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Search Results: 1 - 10 of 53048 matches for " Dong-Jing Ni1 "
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Cross-immunizing potential of tumor MAGE-A epitopes recognized by HLA-A*02:01-restricted cytotoxic T lymphocytes
Ze-Min Huang1,#, Zheng-Cai Jia2,#, Jun Tang3, Yi Zhang1, Yi Tian1, Dong-Jing Ni1, Fang Wang2, Yu-Zhang Wu1,* & Bing Ni1,*
BMB Reports , 2012,
Abstract: Almost all melanoma cells express at least one member of theMAGE-A antigen family, making the cytotoxic T cells (CTLs)epitopes with cross-immunizing potential in this family attractivecandidates for the broad spectrum of anti-melanomaimmunotherapy. In this study, four highly homologous peptides(P264: FLWGPRALA, P264I9: FLWGPRALI, P264V9:FLWGPRALV, and P264H8: FLWGPRAHA) from the MAGE-Aantigens were selected by homologous alignment. All fourpeptides showed high binding affinity and stability toHLA-A*02:01 molecules, and could prime CTL immune responsesin human PBMCs and in HLA-A*02:01/Kb transgenicmice. CTLs elicited by the four epitope peptides couldcross-lyse tumor cells expressing the mutual target antigens,except MAGE-A11 which was not tested. However, CTLs inducedby P264V9 and P264I9 showed the strongest target celllysis capabilities, suggesting both peptides may represent thecommon CTL epitopes shared by the eight MAGE-A antigens,which could induce more potent and broad-spectrum antitumorresponses in immunotherapy.
Optimization Model of Loan Portfolio with Fuzzy Random Return Rates under Semivariance Constraint
半方差约束下的模糊随机收益率贷款组合优化模型

PAN Dong-jing,
潘东静

计算机科学 , 2010,
Abstract: The return rates of loan in bank often have fuzzy random characteristic in many cases,this paper described the return rates as fuzzy random variables,used semivariance as the risk measure method,constructed the optimization model of loan portfolio with fuzzy random return rates under semivariance constraints.The purpose of the model is to maximize the primitive chance measure when the total return rate is no less than the preset value at a given confidence level under semivariance constraints.The hybrid int...
Onset of efficacy and tolerability following the initiation dosing of long-acting paliperidone palmitate: post-hoc analyses of a randomized, double-blind clinical trial
Cynthia A Bossie, Jennifer K Sliwa, Yi-Wen Ma, Dong-Jing Fu, Larry Alphs
BMC Psychiatry , 2011, DOI: 10.1186/1471-244x-11-79
Abstract: In a 13-week double-blind trial, 652 subjects with schizophrenia were randomized to paliperidone palmitate 39, 156, or 234 mg (corresponding to 25, 100, or 150 mg equivalents of paliperidone, respectively) or placebo (NCT#00590577). Subjects randomized to paliperidone palmitate received 234 mg on Day 1, followed by their randomized fixed dose on Day 8, and monthly thereafter, with no oral antipsychotic supplementation. The onset of efficacy was defined as the first timepoint where the paliperidone palmitate group showed significant improvement in the Positive and Negative Syndrome Scale (PANSS) score compared to placebo (Analysis of Covariance [ANCOVA] models and Last Observation Carried Forward [LOCF] methodology without adjusting for multiplicity) using data from the Days 4, 8, 22, and 36 assessments. Adverse event (AE) rates and relative risks (RR) with 95% confidence intervals (CI) versus placebo were determined.Paliperidone palmitate 234 mg on Day 1 was associated with greater improvement than placebo on Least Squares (LS) mean PANSS total score at Day 8 (p = 0.037). After the Day 8 injection of 156 mg, there was continued PANSS improvement at Day 22 (p ≤ 0.007 vs. placebo) and Day 36 (p < 0.001). Taken together with results in the 39 mg and 234 mg Day 8 arms, these findings suggest a trend towards a dose-dependent response. During Days 1 to 7, AEs reported in ≥2% of paliperidone palmitate subjects (234 mg) and a greater proportion of paliperidone palmitate than placebo subjects were: agitation (3.2% vs. 1.3%; RR 2.52 [95% CI 0.583, 10.904]), headache (4.0% vs. 3.8%; RR 1.06 [95% CI 0.433, 2.619]), and injection site pain (6.7% vs. 3.8%; RR 1.79 [95% CI 0.764, 4.208]). Days 8 to 36 AEs meeting the same criteria in the 156 mg Day 8 arm were: anxiety (3.1% vs. 2.5%; RR 1.24 [95% CI 0.340, 4.542]), psychotic disorder (2.5% vs. 1.3%; RR 1.99 [95% CI 0.369, 10.699]), dizziness (2.5% vs. 1.3%; RR 1.99 [95% CI 0.369, 10.699]), and injection site pain (2.5% vs. 1.3%; R
Axon fasciculation in the developing olfactory nerve
Alexandra M Miller, Lydia R Maurer, Dong-Jing Zou, Stuart Firestein, Charles A Greer
Neural Development , 2010, DOI: 10.1186/1749-8104-5-20
Abstract: In the adult mouse olfactory system, there is a precise topographic organization between the olfactory epithelium (OE) and the olfactory bulb (OB). Regionally defined markers, such as olfactory cell adhesion molecule (OCAM), discriminate between olfactory sensory neuron (OSN) axons innervating the dorsal and ventral domains in the OB, while the final convergence of OSN axons into glomeruli reflects odor receptor (OR) expression [1-4]. However, the spatio-temporal correlates related to the segregation of subpopulations of OSN axons within the developing olfactory nerve remain unknown.The initial development of the primary olfactory pathway, from the OE to the OB, begins at embryonic day (E)9 with the differentiation of neurons within the olfactory placode (OP). The first OSN axons that cross the basal lamina of the developing OE are seen at E10 to E10.5 [5]; at later ages these coalesce into fascicles surrounded by presumptive olfactory ensheathing cells. The OSN axons appear to follow a scaffold of migrating neurons that emerge from the OP beginning at E10. In what is collectively termed the migratory mass (MM), the OSN axons intermingle with these migrating neurons as they extend towards the presumptive OB. OSN axons first contact and penetrate the telencephalic vesicle on approximately E11 [5-7]. However, most OSN axons remain restricted to the presumptive olfactory nerve layer (pONL) until E15 when glomerulogenesis begins. This phase, the 'waiting period', is similar to that seen for thalamocortical axons in the subcortical plate and may contribute to the segregation of molecularly distinct subpopulations of OSN axons [8].Each mouse OSN expresses only 1 of approximately 1,200 OR genes, and axons from OSNs expressing the same OR coalesce in two to three glomeruli per OB, typically one lateral and one medial glomerulus [9-12]. Consistent with a possible role in axon-axon interactions, ORs are expressed in OSN growth cones where they may contribute to ligand-induced
Optimal Model of Portfolio Selection Based on VaR and CVaR under Uncertain Environment
不确定环境下基于VaR和CVaR的投资组合优化模型

PAN Dong-jing,NING Yu-fu,
潘东静
,宁玉富

计算机科学 , 2012,
Abstract: This paper discussed the portfolio selection problem under uncertain environment, using uncertain measure to define VaR and CVaR. VaR and CVaR were used to measure risk. An optimal model of portfolio selection based on VaR and CVaR was established, and the hybrid intelligence algorithm integrating genetic algorithm and 99-method was designed to solve the model. Finally, an numerical example was given to illustrate the feasibility and effectiveness of the model and the algorithm.
Selective Gene Expression by Postnatal Electroporation during Olfactory Interneuron Neurogenesis
Alexander T. Chesler, Claire E. Le Pichon, Jessica H. Brann, Ricardo C. Araneda, Dong-Jing Zou, Stuart Firestein
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0001517
Abstract: Neurogenesis persists in the olfactory system throughout life. The mechanisms of how new neurons are generated, how they integrate into circuits, and their role in coding remain mysteries. Here we report a technique that will greatly facilitate research into these questions. We found that electroporation can be used to robustly and selectively label progenitors in the Subventicular Zone. The approach was performed postnatally, without surgery, and with near 100% success rates. Labeling was found in all classes of interneurons in the olfactory bulb, persisted to adulthood and had no adverse effects. The broad utility of electroporation was demonstrated by encoding a calcium sensor and markers of intracellular organelles. The approach was found to be effective in wildtype and transgenic mice as well as rats. Given its versatility, robustness, and both time and cost effectiveness, this method offers a powerful new way to use genetic manipulation to understand adult neurogenesis.
Biological Control of Alternaria solani by Bacillus subtilis NJ-18
Bacillus subtilis NJ-18菌株对番茄早疫病菌的颉颃作用研究

YANG Dong-Jing,WANG Jian-Xin,ZHOU Ming-Guo,
杨冬静
,王建新,周明国

微生物学通报 , 2009,
Abstract: 采用杯碟法测定表明, 枯草芽孢杆菌Bacillus subtilis NJ-18菌株对番茄早疫病菌Alternaria solani的菌丝生长有强烈颉颃作用, 抑菌带宽度为21.5 mm。NJ-18的培养滤液能使A. solani菌丝肿胀畸形。利用利福平抗性标记证明NJ-18能够在番茄根、茎、叶内定殖, 土壤浇灌30 d后, NJ-18在番茄根茎内定殖的菌量仍然达到103 CFU/g植株鲜重。NJ-18发酵液喷施处理盆栽番茄苗后接种, 14 d后对番茄早疫病的防治效果为72.9%, 显著高于50%异菌脲2
Consistency check of charged hadron multiplicities and fragmentation functions in SIDIS
Dong-Jing Yang,Fu-Jiun Jiang,Wen-Chen Chang,Chung-Wen Kao,Seung-il Nam
Physics , 2015,
Abstract: We derived the conditions on certain combinations of integrals of the fragmentation functions of pion using HERMES data of the sum for the charged pion multiplicities from semi-inclusive deep-inelastic scattering (SIDIS) off the deuteron target. In our derivation the nucleon parton distribution functions (PDFs) are assumed to be isospin SU(2) symmetric. Similar conditions have also been obtained for the fragmentation functions (FFs) of kaon by the sum of charged kaon multiplicities as well. We have chosen several FFs to study the impact of those conditions we have derived. Among those FFs, only that produced in the nonlocal chiral-quark model (NL$\chi$QM) constantly satisfy the conditions. Furthermore, the ratios of the strange PDFs $S(x)$ and the nonstrange PDFs $Q(x,Q^2)$ extracted from the charged pion and kaon multiplicities differ from each other significantly. Finally, we demonstrate that the HERMES pion multiplicity data is unlikely to be compatible with the two widely-used PDFs, namely CTEQ6M and NNPDF3.0.
STAT6在涎腺腺样囊性癌组织中的表达及对细胞增殖和侵袭的影响
Expression of STAT6 in Salivary Gland Adenoid Cystic Carcinoma and Its Effect on Cell Proliferation and Invasion

裴浩, 夏冬景, 黄莹莹
PEI Hao
, XIA Dong-jing, HUANG Ying-ying

- , 2018, DOI: 10.13701/j.cnki.kqyxyj.2018.11.016
Abstract: 摘要 目的:探讨STAT6在涎腺腺样囊性癌(SACC)组织中的表达,以及下调STAT6基因表达对细胞增殖和侵袭的影响。方法:选取SACC患者53例,并留取涎腺良性肿瘤正常涎腺腺组织40例作为对照组,免疫组化法检测SACC和对照组组织中STAT6蛋白表达,培养ACC-2细胞,分为STAT6干扰序列组、阴性对照组和空白组,STAT6干扰序列组采用小分子干扰RNA(siRNA)技术下调细胞中STAT6基因表达,实时荧光定量PCR技术检测STAT6基因表达,MTT比色法检测细胞增殖能力,Transwell法检测细胞迁移和侵袭能力。结果:SACC组织中STAT6蛋白阳性表达率为71.70%,高于对照组的28.30%(χ2=19.962,P=0.000);SACC组织中STAT6蛋白阳性表达与TNM分期、淋巴结转移和远处转移有关(P<0.05);STAT6干扰序列组细胞中STAT6 mRNA相对表达量低于阴性对照组和空白组(P<0.05);MTT实验结果显示,STAT6干扰序列组24~96 h细胞A值低于阴性对照组和空白组(P<0.05);STAT6干扰序列组迁移细胞数和侵袭细胞数低于阴性对照组和空白组(P<0.05)。结论:SACC组织中STAT6蛋白呈高表达,下调STAT6基因表达可抑制细胞增殖、迁移及侵袭
Identification of interacting proteins of retinoid-related orphan nuclear receptor gamma in HepG2 cells
Ze-Min Huang1,#, Jun Wu2,#, Zheng-Cai Jia1, Yi Tian1, Jun Tang3, Yan Tang1, Ying Wang2, Yu-Zhang Wu1,* & Bing Ni1,*
BMB Reports , 2012,
Abstract: The retinoid-related orphan nuclear receptor gamma (RORγ)plays critical roles in regulation of development, immunity andmetabolism. As transcription factor usually forms a proteincomplex to function, thus capturing and dissecting of theRORγ protein complex will be helpful for exploring themechanisms underlying those functions. After construction ofthe recombinant tandem affinity purification (TAP) plasmid,pMSCVpuro RORγ-CTAP(SG), the nuclear localization ofRORγ-CTAP(SG) fusion protein was verified. Followingisolation of RORγ protein complex by TAP strategy, sevencandidate interacting proteins were identified. Finally, the heatshock protein 90 (HSP90) and receptor-interacting protein 140(RIP140) were confirmed to interplay with RORγ byco-immunoprecipitation. Interference of HSP90 or/and RIP140genes resulted in dramatically decreased expression ofCYP2C8 gene, the RORγ target gene. Data from this studydemonstrate that HSP90 and RIP140 proteins interact withRORγ protein in a complex format and function asco-activators in the RORγ-mediated regulatory processes ofHepG2 cells.
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