describe the expression of an anti-z-dna single chain variable region antibody fragment (scfv) on a filamentous phage surface. four vectors for phage display were constructed. two of them are able to display multiple copies of the antibody fragment, and the others can be used to make monovalent libraries. the vectors use different promoter/leader sequences to direct the expression of the fused proteins. all were able to promote the assembly of fusion virion particles. in this paper we also show the affinity selection (biopanning) of those phage-antibodies based on the capacity of their products to recognize the antigen. we used biotinylated z-dna and the selection was performed in a solution phase fashion. the data presented here indicate that these vectors can be further used to construct anti-nucleic acid antibody fragment libraries that can be used to study the basis of nucleic acid-protein interaction and its role in autoimmunity mechanisms.
Expression of anti-Z-DNA single chain antibody variable fragment on the filamentous phage surface
Maranho A.Q.,Brígido M.M.
Brazilian Journal of Medical and Biological Research , 2000,
Abstract: We describe the expression of an anti-Z-DNA single chain variable region antibody fragment (scFv) on a filamentous phage surface. Four vectors for phage display were constructed. Two of them are able to display multiple copies of the antibody fragment, and the others can be used to make monovalent libraries. The vectors use different promoter/leader sequences to direct the expression of the fused proteins. All were able to promote the assembly of fusion virion particles. In this paper we also show the affinity selection (biopanning) of those phage-antibodies based on the capacity of their products to recognize the antigen. We used biotinylated Z-DNA and the selection was performed in a solution phase fashion. The data presented here indicate that these vectors can be further used to construct anti-nucleic acid antibody fragment libraries that can be used to study the basis of nucleic acid-protein interaction and its role in autoimmunity mechanisms.
Concentra??o de uranio em plantas desenvolvidas em solos agrícolas e de escombreira da área mineira da Cunha Baixa (Mangualde)
Neves,O.; Abreu,M.M.;
Revista de Ciências Agrárias , 2010,
Abstract: the uranium concentration and the bioco-centration capacity (bc) in several plant species (aboveground part) were evaluated and compared among species grown on soils developed on waste materials (pinus pinaster, cytisus striatus, cytisus multiflo-rus) and agricultural soils (zea mays l., phaseolus vulgaris l., lactuca sativa l.) from the surrounding area of cunha baixa mine (mangualde). the species colonizing waste materials are well adapted to the substratum, which contains high total and available uranium concentration (118 mg kg-1 and 43 mg kg-1 , respectively). pinus pinaster concentrated more uranium (13.9 mg kg-1) than the spe-cies of genus cytisus. as a consequence, and also due to the effective vegetation cover these plants can contribute to the sta-bilization of mining wastes dumps. lactuca sativa concentrated more uranium (on ave-rage, 5.37 mg kg-1 dry weight) than the other cultivated plants. none of the studied species was uranium accumulator (bc <1), even if they are growing in high-contaminated soils and irrigated with con-taminated water.
Concentra o de uranio em plantas desenvolvidas em solos agrícolas e de escombreira da área mineira da Cunha Baixa (Mangualde) Uranium concentration in plants developed on agricultural soils and waste dumps in Cunha Baixa mine site (Mangualde)
O. Neves,M.M. Abreu
Revista de Ciências Agrárias , 2010,
Abstract: Neste trabalho avalia-se e comparara-se a concentra o e capacidade de bioconcentra- o (CB) do uranio em diversas espécies vegetais (parte aérea) que se desenvolveram em solos de escombreira (Pinus pinaster, Cytisus striatus, Cytisus multiflorus) e culti-vadas (Zea mays L., Phaseolus vulgaris L., Lactuca sativa L.) em solos da zona agríco-la, envolvente à área mineira da Cunha Bai-xa (Mangualde). As espécies colonizadoras da escombreira est o bem adaptadas ao substrato, sendo o Pinus pinaster aquela que mais uranio concentrou na parte aérea (13,9 mg kg-1) podendo, juntamente com as espé-cies do género Cytisus, contribuir para a estabiliza o dos resíduos mineiros, ainda com elevada concentra es em uranio total e disponível (118 mg kg-1 e 43 mg kg-1, res-pectivamente). Entre as espécies cultivadas destaca-se a Lactuca sativa que concentrou, em média, 5,37 mg kg-1 de uranio (peso seco). Nenhuma das espécies estudadas se revelou acumuladora deste elemento (CB < 1), mesmo em situa o de água de rega e solo ainda bastante contaminados. The uranium concentration and the bioco-centration capacity (BC) in several plant species (aboveground part) were evaluated and compared among species grown on soils developed on waste materials (Pinus pinaster, Cytisus striatus, Cytisus multiflo-rus) and agricultural soils (Zea mays L., Phaseolus vulgaris L., Lactuca sativa L.) from the surrounding area of Cunha Baixa mine (Mangualde). The species colonizing waste materials are well adapted to the substratum, which contains high total and available uranium concentration (118 mg kg-1 and 43 mg kg-1 , respectively). Pinus pinaster concentrated more uranium (13.9 mg kg-1) than the spe-cies of genus Cytisus. As a consequence, and also due to the effective vegetation cover these plants can contribute to the sta-bilization of mining wastes dumps. Lactuca sativa concentrated more uranium (on ave-rage, 5.37 mg kg-1 dry weight) than the other cultivated plants. None of the studied species was uranium accumulator (BC <1), even if they are growing in high-contaminated soils and irrigated with con-taminated water.
Distribui??o do uranio nas várias fases-suporte em solos da área mineira da Cunha Baixa (Portugal)
Neves,O.; Abreu,M.M.; Matias,M.J.;
Revista de Ciências Agrárias , 2009,
Abstract: the present study concerns the application of partial chemical extraction, in a parallel procedure, to evaluate the uranium distribution in different solid phases constituents of the soils in the vicinity of cunha baixa mining area in order to assess its environmental risk. in the surface horizon of the soils, uranium that reached total concentrations between 9.8 to 362 mg/kg was preferential bound to non-crystalline iron oxides. these phases represent a small environmental risk. the contaminated irrigation water (>100 μg u/l) and the exchangeable complex of the acidic soils (ph <5), are important sources for the available fraction of uranium for crops (up to 30% of total u). the transference of uranium into the soil-water-plant system could be a factor of risk for cunha baixa population through the ingestion of vegetal foodstuffs, due to its possible uranium bioaccumulation capacity.
Systems-synergetic thinking to the environmental conflicts management at the territorial level
O.V. Prokopenko,M.M. Petrushenko
Marketing ì Mened?ment Innovacìj , 2013,
Abstract: The aim of the article. The objective of the work is to develop the system-synergetic approach to managing environmental contradictions at the level of the territory, on the example of Sumy region in Ukraine.The results of the analysis. The main results are as follows. Firstly, as a result, the research has shown that the causes and consequences of social and natural confrontations have less to do with the essence of man environment and more of a system of social environment environment. This shows that environmental conflicts are one of the main factors existing crisis in the economy and in society in general, and the fact that in conjunction with heterogeneous, especially social aspects, the actual environmental conflicts that can be seen in the form of potential environmental, particular natural resource conflicts are complex objects on their research and management.Secondly, we study the set of environmental contradictions in the Sumy region, using fractal method (the geometric tool of synergetics) establishing the relationship between social and natural-environmental factors in the development of the territory under different scenarios of conflicts. The degree of social conflict predicted impact factors formalized and reflected in the value of the corresponding coefficient (similar to defined coefficient environmental conflict). Application of approximated variation of fractal method allows to determine the synergistic profile of prognostic impact of the environmental contradictions: under threshold conditions (i.e. in cases escalating threats of potential conflict in the crisis).Thirdly, the methodological approach for the application of system-synergetic thinking is proposed on the practical level of management of environmental contradictions that arise between economic entities at the level of territory. Namely, it is about improving techniques of environmental standards. It is proved that international standards series ISO and OHSAS 18001are built on the principles of system-synergetic approach: for each direction formed a system of standards, and indicated systems are interrelated, including the latest trends in business, environmental protection, development of social relationships others. In general improvement of the relationship between management instruments of ecological contradictions in a territorial-economic system we see in the complex synthesis of tools in the mechanism of contradictions taking place in a territorial-economic system, as well as in the implementation of the bilateral process improvements on the one hand, on ecologica
Role of Plant Host in Determining Differential Responses to Ralstonia solanacearum and Glomus mosseae
M.M. Tahat,O. Radziah,S. Kamaruzaman,J. Kadir
Plant Pathology Journal , 2008,
Abstract: A pot study was aimed to investigate the role of tomato in determining differential response to bacterial wilt causal agent Ralstonia solanacearum pathogen and arbuscular mycorrhizal fungi (AMF) Glomus mosseae. Disease severity was measured after 10, 20 and 30 days of plant growth. The pathogen and dual treatment (R. solanacearum with G. mosseae) were not significantly different at the end of this experiment. Soil pH was greatly influencing the pathogen and AMF microbe. Glomus mosseae mycorrhizosphere was more alkaline (pH 5.9) compared to the pathogen mycorrhizosphere (pH 4.9). The concentration of bacterial cell in the R. solancearum soil was not different from the dual treatment after 60 days of plant growth. Spore germination was influenced by the interaction between the soil pathogen and AMF. Spores number in the dual treatment at 60 days was less than the original number added. Root colonization percentage in G. mosseae (61%) was significantly more than the dual treatment (16%). This provide an evidence about the role of plant host in increasing the spores germination influenced by many substances produced by the host root (root exudates). The results demonstrated that the role of plant in determination the relationship between soil-borne pathogen and antagonistic microbe was critical.
A Biometric Model for Examination Screening and Attendance Monitoring in Yaba College of Technology
Rufai M.M,Adigun J. O, N. A. Yekini
World of Computer Science and Information Technology Journal , 2012,
Abstract: Examination malpractices have consistently remained a bane of Nigerian educational system. A common form of examination malpractices is the deliberate impersonation of the applicant. Part of the requirement of a credible examination is that the real applicants wrote the exams. Several steps have been taken to check this crime unabated. Some of the methods adopted are: the use of Identity card; the presence of invigilators to identify fake students; the allocation of sitting arrangement number that determines the hall where the student will write exam and the need to sign in and out on the attendance sheets. This research work proffers solution to the problem of student impersonation during exams. A biometric model is designed to identify every applicant at the point of entry into the examination hall. A biometric verification exercise is also conducted while the examination is going and at the point of submission of examination papers. The students’ attendance is captured automatically as their identity is verified on the biometric systems. The Biometric Access Control Techniques is explained. A model describing its application to examination screening and attendance monitoring is designed using denotational mathematics.
Comparison of pharmacokinetics and pharmacodynamics of the original and generic enalapril in the elderly patients with arterial hypertension
O.P. Bobrova,M.M. Petrova
Rational Pharmacotherapy in Cardiology , 2012,
Abstract: Aim. To study the pharmacokinetic, pharmacodynamic and pharmacoeconomic parameters of the original and generic enalaprils in the treatment of the elderly patients with hypertension (HT).Material and methods. Patients (n=40) 75–90 years with HT were included in the open randomized comparative study. Patients were randomized into two groups. Patients of the group 1 received generic enalapril, patients of the group 2 — the original enalapril consisting of combined therapy. Pharmacokinetic single-dose study of original and generic enalapril were carried out with high-performance liquid chromatography. Pharmacodynamic study was carried out in single-dose administration as well as after 2 and 4 weeks of treatment with original and generic enalapril. Pharmacoeconomic evaluation of antihypertensive drugs was carried out on the basis of cost minimization analysis.Results. Original enalapril dose necessary to achieve the target blood pressure (BP) was 10 mg/day as a part of two-component therapy. This for generic enalapril was 20 mg/day consisting of three- or four-component therapy. Both drugs have shown an acceptable safety profile. Pharmacokinetic differences were revealed between original and generic enalapril: area under pharmacokinetic curve 204.14 (202.25–206.05) vs 136.23 (134.17–137.65) ng*h/ml, respectively; time of the drug retention in the blood plasma 5.42 (5.26–5.76) vs 4.88 (4.86–4.94) hours, respectively; p<0.001. Original enalapril demonstrated more stable 24-hour antihypertensive effect in once daily administration in comparison with this in generic enalapril: trough/peak ratio 78.67% (47.61–91.35%) vs 44.96% (32.44–55.49%), respectively, p<0.01. The average daily cost of combined therapy containing generic enalapril was 15.91 rubles per patient, while this in combined therapy containing original enalapril — 13.78 rubles per patient.Conclusion. Medicines on the basis of original and generic enalapril have pharmacokinetic, pharmacodynamic and pharmacoeconomic differences.
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