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Nitric oxide paradox in asthma
Keller, Alexandre Castro;Rodriguez, Dunia;Russo, Momtchilo;
Memórias do Instituto Oswaldo Cruz , 2005, DOI: 10.1590/S0074-02762005000900005
Abstract: asthma results from allergen-driven intrapulmonary th2 response, and is characterized by intermittent airway obstruction, airway hyperreactivity (ahr), and airway inflammation. accumulating evidence indicates that inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (no). it has been shown that exhaled no may be derived from constitutive no synthase (nos) such as endothelial (nos 3) and neural (nos 1) in normal airways, while increased levels of no in asthma appear to be derived from inducible nos2 expressed in the inflamed airways. nevertheless, the functional role of no and nos isoforms in the regulation of ahr and airway inflammation in human or experimental models of asthma is still highly controversial. in the present commentary we will discuss the role of lipopolysaccharides contamination of allergens as key element in the controversy related to the regulation of nos2 activity in experimental asthma.
Accurate Tools for Analyzing the Behavior of Impulse Noise Reduction Filters in Color Images  [PDF]
Fabrizio Russo
Journal of Signal and Information Processing (JSIP) , 2013, DOI: 10.4236/jsip.2013.41005

Effective cancellation of noise and preservation of color/structural information are features of paramount importance for any filter devoted to impulse noise removal in color images. In this paper novel full-reference tools for analyzing the behavior of this family of filters are presented. The proposed approach is based on the classification of color errors into two main classes that separately take into account the inaccuracy in removing noise pulses and the filtering distortion. The distortion errors are then classified into two subclasses for a deeper analysis of the filtering behavior. Computer simulations show that the proposed method gives more accurate results than using other measures of filtering performance in the literature. Furthermore, the method can easily yield the spatial location of the different filtering features in the image.

Aluminum silicon carbide and aluminum graphite particulate composites
Dunia Abdul Saheb
Journal of Engineering and Applied Sciences , 2011,
Abstract: Metal Matrix Composites (MMCs) have been used in several applications in aerospace and automotive industries. Although several technical challenges exist with casting technology. Achieving a uniform distribution of reinforcement within the matrix is one such challenge, which affects directly on the properties and quality of composite. In the present study a modest attempt has been made to develop aluminium based silicon carbide particulate MMCs, graphite particulate MMCs with an objective to develop a conventional low cost method of producing MMCs and to obtain homogenous dispersion of ceramic material. Experiments have been conducted by varying weight fraction of SiC, graphite and alumina (5%, 10%, 15%, 20%, 25%, and 30%), while graphite weight fraction 2%, 4%, 6%, 8% and 10% keep all other parameters constant. The results indicated that the ‘developed method’ is quite successful to obtain uniform dispersion of reinforcement in the matrix. An increasing of hardness and with increase in weight percentage of ceramic materials have been observed. The best results (maximum hardness) have been obtained at % weight fraction of SiC and at4 % weight fraction of graphite.
La hemofilia: situación actual en Cuba y perspectivas Hemophilia: current situation and perspectives in Cuba
Dunia Castillo González
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2013,
Antinutritive Compounds in Twelve Camelina sativa Genotypes  [PDF]
Roberto Russo, Remo Reggiani
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.310170
Abstract: Camelina sativa is an oilseed crop becoming important in North America and Europe for biodiesel production. The use of Camelina flours in animal diet may be limited by antinutritive compounds. The content of glucosinolates, phytic acid, sinapine and condensed tannins was evaluated in twelve accessions of Camelina sativa. All compounds showed significant differences among genotypes. Only the concentration of glucosinolates in the flour deserves attention, while the content of phytic acid, sinapine and condensed tannins are to acceptable levels. Camelina showed the presence of three different glucosinolates (GSL1, GSL2 and GSL3) in the flour, with differences among genotypes regarding the relative abundance of each glucosinolate. The content of glucosinolates is inversely correlated with that of sinapine. The glucosinolate content in Camelina flour has to be reduced to increase the use of this flour in animal diet, but avoiding altering the sinapine content.
Problems of Connectivity between the Sylow Graph,the Prime Graph and the Non-Commuting Graph of a Group  [PDF]
Francesco G. Russo
Advances in Pure Mathematics (APM) , 2012, DOI: 10.4236/apm.2012.26058
Abstract: The Sylow graph of a finite group originates from recent investigations on certain classes of groups, defined in terms of normalizers of Sylow subgroups. The connectivity of this graph has been proved only last year with the use of the classification of finite simple groups (CFSG). A series of interesting questions arise naturally. First of all, it is not clear whether it is possible to avoid CFSG or not. On the other hand, what happens for infinite groups? Since the status of knowledge of the non-commuting graph and of the prime graph is satisfactory, is it possible to find relations between these two graphs and the Sylow graph? In the present note we make the point of the situation and formulate the above questions in appropriate way.
Variation in the Content of Cyanogenic Glycosides in Flaxseed Meal from Twenty-One Varieties  [PDF]
Roberto Russo, Remo Reggiani
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.515159

Flaxseed meal from twenty-one varieties has been evaluated for content of cyanogenic glycosides (linamarin, linustatin and neolinustatin). Varieties belonging to three different groups of productive attitude (oil, fiber and intermediate) were considered. The total content of cyanogenic glycosides ranged from 0.74 to 1.60 g?Kg?1 CN?. As expected, linamarin was a minority component accounting for only 2% - 14% of total glycosides. Linustatin resulted statistically lower in the intermediate group than that in the other groups and, in particular, it was the lowest in the Festival variety. Neolinustatin resulted lower in the fiber group although the variety Ventimiglia (belonging to oil group) showed a negligible level of this compound. Neolinustatin was positively correlated to total cyanogenic glycosides (r = 0.709) and inversely correlated to linustatin (r = ?0.326). The variability observed in the content of the various forms of glycosides could be exploited in breeding programs to reduce the content of these toxic compounds in flaxseed meal.

Evaluation of Protein Concentration, Amino Acid Profile and Antinutritional Compounds in Hempseed Meal from Dioecious and Monoecious Varieties  [PDF]
Roberto Russo, Remo Reggiani
American Journal of Plant Sciences (AJPS) , 2015, DOI: 10.4236/ajps.2015.61003
Abstract: Hempseed meal from three dioecious and three monoecious varieties has been evaluated for content and quality of the protein and for the concentration of antinutritional compounds. Hemp seeds were obtained from plants grown in two experimental fields for two consecutive years (2011-2012). For all the varieties, hempseed meal resulted in a rich source of protein (34% mean content) with an amino acid profile extremely rich in arginine and slightly poor in lysine. Differences between dioecious and monoecious varieties were observed in the content of antinutritional compounds. They were more concentrated in monoecious varieties in comparison with those dioecious. The concentration of phytic acid in hempseed meal deserves attention in both groups, being 63 and 75.4 g·kg-1 of dry matter in dioecious and monocieous varieties, respectively. The results show that, besides the recognized value of hemp oil, also the hempseed cake could find application in animal feed as a substitute of other cakes (soybean, rapeseed). From this point of view, the dioecious varieties showing lower contents of antinutritional compounds with respect to the monoecious varieties would be preferred.
Selective Posterior Epiphysiodesis of the Triradiate Cartilage of the Acetabulum: Preliminary Results of an Experimental Study in Rabbits  [PDF]
Bibiana Dello Russo
Open Journal of Orthopedics (OJO) , 2016, DOI: 10.4236/ojo.2016.68032
Abstract: Background: Residual acetabular dysplasia is one of the main complications of developmental dysplasia of the hip (DDH). Without treatment, over time degenerative osteoarthritis of the joint will develop, inexorably leading to the need for joint replacement. Acetabular and/or femoral osteotomies do not avoid the appearance of osteoarthritis in a significant number of patients. The purpose of this study was to assess the possibility of provoking changes in the morphology of the acetabulum through selective epiphysiodesis of the extra-articular portion of the ilioischial arm of the triradiate cartilage, using a percutaneous cannulated screw with the guidance of an imaging intensifier in an experimental model in rabbits. Methods: In a pilot study, 3-week-old New Zealand rabbits (n = 20) were submitted to unilateral surgery of the hip while the contralateral hip of the same group was used as a control. Posterior epiphysiodesis to the triradiate cartilage of the acetabulum was performed by placement of a cannulated screw. The rabbits were followed-up until 18 weeks of life. Radiographic measurements of the hips were performed immediately postoperatively and at 12 weeks of life and before the rabbits were sacrificed at week 18. Three-dimensional computed tomography (3D-CT) scans were performed. Non-parametric tests for paired samples and the Wilcoxon test were used to compare the differences between group 1 and group 2. A p < 0.05 was considered significant. Results: The non-intervened hips showed that, when the rabbit matured, the acetabulum lost concavity and depth. When comparing the median differences of the angles evaluated at 12 weeks between groups, a statistically significant difference was found in all radiographic measurements: an increase in Wiberg’s angle but a decrease in acetabular index, acetabular angle of Sharp, acetabular depth index, and acetabular anteversion. Evaluating the operated hips at 12 and 18 weeks (three months after having removed the screw) using 3D-CT, we observed a rebound effect in the correction confirming that the effect obtained through selective epiphysiodesis did not cause the definitive closure of the cartilage. Conclusions: Selective growth arrest of the ilioischial arm of the triradiate cartilage (posterior epiphysiodesis) can alter growth and change the shape of the acetabulum in rabbits. A rebound effect was observed when the screw was removed, confirming that the technique did not provoke definitive closure of the physis. Level of evidence: Level-2, therapeutic study.
Glucosinolates and Sinapine in Camelina Meal  [PDF]
Roberto Russo, Remo Reggiani
Food and Nutrition Sciences (FNS) , 2017, DOI: 10.4236/fns.2017.812078
Forty seven accessions of camelina (Camelina sativa L. Crantz) were analyzed for glucosinolates (GSLs) and sinapine in defatted meal. These antinutritional compounds are undesirable in camelina meal for use in animal feeding and therefore we show their variability to identify the best varieties for future breeding programs. Total GSLs ranged from 19.6 to 40.3 mmol Kg-1 dry weight (DW) with an average of 30.3 mmol kg-1 DW. Great variability has also been observed in the levels of individual GSLs (GSL1, GSL2 and GSL3), so that the content of GSL1 and GSL3 were not correlated to each other in the accessions of camelina. Five out of six winter forms of camelina showed low content of GSLs. Sinapine ranged from 1.09 to 4.75 g Kg-1 DW with an average of 2.57 g kg-1 DW. The sinapine content was not correlated with that of GSLs. The use of camelina meal is only limited by the presence of GSLs while sinapine content can be ignored in camelina varieties.
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