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Search Results: 1 - 10 of 52260 matches for " Eliézer Silva "
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Sepse, um problema do tamanho do Brasil Sepsis, a problem with the size of Brazil
Eliézer Silva
Revista Brasileira de Terapia Intensiva , 2006, DOI: 10.1590/s0103-507x2006000100001
Abstract:
Surviving sepsis campaign: um esfor o mundial para mudar a trajetória da sepse grave
Eliézer Silva
Revista Brasileira de Terapia Intensiva , 2006, DOI: 10.1590/s0103-507x2006000400001
Abstract:
Sepse: um problema de todos Sepsis: a problem for everyone
Eliézer Silva
Revista Brasileira de Terapia Intensiva , 2011, DOI: 10.1590/s0103-507x2011000200001
Abstract:
Infus o de proteína C ativada recombinante humana diminui mortalidade em pacientes com sepse grave
Silva Eliézer
Revista da Associa??o Médica Brasileira , 2001,
Abstract:
Quando transfundir hemácias em pacientes sob ventila o mecanica?
SILVA ELIéZER
Revista da Associa??o Médica Brasileira , 2002,
Abstract:
Surviving sepsis campaign: reflex es e revis es Surviving sepsis campaign: reflections and revisions
Eliézer Silva,Jorge I. F. Salluh
Revista Brasileira de Terapia Intensiva , 2007, DOI: 10.1590/s0103-507x2007000300002
Abstract:
Como diagnosticar acidose metabólica em pacientes graves?
SILVA ELIéZER,DUR?O JR MARCELINO DE SOUZA
Revista da Associa??o Médica Brasileira , 2002,
Abstract:
Quando indicar proteína c ativada na sepse grave e choque séptico?
SILVA ELIéZER,FIGUEIREDO LUIZ FRANCISCO POLI DE
Revista da Associa??o Médica Brasileira , 2002,
Abstract:
Effects of volume resuscitation on splanchnic perfusion in canine model of severe sepsis induced by live Escherichia coli infusion
Claudio Lagoa, Luiz de Figueiredo, Ruy Cruz, Eliézer Silva, Maurício Rocha e Silva
Critical Care , 2004, DOI: 10.1186/cc2871
Abstract: Anesthetized and mechanically ventilated male mongrel dogs were challenged with intravenous injection of live Escherichia coli (6 × 109 colony-forming units/ml per kg over 15 min). After 90 min they were randomly assigned to one of two groups – control (no fluids; n = 13) or lactated Ringer's solution (32 ml/kg per hour; n = 14) – and followed for 60 min. Cardiac index, mesenteric blood flow, mean arterial pressure, systemic and mesenteric oxygen-derived variables, blood lactate and gastric carbon dioxide tension (PCO2; by gas tonometry) were assessed throughout the study.E. coli infusion significantly decreased arterial pressure, cardiac index, mesenteric blood flow, and systemic and mesenteric oxygen delivery, and increased arterial and portal lactate, intramucosal PCO2, PCO2 gap (the difference between gastric mucosal and arterial PCO2), and systemic and mesenteric oxygen extraction ratio in both groups. The Ringer's solution group had significantly higher cardiac index and systemic oxygen delivery, and lower oxygen extraction ratio and PCO2 gap at 165 min as compared with control animals. However, infusion of lactated Ringer's solution was unable to restore the PCO2 gap. There were no significant differences between groups in mesenteric oxygen delivery, oxygen extraction ratio, or portal lactate at the end of study.Significant disturbances occur in the systemic and mesenteric beds during bacteremic severe sepsis. Although large-volume infusion of lactated Ringer's solution restored systemic hemodynamic parameters, it was unable to correct gut mucosal PCO2 gap.Sepsis leads to endothelial damage, marked alterations in blood flow distribution and altered tissue oxygen metabolism, which are associated with high mortality rates among critically ill patients [1-3]. Although volume replacement is among the cornerstones of therapy for septic shock [4], studies conducted to elucidate the actual impact of fluid infusion on both experimental and clinical sepsis with respec
Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function
Thiago Corrêa, Madhusudanarao Vuda, Jukka Takala, Siamak Djafarzadeh, Eliézer Silva, Stephan Jakob
Critical Care , 2013, DOI: 10.1186/cc12495
Abstract: Twenty-four anesthetized and mechanically ventilated pigs were randomly assigned (n = 8 per group) to a septic control group (Septic-CG) without resuscitation until death or one of two groups in which resuscitation was performed after 12 hours of untreated sepsis for 48 hours, targeting MAP between 50 and 60 mmHg (Low-MAP) or between 75 and 85 mmHg (High-MAP).MAP at the end of resuscitation was 56+/-13 mmHg (mean+/-SD) and 76+/-17 mmHg respectively, for Low-MAP and High-MAP groups. One animal each in High- and Low-MAP groups, and all animals in the septic control group died [median survival time: 21.8 hours (inter-quartile range: 16.3-27.5 hours). Norepinephrine was administered to all animals of the High-MAP group [0.38 (0.21-0.56) mcg/kg/min], and to three animals of the Low-MAP group [0.00 (0.00-0.25) mcg/kg/min; p=0.009]. The High-MAP group had a more positive fluid balance (3.3+/-1.0 ml/kg/h vs. 2.3+/-0.7 ml/kg/h; p=0.001). Inflammatory markers, skeletal muscle ATP content and hemodynamics other than MAP did not differ between Low- and High-MAP groups. The incidence of acute kidney injury (AKI) after 12 hours of untreated sepsis was, respectively for Low- and High-MAP groups, 50% (4/8) and 38% (3/8), and in the end of the study 57% (4/7) and 0% (p=0.026). In Septic-CG, maximal isolated skeletal muscle mitochondrial Complex I, State 3 respiration increased from 1357+/-149 pmol/s/mg to 1822+/-385 pmol/s/mg, (p=0.020). In High- and Low-MAP groups, permeabilized skeletal muscle fibers Complex IV-state 3 respiration increased during resuscitation (p=0.003).The MAP targets during resuscitation did not alter the inflammatory response, nor affected skeletal muscle ATP content and mitochondrial respiration. While targeting a lower MAP was associated with increased incidence of AKI, targeting a higher MAP resulted in increased net positive fluid balance and vasopressor load during resuscitation. The long-term effects of using lower MAP targets on kidney function and whet
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