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Search Results: 1 - 10 of 2401 matches for " Elsa Veronica Mignini "
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Coeliac Disease: Gluten Free Diet and… What Else?  [PDF]
Marina Taus, Elsa Veronica Mignini, Daniele Fumelli, Debora Busni, Giulia Nicolai, Carla Carletti, Albano Nicolai
Open Journal of Gastroenterology (OJGas) , 2016, DOI: 10.4236/ojgas.2016.611035
Abstract: Coeliac Disease (CD) is a permanent gluten intolerance, whose pathogenesis involves multiple factors including genetics and environment. CD has different representations and non-specific symptoms such as diarrhea, bloating, pain, flatulence and constipation may sometimes be misleading. Once diagnosed of CD, patients must adhere to Gluten Free Diet, which consists in the lifelong avoidance of gluten containing foods and of those naturally gluten free but at risk of contamination. This dietary approach is considered the only therapy in order to avoid symptoms exacerbation and to reduce the digestive mucosa inflammation, which has been related to higher risks of lymphoproliferative malignancy and other immunological disorders. However, being on a Gluten Free Diet is not as resolving as it may seem since it has several criticalities. First of all, excluding gluten means limiting food variety so that coeliac patients may have unbalanced intake of several nutrients and develop clinical or subclinical deficiencies. This can be due to scarce attention to qualitative and quantitative composition of diets and poor information about gluten-containing foods, which only patient-tailored dietetic protocol and long-term follow-up can achieve. Secondly, Gluten Free Diet may not result in complete remission of mucosal damage or in resolution of symptoms. Unintentional contamination of gluten or poor adherence to diet are the main culprits of the incomplete mucosal healing but other triggers may be involved. Recent research has focused on the role of FODMAPs in changing gut microbiota and on the improvement of Irritable Bowel Syndrome (IBS) symptoms after their dietary avoidance or reduction. Since CD and IBS may share many clinical presentations, further studies are needed to evaluate if a subgroup of CD patients whose symptoms are not improved by Gluten Free Diet could benefit from a new therapeutic approach consisting in both gluten/wheat and FODMAPs avoidance.
On Schoedinger operators with multipolar inverse-square potentials
Veronica Felli,Elsa M. Marchini,Susanna Terracini
Mathematics , 2006,
Abstract: Positivity, essential self-adjointness, and spectral properties of a class of Schroedinger operators with multipolar inverse-square potentials are discussed. In particular a necessary and sufficient condition on the masses of singularities for the existence of at least a configuration of poles ensuring the positivity of the associated quadratic form is established.
On the behavior of solutions to Schr?dinger equations with dipole-type potentials near the singularity
Veronica Felli,Elsa M. Marchini,Susanna Terracini
Mathematics , 2007,
Abstract: Asymptotics of solutions to Schroedinger equations with singular dipole-type potentials is investigated. We evaluate the exact behavior near the singularity of solutions to elliptic equations with potentials which are purely angular multiples of radial inverse-square functions. Both the linear and the semilinear (critical and subcritical) cases are considered.
On Schr?dinger operators with multisingular inverse-square anisotropic potentials
Veronica Felli,Elsa M. Marchini,Susanna Terracini
Mathematics , 2007,
Abstract: We study positivity, localization of binding and essential self-adjointness properties of a class of Schroedinger operators with many anisotropic inverse square singularities, including the case of multiple dipole potentials.
The safety profile of drotrecogin alfa (activated)
Roberto Fumagalli, Mariano A Mignini
Critical Care , 2007, DOI: 10.1186/cc6157
Abstract: Drotrecogin alfa (activated; DrotAA) is the first and thus far only compound proven to improve survival in patients with severe sepsis. The mechanisms that underlie the improved survival are not entirely clear. A number of studies have demonstrated that DrotAA exerts an anticoagulant effect through inactivation of coagulation factors Va and VIIIa [1], an anti-inflammatory effect [2] and a profibrinolytic effect [3], as well as antiapoptotic [4] and cytoprotective effects [5]. Of these, the anticoagulant property is the action associated with the only known adverse effect of treatment, namely an increased risk for bleeding.Continued assessment of safety is essential in any newly approved therapy. DrotAA has been studied in clinical trials since 1995 (Table 1). It was approved for use in adult patients with severe sepsis at high risk of death in the USA in November 2001 [6] and in the European Union in August 2002 [7]. The European Medicines Agency indicates that DrotAA may be used in the treatment of adult patients with severe sepsis and multiple organ failure, and reaffirmed this indication as a result of the second annual licence reassessment, stating that DrotAA should be considered mainly in situations in which therapy can be initiated within 24 hours after the onset of organ failure [8].From the very first clinical study, safety analyses have been included in each controlled trial conducted in DrotAA, and continuous safety surveillance has formed part of all studies undertaken for the purposes of registering the drug for commercial use. In this review we analyze the available literature regarding the safety of DrotAA, together with some previously unpublished data.In the early phase I studies, begun more than 10 years ago, adverse events with a frequency of 5% or greater included headache (30.9%), ecchymosis (23.0%), and pain (5.8%), primarily at the site of venopuncture [9]. These studies were conducted in healthy volunteers mainly to evaluate pharmacokinetics,
Analysis of human skin tissue by a skin-meter: A preliminary study  [PDF]
Sergio Mazzulla, Annarita Carino, Antonino Miano, Fiorenzo Mignini, Giovanni Bartolomei, Guglielmo Martino
Open Journal of Molecular and Integrative Physiology (OJMIP) , 2012, DOI: 10.4236/ojmip.2012.24015
Abstract: The aim of this study is to evaluate the skin elasticity in individuals who practise spinning. Mechanical eva- luations were conducted, under environmental and physical established conditions, during a physical training period. A total of 12 volunteers aged 35 ± 5 years were enrolled in this study, (60 min) before (control) and (60 min) after practicing spinning. Skin elasticity and area were measured by a Skin Meter and analysed with the Skin Meter software 1.3. In subjects who practiced spinning, the data shown a sig-nificant effect: on elasticity, evaluated as the ratio of final retraction (UA) and final distension (UF), on viscoelasticity express as the ratio delayed distension (UV) and immediate distension (UE); and on measurements of skin area vs control subjects. Skin Meter can be useful for a non-invasive screening of skin condition with also a potential extension in subjects with skin pathologies or to monitor skin oxidative stress in sportive subjects.
Peripheral arterial blood pressure monitoring adequately tracks central arterial blood pressure in critically ill patients: an observational study
Mariano Mignini, Enrique Piacentini, Arnaldo Dubin
Critical Care , 2006, DOI: 10.1186/cc4852
Abstract: This is a prospective, observational study carried out in a surgical-medical ICU in a teaching hospital. Fifty-five critically ill patients with clinical indication of invasive arterial pressure monitoring were included in the study. No interventions were made. Simultaneous measurements were registered in central (femoral) and peripheral (radial) arteries. Bias and precision between both measurements were calculated with Bland-Altman analysis for the whole group. Bias and precision were compared between patients receiving high doses of vasoactive drugs (norepinephrine or epinephrine >0.1 μg/kg/minute or dopamine >10 μg/kg/minute) and those receiving low doses (norepinephrine or epinephrine <0.1 μg/kg/minute or dopamine <10 μg/kg/minute).Central mean arterial pressure was 3 ± 4 mmHg higher than peripheral mean arterial pressure for the whole population and there were no differences between groups (3 ± 4 mmHg for both groups).Measurement of mean arterial blood pressure in radial or femoral arteries is clinically interchangeable. It is not mandatory to cannulate the femoral artery, even in critically ill patients receiving high doses of vasoactive drugs.Invasive arterial blood pressure monitoring is a common practice in intensive care units (ICUs). The most frequent indication for invasive arterial blood pressure monitoring is for continuous measurement in hemodynamically unstable patients [1]. The radial artery is most commonly used, with the femoral artery being the second choice. One or the other is used in 92% of arterial cannulations [2]. Accuracy of invasive blood pressure monitoring is crucial in evaluating the cardiocirculatory system and adjusting drug therapy for hemodynamic support. However, the best site for catheter insertion is controversial. For some clinicians, the femoral artery is the preferred site because of its lower rate of mechanical (occlusion, accidental loss, thrombosis) and infectious complications [2-4]. The accuracy of peripheral blood pres
Methodological quality of systematic reviews of animal studies: a survey of reviews of basic research
Luciano E Mignini, Khalid S Khan
BMC Medical Research Methodology , 2006, DOI: 10.1186/1471-2288-6-10
Abstract: We searched, without language restrictions, Medline, Embase, bibliographies of known reviews (1996–2004) and contacted experts to identify citations of reviews of basic science literature which, as a minimum, performed search of a publicly available resource. From these we identified reviews of animal studies where laboratory variables were measured or where treatments were administered to live animals to examine their effects, and compared them with reviews of bench studies in which human or animal tissues, cell systems or organ preparations were examined in laboratories to better understand mechanisms of diseases.Systematic reviews of animal studies often lacked methodological features such as specification of a testable hypothesis (9/30, 30%); literature search without language restriction (8/30, 26.6%); assessment of publication bias (5/30, 16.6%), study validity (15/30, 50%) and heterogeneity (10/30, 33.3%); and meta-analysis for quantitative synthesis (12/30, 40%). Compared to reviews of bench studies, they were less prone to bias as they specified the question (96.6% vs. 80%, p = 0.04), searched multiple databases (60% vs. 26.6%, p = 0.01), assessed study quality (50% vs. 20%, p = 0.01), and explored heterogeneity (33.3% vs. 2.2%, p = 0.001) more often.There seems to be a gradient of frequency of methodological weaknesses among reviews: Attempted systematic reviews of whole animal research tend to be better than those of bench studies, though compared to systematic reviews of human clinical trials they are apparently poorer. There is a need for rigour when reviewing animal research.In the development of new health technologies, it is widely held that drugs or procedures should first be assessed in animal models before proceeding to clinical trials in humans[1]. High quality systematic reviews provide unbiased overviews of the available evidence[2]. There have been calls for application of this approach in basic research, particularly in animal research[3], to
Extremely Early Diagnostic Test for Prostate Cancer  [PDF]
Veronica Jean James
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.23051
Abstract: Purpose: This article reports the results of a blinded fibre diffraction study of skin samples taken from TRAMP mice and age-matched controls to determine whether changes noted in fibre diffraction studies of human skin were present in these TRAMP mice studies. These mice are bred to progress to Gleeson Type 3 to Type 5 prostate cancer. Methods: Small strips, 1 mm × 5 mm, cut from the mouse skin samples were loaded into cells in the same way as human samples and slightly stretched to remove the crimp. They remained fully hydrated throughout exposure to the synchrotron beam. Results: The added change that was reported for prostate cancer in 2009 was obtained for all TRAMP mice samples, indicating that this change can be read as High Grade Cancer in human diagnostic tests. Discussion: These changes were evident for all 3 and 7 week old TRAMP mice samples but not for any of the control samples. This indicates that the changes in the fibre diffraction patterns appear much earlier than in any other available prostate cancer diagnostic test, as none of these can verify the presence of prostate cancer in the TRAMP mice before 10 weeks of age. The fibre diffraction test is therefore the most accurate and earliest test for high grade prostate cancer.
Intrinsic innervation and dopaminergic markers after experimental denervation in rat thymus
F. Mignini,M. Sabbatini,V. D'Andrea,C. Cavallotti
European Journal of Histochemistry , 2010, DOI: 10.4081/ejh.2010.e17
Abstract: The aim of this study was to examine rat thymus innervation using denervation techniques and to explore the related micro-anatomical localization of dopamine, D1, D2 receptors and dopamine membrane transporter (DAT). In the thymus subcapsular region, the parenchymal cholinergic fibers belong exclusively to phrenic nerve branching. No somatic phrenic nerve branching was detected in any other analysed thymus lobule regions. In rats subjected to sympathetic or parasympathetic ablation, it was observed that catecholaminergic and cholinergic nerve fibers respectively contributed to forming plexuses along vessel walls. In the subcapsular and septal region, no parenchymal nerve branching, belonging to sympathetic or parasympathetic nervous system was noted. Instead, in the deep cortical region, cortico-medullary junction (CM-j) and medulla, catecholaminergic and cholinergic nerve fibers were detected along the vessels and parenchyma. Dopamine and dopamine receptors were widely diffused in the lobular cortico-medullary junction region and in the medulla, where the final steps of thymocyte maturation and their trafficking take place. No variation in dopamine and DAT immune reaction was observed following total or partial parasympathectomy or phrenic nerve cutting. After chemical or surgical sympathectomy however, neither dopamine nor DAT immune reaction was noted again. Instead, D1 and D2 dopamine receptor expression was not affected by thymus denervation. In rats subjected to specific denervation, it was observed the direct intraparenchymal branching of the phrenic nerve and sympathetic and parasympathetic fibers into thymus parenchyma along vessels. These findings on the dopaminergic system highlight the importance of neurotransmitter receptor expression in the homeostasis of neuroimmune modulation.
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