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Search Results: 1 - 10 of 167489 matches for " E Minas "
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Bladder Tumours at Tikur Anbessa Hospital in Ethiopia.
H Biluts, E Minas
East and Central African Journal of Surgery , 2011,
Abstract: Background: Bladder cancer is the fourth to fifth most common cancer in men, and the eighth in women These t umors are commonest in the 50 to 70 year age group The aim of this study was to review the pattern and surgical management of bladder tumors at TAS in Ethiopia. Methods: A hospital based retrospective cross sectional analysis was conducted in TASH, department of surgery, Addis Ababa, Ethiopia. Patients’ medical records and operation theater registers of 97 patients operated upon for bladder tumors, between January2006 and December 2008 were analyzed. Results: Sixty patients were male and 37 female (M: F of 1.6:1). Their age ranged from 20 to79 years, with mean age of 49.73±1.5.Duration of symptoms ranged between 1and 48 months (mean 13.9). The most common presenting symptoms were hematuria in 89(91.8%). cystoscopy and sonographic examination of the bladder were the main modalities of investigation in the diagnosis of bladder tumors in 100% and 96.9% patients respectively. Histopathologically, 87(89.7%) and 10(10.3%) patients had malignant and benign bladder tumors respectively. Of the patients with malignant bladder tumors, 78 (80.4%) had TCC, 5(5.2% SCC, and 3 (3.1%) adenocarcinoma. Common patterns of bladder masses were papillary 77(79.7%), sessile or mixed 10(10.3%), and nodular 6(6.2%).Upon presentation, 66(74.7%) of patients had lowgrade, whilst 20(23.0%) had high-grade disease, 85.5% of bladder tumors were nonmuscle invasive, while 14.9% were muscle invasive, and 2.4% metastatic. The commonest surgical technique employed for bladder tumor removal was TURBT in 80 (82.5%) patients. Forty-four (45%) of the patients had additional surgery such as repeated TURBT in 16(16.5%), cystectomy+ureterosigmoidostomy in 8(8.2%),radical cystectomy+neobladder in 5(5.2%), antiincontinence procedure in 4(4.1%),partial cystectomy in 4(4.1% ) and redo cystectomy+sigmoid bladder in 4( 4.1%). In 83(85.6%) patients the postoperative course was uneventful, while 17(17.5%) developed immediate postoperative complications. Twelve developed late complications. There were 6(6.2%) deaths. Post operative hospital stay of 1-70 days (mean 12.1) and a follow up period ranging from 1 to 26 month (mean 3.7 months) were also the outcome of this review. Conclusion: The most common type of bladder cancer in TASH is TCC.Bladder tumor is more frequent in men than in women. The commonest procedure for bladder tumors was TURBT (p<0.001) which is the golden standared for non-muscle invasive tumors.
Two-year mortality of patients with COPD in primary health care: an observational study
Minas M,Verrou-Katsarou I,Mystridou P,Apostolidou E
International Journal of General Medicine , 2012,
Abstract: Markos Minas, Ioanna Verou-Katsarou, Parthena Mystridou, Eleni Apostolidou, Chrisi Hatzoglou, Konstantinos I GourgoulianisRespiratory Medicine Department, University of Thessaly Medical School, Larissa, GreeceBackground: Chronic obstructive pulmonary disease (COPD) remains a significant cause of morbidity and mortality, with high rates of underdiagnosis. There are no studies about following up COPD patients in primary health care. The aim of the current study was to estimate two-year mortality for COPD patients in primary care and assess the parameters associated with mortality.Methods: A total of 263 patients with a new COPD diagnosis were followed up for two years. Follow-up included phone contacts every six months for assessment of vital status, and re-examination visits every year after the initial diagnosis. Visits included performance on spirometry, assessment of smoking status, evaluation of adherence with treatment, and assessment of the number of exacerbations during the previous year.Results: One hundred and eighteen patients with COPD completed the study. The overall mortality was 27.9%. Most patients had quit smoking two years after the initial diagnosis, whereas the percentage of patients showing high adherence with treatment was 68%. Parameters associated with two-year mortality were age and coronary heart disease comorbidity.Conclusion: The mortality of patients with COPD in primary care remains significantly high, whereas adherence with treatment remains significant low. Age, smoking status, and a history of depression are major determinants of mortality in primary health care.Keywords: chronic obstructive pulmonary disease, mortality, primary health care, depression
Mental health and human rights: never waste a serious crisis
Harry Minas
International Journal of Mental Health Systems , 2009, DOI: 10.1186/1752-4458-3-12
Abstract: In an interview with the New York Times soon after the US election [1] Barack Obama's Chief of Staff, Rahm Emanuel, said: "Never let a serious crisis go to waste" asserting that crises are "opportunities to do big things." In an interview with the Wall Street Journal [2] he elaborated on the meaning of these statements as he set out a series of essential principles for the Obama administration's program of reform. Emanuel identified previous missed opportunities to deal with major problems, including health, energy, education, fiscal and tax policy, and regulatory reform. "Things we had postponed for too long that were long term are now immediate and must be dealt with ... The problems are big enough that they lend themselves to ideas from both parties for the solution."During the weekend of 23/24 May 2009 the Jakarta newspapers were focusing on an unfolding crisis in mental health. The headlines in front page and page 2 news stories read: Mental illness patients die of diarrhea and malnutrition [3]Doctors to inspect overcrowded shelters where mentally ill patients are dying [4]Mentally ill enter shelters 'for life' [5]. The flurry of media interest was precipitated by a report from the Jakarta Social Agency that in the city's four 'shelters' for people with chronic mental illness residents are dying of from malnutrition, over-crowding and diarrhoea. "There was not much of an outcry about it; for six months three people every four days died from diarrhea and malnutrition at shelters for mentally ill people in the capital. No fuss was made until the city administration received a report from an agency about the staggering numbers. Recent data from the Jakarta social agency revealed that 181 people died between October 2008 and May 22, 2009, at four shelters in Daan Mogot and Cengkareng, both in West Jakarta, and Cipayung and Ceger, in East Jakarta." [3] A further 57 people who had been transferred from the shelters to the responsible mental hospital had died in the s
International observatory on mental health systems: structure and operation
Harry Minas
International Journal of Mental Health Systems , 2009, DOI: 10.1186/1752-4458-3-8
Abstract: The International Observatory on Mental Health Systems is a mental health systems research, education and development network that will contribute to the development of high quality mental health systems in low and middle-income countries. The work of the Observatory will be done by mental health systems research, education and development groups that are located in and managed by collaborating organisations. These groups will be supported by the IOMHS Secretariat, the International IOMHS Steering Group and a Technical Reference Group.The International Observatory on Mental Health Systems is: 1) the mental health systems research, education and development groups; 2) the IOMHS Steering Group; 3) the IOMHS Technical Reference Group; and 4) the IOMHS Secretariat. The work of the Observatory will depend on free and open collaboration, sharing of knowledge and skills, and governance arrangements that are inclusive and that put the needs and interests of people with mental illness and their families at the centre of decision-making. We welcome contact from individuals and institutions that wish to contribute to achieving the goals of the Observatory.Now is the time to make it happen where it matters, by turning scientific knowledge into effective action for people's health. (J.W. Lee, in his acceptance speech on his appointment as the Director-General of the World Health Organization) [1].Sustained cooperative action is required to improve the mental health of populations everywhere [2]. This is particularly so in low and middle-income countries where mental health system performance is poor as a result of meagre mental health investment [3,4] and strikingly insufficient and inequitably distributed human and other resources [5,6]. While many aspects of health and illness are universal, they are imbedded, and must be understood, in local socio-cultural, economic and political contexts. Such understandings can only be gained through high quality locally relevant research.T
International Observatory on Mental Health Systems: a mental health research and development network
Harry Minas
International Journal of Mental Health Systems , 2009, DOI: 10.1186/1752-4458-3-2
Abstract: The International Observatory on Mental Health Systems (IOMHS) will build capacity to measure and to track mental health system performance in participating countries at national and sub-national (provincial and district) levels. The work of IOMHS will depend on the establishment of robust partnerships among the key stakeholder groups. The Observatory will build the capability of partner organisations and networks to provide evidence-based advice to policy makers, service planners and implementers, and will monitor the progress of mental health service scaling up activities.The International Observatory on Mental Health Systems will be a mental health research and development network that will monitor and evaluate mental health system performance in low and middle-income countries.Health systems in low and middle-income countries are characterised by massive under-investment in mental health [1]. The consequences of this are many. There is an almost total reliance on mental hospitals, where quality of treatment and care is generally poor, and there are very few community mental health services [2]. In many places there is a serious shortage of skilled mental health professionals [1] and lack of legislative protections. Poor facilities and lack of skilled mental health workers too often results in neglect and abuse of the human rights of people with mental illness and their families [3].While effective mental health services are unavailable for most people in low and middle-income countries there is a renewed commitment to focus attention on the mental health of populations and on the scaling up of mental health services that have the capacity to respond to mental health service needs [4]. In October 2008 the World Health Organization Mental Health Gap Action Programme (mhGAP) [5], and the Movement for Global Mental Health [6] were launched. The intent of mhGAP is to scale up care for mental, neurological, and substance use disorders, with strategies identified parti
Generation and Validation of Custom Multiplication IP Blocks from the Web
Minas Dasygenis
Computer Science , 2015,
Abstract: Every CPU carries one or more arithmetical and logical units. One popular operation that is performed by these units is multiplication. Automatic generation of custom VHDL models for performing this operation, allows the designer to achieve a time efficient design space exploration. Although these units are heavily utilized in modern digital circuits and DSP, there is no tool, accessible from the web, to generate the HDL description of such designs for arbitrary and different input bitwidths. In this paper, we present our web accessible tool to construct completely custom optimized multiplication units together with random generated test vectors for their verification. Our novel tool is one of the firsts web based EDA tools to automate the design of such units and simultaneously provide custom testbenches to verify their correctness. Our synthesized circuits on Xilinx Virtex 6 FPGA, operate up to 589 Mhz.
Association of TLR4-T399I Polymorphism with Chronic Obstructive Pulmonary Disease in Smokers
Matthaios Speletas,Vassiliki Merentiti,Konstantinos Kostikas,Kyriaki Liadaki,Markos Minas,Konstantinos Gourgoulianis,Anastasios E. Germenis
Clinical and Developmental Immunology , 2009, DOI: 10.1155/2009/260286
Abstract: Tobacco smoking has been considered the most important risk factor for chronic obstructive pulmonary disease (COPD) development. However, not all smokers develop COPD and other environmental and genetic susceptibility factors underlie disease pathogenesis. Recent studies have indicated that the impairment of TLR signaling might play a crucial role in the development of emphysema. For this purpose we investigated the prevalence and any possible associations of common TLR polymorphisms (2-R753Q, 4-D299G, and 4-T399I) in a group of 240 heavy smokers (>20 pack years), without overt atherosclerosis disease, of whom 136 had developed COPD and 104 had not. The presence of 4-T399I polymorphism was associated with a 2.4-fold increased risk for COPD development (=.044), but not with disease stage or frequency of exacerbations. Considering that infections contribute to COPD and emphysema pathogenesis, our findings possibly indicate that dysfunctional polymorphisms of innate immune genes can affect the development of COPD in smokers. Although this finding warrants further investigation, it highlights the importance of impaired innate immunity towards COPD development.
Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1alpha) expression in serous ovarian cancer: an immunohistochemical study
Alexandros Daponte, Maria Ioannou, Ilias Mylonis, George Simos, Marcos Minas, Ioannis E Messinis, George Koukoulis
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-335
Abstract: One hundred (n = 100) neoplastic and 20 benign (controls) pathological samples from paraffin-embedded tissue were included. They were classified after surgery as stage I (n = 23) and stage III G3 (n = 55). Also 22 borderline serous adenocarcinoma patients and 20 benign controls were stained. The mean follow up was 3 years. Only patients with the diagnosis of serous carcinoma of stage III, G3 who received 6 cycles of postoperative TC (175–180 mg/m2 paclitaxel and carboplatin after calculating the area under the concentration curve) with complete medical records (n = 55) were selected for survival analysis. The survival analysis of the samples compared two groups after the patients were dichotomized by HIF-1α final score to positive and negative.The frequency of the nuclear expression of HIF-1α in benign tumours was significantly lower (median: no expression) than in borderline and ovarian cancer tumours combined (p < 0.001). HIF-1α expression in serous ovarian carcinoma was not stage dependent. The overall survival of patients with tumours that stained strongly for HIF-1α was significantly shorter than that of patients with tumours that stained weakly or were negative for HIF-1α (p = 0.01). Kaplan-Meier survival curves confirmed that HIF-1α "positive" had decreased overall survival compared to HIF-1α "negative" patients (p = 0.003) and this was an independent adverse prognostic factor (multivariable analysis p = 0.006). HIF-1α "positive" patients displayed a shorter median progress free interval (PFI) (not statistically significant p > 0.05). Interestingly the overall PFI of the subgroup of patients that have undergone suboptimal cytoreduction at primary surgery (n = 21) with tumours that stained strongly for HIF-1α was significantly worse than that of patients with tumours that stained weakly or were negative for HIF-1α (p = 0.03).Our report confirms the prognostic value of HIF-1α when restricted to poorly differentiated serous ovarian carcinoma. In addition it show
Determination of Sodium and Potassium Electrolytes in Human Serum by Indirect and Direct ISE Methods in Linical and Biochemical Laboratories
A. Papaioannou,P. Plageras,E. Dovriki,A.G. Paliatsos,A. Minas,Zoe Roupa
Research Journal of Medical Sciences , 2012,
Abstract: The determination of sodium and potassium electrolytes in human serum requires particular attention, because the alternation of different analyzers/methodologies during the day, in a general hospital. This research compares the data produced by 2 different analyzers that applied different methodologies which are commonly used in clinical chemistry laboratories to measure sodium and potassium ions. Olympus AU640 analyzer (Olympus, Japan) uses indirect ISE method while Microlyte 6.0 analyzer (KONELAB, Finland) uses direct ISE. It is shown that for the potassium a linear fitting model was the most appropriate for data transformation from Olympus AU640 to Microlyte 6.0. Also it is shown that a linear transformation model was not the most appropriate for transformation in the case of sodium concentrations. Finally some tentative conclusions are derived concerning the problem of transferability of results exists when laboratories use the above analyzers for the determination of the electrolytes sodium and potassium.
Two-year mortality of patients with COPD in primary health care: an observational study
Minas M, Verrou-Katsarou I, Mystridou P, Apostolidou E, Hatzoglou C, Gourgoulianis KI
International Journal of General Medicine , 2012, DOI: http://dx.doi.org/10.2147/IJGM.S27411
Abstract: -year mortality of patients with COPD in primary health care: an observational study Original Research (887) Total Article Views Authors: Minas M, Verrou-Katsarou I, Mystridou P, Apostolidou E, Hatzoglou C, Gourgoulianis KI Published Date October 2012 Volume 2012:5 Pages 815 - 822 DOI: http://dx.doi.org/10.2147/IJGM.S27411 Received: 17 October 2011 Accepted: 27 April 2012 Published: 05 October 2012 Markos Minas, Ioanna Verou-Katsarou, Parthena Mystridou, Eleni Apostolidou, Chrisi Hatzoglou, Konstantinos I Gourgoulianis Respiratory Medicine Department, University of Thessaly Medical School, Larissa, Greece Background: Chronic obstructive pulmonary disease (COPD) remains a significant cause of morbidity and mortality, with high rates of underdiagnosis. There are no studies about following up COPD patients in primary health care. The aim of the current study was to estimate two-year mortality for COPD patients in primary care and assess the parameters associated with mortality. Methods: A total of 263 patients with a new COPD diagnosis were followed up for two years. Follow-up included phone contacts every six months for assessment of vital status, and re-examination visits every year after the initial diagnosis. Visits included performance on spirometry, assessment of smoking status, evaluation of adherence with treatment, and assessment of the number of exacerbations during the previous year. Results: One hundred and eighteen patients with COPD completed the study. The overall mortality was 27.9%. Most patients had quit smoking two years after the initial diagnosis, whereas the percentage of patients showing high adherence with treatment was 68%. Parameters associated with two-year mortality were age and coronary heart disease comorbidity. Conclusion: The mortality of patients with COPD in primary care remains significantly high, whereas adherence with treatment remains significant low. Age, smoking status, and a history of depression are major determinants of mortality in primary health care.
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