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Search Results: 1 - 10 of 1284 matches for " Ed Iversen "
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A Latent Model for Prioritization of SNPs for Functional Studies
Brooke L. Fridley,Ed Iversen,Ya-Yu Tsai,Gregory D. Jenkins,Ellen L. Goode,Thomas A. Sellers
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020764
Abstract: One difficult question facing researchers is how to prioritize SNPs detected from genetic association studies for functional studies. Often a list of the top M SNPs is determined based on solely the p-value from an association analysis, where M is determined by financial/time constraints. For many studies of complex diseases, multiple analyses have been completed and integrating these multiple sets of results may be difficult. One may also wish to incorporate biological knowledge, such as whether the SNP is in the exon of a gene or a regulatory region, into the selection of markers to follow-up. In this manuscript, we propose a Bayesian latent variable model (BLVM) for incorporating “features” about a SNP to estimate a latent “quality score”, with SNPs prioritized based on the posterior probability distribution of the rankings of these quality scores. We illustrate the method using data from an ovarian cancer genome-wide association study (GWAS). In addition to the application of the BLVM to the ovarian GWAS, we applied the BLVM to simulated data which mimics the setting involving the prioritization of markers across multiple GWAS for related diseases/traits. The top ranked SNP by BLVM for the ovarian GWAS, ranked 2nd and 7th based on p-values from analyses of all invasive and invasive serous cases. The top SNP based on serous case analysis p-value (which ranked 197th for invasive case analysis), was ranked 8th based on the posterior probability of being in the top 5 markers (0.13). In summary, the application of the BLVM allows for the systematic integration of multiple SNP “features” for the prioritization of loci for fine-mapping or functional studies, taking into account the uncertainty in ranking.
Editorial: reviewers for 2008
Ed.
Web Ecology (WE) , 2008, DOI: 10.5194/we-8-160-2008
Abstract: No abstract available.
Reviewers for 2009
Ed.
Web Ecology (WE) , 2009, DOI: 10.5194/we-9-82-2009
Abstract: No abstract available.
Referees serving 2007
Ed.
Web Ecology (WE) , 2007, DOI: 10.5194/we-7-132-2007
Abstract: No abstract available.
Reviewers for 2010
Ed.
Web Ecology (WE) , 2010, DOI: 10.5194/we-10-58-2010
Abstract: No abstract available.
Ad hoc Editors and reviewers for Web Ecology for 2006
Ed.
Web Ecology (WE) , 2006, DOI: 10.5194/we-6-102-2006
Abstract: No abstract available.
Quinquennial Terror: Machiavelli’s Understanding of the Political Sublime  [PDF]
Ed King
Open Journal of Political Science (OJPS) , 2013, DOI: 10.4236/ojps.2013.32010
Abstract:

This paper argues that far from advocating fear of violence as a continuous source of civic provocation Machiavelli’s ideal ruler employs an aesthetic approach to civic violence; one that actually harms few citizens and moderates their fear with admiration through carefully considered psychological imperatives similar to those articulated two hundred years later in theories of the sublime. Such violence as there was would occur half a decade at a time in between which the citizens and the patria would enjoy stability, wealth and honor. It had a proven Medici provenance, having been developed through Cosimo de Medici’s intuitive genius for governance and was maintained by Piero and Lorenzo the Magnificent. The insight was empirically confirmed by Niccolò’s observations of similarly intuitive political savants; namely Cesare Borgia and Julius II. It was not given a technical title by Machiavelli, who unhelpfully referred to it as crudeltà bene usate (cruelty well used) but we might call it “the politics of the sublime”. Despite its most dramatic (and consequentially disproportionate) evocation in the Prince, Machiavelli’s reliance on the political sublime waned throughout his literary career, until he rejected it in a stunning critique of Cosimo’s reign in the Florentine Histories.

Control elements in mechanism simulation
Torleif Iversen
Modeling, Identification and Control , 1989, DOI: 10.4173/mic.1989.3.5
Abstract: The work reported in this paper is a step towards a system for multidisciplinary simulation of structure, mechanism and control elements. The control part of the system is implemented as a subroutine called from the mechanism/FEM package. While Newmark's/beta-method is used to integrate the second order mechanism/FEM part, the Lobatto IIIC algorithm is applied to the first order control elements. Preliminary experiments show that this is a workable solution. The package will be further developed to include more elements, improve the performance and add enhanced graphics. The control part can easily be used as a stand alone simulator for the integration of first order differential/algebraic equations.
Résidence du Corpus Troporum
Gunilla Iversen
Bulletin du Centre d’études Médiévales d’Auxerre , 2005, DOI: 10.4000/cem.780
Abstract: Les membres du Corpus Troporum, animé depuis des années par Gunilla Iversen (Stockholm), sont invités en résidence au Centre d’études médiévales d’Auxerre. Ce court séjour est destiné à mettre au point la publication du projet Sapientia- eloquentia. Il a été demandé au groupe d’organiser une journée sur les séquences et tropes de dédicace d’église (dimanche 23 octobre 2005).Presentation of the research project Corpus TroporumThe research project Corpus Troporum (formerly “Projektet Troper”) h...
The Prince of Pine Avenue and the Père de la Patrie: A Machiavellian Analysis of Pierre Trudeau and Rene Lévesque  [PDF]
Ed King, Charles Sancy
Open Journal of Political Science (OJPS) , 2015, DOI: 10.4236/ojps.2015.54024
Abstract: This study was inspired by the remarkable number of Machiavellian references we noted in journalistic and scholarly accounts of the 1970 War Measures Act and the Québec Referendum that followed a decade later. The notion that Machiavelli’s insights in the sixteenth century might have utility for a critique of 20th century Quebecois political life seemed outrageous and we wanted to explore the validity of such associations. There’s nothing wrong with this. We wanted to see if there was more to them than the shorthand of short-cycle journalism or if they actually possessed enough analytical force to usefully illustrate aspects of that period of Quebec’s history. We discovered that the Machiavellian lens was remarkably illuminating, especially with respect to the clash of two of Quebec’s most influential personalities, Pierre Trudeau and Rene Lévesque although, with the notable exception of Denis Arcand, the connections made at the time failed to extend much beyond attempts to make ad hominum slurs against the principle actors in the drama.
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