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Search Results: 1 - 10 of 403694 matches for " Dulcineia M Albuquerque "
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Molecular characteristics and chromatin texture features in acute promyelocytic leukemia
Mariana R B De Mello, Dulcineia M Albuquerque, Fernanda Pereira-Cunha, Krizzia B Albanez, Katia B B Pagnano, Fernando F Costa, Konradin Metze, Irene Lorand-Metze
Diagnostic Pathology , 2012, DOI: 10.1186/1746-1596-7-75
Abstract: In a prospective study, we analyzed peripheral (PB) leukocyte count, immunophenotype, methylation status of CDKN2B, CDKN2A and TP73; FLT3 and NPM1 mutations besides nuclear chromatin texture characteristics of the leukemic cells. We also examined the relation of these features with patient’s outcome.Among 19 cases, 4 had a microgranular morphology, 7 presented PB leukocytes >10x109/l, 2 had FLT3-ITD and 3 had FLT3-TKD (all three presenting a methylated CDKN2B). NPM1 mutation was not observed. PB leukocyte count showed an inverse relation with standard deviation of gray levels, contrast, cluster prominence, and chromatin fractal dimension (FD). Cases with FLT3-ITD presented a microgranular morphology, PB leukocytosis and expression of HLA-DR, CD34 and CD11b. Concerning nuclear chromatin texture variables, these cases had a lower entropy, contrast, cluster prominence and FD, but higher local homogeneity, and R245, in keeping with more homogeneously distributed chromatin. In the univariate Cox analysis, a higher leukocyte count, FLT3-ITD mutation, microgranular morphology, methylation of CDKN2B, besides a higher local homogeneity of nuclear chromatin, a lower chromatin entropy and FD were associated to a worse outcome. All these features lost significance when the cases were stratified for FLT3-ITD mutation. Methylation status of CDNK2A and TP73 showed no relation to patient’s survival.in APL, patients with FLT3-ITD mutation show different clinical characteristics and have blasts with a more homogeneous chromatin texture. Texture analysis demonstrated that FLTD-ITD was accompanied not only by different cytoplasmic features, but also by a change in chromatin structure in routine cytologic preparations. Yet we were not able to detect chromatin changes by nuclear texture analysis of patients with the FTLD-TKD or methylation of specific genes.Acute promyelocytic leukemia (APL) is a well characterized subtype of acute myeloid leukemia (AML) defined by a specific cytogenetic
Inbreeding effect on reproductive traits in a herd of Mangalarga Marchador Brazilian horses Efeito da endogamia sobre características reprodutivas em um rebanho da ra a Mangalarga Marchador
Renderson Welington Gon?alves,Maria Dulcineia Costa,Vicente Ribeiro Rocha junior,Márcia Regina da Costa
Revista Brasileira de Saúde e Produ??o Animal , 2011,
Abstract: This work aimed to evaluate the effect of inbreeding on the reproductive characteristics such as age at first foaling, gestation length, foaling interval in a “Mangalarga Marchador” herd in the North of Minas Gerais State, Brazil. The relationship matrix involved 2186 animals from the general register of the Catuni Farm. The inbreeding coefficient (F) was calculated using the subroutine MTDFNRM present in the MTDFREML program and its effect on the reproductive indexes was evaluated through simple linear regression. Average F of the population was of 1.45% and, of the total, 27.59% of the animals were inbred. Among the inbred animals, average F reached 5.28% (minimum of 0.1 and maximum of 28.13%). The average age of the stallions, when their foals were born, was 9.06 years while for mares it was of 8.90 years giving a medium interval of 8.98 years. The age at first foaling, gestation length and foaling interval were on average 4.71 ± 1.832 years, 327.94 ± 15.58 days and 547.78 ± 316.62 days, respectively while the herd effective size was of 185.25 animals. Effect of inbreeding on the reproductive characteristics was not significant. The inbred matings did not affect the reproductive characteristics of the Mangalarga Marchador herd. Controlled mating keep inbreeding at low values, what avoids inbreeding depression. Objetivou-se com este trabalho avaliar o efeito da endogamia sobre as características reprodutivas idade ao primeiro parto, dura o da gesta o e intervalo de partos em equinos da ra a Mangalarga Marchador criados em um rebanho na regi o Norte de Minas Gerais. A matriz de parentesco envolveu 2186 animais do arquivo zootécnico da Fazenda Catuni. O coeficiente de endogamia (F) foi calculado mediante utiliza o da subrotina MTDFNRM presente no programa MTDFREML e seu efeito sobre os índices reprodutivos por meio de regress o linear simples. O F médio da popula o foi de 1,45% e, do total de animais, 27,59% mostraram-se endogamicos. Entre os animais endogamicos, o F médio foi de 5,28% (mínimo de 0,1 e máximo de 28,13%). A média de idade dos garanh es, quando nasceram seus filhos, foi 9,06 anos enquanto a das m es foi de 8,90 anos, proporcionando um intervalo médio de gera es de 8,98 anos. A idade ao primeiro parto, a dura o da gesta o e o intervalo de partos tiveram médias de 4,71 ± 1,832 anos, 327,94 ± 15,58 dias e 547,78 ± 316,62 dias, respectivamente enquanto o tamanho efetivo para o rebanho foi de 185,25 animais. Os acasalamentos endogamicos n o comprometeram as características reprodutivas do rebanho da ra a Mangalarga Marchador. Acasalamen
Nutri o e doen as cardiovasculares: preven o primária e secundária
Dulcineia Saes Parra Abdalla
Revista Brasileira de Ciências Farmacêuticas , 2004, DOI: 10.1590/s1516-93322004000400014
Abstract:
Molecular mechanisms of atherosclerosis
Dulcineia Saes Parra Abdalla
Revista Brasileira de Ciências Farmacêuticas , 2006, DOI: 10.1590/s1516-93322006000400022
Abstract:
Editorial
Dulcineia Saes Parra Abdalla
Revista Brasileira de Ciências Farmacêuticas , 2008, DOI: 10.1590/s1516-93322008000100001
Abstract:
Patologia
Dulcineia Saes Parra Abdalla
Revista Brasileira de Ciências Farmacêuticas , 2002, DOI: 10.1590/s1516-93322002000300017
Abstract:
Mass-splittings of doubly heavy baryons in QCD
R. M. Albuquerque,S. Narison
Physics , 2010, DOI: 10.1016/j.physletb.2010.09.051
Abstract: We consider (for the first time) the ratios of doubly heavy baryon masses (spin 3/2 over spin 1/2 and SU(3) mass-splittings) using double ratios of sum rules (DRSR), which are more accurate than the usual simple ratios often used in the literature for getting the hadron masses. In general, our results agree and compete in precision with potential model predictions. In our approach, the alpha_s corrections induced by the anomalous dimensions of the correlators are the main sources of the Xi^*_{QQ}- Xi_{QQ} mass-splittings, which seem to indicate a 1/M_Q behaviour and can only allow the electromagnetic decay Xi^*_{QQ} to Xi_{QQ}+ gamma but not to Xi_{QQ}+ pi. Our results also show that the SU(3) mass-splittings are (almost) independent of the spin of the baryons and behave approximately like 1/M_Q, which could be understood from the QCD expressions of the corresponding two-point correlator. Our results can improved by including radiative corrections to the SU(3) breaking terms and can be tested, in the near future, at Tevatron and LHCb.
Doubly heavy Baryons from QCD Spectral Sum Rules
R. M. Albuquerque,S. Narison
Physics , 2010, DOI: 10.1016/j.nuclphysbps.2010.10.068
Abstract: We consider the ratios of doubly heavy baryon masses using Double Ratios of Sum Rules (DRSR), which are more accurate than the usual simple ratios used for getting hadron masses. Our results are comparable with the ones from potential models. The Xi^*_{QQ}-Xi_{QQ} splittings seem to behave like 1/M_Q and can only allow the electromagnetic decay Xi^*_{QQ} to Xi_{QQ}+gamma but not to Xi_{QQ}+ pi. Our results also show that the SU(3) mass-splittings are (almost) independent of the spin of the baryons and behave approximately like 1/M_Q, which could be understood from the QCD expressions of the corresponding two-point correlator. Our results can improved by including radiative corrections to the SU(3) breaking terms and can be tested, in the near future, at Tevatron and LHCb.
PET Oligomer Waste to Modify CAP Characteristics  [PDF]
L. C. Mendes, M. L. Dias, P. S. C. Pereira, L. M. R. Albuquerque
Materials Sciences and Applications (MSA) , 2012, DOI: 10.4236/msa.2012.38082
Abstract: To develop an improved method of reusing poly(ethylene terephthalate) (PET) waste in the production chain, it was chemically modified with pentaerythritol (PENTE), resulting in PET/PENTE (60/40) oligomer. This was added to petroleum asphalt cement (CAP) in different proportions—5, 10 and 20 wt%—as a modifier of bitumen characteristics. The mixture was evaluated by thermogravimetry (TG/DTG), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), optical microscopy (OM) and the adhesion-peel test. The oligomer enhanced substantially the asphalt thermal stability-Tonset. OM images showed strong compatibility between components and PET’s amorphization. PET oligomer increased CAP’s wettability and the mixture presented cohesive fracture through the peel test. The mixture has excellent potential as paving material.
SU(3) mass-splittings of heavy-baryons in QCD
R. M. Albuquerque,S. Narison,M. Nielsen
Physics , 2009, DOI: 10.1016/j.physletb.2010.01.011
Abstract: We extract directly (for the first time) the charmed (C=1) and bottom (B=-1) heavy-baryons (spin 1/2 and 3/2) mass-splittings due to SU(3) breaking using double ratios of QCD spectral sum rules (QSSR) in full QCD, which are less sensitive to the exact value and definition of the heavy quark mass, to the perturbative radiative corrections and to the QCD continuum contributions than the simple ratios commonly used for determining the heavy baryon masses. Noticing that most of the mass-splittings are mainly controlled by the ratio kappa= <\bar ss>/<\bar dd> of the condensate, we extract this ratio, by allowing 1 sigma deviation from the observed masses of the Xi_{c,b} and of the Omega_c. We obtain: kappa=0.74(3), which improves the existing estimates: \kappa=0.70(10) from light hadrons. Using this value, we deduce M_{Omega_b}=6078.5(27.4) MeV which agrees with the recent CDF data but disagrees by 2.4 sigma with the one from D0. Predictions of the Xi'_Q and of the spectra of spin 3/2 baryons containing one or two strange quark are given in Table 2. Predictions of the hyperfine splittings Omega*_Q- Omega_Q and Xi*_Q-Xi_Q are also given in Table 3. Starting for a general choice of the interpolating currents for the spin 1/2 baryons, our analysis favours the optimal value of the mixing angle b= (-1/5 -- 0) found from light and non-strange heavy baryons.
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