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Search Results: 1 - 10 of 4511 matches for " Donghun Shin "
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Sfrp5 Modulates Both Wnt and BMP Signaling and Regulates Gastrointestinal Organogensis in the Zebrafish, Danio rerio
Carsten Stuckenholz, Lili Lu, Prakash C. Thakur, Tae-Young Choi, Donghun Shin, Nathan Bahary
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062470
Abstract: Sfrp5 belongs to the family of secreted frizzled related proteins (Sfrp), secreted inhibitors of Wingless-MMTV Integration Site (Wnt) signaling, which play an important role in cancer and development. We selected sfrp5 because of its compelling expression profile in the developing endoderm in zebrafish, Danio rerio. In this study, overexpression of sfrp5 in embryos results in defects in both convergent extension (CE) by inhibition of non-canonical Wnt signaling and defects in dorsoventral patterning by inhibition of Tolloid-mediated proteolysis of the BMP inhibitor Chordin. From 25 hours post fertilization (hpf) to 3 days post fertilization (dpf), both overexpression and knockdown of Sfrp5 decrease the size of the endoderm, significantly reducing liver cell number. At 3 dpf, insulin-positive endodermal cells fail to coalesce into a single pancreatic islet. We show that Sfrp5 inhibits both canonical and non-canonical Wnt signaling during embryonic and endodermal development, resulting in endodermal abnormalities.
User Behavior Information and Diffusion Process for IC-Card System
Donghun Yoon
Journal of Advances in Information Technology , 2010, DOI: 10.4304/jait.1.2.84-91
Abstract: The IC-Chip for IC-Cards (contactless smart card) has various field applications (traffic IC-Card, electronic money, mobile IC-Card, identification, credit card, and cash card) and is capable of high-level functions (security, anti-collision algorithm, multi-functionality, reliability, convenience). The IC-Card has larger information storage capacity than that of the existing magnetic stripe card. Japan’s IC-Card (Felica: Sony) is a type of a multi–functional card system devised to resolve many payment problems, to improve public payment service, to build advanced transit information system, to encourage reasonable operation of the public transit company, and to obtain basic information for the formulation of public policy. Japan’s IC-Card is applied to various kinds of technologies and services in Japan. In this paper, we discuss the diffusion process and user behavior information regarding Japan’s IC-Card system. In this study, we hope to contribute to studies in modern means of public payment based on RFID technology and diffusion process study of IC-Card technology.
sox9b Is a Key Regulator of Pancreaticobiliary Ductal System Development
Marion Delous equal contributor ,Chunyue Yin equal contributor,Donghun Shin,Nikolay Ninov,Juliana Debrito Carten,Luyuan Pan,Taylur P. Ma,Steven A. Farber,Cecilia B. Moens,Didier Y. R. Stainier
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1002754
Abstract: The pancreaticobiliary ductal system connects the liver and pancreas to the intestine. It is composed of the hepatopancreatic ductal (HPD) system as well as the intrahepatic biliary ducts and the intrapancreatic ducts. Despite its physiological importance, the development of the pancreaticobiliary ductal system remains poorly understood. The SRY-related transcription factor SOX9 is expressed in the mammalian pancreaticobiliary ductal system, but the perinatal lethality of Sox9 heterozygous mice makes loss-of-function analyses challenging. We turned to the zebrafish to assess the role of SOX9 in pancreaticobiliary ductal system development. We first show that zebrafish sox9b recapitulates the expression pattern of mouse Sox9 in the pancreaticobiliary ductal system and use a nonsense allele of sox9b, sox9bfh313, to dissect its function in the morphogenesis of this structure. Strikingly, sox9bfh313 homozygous mutants survive to adulthood and exhibit cholestasis associated with hepatic and pancreatic duct proliferation, cyst formation, and fibrosis. Analysis of sox9bfh313 mutant embryos and larvae reveals that the HPD cells appear to mis-differentiate towards hepatic and/or pancreatic fates, resulting in a dysmorphic structure. The intrahepatic biliary cells are specified but fail to assemble into a functional network. Similarly, intrapancreatic duct formation is severely impaired in sox9bfh313 mutants, while the embryonic endocrine and acinar compartments appear unaffected. The defects in the intrahepatic and intrapancreatic ducts of sox9bfh313 mutants worsen during larval and juvenile stages, prompting the adult phenotype. We further show that Sox9b interacts with Notch signaling to regulate intrahepatic biliary network formation: sox9b expression is positively regulated by Notch signaling, while Sox9b function is required to maintain Notch signaling in the intrahepatic biliary cells. Together, these data reveal key roles for SOX9 in the morphogenesis of the pancreaticobiliary ductal system, and they cast human Sox9 as a candidate gene for pancreaticobiliary duct malformation-related pathologies.
Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis
Yeliz Boglev,Andrew P. Badrock,Andrew J. Trotter,Qian Du,Elsbeth J. Richardson,Adam C. Parslow,Sebastian J. Markmiller,Nathan E. Hall,Tanya A. de Jong-Curtain,Annie Y. Ng,Heather Verkade,Elke A. Ober,Holly A. Field,Donghun Shin,Chong H. Shin,Katherine M. Hannan,Ross D. Hannan,Richard B. Pearson,Seok-Hyung Kim,Kevin C. Ess,Graham J. Lieschke,Didier Y. R. Stainier,Joan K. Heath
PLOS Genetics , 2013, DOI: 10.1371/journal.pgen.1003279
Abstract: Ribosome biogenesis underpins cell growth and division. Disruptions in ribosome biogenesis and translation initiation are deleterious to development and underlie a spectrum of diseases known collectively as ribosomopathies. Here, we describe a novel zebrafish mutant, titania (ttis450), which harbours a recessive lethal mutation in pwp2h, a gene encoding a protein component of the small subunit processome. The biochemical impacts of this lesion are decreased production of mature 18S rRNA molecules, activation of Tp53, and impaired ribosome biogenesis. In ttis450, the growth of the endodermal organs, eyes, brain, and craniofacial structures is severely arrested and autophagy is up-regulated, allowing intestinal epithelial cells to evade cell death. Inhibiting autophagy in ttis450 larvae markedly reduces their lifespan. Somewhat surprisingly, autophagy induction in ttis450 larvae is independent of the state of the Tor pathway and proceeds unabated in Tp53-mutant larvae. These data demonstrate that autophagy is a survival mechanism invoked in response to ribosomal stress. This response may be of relevance to therapeutic strategies aimed at killing cancer cells by targeting ribosome biogenesis. In certain contexts, these treatments may promote autophagy and contribute to cancer cells evading cell death.
A Semantic-Based Approach for Detecting and Decomposing God Classes
Junha Lee,Donghun Lee,Dae-Kyoo Kim,Sooyong Park
Computer Science , 2012,
Abstract: Cohesion is a core design quality that has a great impact on posterior development and maintenance. By the nature of software, the cohesion of a system is diminished as the system evolves. God classes are code defects resulting from software evolution, having heterogeneous responsibilities highly coupled with other classes and often large in size, which makes it difficult to maintain the system. The existing work on identifying and decomposing God classes heavily relies on internal class information to identify God classes and responsibilities. However, in object-oriented systems, responsibilities should be analyzed with respect to not only internal class information, but also method interactions. In this paper, we present a novel approach for detecting God classes and decomposing their responsibilities based on the semantics of methods and method interactions. We evaluate the approach using JMeter v2.5.1 and the results are promising.
Introducing a Function with Plural Derivatives  [PDF]
Changsoo Shin
Journal of Applied Mathematics and Physics (JAMP) , 2016, DOI: 10.4236/jamp.2016.43056
Abstract: It is a solid truth in mathematics that the derivative of a function is unique. We want to show that there exist particular functions all of which have the same form but their derivatives are different. Even though this may seem quite novel, such function could be crucial for the purpose of describing the world such as related to mental phenomena where the logic of the current mathematics is not adequate.
Possible Effect of Pressure Solution on the Movement of a Canister in the Buffer of Geological Disposal System  [PDF]
Koichi Shin
International Journal of Geosciences (IJG) , 2017, DOI: 10.4236/ijg.2017.82006
Abstract: One of the major concepts of the geological disposal of high level radioactive waste is to enclose a metallic container with bentonite buffer which is considered to be impermeable and chemically stable. Since the average density of the container is around 6 to 7 and very heavy compared to bentonite, the scenario of container sinking has been evaluated because excess sinking makes short the pathway of nuclide migration in the bentonite and is detrimental to the safety of the disposal system. Previous considerations on container sinking have been made from the viewpoint of mechanical deformation of the bentonite. In this paper, a chemical deformation process is presented as another mechanism of container sinking, which has not been previously considered for the container sinking in the field of radioactive waste disposal. The chemical deformation mentioned in this paper is the deformation through the process of pressure solution of minerals constituting the buffer, transportation by diffusion and precipitation. That such chemical deformation is a ubiquitous phenomenon occurring in various scales in the crust of the earth will be shown through the review of previous works. Then, some future research topics will be suggested which would be required in order to evaluate the container sinking in the safety case for radioactive waste disposal.
Inorganic Molecularly Imprinted Polymer by Sol-Gel Process for Recognition of Caffeine  [PDF]
Min Jae Shin, Young Jae Shin, Jae Sup Shin
Open Journal of Organic Polymer Materials (OJOPM) , 2013, DOI: 10.4236/ojopm.2013.31001
Abstract: A molecularly imprinted polymer (MIP) was formed using an inorganic polymer by a sol-gel process. The monomers which were used to synthesize the inorganic polymer were tetraethoxysilane (TEOS), triethoxymethylsilane (MTES), and triethoxyphenylsilane (PTES). Caffeine was chosen as a template for the molecular imprinting, and theophylline was chosen as the analogous counterpart compound. The discriminating ability of the synthesized MIP to these two-compounds was estimated in this study. The MIP showed the highest discriminating ability when the ratio of TEOS:MTES: PTES in the synthesis of the inorganic polymer was 1:1:3, the reaction temperature was 50?C, and the pH of the reaction system was ~6.5.
Risperidone Versus Yokukansan in the Treatment of Severe Alzheimer’s Disease  [PDF]
Yuko Furuhashi, Kouichi Shin
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.22028
Abstract: PURPOSE: Patients with AD commonly exhibit behavioral and psychological symptoms of dementia (BPSD). This study is aimed to compare the efficacy of yokukansan (YKS) and risperidone (RIS) on BPSD in patients with severe Alzheimer’s disease (AD). METHODS: Thirty eight inpatients with AD were investigated. Patients were randomly as-signed to the YKS group (N = 18) or the RIS group (N = 20) and treated for 4 weeks. The primary outcomes were changes in the scores on the Neuropsychiatric Inventory (NPI), the Mini-Mental State Examination (MMSE), the Bar-thel Index, and the Cohen-Mansfield Agitation Inventory (CMAI). The frequency of extrapyramidal symptoms (EPS) and other adverse events were recorded at every visit. RESULTS: All participants in both groups completed the trial. The Barthel Index did not significantly change either in the RIS group or the YKS group. The MMSE scores did not change either in the RIS group or the YKS group. Significant improvements in mean total NPI and CMAI scores showed in both groups. Between the YKS and the RIS groups, there were no significant differences in the NPI or the CMAI scores. EPS and other serious adverse effects were not observed in either group. CONCLUSIONS: In this 4-week trial, YKS treatment significantly improved BPSD in the patients with severe AD. The present study suggests that YKS is as effective as RIS on BPSD with severe AD.
Packet Compression Ratio Dependent Spanning Tree for Convergecast  [PDF]
Changjin Suh, Jisoo Shin
Wireless Sensor Network (WSN) , 2010, DOI: 10.4236/wsn.201027062
Abstract: A convergecast is a popular routing in sensor networks. It periodically forwards collected data at every sensor node along a configured routing path to the outside of a sensor network via the base station (BS). To extend the lifetime of energy-limited sensor networks, many previous researches proposed schemes for data compression. However, few researches investigated the relation between packet compression ratio and spanning trees. We propose packet Compression ratio dependent Spanning Tree (CST) which can provide effective routing paths in terms of the tree length for all ranges of compression ratio f. CST is equivalent to the Shortest Path spanning Tree (SPT) which is optimum in the case of no-compression (f = 0) and is equivalent to the Minimum Spanning Tree (MST) in the case of full-compression (f = 1). CST outperforms SPT and MST for any range of f (0 < f < 1). Through simulation we show CST provides shorter paths than MST and SPT in terms of the tree length by 34.1% and 7.8% respectively. We confirm CST is very useful in convergecasts.
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