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Search Results: 1 - 10 of 187002 matches for " Edésia Martins Barros de Sousa "
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Multifunctional Nanostructured Materials Applied in Controlled Radiopharmaceuticals Release  [PDF]
Raquel Cristina de Sousa Azevedo, Daniel Crístian Ferreira Soares, Ricardo Geraldo de Sousa, Edésia Martins Barros de Sousa
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.32022
Abstract: The metaiodobenzylguanidine (MIBG) radiopharmaceutical, an analogue of norepinephrine, has been used to diagnose certain diseases in the cardiovascular system when radiolabeled with 123I. This radiopharmaceutical can also be used to treat tumors, such as neuroblastomas and pheochromocytomas, when radiolabeled with 131I. Its clinical use is often accompanied by a slow intravenous administration, where a significant dose of radiation can directly affect workers in nuclear medicine services. To overcome this problem, the incorporation and controlled release of radiopharmaceuticals from the matrix of mesoporous systems based on silica, such as SBA-15 and hybrid [SBA-15/P(N-iPAAm)], can lead to a significant reduction in radiation doses received by workers. In the present study, silica matrices SBA-15 and hybrid [SBA-15/P(N-iPAAm)] containing the radiopharmaceutical MIBG were prepared and physicochemically characterized through FTIR, SEM, and small angle X-ray diffraction techniques. The release profiles of MIBG from SBA-15 and [SBA-15/P(N-iPAAm)] were studied in a simulated body fluid (SBF) to evaluate their potential application as vehicles for controlled releases. Furthermore, in vitro studies were performed to assess the cytotoxicity of matrices as compared to human lung fibroblast cells (MRC-5). The results revealed that the amount of MIBG incorporated within the studied matrices was indeed quite different, showing that only the hybrid [SBA-15/P(N-iPAAm)] system allowed for a more adequate release profile of MIGB. Taking all results into consideration, it can be concluded that the hybrid matrix [SBA-15/P(N-iPAAm)] can be considered a potential alternative material for the controlled release delivery of radio-pharmaceuticals.
Boron Nitride Nanostructured: Synthesis, Characterization and Potential Use in Cosmetics  [PDF]
Líliam Márcia Silva Ansaloni, Edésia Martins Barros de Sousa
Materials Sciences and Applications (MSA) , 2013, DOI: 10.4236/msa.2013.41004
Abstract:

The hexagonal boron nitride has been well investigated. Its layered structure is similar to that of graphite. In the manufacture of cosmetics, this structure is intended to improve the appearance, sensory aspect and makes it easy to mix excipients contained in the formulation in the mixture process. In cosmetology, the efficiency and the penetration of active substances into skin are known to be directly related to the particle size. However, only recently their nanostructured properties have been explored. In this work, the synthesis of hexagonal boron nitride in the nanoscale, its composition, structure, morphology and potential for future application in sunscreens are being investigated. The boron nitride was synthesized from boric acid and melamine to a heat treatment at 1600. The crystal structure was characterized by (XRD) and its morphology was examined by (SEM) and (TEM); the chemical composition was studied by (FTIR), (EDS) and (EELS), the texture characterization by (BET) and its potential in sunscreens by (FTIR and UV/VIS). Results have shown that boron nitride may be synthesized in the nanoscale and that this material has the potential to be incorporated into cosmetics.

Ordered mesoporous silica carrier system applied in nanobiothecnology
Sousa, Andreza de;Sousa, Edésia Martins Barros de;
Brazilian Archives of Biology and Technology , 2005, DOI: 10.1590/S1516-89132005000700036
Abstract: ordered mesoporous materials like sba15 possess a network of channels and pores of well-defined size in the nanoscale range (2-50 nm). this particular pore architecture makes them suitable candidates for hosting and delivery under appropriate conditions of a variety of molecules of pharmaceutical interest, including radiopharmaceuticals. the characteristics of sba-15 prepared in different temperatures and the behavior of this system regarding microencapsulation of a model drug were investigated. the calcined samples were formed in 0.2 g disks and were soaked in a solution of atenolol used as a model drug. the modification of the aging temperature provoked changes in the structure of the pores, indicating the presence of microporosity and connections between mesopores. aging the materials at a higher temperature resulted in no microporosity and this fact influenced the control of the release of the model drug.
Nanocompósitos magnéticos: potencialidades de aplica??es em Biomedicina
Souza, Karynne Cristina de;Mohallem, Nelcy Della Santina;Sousa, Edésia Martins Barros de;
Química Nova , 2011, DOI: 10.1590/S0100-40422011001000003
Abstract: the synthesis of magnetic materials such as nanostructured iron oxide has been intensively researched due to their broad applications in biomedicine. as these nanoparticles have high specific surface area, they are very reactive and can aggregate easily, and biodegrade when exposed to biological systems. mesoporous silica is often employed as support matrix to protect the magnetic functional component, avoiding undesirable effects. in this context, this review describes various syntheses of silica-coated iron oxide nanoparticles, and their use in applications such as bioseparation, magnetic resonance imaging, hyperthermia and drug delivery systems showing the growing interest of these materials in biological area.
Mesoporous Silica SBA-16 Functionalized with Alkoxysilane Groups: Preparation, Characterization, and Release Profile Study
Gracielle Ferreira Andrade,Daniel Cristian Ferreira Soares,Ramon Kenned de Sousa Almeida,Edésia Martins Barros Sousa
Journal of Nanomaterials , 2012, DOI: 10.1155/2012/816496
Abstract: A mesoporous material sphere based on silica, SBA-16, was chemically modified with alkoxysilane using two different solvents: methanol and toluene. The influence of the chemical modification of the matrix on the release rate of a model drug was also studied. The structural characteristics of the materials were evaluated by small-angle X-ray diffraction, N2 adsorption, and transmission electron microscopy. The functionalization of the matrix was evaluated using thermal analysis, FTIR spectroscopy, 13C and 29Si solid-state nuclear magnetic resonance, and elemental analysis, CHN. The results show that alkoxysilane groups have been chemically bonded to silicon atoms on the surface of cubic Im3m mesoporous silica. The influence of the release rate of atenolol molecules from chemically modified mesoporous SBA-16 could be identified, since significant differences could be observed among the release patterns of the different materials.
Postural control in children with typical development and children with profound hearing loss
Monteiro de Sousa AM, de Fran a Barros J, Martins de Sousa Neto B
International Journal of General Medicine , 2012, DOI: http://dx.doi.org/10.2147/IJGM.S28693
Abstract: stural control in children with typical development and children with profound hearing loss Original Research (1969) Total Article Views Authors: Monteiro de Sousa AM, de Fran a Barros J, Martins de Sousa Neto B Published Date May 2012 Volume 2012:5 Pages 433 - 439 DOI: http://dx.doi.org/10.2147/IJGM.S28693 Received: 30 November 2011 Accepted: 17 January 2012 Published: 09 May 2012 Aneliza Maria Monteiro de Sousa,1 J natas de Fran a Barros,2 Brígido Martins de Sousa Neto3 1Faculty of Health Sciences, University of Brasilia, Brasilia, Federal District, Brazil; 2Department of Physical Education at the Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil; 3University Center UNIEURO, Brasilia, Federal District, Brazil Purpose: To describe the behavior of the postural control in children with profound sensorineural hearing loss and compare the results of experimental tests with hearing children aged 7 to 10 years. Patients and methods: This is a cross-sectional study where 100 children were divided into experimental and control groups. We used a force platform, AccuSway Plus, where the tests were conducted under the experimental conditions: open base, eyes open (OBEO); open base, eyes closed (OBEC); closed base, eyes open (CBEO); closed base, eyes closed (CBEC). The body sway velocity (V) of the center of pressure, the displacement in the anteroposterior direction (COPap) and mediolateral (COPml) of the center of pressure were the parameters to evaluate the postural control. For statistical analysis we used the nonparametric Mann–Whitney U test, with a significance level of 5%. Results: In comparisons of variables between the groups, the experimental group outperformed by at least 75% of the control group values. In terms of global trends, the experimental group shows higher values of body oscillations in all experimental conditions and variables evaluated. Children with hearing loss had poorer balance performance compared to the group of hearing. The inferential analysis revealed a statistically significant difference in the balance between deaf and hearing children in the OBEC experimental condition in relation to the COPml parameter (P = 0.04). There were no statistically significant differences in comparisons between the sexes when the groups were analyzed separately. The prevalence of unknown etiology showed 58% of cases and congenital rubella in 16%. The discovery of deafness occurred in 70% of children before the age of 3 years. Conclusion: In this study, children with hearing loss had poorer balance performance compared to the group of hearing children. This finding confirms the need to investigate postural control through longitudinal studies to identify the area of sensory deficit causing poor balance performance and promote more specific early interventions.
Postural control in children with typical development and children with profound hearing loss
Monteiro de Sousa AM,de França Barros J,Martins de Sousa Neto B
International Journal of General Medicine , 2012,
Abstract: Aneliza Maria Monteiro de Sousa,1 J natas de Fran a Barros,2 Brígido Martins de Sousa Neto31Faculty of Health Sciences, University of Brasilia, Brasilia, Federal District, Brazil; 2Department of Physical Education at the Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil; 3University Center UNIEURO, Brasilia, Federal District, BrazilPurpose: To describe the behavior of the postural control in children with profound sensorineural hearing loss and compare the results of experimental tests with hearing children aged 7 to 10 years.Patients and methods: This is a cross-sectional study where 100 children were divided into experimental and control groups. We used a force platform, AccuSway Plus, where the tests were conducted under the experimental conditions: open base, eyes open (OBEO); open base, eyes closed (OBEC); closed base, eyes open (CBEO); closed base, eyes closed (CBEC). The body sway velocity (V) of the center of pressure, the displacement in the anteroposterior direction (COPap) and mediolateral (COPml) of the center of pressure were the parameters to evaluate the postural control. For statistical analysis we used the nonparametric Mann–Whitney U test, with a significance level of 5%.Results: In comparisons of variables between the groups, the experimental group outperformed by at least 75% of the control group values. In terms of global trends, the experimental group shows higher values of body oscillations in all experimental conditions and variables evaluated. Children with hearing loss had poorer balance performance compared to the group of hearing. The inferential analysis revealed a statistically significant difference in the balance between deaf and hearing children in the OBEC experimental condition in relation to the COPml parameter (P = 0.04). There were no statistically significant differences in comparisons between the sexes when the groups were analyzed separately. The prevalence of unknown etiology showed 58% of cases and congenital rubella in 16%. The discovery of deafness occurred in 70% of children before the age of 3 years.Conclusion: In this study, children with hearing loss had poorer balance performance compared to the group of hearing children. This finding confirms the need to investigate postural control through longitudinal studies to identify the area of sensory deficit causing poor balance performance and promote more specific early interventions.Keywords: postural control, hearing impairment, balance, children, sensory deprivation, early intervention
Effect of non-surgical periodontal treatment on chronic kidney disease patients
Artese, Hilana Paula Carillo;Sousa, Celso Oliveira de;Luiz, Ronir Raggio;Sansone, Carmelo;Torres, Maria Cynésia Medeiros de Barros;
Brazilian Oral Research , 2010, DOI: 10.1590/S1806-83242010000400013
Abstract: chronic kidney disease (ckd) is a debilitating systemic condition. our working hypothesis is that ckd predialysis patients with periodontitis would respond poorly to periodontal treatment owing to immunologic compromise. twenty-one predialysis patients (group 1) and 19 individuals without clinical evidence of kidney disease (group 2) with chronic periodontitis were subjected to non-surgical periodontal treatment with no antibiotics. clinical periodontal and systemic parameters were evaluated at baseline and 3 months after treatment. both groups showed significant and similar post-treatment improvements in all periodontal parameters examined. most interestingly, periodontal treatment had a statistically significant positive effect on the glomerular filtration rate of each individual (group 1, p = 0.04; group 2, p = 0.002). our results indicate that chronic periodontitis in predialysis kidney disease patients improved similarly in patients with chronic periodontitis and no history of ckd after receiving non-surgical periodontal therapy. this study demonstrates that ckd predialysis patients show a good response to non-surgical periodontal treatment.
Effect of non-surgical periodontal treatment on the subgingival microbiota of patients with chronic kidney disease
Hilana Paula Carillo Artese,Celso Oliveira de Sousa,Maria Cynésia Medeiros de Barros Torres,Carina Maciel Silva-Boghossian
Brazilian Oral Research , 2012,
Abstract: This study investigated the effect of non-surgical periodontal therapy on the composition of subgingival microbiota of patients with chronic kidney disease (CKD). Sixteen CKD pre-dialysis individuals (CKD) and 14 individuals without clinical evidence of kidney disease (C) presenting chronic periodontitis were treated by scaling and root planing. Subgingival samples were collected from each patient and analyzed for their composition by checkerboard at baseline and 3 months post-therapy. Significant differences between groups at baseline were sought by the Mann-Whitney and χ2 tests. Changes over time were examined by the Wilcoxon test. At baseline, the CKD group had significantly lower counts of E. faecalis compared to the C group (p < 0.05). After treatment, the levels of a greater number of species were reduced in the C group. Higher levels of A. israelii, C. rectus, F. periodonticum, P. micra, P. nigrescens, T. forsythia, N. mucosa, and S. anginosus (p < 0.05) were found in the CKD group compared to the C group. Also, non-responsive sites in CKD individuals harbored significantly higher levels of pathogenic species (T. forsythia, P. gingivalis, T. denticola, Fusobacterium spp., D. pneumosintes, E. faecalis and S. aureus; p < 0.05) than sites that responded to therapy, as well as non-responsive sites in the C group. The periodontitis-associated subgingival microbiota of CKD and systemically healthy individuals was similar in composition. However, high levels of pathogenic species persisted in the subgingival microbiota of patients with CKD after treatment.
Effect of non-surgical periodontal treatment on the subgingival microbiota of patients with chronic kidney disease
Artese, Hilana Paula Carillo;Sousa, Celso Oliveira de;Torres, Maria Cynésia Medeiros de Barros;Silva-Boghossian, Carina Maciel;Colombo, Ana Paula Vieira;
Brazilian Oral Research , 2012, DOI: 10.1590/S1806-83242012005000008
Abstract: this study investigated the effect of non-surgical periodontal therapy on the composition of subgingival microbiota of patients with chronic kidney disease (ckd). sixteen ckd pre-dialysis individuals (ckd) and 14 individuals without clinical evidence of kidney disease (c) presenting chronic periodontitis were treated by scaling and root planing. subgingival samples were collected from each patient and analyzed for their composition by checkerboard at baseline and 3 months post-therapy. significant differences between groups at baseline were sought by the mann-whitney and χ2 tests. changes over time were examined by the wilcoxon test. at baseline, the ckd group had significantly lower counts of e. faecalis compared to the c group (p < 0.05). after treatment, the levels of a greater number of species were reduced in the c group. higher levels of a. israelii, c. rectus, f. periodonticum, p. micra, p. nigrescens, t. forsythia, n. mucosa, and s. anginosus (p < 0.05) were found in the ckd group compared to the c group. also, non-responsive sites in ckd individuals harbored significantly higher levels of pathogenic species (t. forsythia, p. gingivalis, t. denticola, fusobacterium spp., d. pneumosintes, e. faecalis and s. aureus; p < 0.05) than sites that responded to therapy, as well as non-responsive sites in the c group. the periodontitis-associated subgingival microbiota of ckd and systemically healthy individuals was similar in composition. however, high levels of pathogenic species persisted in the subgingival microbiota of patients with ckd after treatment.
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