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Effect of lipopenic and hypotensive treatment on homocysteine levels in type 2 diabetics
Mabrouka El Oudi, Zied Aouni, Haroun Ouertani, et al
Vascular Health and Risk Management , 2010, DOI: http://dx.doi.org/10.2147/VHRM.S8240
Abstract: t of lipopenic and hypotensive treatment on homocysteine levels in type 2 diabetics Original Research (3839) Total Article Views Authors: Mabrouka El Oudi, Zied Aouni, Haroun Ouertani, et al Published Date May 2010 Volume 2010:6 Pages 327 - 332 DOI: http://dx.doi.org/10.2147/VHRM.S8240 Mabrouka El Oudi1, Zied Aouni1, Haroun Ouertani2, Chakib Mazigh2, Salem Machghoul1 1Département de biochimie, 2Service d’endocrinologie, H pital militaire de Tunis, 1008 Montfleury, Tunisie Aim: Evaluate the effect of lipopenic and hypotensive treatment on homocysteine levels. Methods: We recruited 145 type 2 diabetics and 130 control subjects. Thirty-seven diabetics had no complications, 54 had microvascular complications and 54 had macrovascular complications. We determined the parameters homocysteine of lipid, vitamin B12, triglycerides, and folates for all subjects. Associated treatments used one or more of the following drugs, statin, fibrate, angiotensin-converting enzyme inhibitor and beta-blockers. Results: Hyperhomocysteinemia was present in 35.6% of patients. Diabetics had elevated serum levels of triglycerides (P < 0.001), homocysteine (P < 0.01), folates (P < 0.01) and vitamin B12 (P < 0.001). A strong association was found between type 2 diabetes and hyperhomocysteinemia (P < 0.001). Diabetics with associated treatment had elevated homocysteine, vitamin B12 and folate levels when compared to diabetes-free controls. For diabetics with macrovascular complications, we found significant differences in homocysteine (P = 0.010) and folate (P = 0.014) between those taking associated drugs and those who did not. For diabetics with microvascular complications, a significant difference was found in folate only (P = 0.012). Conclusion: Drugs used for hypertension and hyperlipidemia may have an effect on homocysteine levels, for this reason the interaction between drug action and homocysteine levels should be taken into consideration.
Effect of lipopenic and hypotensive treatment on homocysteine levels in type 2 diabetics
Mabrouka El Oudi,Zied Aouni,Haroun Ouertani,et al
Vascular Health and Risk Management , 2010,
Abstract: Mabrouka El Oudi1, Zied Aouni1, Haroun Ouertani2, Chakib Mazigh2, Salem Machghoul11Département de biochimie, 2Service d’endocrinologie, H pital militaire de Tunis, 1008 Montfleury, TunisieAim: Evaluate the effect of lipopenic and hypotensive treatment on homocysteine levels.Methods: We recruited 145 type 2 diabetics and 130 control subjects. Thirty-seven diabetics had no complications, 54 had microvascular complications and 54 had macrovascular complications. We determined the parameters homocysteine of lipid, vitamin B12, triglycerides, and folates for all subjects. Associated treatments used one or more of the following drugs, statin, fibrate, angiotensin-converting enzyme inhibitor and beta-blockers.Results: Hyperhomocysteinemia was present in 35.6% of patients. Diabetics had elevated serum levels of triglycerides (P < 0.001), homocysteine (P < 0.01), folates (P < 0.01) and vitamin B12 (P < 0.001). A strong association was found between type 2 diabetes and hyperhomocysteinemia (P < 0.001). Diabetics with associated treatment had elevated homocysteine, vitamin B12 and folate levels when compared to diabetes-free controls. For diabetics with macrovascular complications, we found significant differences in homocysteine (P = 0.010) and folate (P = 0.014) between those taking associated drugs and those who did not. For diabetics with microvascular complications, a significant difference was found in folate only (P = 0.012). Conclusion: Drugs used for hypertension and hyperlipidemia may have an effect on homocysteine levels, for this reason the interaction between drug action and homocysteine levels should be taken into consideration.Keywords: type 2 diabetes, complications, homocysteine, hypolipemiant drug, hypotensive drug
Evaluation of Cardiovascular Risk Factors in a Young Adults Tunisian Group  [PDF]
Lamine Oussama, Aboulkacem Sana, Grira Nedra, Ayoub Manel, Sendesni Rihab, El Oudi Mabrouka, Stambouli Nejla, Mazigh Chakib, Aouni Zied
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.63001
Abstract: Introduction: Cardiovascular diseases have become more common in young adults. Their emergence is due to the prevalence of cardiovascular risk factors. The aim of this study is to determine the prevalence of cardiovascular risk factors in a Tunisian young adult group. Material and methods: This is an epidemiological study of 705 Tunisians volunteers, free from any cardiovascular pathology; who are recruited at the Military Hospital of Tunis. Besides the classical cardiovascular risk factors (obesity, dyslipidemia, smoking, alcohol…), we evaluate the level of homocysteinemia and determined the C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene by PCR-RFLP method. Results and conclusions: The mean age of our population is 28.25 ± 9.08 with a male majority (83.8%). We have 43.8% obese subject or overweight, 54.3% smokers and 12.9% alcoholics. The lipid profile showed that 12.6% of the population had hypercholesterolemia and 39.5% had hypoHDLemia, 7.9% had a high lipoprotein(a) concentration. In our study population we found that 10.9% of subjects had an hs-CRP concentration greater than 3 mg/L. Genotyping of the MTHFR gene revealed that 34% of young adults had a mutated genome (CT). The results showed a significant correlation between different factors, such as cholesterolemia and obesity. The prevalence of these risk factors showed the severity of our young people’s health status and imposes a change in the way of Tunisians life.
Correlation between Inflammatory Markers and Lipid Parameters in a Tunisian Coronary Artery Disease Group  [PDF]
Rihab Sendesni, Dhaker Lahidheb, Manel Ayoub, Nedra Grira, Dhekra Lafi, Nejla Stambouli, Mabrouka El Oudi, Ezzedine Ghazouani, Habib Haouala, Zied Aouni, Chakib Mazigh
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102635
Abstract:
Aims: To evaluate the relationship between inflammatory biomarkers and lipid parameters in a Tunisian coronary artery disease group. Material and Methods: In the study, we have included 122 subjects with acute coronary syndrome (ACS) confirmed by coronary angiography, selected among patients admitted to the cardiology department and 162 subjects free of any cardiovascular disease, recruited from medical and paramedical volunteers. Lipid parameters, high sensitivity CRP (hsCRP) and proinflammatory cytokines (IL6, IL8 and TNFα) were determined for all patients and controls. Results: A highly significant difference (P < 103) was noted between the mean of the hsCRP in coronary patients (14.65 ± 9.81 mg/L) compared to controls (1.63 ± 1.75 mg/L). We note also a significant difference between the means of IL6 in the diseased population (11.56 ± 8.23 pg/mL) compared to controls (2.5 ± 0.84 pg/mL) with a value of P < 103. The hsCRP values are inversely correlated with the HDLc values. No association was found between IL 8 and the various lipid parameters. Patients having high IL6 values had higher levels of CT and CT/HDLc ratio. This correlation is statistically significant. Regarding TNFα, there is a positive and significant correlation with CT and LDLc. Conclusion: Significant correlation was found between inflammatory markers and lipids profile. This may explain the role of inflammation in the development of cardiovascular disease.
Evaluation of Cardiovascular Risk Factors in Tunisian Coronary Patients  [PDF]
Grira Nadra, Sandesni Rihab, Lamine Ossama, Aboulkassem Sana, Ayoub Manel, El Oudi Mabrouka, Stambouli Najla, Lahidheb Thaker, Haouala Habib, Mazigh Chakib, Aouni Zied
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104214
Abstract:
Introduction: Ischemic heart disease ranked among the leading causes of death worldwide. Several biological and genetic risk factors associated with acute coronary syndrome. By addressing the risk factors, it is possible to prevent most of the cardiovascular diseases and contribute to the reduction of complications of acute coronary syndrome. Material and Methods: Our study is a prospective study that was conducted to the main military hospital of instruction of Tunis. Recruitment involved 122 coronary (n = 122) and 705 controls (n = 705) totaling a population of 827 subjects. Data collection concerned socio-demographic characteristics, anthropometric measurements, habits and lifestyle, health status and biological assessment. Results: Our study reported a high prevalence of cardiovascular classic risk factor particularly overweight (62.3%), diabetes (63.1%) and hypertension (50%). In 55% of coronary patients, moderate to intermediate hyperhomocysteinemia was found, but it appears to be an independent risk factor. The results of our study show a significant difference in the genotypic frequencies of the C677T mutation in the MTHFR gene between the two populations, cases and controls. Conclusion: Acute coronary syndromes are the leading cause of sudden death in adults. The evaluation of risk factors after acute coronary syndrome episode is essential for a better management according to the recommendations of learned societies and standards of good practice.
Diagnostic Accuracy of Transvaginal Sonography in Infertile Patients with Endometrial Polyps
Mona Oudi,Reza Omani Samani
International Journal of Fertility & Sterility , 2010,
Abstract:
Determination of Some Heavy Metal Pollutants in Sediments of the Seybouse River in Annaba, Algeria
Achour Louhi, Atika Hammadi and Mabrouka Achouri
Air, Soil and Water Research , 2012, DOI: 10.4137/ASWR.S10081
Abstract: This study was conducted in order to fight against pollution of the environment. The study concerns river sediment of the Seybouse River in northeastern Algeria. Northeastern Algeria is known for its various industries (steel, fertilizer, metal processing, etc), and the sediment deposited by the Seybouse River, is probably polluted by heavy metals. For this study, we used two protocols of digestion of sediments, the first, using a mixture of hydrofluoric acid and perchloric acid, and the second, using aqua regia. The comparison of these two protocols will help us to find the best solubilization and thus facilitate the extraction and determination of heavy metals in sediment. Before determining the concentration of some heavy metals (Fe, Zn, Mn, Sn, Ni, Cr, Pb and Cu), we first analyzed parameters of sediments such as pH and organic matter. We used atomic absorption spectrometry (AAS) to measure these heavy metals. The functional groups characteristic of organic matter and particularly clays were identified by infrared spectroscopy. The average concentrations of metals exceeded acceptable standards for sediment pollution with heavy metals. Maximum concentrations in mg/kg respectively of the elements studied (Fe, Zn, Mn, Sn, Ni, Cr, Pb and Cu) were, respectively, 2460.20 ± 74.8; 1140.65 ± 38.2; 3.60 ± 1.2; 1.20 ± 0.5; 16.80 ± 2.6; 9.50 ± 3.2; 476.31 ± 21.6 and 145.15 ± 35.2. These results clearly show that the sediments deposited by the Seybouse River are heavily polluted.
Determination of Some Heavy Metal Pollutants in Sediments of the Seybouse River in Annaba, Algeria
Achour Louhi,Atika Hammadi,Mabrouka Achouri
Air, Soil and Water Research , 2012,
Abstract:
A novel surgical technique to localize small enteropouch fistula
Abbas Basiri, Emadoddin Mo'oudi, Hamed Akhavizadegan, Naser ShakhsSalim
BMC Urology , 2005, DOI: 10.1186/1471-2490-5-16
Abstract: An entero-pouch fistula was occurred in a patient after radical cystectomy with illeal orthotopic pouch. Because of failed conservative management, the patient was candidate for surgery. The hidden small fistula in the small intestine was diagnosed by high intraluminal hydrostatic pressure (by intraluminal saline injection).Intraoperative diagnosis the intestinal opening of a small fistula is very important. At the time of surgery if the fistula tract becomes open (during releasing the adhesions), it may leak in the peritoneum in postoperative period. Intraluminal high pressure is a useful method for intraoperative small hidden intestine opening.One of the complications of ileal neobladder after radical cystectomy is pouch-to-intestine fistula [1]. To date cases with enteropouch [2], enteroconduit [3] and ureteroenteric [4] fistulae have been reported. Patients more often have a history of irradiation [2], but there have been cases observed without it too [5]. Conservative management and surgery both have been used to treat such fistulae [5,6]. To our knowledge there is no published report on the surgical technique used to treat enteropouch fistulae. We report a novel intraoperative technique to identify non-visible fistula.A 52-year-old male with muscle invasive TCC (grade III) had undergone radical cystectomy and ileal orthotopic pouch reconstruction. Anastomosis of small intestine was performed in two layers (first runing chromic and second with simple separate silk sutures). On the 10th day after the operation while the patient was on normal diet and had no abdominal symptom or defecation disorder, fecaloid materials were found in urine and drained secretions. Enteropouch and entrocutaneous fistulae were confirmed using oral activated charcoal. The patient was put on fasting and TPN. Antibiotic therapy was initiated, consequently, urinary fecaloid drainage and enterocutoneous fistula improved. However enteropouch fistula remained unresolved even after one month
Study of salt tolerance in wheat (Triticum aestium L.) cultivar Banysoif 1
Amel A Tammam,Mona F Abou Alhamd,Mabrouka M Hemeda
Australian Journal of Crop Science , 2008,
Abstract: Salt tolerance of new wheat cultivar Banysoif 1 was investigated to find relevant culturing strategy in saline areas. Wheat cv. Banysoif 1 was grown in clay soil for 7 days in different pots. Then seedlings were irrigated by different saline waters (0, 60, 120, 180, 240 and 320 mM NaCl) near the field capacity. Plants were kept in the natural condition under these saline levels for 155 days. Fresh and dry weight of roots were measured unchanged up to the level of 120 mM NaCl then a significant reduction obtained at 240 and 320 mM NaCl. In shoots and spikes, dry matters were either unchanged or even stimulated to increase toward 180 mM NaCl then a quick reduction was observed. We assumed that it is associated with the increase of leaf area and photosynthetic pigments up to 180 mM NaCl. There was also a remarkable variation in accumulation of different carbohydrate fractions among wheat studied organs. In root, the drastic effect in soluble fraction was accompanied with a remarkable accumulation of insoluble components. In shoots, the production of carbohydrates remained mostly unaffected even at the highest salinity level. In spikes, the soluble fractions were increased significantly by salt stress while the insoluble slightly reduced. Protein content reduced at high levels of salinity in roots while has been increased significantly in shoots and spikes. Amino acid content increased significantly towards 120 mM and 180 mM NaCl then a quick reduction about 55% and 45% recorded in roots and shoots respectively. In spike, there was a significant reduction in amino acids by increasing salt stress. In roots, there was a large accumulation of proline even at the lowest salinity level. Accumulation of proline was failed in spikes and shoots and therefore a non-significant increase in proline content even at the highest salinity level was observed. Sodium content increased significantly in the three organ but the percent of increase was varied considerably among the three organs especially at sever salinity and the opposite pattern was observed in the accumulation and distribution of K+ , Ca+2 and Mg2+. K+ / Na+ ratio decreased in response to salt stress in root, shoot and spikes.
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