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Search Results: 1 - 10 of 451510 matches for " Elias M. da;Melo "
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Novel neutral iron(II) isocyanide maleonitrile dithiolate [Fe(S2C2(CN)2)(t-BuNC) 4] compound
Morigaki Milton K.,Silva Elias M. da,Melo Carlos V. P. de,Larica Carlos
Química Nova , 2004,
Abstract: FeBr2 reacts with the S2C2(CN)2(2-) ion (1:1 ratio) in the presence of an excess of t-BuNC in THF to give the mixed ligand [Fe(S2C2(CN)2)(t-BuNC) 4] compound. This neutral product with a formal oxidation state of two for the iron atom was characterized by conductivity measurements, and, i.r., M ssbauer, 13C and 1H n.m.r. spectroscopy. There is a Fe-C pi back-donation strengthened towards isocyanide ligands, according to the data of 13C, 1H n.m.r. and M ssbauer spectroscopy.
Novel neutral iron(II) isocyanide maleonitrile dithiolate [Fe(S2C2(CN)2)(t-BuNC) 4] compound
Morigaki, Milton K.;Silva, Elias M. da;Melo, Carlos V. P. de;Larica, Carlos;Biondo, Armando;Freitas, Jair C. C.;Dias, Gilson H. M.;Ribeiro, Holgadinei R.;
Química Nova , 2004, DOI: 10.1590/S0100-40422004000100016
Abstract: febr2 reacts with the s2c2(cn)22- ion (1:1 ratio) in the presence of an excess of t-bunc in thf to give the mixed ligand [fe(s2c2(cn)2)(t-bunc) 4] compound. this neutral product with a formal oxidation state of two for the iron atom was characterized by conductivity measurements, and, i.r., m?ssbauer, 13c and 1h n.m.r. spectroscopy. there is a fe-c p back-donation strengthened towards isocyanide ligands, according to the data of 13c, 1h n.m.r. and m?ssbauer spectroscopy.
Synthesis, characterization, DFT and Td-dfT study of the [Fe(mnt)(L)(t-BuNC) 2] octahedral complex (L = phen, bipy)
MorigakiI, Milton K.;Silva, Elias M. da;Melo, Carlos V. P. de;Pavan, Jamile R.;Silva, Renzo C.;Biondo, Armando;Freitas, Jair C. C.;Dias, Gilson H. M.;
Química Nova , 2009, DOI: 10.1590/S0100-40422009000700024
Abstract: febr2 has reacted with an equivalent of mnt2- (mnt = cis-1,2-dicyanoethylene-1,2-dithiolate) and the α-diimine l (l = 1,10'-phenantroline, 2,2'-bipyridine) in thf solution, and followed by adding of t-butyl-isocyanide to give [fe(mnt)(l)(t-bunc)2] neutral compound. the products were characterized by infrared, uv-visible and m?ssbauer spectroscopy, besides thermogravimetric and conductivity data. the geometry in the equilibrium was calculated by the density functional theory and the electronic spectrum by the time-dependent. the experimental and theoretical results in good agreement have defined an octahedral geometry with two isocyanide neighbours. the π→π* intraligand electronic transition was not observed for cis-isomers in the near-ir spectral region.
Trypanosome Prereplication Machinery: A Potential New Target for an Old Problem
Simone Guedes Calderano,Patricia Diogo de Melo Godoy,Julia Pinheiro Chagas da Cunha,Maria Carolina Elias
Enzyme Research , 2011, DOI: 10.4061/2011/518258
Abstract: Approximately ten million people suffer from Chagas disease worldwide, caused by Trypanosoma cruzi, with the disease burden predominately focused in Latin America. Sleeping sickness is another serious health problem, caused by Trypanosoma brucei, especially in sub-Saharan countries. Unfortunately, the drugs currently available to treat these diseases have toxic effects and are not effective against all disease phases or parasite strains. Therefore, there is a clear need for the development of novel drugs and drug targets to treat these diseases. We propose the trypanosome prereplication machinery component, Orc1/Cdc6, as a potential target for drug development. In trypanosomes, Orc1/Cdc6 is involved in nuclear DNA replication, and, despite its involvement in such a conserved process, Orc1/Cdc6 is distinct from mammalian Orc1 and Cdc6 proteins. Moreover, RNAi-mediated silencing of trypanosome Orc1/Cdc6 expression in T. brucei decreased cell survival, indicating that Orc1/Cdc6 is critical for trypanosome survival. 1. Introduction Currently, approximately ten million people have Chagas disease worldwide, with the disease burden being centered in Latin America. In 2008, approximately ten thousand people died from this disease. Sleeping sickness is another serious health problem, particularly in sub-Saharan countries; in the first half of the twentieth century, this disease practically decimated entire communities in central Africa [1]. After many surveillance programs, 2009 marked the first time in 50 years that less than ten thousand new cases of sleeping sickness were reported in Africa (http://www.who.org/). The causal agents of Chagas disease and sleeping sickness are, respectively, the protozoan parasites Trypanosoma cruzi and T. brucei of the Kinetoplastida order. Two subspecies of T. brucei, T. b. rhodesiense, and T. b. gambiense, are responsible for acute sleeping sickness in Eastern and Southern Africa and chronic sleeping sickness in Western and Central Africa, respectively. Chronic sleeping sickness accounts for approximately 95% of all reported cases. These protozoa have life cycles that alternate between a mammalian host and an insect host. T. cruzi epimastigotes are a noninfective life cycle stage of the parasite that proliferate by binary fission in the guts of Triatoma infestans insects, which are more commonly known as kissing bugs. These epimastigotes then transform into the infective metacyclic form in the insect hindgut. Then, when the insect vector bites a mammalian host, they eliminate the metacyclic parasites in their feces. This
Comunidades de fungos micorrízicos arbusculares associados ao amendoim forrageiro em pastagens consorciadas no Estado do Acre, Brasil
Miranda, Elias Melo de;Silva, Eliane Maria Ribeiro da;Sagin Júnior, Orivaldo José;
Acta Amazonica , 2010, DOI: 10.1590/S0044-59672010000100002
Abstract: the purpose of this study was to identify the autochthonous communities of arbuscular mycorrhizal fungi (amf) associated with arachis pintoi and estimate its diversity. samples of soil were collected in a field at rio branco, ac. the sampling was carried out in seven areas, being collected four samples from soil in each area, in a depth of 0-10cm, in dry season (june 2004) and rainy season (january 2005). the areas cultivated with a. pintoi were: monoculture, grass pasture and others legumes intercropped, coffee plant under cover of a. pintoi, besides brush and forest adjacent like a control. it was verified the occurrence of 21 species of amf in the two seasons, 18 species in the dry period and 16 in the rainy. the species were distributed in five genres: acaulospora, entrophospora, gigaspora, glomus and scutellospora. the densities of spores were higher in a. pintoi x brachiaria brizantha x pueraria phaseoloides intercropped and lowest in the areas of a. pintoi x coffee plants, brush and forest. mycorrhizal colonization was higher in the rainy season (15 to 63%) than in the dry season (5 to 37%). the diversity indices in monoculture were similar to those of other areas evaluated, indicating that the a. pintoi serves as host of amf of different species and that its cultivation may increase the presence of these organisms in production systems, improving the biological soil quality.
Sele??o de fungos micorrízicos arbusculares para o amendoim forrageiro consorciado com braquiária
Miranda, Elias Melo de;Saggin Júnior, Orivaldo José;Silva, Eliane Maria Ribeiro da;
Pesquisa Agropecuária Brasileira , 2008, DOI: 10.1590/S0100-204X2008000900013
Abstract: the objective of this work was to evaluate and select efficient arbuscular mycorrhizal fungi (amf) to promote growth of the intercropped arachis pintoi and brachiaria decumbens, in the presence and absence of competing autochthonous amf. the experiment was performed under greenhouse conditions at embrapa agrobiologia, in seropédica, rj. the experimental design was completely randomized with three repetitions, in a 2x6 factorial arrangement, with two substrates (non sterile and sterile) derivative of a fragiudult (planosol) and six treatments of inoculation (acaulospora morrowiae, entrophospora colombiana, gigaspora margarita, glomus clarum, scutellospora heterogama, and a noninoculated control); besides a monoculture of each forage as a reference control. three cuts were made during the experimental period, at different intervals, until the competition and substrate depletion made the permanence of the leguminous unviable in the consortium. benefits were observed for amf inoculation to the production of a. pintoi dry matter, being g. clarum the more efficient species. the use of seedlings efficiently colonized by amf facilitates the establishment and initial growth of forage peanuts plants, increasing their competitive capacity with brachiaria.
Levantamento malacológico da Bacia Hidrográfica do Lago Soledade, Ouro Branco, (Minas Gerais, Brasil)
Silva, Roney Elias da;Melo, Alan Lane de;Pereira, Leógenes Horácio;Frederico, Lilian Fontes;
Revista do Instituto de Medicina Tropical de S?o Paulo , 1994, DOI: 10.1590/S0036-46651994000500008
Abstract: a malacological survey was carried out at the soledade lake, in ouro branco, state of minas gerais, for the period 1986-1991. a total amount of 46,579 mollusks was collected, and among them seven species corresponding to five families could be found, as follows: 39,176 specimens of biomphalaria tenagophila; 1,296 b. glabrata; 7 drepanotrema cimex; 2,527 physa sp; 417 lymnaea sp; 92 pomacea hastrum, and 3,064 specimens of melanoides tuberculata (melanniidae=thiaridae) were collected from march/1990 onwards. four specimens of b. tenagophila were found to be positive for schistosoma mansoni.
Suscetibilidade de Biomphalaria tenagophila e Biomphalaria glabrata de uma mesma regi?o a duas cepas de Schistosoma mansoni
Silva, Roney Elias da;Melo, Alan Lane de;Pereira, Leógenes Horácio;
Revista do Instituto de Medicina Tropical de S?o Paulo , 1994, DOI: 10.1590/S0036-46651994000500004
Abstract: b. tenagophila snails from ouro branco, mg, showed positivity for s. mansoni, with infection rates of 5%, 10%, (sj strain), and 1% (le strain) using a pool of miracidia. the mollusks were found to be susceptive from the 3rd generation reared in laboratory onwards. the b. tenagophila (ob, mg) when individually exposed to 10 miracidia, showed infection rate of 2% for le strain. b. glabrata snails from gagé, mg, showed a positivity rate of 58% for s. mansoni (le strain), under experimental conditions. the b. tenagophila from cabo frio, rj and b. glabrata from belo horizonte, mg used as a control for sj strain showed infection rates of 47% - 85% and 36% respectivily. for the le strain, b. glabrata (bh, mg) used as control showed infection rate of 40% - 75%.
Effect of perimuscular injection of Bothrops jararacussu venom on plasma creatine kinase levels in mice: influence of dose and volume
Calil-Elias, S.;Thattassery, E.;Martinez, A.M.B.;Melo, P.A.;
Brazilian Journal of Medical and Biological Research , 2002, DOI: 10.1590/S0100-879X2002001000018
Abstract: the effect of dose and volume of a perimuscular injection of bothrops jararacussu venom on myonecrosis of skeletal muscle was studied in mice. an increase of the venom dose (0.25 to 2.0 μg/g) at a given volume (50 μl) resulted in an increase in plasma creatine kinase (ck) levels 2 h after injection. plasma ck activity increased from the basal level of 129.27 ± 11.83 (n = 20) to 2392.80 ± 709.43 iu/l (n = 4) for the 1.0 μg/g dose. histological analysis of extensor digitorum longus muscle 4 h after injection showed lesion of peripheral muscle fibers, disorganization of the bundles or the complete degeneration of muscle fibers. these lesions were more extensive when higher doses were injected. furthermore, an increase in volume (12.5 to 100 μl) by dilution of a given dose (0.5 μg/g) also increased plasma ck levels from 482.31 ± 122.79 to 919.07 ± 133.33 iu/l (n = 4), respectively. these results indicate that care should be taken to standardize volumes and sites of venom injections.
Effect of perimuscular injection of Bothrops jararacussu venom on plasma creatine kinase levels in mice: influence of dose and volume
Calil-Elias S.,Thattassery E.,Martinez A.M.B.,Melo P.A.
Brazilian Journal of Medical and Biological Research , 2002,
Abstract: The effect of dose and volume of a perimuscular injection of Bothrops jararacussu venom on myonecrosis of skeletal muscle was studied in mice. An increase of the venom dose (0.25 to 2.0 μg/g) at a given volume (50 μl) resulted in an increase in plasma creatine kinase (CK) levels 2 h after injection. Plasma CK activity increased from the basal level of 129.27 ± 11.83 (N = 20) to 2392.80 ± 709.43 IU/l (N = 4) for the 1.0 μg/g dose. Histological analysis of extensor digitorum longus muscle 4 h after injection showed lesion of peripheral muscle fibers, disorganization of the bundles or the complete degeneration of muscle fibers. These lesions were more extensive when higher doses were injected. Furthermore, an increase in volume (12.5 to 100 μl) by dilution of a given dose (0.5 μg/g) also increased plasma CK levels from 482.31 ± 122.79 to 919.07 ± 133.33 IU/l (N = 4), respectively. These results indicate that care should be taken to standardize volumes and sites of venom injections.
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