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Search Results: 1 - 10 of 297771 matches for " Eliezer J.; "
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Estratégia de simplifica??o molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo
Barreiro, Eliezer J.;
Química Nova , 2002, DOI: 10.1590/S0100-40422002000700018
Abstract: in this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. the discovery of a new cardiotonic derivative (37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; lassbio-294), efficiently synthesized from brazilian natural product and structurally designed by molecular simplification of active pyridazinone compounds reported in the literature, is described. a brief description of the pharmacological profile of this new cardiotonic lead-compound, belonging to the n-acylhydrazone (nah) class, is also reported herein.
Editorial
Barreiro Eliezer J.
Química Nova , 2001,
Abstract:
Abstract
Barreiro Eliezer J.
Química Nova , 2002,
Abstract:
Editorial
Barreiro Eliezer J.
Química Nova , 2001,
Abstract:
Estratégia de simplifica o molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo
Barreiro Eliezer J.
Química Nova , 2002,
Abstract: In this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. The discovery of a new cardiotonic derivative (37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; LASSBio-294), efficiently synthesized from Brazilian natural product and structurally designed by molecular simplification of active pyridazinone compounds reported in the literature, is described. A brief description of the pharmacological profile of this new cardiotonic lead-compound, belonging to the N-acylhydrazone (NAH) class, is also reported herein.
Inside the FDA - The business and politics behind the drugs we take and the food we eat; Fran Hawthorne - DOI: 10.3395/reciis.v2i2.226en
Eliezer J. Barreiro
RECIIS : Electronic Journal of Communication, Information & Innovation in Health , 2009,
Abstract:
Abstract
Eliezer J. Barreiro
Revista Brasileira de Ciências Farmacêuticas , 2005, DOI: 10.1590/s1516-93322005000100001
Abstract:
Medicinal Chemistry and the paradigm of the lead compound [A Química Medicinal e o paradigma do composto-protótipo]
Eliezer J. Barreiro
Revista Virtual de Química , 2009,
Abstract: This paper briefly describes the application of the physiological approach strategy to the invention of new lead compounds, candidates for drugs from different therapeutic classes, exemplified by the discovery of some hits in the Laboratory of Synthesis and Evaluation of Bioactive Substances (LASSBio ) of the Federal University do Rio de Janeiro.
Um paradigma da química medicinal: a flexibilidade dos ligantes e receptores
Verli, Hugo;Barreiro, Eliezer J.;
Química Nova , 2005, DOI: 10.1590/S0100-40422005000100018
Abstract: in general, molecular modeling techniques applied in medicinal chemistry have been static and drug based. however the active site geometry and the intrinsic flexibility of both receptor and ligand are fundamental properties for molecular recognition and drug action. as a consequence, the use of dynamic models to describe the ligand-receptor complex is becoming a more common procedure. in this work we discuss the relevance of considering the receptor structure in medicinal chemistry studies as well as the flexibility of the ligand-receptor complex.
Abstract
Barreiro Eliezer J. de L.
Química Nova , 1999,
Abstract:
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