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Search Results: 1 - 10 of 415101 matches for " E. J.;Salvado "
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Low temperature synthesis of bioactive materials
Bandeira, L. C.;Calefi, P. S.;Ciuffi, K. J.;Nassar, E. J.;Salvado, I. M. M.;Fernandes, M. H. F. V.;
Ceramica , 2011, DOI: 10.1590/S0366-69132011000200006
Abstract: bioactive materials possess properties that allow them to interact with natural tissues to induce reactions that favor the development and regeneration of those tissues. in this study, silica was prepared by the sol-gel method, using tetraethylorthosilicate as the precursor. the calcium and phosphor sources used here were calcium ethoxy and phosphoric acid, respectively, in ethanol solvent. the solid obtained was dried at 50 oc. in vitro bioactivity assays were performed by soaking the materials in simulated body fluid (sbf). the samples were characterized by transmission electron microscopy (tem), thermal analysis and photoluminescence. tem images of the samples before contact with sbf revealed amorphous aggregates and after 12 days in sbf showed two phases, one amorphous with large quantities of si and o, and the other a crystalline phase whose composition contained ca and p. the electron diffraction pattern showed a planar distance of 2.86 ?, corresponding to 2θ = 32.2o. this was ascribed to hydroxyapatite. the eu iii was used as structural probe. the relative band intensity correspondent the transition 5d0 → 7f2 / 5d0 → 7f1 showed a high symmetry surrounding the eu iii ion. these materials, produced by the sol-gel route, open up new possibilities for obtaining bioactive biomaterials for medical applications.
Neutrino Lighthouse at Sagittarius A*
Y. Bai,A. J. Barger,V. Barger,R. Lu,A. D. Peterson,J. Salvado
Physics , 2014, DOI: 10.1103/PhysRevD.90.063012
Abstract: We investigate whether a subset of high-energy events observed by IceCube may be due to neutrinos from Sagittarius A*. We check both spatial and temporal coincidences of IceCube events with other transient activities of Sagittarius A*. Among the seven IceCube shower events nearest to the galactic center, we have found that event 25 has a time very close to (around three hours after) the brightest X-ray flare of Sagittarius A* observed by the Chandra X-ray Observatory with a p-value of 0.9%. Furthermore, two of the seven events occurred within one day of each other (there is a 1.6% probability that this would occur for a random distribution in time). Thus, the determination that some IceCube events occur at similar times as X-ray flares and others occur in a burst could be the smoking gun that Sagittarius A* is a point source of very high energy neutrinos. We point out that if IceCube galactic center neutrino events originate from charged pion decays, then TeV gamma rays should come from neutral pion decays at a similar rate. We show that the CTA, HAWC, H.E.S.S. and VERITAS experiments should be sensitive enough to test this.
Roadmap Proposal for Implementing Building Information Modelling (BIM) in Portugal  [PDF]
Maria Jo?o Falc?o Silva, Filipa Salvado, Paula Couto, álvaro Vale e Azevedo
Open Journal of Civil Engineering (OJCE) , 2016, DOI: 10.4236/ojce.2016.63040
Abstract: Building Information Modeling (BIM) is a process involving generation and management of digital representations of physical and functional characteristics of places, which can be exchanged or networked to support decision-making in architecture, engineering and construction (AEC) sector. BIM is a relatively new technology in an industry typically slow to adopt changes, especially in Portugal. The present paper aims to frame the international implementation of BIM in order to propose a roadmap to spread the use of BIM methodologies in Portugal in the next decade.
Standardization of BIM Objects: Development of a Proposal for Portugal  [PDF]
Filipa Salvado, Maria Jo?o Falc?o Silva, Paula Couto, álvaro Vale e Azevedo
Open Journal of Civil Engineering (OJCE) , 2016, DOI: 10.4236/ojce.2016.63039
Abstract: The management of information systems contributes to the economic development of the construction sector by organizing and structuring technical and economic information. It is proposed how BIM (Building Information Modelling) and a Portuguese information system-ProNIC (abbreviation for Protocol for the Standardization of Construction Technical Information) may be interconnected. The scope of this information transmission in construction sector is a step to solve several problems that have been identified in conception of BIM models.
Statistical tests of sterile neutrinos using cosmology and short-baseline data
Johannes Bergstr?m,M. C. Gonzalez-Garcia,V. Niro,J. Salvado
Physics , 2014, DOI: 10.1007/JHEP10(2014)104
Abstract: In this paper we revisit the question of the information which cosmology provides on the scenarios with sterile neutrinos invoked to describe the SBL anomalies using Bayesian statistical tests. We perform an analysis of the cosmological data in $\Lambda$CDM$+r+\nu_s$ cosmologies for different cosmological data combinations, and obtain the marginalized cosmological likelihood in terms of the two relevant parameters, the sterile neutrino mass $m_s$ and its contribution to the energy density of the early Universe $N_{\rm eff}$. We then present an analysis to quantify at which level a model with one sterile neutrino is (dis)favoured with respect to a model with only three active neutrinos, using results from both short-baseline experiments and cosmology. We study the dependence of the results on the cosmological data considered, in particular on the inclusion of the recent BICEP2 results and the SZ cluster data from the Planck mission. We find that only when the cluster data is included the model with one extra sterile neutrino can become more favoured that the model with only the three active ones provided the sterile neutrino contribution to radiation density is suppressed with respect to the fully thermalized scenario. We have also quantified the level of (in)compatibility between the sterile neutrino masses implied by the cosmological and SBL results.
An Approach to Foster Engineering Skills at Graduation Level: Meeting the Industry Needs
Jose Antonio Salvado
International Journal of Advanced Corporate Learning (iJAC) , 2012, DOI: 10.3991/ijac.v5i2.2124
Abstract: This paper describes a Group Problem Solving approach used for Electrical and Telecommunication engineering graduation students, to foster technical and personal skills while overcoming the consequences on the reduction on courses duration, due to the Bologna agreement format. The approach is described; success experiences and results are discussed.
Cosmogenic gamma-rays and the composition of cosmic rays
Markus Ahlers,Jordi Salvado
Physics , 2011, DOI: 10.1103/PhysRevD.84.085019
Abstract: We discuss the prospects of detecting the sources of ultra-high energy (UHE) cosmic ray (CR) nuclei via their emission of cosmogenic gamma-rays in the GeV to TeV energy range. These gamma-rays result from electromagnetic cascades initiated by high energy photons, electrons and positrons that are emitted by CRs during their propagation in the cosmic radiation background and are independent of the simultaneous emission of gamma-rays in the vicinity of the source. The corresponding production power by UHE CR nuclei (with mass number A and charge Z) is dominated by pion photo-production (~ A) and Bethe-Heitler pair production (~ Z^2). We show that the cosmogenic gamma-ray signal from a single steady UHE CR source is typically more robust with respect to variations of the source composition and injection spectrum than the accompanying signal of cosmogenic neutrinos. We study the diffuse emission from the sum of extragalactic CR sources as well as the point source emission of the closest sources.
CX3CR1 Is a Modifying Gene of Survival and Progression in Amyotrophic Lateral Sclerosis
Alan Lopez-Lopez, Josep Gamez, Emilio Syriani, Miguel Morales, Maria Salvado, Manuel J. Rodríguez, Nicole Mahy, Jose M. Vidal-Taboada
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096528
Abstract: The objective of this study was to investigate the association of functional variants of the human CX3CR1 gene (Fractalkine receptor) with the risk of Amyotrophic Lateral Sclerosis (ALS), the survival and the progression rate of the disease symptoms in a Spanish ALS cohort. 187 ALS patients (142 sporadic [sALS] and 45 familial) and 378 controls were recruited. We investigated CX3CR1 V249I (rs3732379) and T280M (rs3732378) genotypes and their haplotypes as predictors of survival, the progression rate of the symptoms (as measured by ALSFRS-R and FVC decline) and the risk of suffering ALS disease. The results indicated that sALS patients with CX3CR1 249I/I or 249V/I genotypes presented a shorter survival time (42.27±4.90) than patients with 249V/V genotype (67.65±7.42; diff ?25.49 months 95%CI [?42.79,?8.18]; p = 0.004; adj-p = 0.018). The survival time was shorter in sALS patients with spinal topography and CX3CR1 249I alleles (diff = ?29.78 months; 95%CI [?49.42,?10.14]; p = 0.003). The same effects were also observed in the spinal sALS patients with 249I–280M haplotype (diff = ?27.02 months; 95%CI [?49.57, ?4.48]; p = 0.019). In the sALS group, the CX3CR1 249I variant was associated with a faster progression of the disease symptoms (OR = 2.58; 95IC% [1.32, 5.07]; p = 0.006; adj-p = 0.027). There was no evidence for association of these two CX3CR1 variants with ALS disease risk. The association evidenced herein is clinically relevant and indicates that CX3CR1 could be a disease-modifying gene in sALS. The progression rate of the disease's symptoms and the survival time is affected in patients with one or two copies of the CX3CR1 249I allele. The CX3CR1 is the most potent ALS survival genetic factor reported to date. These results reinforce the role of the immune system in ALS pathogenesis.
Geometric Compatibility of IceCube TeV-PeV Neutrino Excess and its Galactic Dark Matter Origin
Yang Bai,Ran Lu,Jordi Salvado
Physics , 2013,
Abstract: We perform a geometric analysis for the sky map of the IceCube TeV-PeV neutrino excess and test its compatibility with the sky map of decaying dark matter signals in our galaxy. Using both Kolmogorov-Smirnov and the likelihood-ratio tests, we have found that the observed event sky map prefers to have a combination of the galactic dark matter and a homogeneous background contributions, compared to a purely galactic dark matter origin. For the assumption that the galactic dark matter is responsible for all neutrino excess, the current data can also exclude a wide range of dark matter profiles except flatter profiles such as the isothermal one. We also consider several representative decaying dark matter spectra, which can provide a good fit to the observed spectrum at IceCube with a dark matter lifetime of around 12 orders of magnitude longer than the age of the universe.
Effect of calcium phosphate coating on polyamide substrate for biomaterial applications
Bandeira, Lucimara C.;Ciuffi, Kátia J.;Calefi, Paulo S.;Nassar, Eduardo J.;Silva, Jorge V. L.;Oliveira, Marcelo;Maia, Izaque A.;Salvado, Isabel M.;Fernandes, Maria Helena V.;
Journal of the Brazilian Chemical Society , 2012, DOI: 10.1590/S0103-50532012000500004
Abstract: a new type of material from polyamide coated with calcium phosphate was developed aiming to have potential application as biomaterial. coating was obtained by the sol-gel method and calcium phosphate was obtained after contact with body fluid solution. the coated polyamide (before and after contact with body fluid solution) was characterized by thermogravimetric and differential thermal (tga/dta) analyses, differential scanning calorimetry (dsc), scanning electron microscopy (sem) and attenuated total reflectance fourier transform infrared spectroscopy (atr-ftir). these characterizations revealed that the calcium phosphate coating has a thickness of less than 3 μm, which resulted in an increase in the melting point and improved the thermal stability of polyamide. after contact with body fluid, the interactions between the coating and the substrate remained, and there was formation of crystalline and amorphous phosphates on polyamide surface.
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