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Search Results: 1 - 10 of 22193 matches for " Eduardo Castela "
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Transposition of the great arteries
Paula Martins, Eduardo Castela
Orphanet Journal of Rare Diseases , 2008, DOI: 10.1186/1750-1172-3-27
Abstract: The diagnosis is confirmed by echocardiography, which also provides the morphological details required for future surgical management. Prenatal diagnosis by foetal echocardiography is possible and desirable, as it may improve the early neonatal management and reduce morbidity and mortality. Differential diagnosis includes other causes of central neonatal cyanosis. Palliative treatment with prostaglandin E1 and balloon atrial septostomy are usually required soon after birth. Surgical correction is performed at a later stage. Usually, the Jatene arterial switch operation is the procedure of choice. Whenever this operation is not feasible, adequate alternative surgical approach should be implemented. With the advent of newer and improved surgical techniques and post operative intensive care, the long-term survival is approximately 90% at 15 years of age. However, the exercise performance, cognitive function and quality of life may be impaired.Transposition of the great arteries; physiologically uncorrected transposition; complete transposition; atrioventricular concordance with ventriculoarterial discordance. The European paediatric cardiac code for this disease is 01.05.01.The transposition of the great arteries was first described by Mathew Baillie in 1797, in the second edition of the book "The Morbid Anatomy of Some of the Most Important Parts of the Human Body". However, the term transposition was only applied in 1814, by Farre, meaning that aorta and pulmonary trunk were placed (positio) across (trans) the ventricular septum.In fact, this congenital cardiac malformation is characterised by atrioventricular concordance and ventriculoarterial discordance. In other words, the morphological right atrium is connected to the morphological right ventricle which gives rise entirely to or most of the aorta; the morphological left atrium is connected to the morphological left ventricle from where the pulmonary trunk emerges [1].The term congenitally corrected transposition
Ecocardiogra?a por telemedicina em recém-nascidos num hospital de nível II: casuística de quatro anos
Costa,Ana Margarida; Carvalho,Marisa; Calvi?o,Juan; Sousa,Marisa; Sousa,Gra?a; Gaspar,Eurico; Castela,Eduardo;
Nascer e Crescer - Revista do Hospital de Crian?as Maria Pia , 2011,
Abstract: introduction: the echocardiogram by telemedicine (ecotm) between the pediatric department of a level 2 hospital and the pediatric cardiology service of a level 3 hospital began in october 2005. objective: to characterize the newborns (nb) who under-went echotm and emphasize the importance of this practice in the management of the patients. methods: the authors reviewed the reports of echotm conducted between october 1, 2005 and september 30, 2009. the following variables were analyzed: age, sex, reason for the exam, diagnosis and orientation. results: during this period, 139 echotm were done on 122 nb (1.71% of our live nb). male patients predominated (57%). echotm was performed before discharge from the maternity in 30,9% and during the ?rst week in 50%; it was urgent in 11 cases. the most frequent motives for echotm: asymptomatic heart murmur (68,3%), pervious abnormal echotm (11,5%), malformations (5,8%) and hypoxia (3,6%). the most frequent diagnosis were: ventricular septal defect (vsd) (31.3%), inter-auricular communication (25.8%) and patent ductus arteriosus (7%). six infants were transferred (simple transposition of greater arteries (n=2), single ventricle (n=1), malformation of the aortic arch (n=1), aortic coarctation (n=1) and large sub-aortic vsd (n=1). in 26.6% it was excluded cardiopathy. echotm was repeated in 72 % of the infants and 24% were discharged. discussion: the echotm scheduled before discharge or during the ?rst month, in nb with asymptomatic murmur, allows us to make an early diagnosis of heart disease. the possibility of doing an emergency echotm allows a rapid and accurate diagnosis, identifying nb with critical heart disease requiring immediate intervention and transfer to a terti-ary center. the echotm between these two hospitals of different level, brought bene?ts to the health care provided, avoiding discomfort to patients and allowing an adequate referral to pediatric cardiol-ogy when needed.
A paralisia cerebral na adolescência: resultados de uma investiga??o
Matos, Ana Paula;Lobo, Joana Castela;
Psicologia USP , 2009, DOI: 10.1590/S0103-65642009000200006
Abstract: it is very important to study self-concept, coping and mental health in adolescents suffering from cerebral palsy. this population has been rarely studied. besides, these variables can contribute to the adaptation of these youth that face very adverse conditions, and can be protective and risk factors to their psychological health. we studied a sample of 78 subjects suffering from cerebral palsy (aged between 12 and 19 years old). we found the following results: a) girls show higher levels of psychopathology than boys, b) with age, the values of self-concept are lower and the values of “non active coping” are higher, c) some types of diagnosis of cerebral palsy differentiate themselves by the self-concept, d) self-concept correlates negatively with all indexes of psychopathology, e) “non active coping” correlates negatively with anxiety and some indexes of psychopathological symptomatology from bsi.
Testosterone, Endothelial Health, and Erectile Function
Angela Castela,Pedro Vendeira,Carla Costa
ISRN Endocrinology , 2011, DOI: 10.5402/2011/839149
Abstract:
Structural Modeling and In Silico Analysis of Human Superoxide Dismutase 2
Mariana Dias Castela de Carvalho, Joelma Freire De Mesquita
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065558
Abstract: Aging in the world population has increased every year. Superoxide dismutase 2 (Mn-SOD or SOD2) protects against oxidative stress, a main factor influencing cellular longevity. Polymorphisms in SOD2 have been associated with the development of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, as well as psychiatric disorders, such as schizophrenia, depression and bipolar disorder. In this study, all of the described natural variants (S10I, A16V, E66V, G76R, I82T and R156W) of SOD2 were subjected to in silico analysis using eight different algorithms: SNPeffect, PolyPhen-2, PhD-SNP, PMUT, SIFT, SNAP, SNPs&GO and nsSNPAnalyzer. This analysis revealed disparate results for a few of the algorithms. The results showed that, from at least one algorithm, each amino acid substitution appears to harmfully affect the protein. Structural theoretical models were created for variants through comparative modelling performed using the MHOLline server (which includes MODELLER and PROCHECK) and ab initio modelling, using the I-Tasser server. The predicted models were evaluated using TM-align, and the results show that the models were constructed with high accuracy. The RMSD values of the modelled mutants indicated likely pathogenicity for all missense mutations. Structural phylogenetic analysis using ConSurf revealed that human SOD2 is highly conserved. As a result, a human-curated database was generated that enables biologists and clinicians to explore SOD2 nsSNPs, including predictions of their effects and visualisation of the alignment of both the wild-type and mutant structures. The database is freely available at http://bioinfogroup.com/database and will be regularly updated.
Tuberculose ativa entre profissionais de saúde em Portugal
Costa, José Castela Torres da;Silva, Rui;Ferreira, José;Nienhaus, Albert;
Jornal Brasileiro de Pneumologia , 2011, DOI: 10.1590/S1806-37132011000500011
Abstract: objective: to determine the incidence of active tuberculosis (tb) in a cohort of health care workers (hcws). methods: descriptive study of active tb cases identified in an occupational health screening of 6,112 hcws between 2005 and 2010. cases of active tb were defined as those in which mycobacterium tuberculosis was identified by direct microscopy or culture; those in which there were symptoms or clinical signs of tb and necrotizing granuloma, as detected by histology; and those in which the radiological findings were consistent with active tb. results: among the 6,112 hcws evaluated, we identified 62 cases of active tb: pulmonary tb (n = 43); pleural tb (n = 15); lymph node tb (n = 2); pericardial tb (n = 1); and cutaneous tb (n = 1). seven hcws were asymptomatic at the time of diagnosis. of the 62 cases of active tb, 48 developed within the first 10 years of occupational exposure in the workplace, 36 of those occurring within the first 5 years. physicians and nurses accounted for the highest numbers of cases (22 and 21, respectively). conclusions: in hcws employed in portugal, the tb burden is high. physicians and nurses are the hcws who are at the highest risk of developing active tb. we found the risk of developing this disease to be highest in the first years of exposure, as has been reported in previous studies. in high-incidence countries, tb screening of hcws is important for controlling the transmission of this disease.
Weathering of coil-coatings: UV radiation and thermal effects
Castela, A. S.,Sim?es, A. M.,Davies, G.,Ferreira, M. G. S.
Revista de Metalurgia , 2003,
Abstract: The effect of heat and of QUV ageing on coil coatings was tested by electrochemical impedance, and the results compared with surface analysis of the polymers by FTIR and XPS. It was shown that UV radiation is more relevant than heat to chemical degradation. A different correlation between water permeation and chemical degradation was observed depending on the coating thickness: for the thinner coatings, the higher UV degradation has corresponded to increased water absorption, whereas in the thicker coating, the bulk effect of heat was more relevant to water permeation. El efecto del calor y del envejecimiento, QUV, sobre recubrimiemtos de bobinas se probó mediante la impedancia electroquímica, y los resultados se compararon con análisis superficiales de los polímeros usando FTIR y XPS. Se encontró que la radiación UV es más importante que el calor en la degradación química. Una correlación diferente, entre agua infiltrada y degradación química, se observó, dependiendo del espesor del recubrimiento: para los recubrimientos más delgados, mayor degradación UV correspondió a un incremento de absorción de agua; en cambio, para los recubrimientos más gruesos, el efecto del calor fue más importante para la infiltración del agua.
Amniocentesis in HIV Pregnant Women: 16 Years of Experience
Mafalda Sim?es,Catarina Marques,Ana Gon?alves,Ana Paula Pereira,Joaquim Correia,Jo?o Castela,Cristina Guerreiro
Infectious Diseases in Obstetrics and Gynecology , 2013, DOI: 10.1155/2013/914272
Abstract: The iatrogenic risk of HIV vertical transmission, calculated in initial epidemiologic studies, seemed to counterindicate invasive prenatal diagnosis (PND) procedures. The implementation of highly active antiretroviral therapy (HAART) represented a turning point in PND management, owing to a rapid and effective reduction of maternal viral load (VL). In the present study, we identified cases of vertical transmission in HIV-infected pregnant women who did amniocentesis in the second trimester of pregnancy ( ), from 1996 to 2011. We divided our sample into Group A—women under HAART when submitted to amniocentesis ( ) and Group B—women without antiretroviral therapy before amniocentesis ( ). We had 1 case of vertical transmission in Group B. Preconceptional or early first trimester HIV serology is essential to avoid performing an amniocentesis without antiretroviral therapy or viral suppression. When there is an indication for amniocentesis in an HIV-infected pregnant woman, it should be done if the patient is on HAART and, if possible, when VL is undetectable. Nowadays, with combined first trimester screening test to select pregnancies with high risk of aneuploidies, advanced maternal age is a less frequent indication to perform PND invasive procedures, representing an outstanding gain in prenatal diagnosis of this population. 1. Introduction The widespread use of highly active antiretroviral therapy (HAART) during the last decade has significantly reduced the rates of HIV mortality and disease progression [1]. The rate of vertical transmission in HIV-infected pregnant women on HAART is around 1-2%, being almost zero when associated with an elective cesarean delivery and avoidance of breastfeeding [2]. Simultaneously, there has been an increase in pregnancy rates among HIV-infected women, raising new problems and issues in prenatal diagnosis (PND), such as those concerning invasive procedures to diagnose chromosomal abnormalities (amniocentesis and chorionic villus sampling) [3]. The increase in the mean maternal age is a challenge in prenatal diagnosis, particularly in HIV-infected pregnant women. In the past, invasive procedures as amniocentesis were generally discouraged in HIV-infected pregnant women, due to increased risk of vertical transmission. The puncture of the uterine wall or placenta and lesions of the fetal skin or umbilical chord may all increase the fetal exposure to maternal virus [4]. Amniocentesis itself has potential morbidity, such as rupture of membranes, chorioamnionitis, or placental abruption, with consequent fetal loss or vertical
Optimal Stochastic Pine Stands Harvest Rotation Policies  [PDF]
Eduardo Navarrete
Open Journal of Forestry (OJF) , 2015, DOI: 10.4236/ojf.2015.56053
Abstract: A new Faustmann optimal rotation harvesting stands’ problem under Brown geometric price and Logistic and Gompertz wood stock, diffusions is presented. The optimal cut policies for the stochastic Faustmann model and the single harvest rotation or Vicksell model are evaluated in the case of a Chilean Radiata pine forest company. The company cut policy validates the Vicksell model, its optimal cut policies overestimate the company policy cut in 1.2%, in the Gompertz case, and underestimate it in 2.3%, in the Logistic case. The Faustmann optimal cut policies present a larger underestimation of the company cut policy in 10.1%, in the Gompertz case, and in 21.5%, in the Logistic case. The preference for shorter evaluation period that the company shows is due to the organizational risk that the forest economic sectors has in Chile.
Stress prevention by modulation of autonomic nervous system (heart rate variability): A preliminary study using transcranial direct current stimulation  [PDF]
Eduardo Manuel Gon?alves
Open Journal of Psychiatry (OJPsych) , 2012, DOI: 10.4236/ojpsych.2012.22016
Abstract: Introduction: Transcranial Direct Current Stimulation (tDCS) is a non-invasive, technique for brain stimulation. Anodal stimulation causes neuronal depolarisation and long-term potentiation, while cathodal stimulation causes hyperpolarisation and long-term depression. Stressors are associated with an increase in sympathetic cardiac control, a decrease in parasympathetic control, or both. Associated with these reactions is a frequently reported increase in Low Frequency (LF) Heart Rate Variability (HRV), a decrease in High Frequency (HF) power, and/or an increase in the LF/HF ratio. Objectives and aims: The present work aims to explore the tDCS potential in the modulation of the Autonomic Nervous System (ANS), through indirect stimulation of Anterior Cingulate Cortex (ACC). Methods: Two subjects, a 39 year old female and a 49 year old male, gave informed consent. Saline soaked synthetic sponges involving two, thick, metalic (stainless steel) rectangles, with an area of 25 cm2 each have been used as electrodes, connected to Iomed Phoresor II Auto device. It has been delivered a 2 mA current, for 20 minutes, over the left Dorsolateral Prefrontal Cortex (DLPFC) (Anode). Spectrum analysis (cStress software) of HRV has been performed before and after tDCS administration. Results: The female/male subject results of LF power, HF power and LF/HF ratio, before tDCS administration, were, respectively: 50.1 nu/60 nu, 46.1 nu/21.7 nu and 1.087/2.771; and, after tDCS administration, respectively: 33.5 nu/52.7 nu, 47.6 nu/ 22.8 nu and 0.704/2.312. Conclusions: tDCS over the left DLPFC (left ACC) increased parasympathetic activity and decreased sympathetic activity, suggesting the importance of tDCS in the management of stress-related disorders.
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