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Search Results: 1 - 10 of 67121 matches for " Dong-Dong Wu "
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Different level of population differentiation among human genes
Dong-Dong Wu, Ya-Ping Zhang
BMC Evolutionary Biology , 2011, DOI: 10.1186/1471-2148-11-16
Abstract: Here, we study the level of population differentiation among different populations of human genes. Intriguingly, genes involved in osteoblast development were identified as being enriched with higher FST SNPs, a result consistent with the proposed role of the skeletal system in accounting for variation among human populations. Genes involved in the development of hair follicles, where hair is produced, were also found to have higher levels of population differentiation, consistent with hair morphology being a distinctive trait among human populations. Other genes that showed higher levels of population differentiation include those involved in pigmentation, spermatid, nervous system and organ development, and some metabolic pathways, but few involved with the immune system. Disease-related genes demonstrate excessive SNPs with lower levels of population differentiation, probably due to purifying selection. Surprisingly, we find that Mendelian-disease genes appear to have a significant excessive of SNPs with high levels of population differentiation, possibly because the incidence and susceptibility of these diseases show differences among populations. As expected, microRNA regulated genes show lower levels of population differentiation due to purifying selection.Our analysis demonstrates different level of population differentiation among human populations for different gene groups.After dispersal from Africa, humans have evolved to be characterized by substantial phenotypic variation, including variation in skin, hair, and eye color, body mass, height, diet, drug metabolism, susceptibility and resistance to disease, during the colonization of the World. Efforts to reveal the genetic bases of these variations should provide important insight into the history of human evolution, gene function, and the mechanisms of disease [1,2]. Indeed, with the advent of large scale comparative genomic and human polymorphism data, a flood of studies have identified many candidate g
4-(4-Chlorophenyl)-3-cyano-7-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromen-2-aminium methanolate
Rong Sun,Ke Wang,Dong-Dong Wu,Wei Huang
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812007088
Abstract: In the cation of the title organic ion pair compound, C23H20ClN2O3+·CH3O , the cyclohexyl ring shows a half-boat conformation and the dihedral angles between two benzene rings and the pyran ring are 83.14 (7) and 73.18 (9)°. In the crystal, centrosymmetrically related cations are linked into a dimer by pairs of N—H...N hydrogen bonds, generating an R22(12) ring motif. The anion interacts with the dimer through an N—H...O hydrogen bond. π–π interactions between pyran rings of adjacent dimers, with a centroid–centroid distance of 3.861 (2) , are also observed.
(4R,7S)-2-Amino-4-(3,4-dimethoxyphenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile monohydrate
Rong Sun,Dong-Dong Wu,Ke Wang,Wei Huang
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536811056285
Abstract: The title compound, C24H22N2O4·H2O, was obtained by the reaction of 3,4-dimethoxybenzaldehyde, malononitrile and 5-phenylcyclohexane-1,3-dione. The cyclohexyl and pyran rings show half-boat and V-shaped conformations, respectively. The dihedral angle between the phenyl and benzene ring planes is 30.67 (9)°. The organic molecules are packed in a two-dimensional network parallel to the bc plane stabilized by intermolecular N—H...N and N—H...O hydrogen bonds.
Intriguing Balancing Selection on the Intron 5 Region of LMBR1 in Human Population
Fang He, Dong-Dong Wu, Qing-Peng Kong, Ya-Ping Zhang
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0002948
Abstract: Background The intron 5 of gene LMBR1 is the cis-acting regulatory module for the sonic hedgehog (SHH) gene. Mutation in this non-coding region is associated with preaxial polydactyly, and may play crucial roles in the evolution of limb and skeletal system. Methodology/Principal Findings We sequenced a region of the LMBR1 gene intron 5 in East Asian human population, and found a significant deviation of Tajima's D statistics from neutrality taking human population growth into account. Data from HapMap also demonstrated extended linkage disequilibrium in the region in East Asian and European population, and significantly low degree of genetic differentiation among human populations. Conclusion/Significance We proposed that the intron 5 of LMBR1 was presumably subject to balancing selection during the evolution of modern human.
De Novo Origin of Human Protein-Coding Genes
Dong-Dong Wu,David M. Irwin,Ya-Ping Zhang
PLOS Genetics , 2011, DOI: 10.1371/journal.pgen.1002379
Abstract: The de novo origin of a new protein-coding gene from non-coding DNA is considered to be a very rare occurrence in genomes. Here we identify 60 new protein-coding genes that originated de novo on the human lineage since divergence from the chimpanzee. The functionality of these genes is supported by both transcriptional and proteomic evidence. RNA–seq data indicate that these genes have their highest expression levels in the cerebral cortex and testes, which might suggest that these genes contribute to phenotypic traits that are unique to humans, such as improved cognitive ability. Our results are inconsistent with the traditional view that the de novo origin of new genes is very rare, thus there should be greater appreciation of the importance of the de novo origination of genes.
Positive Selection on the Osteoarthritis-Risk and Decreased-Height Associated Variants at the GDF5 Gene in East Asians
Dong-Dong Wu, Gui-Mei Li, Wei Jin, Yan Li, Ya-Ping Zhang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042553
Abstract: GDF5 is a member of the bone morphogenetic protein (BMP) gene family, and plays an important role in the development of the skeletal system. Variants of the gene are associated with osteoarthritis and height in some human populations. Here, we resequenced the gene in individuals from four geographically separated human populations, and found that the evolution of the promoter region deviated from neutral expectations, with the sequence evolution driven by positive selection in the East Asian population, especially the haplotypes carrying the derived alleles of 5′ UTR SNPs rs143384 and rs143383. The derived alleles of rs143384 and rs143383, which are associated with a risk of osteoarthritis and decreased height, have high frequencies in non-Africans and show strong extended haplotype homozygosity and high population differentiation in East Asian. It is concluded that positive selection has driven the rapid evolution of the two osteoarthritis osteoarthritis-risk and decreased height associated variants of the human GDF5 gene, and supports the suggestion that the reduction in body size during the terminal Pleistocene and Holocene period might have been an adaptive process influenced by genetic factors.
Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair
Dong-Dong Wu, David M Irwin, Ya-Ping Zhang
BMC Evolutionary Biology , 2008, DOI: 10.1186/1471-2148-8-241
Abstract: The KRTAP family was identified as being unique to mammals, and near-complete KRTAP gene repertoires for eight mammalian genomes were characterized in this study. An expanded KRTAP gene repertoire was found in rodents. Surprisingly, humans have a similar number of genes as other primates despite the relative hairlessness of humans. We identified several new subfamilies not previously reported in the high/ultrahigh cysteine KRTAP genes. Genes in many subfamilies of the high/ultrahigh cysteine KRTAP genes have evolved by concerted evolution with frequent gene conversion events, yielding a higher GC base content for these gene sequences. In contrast, the high glycine-tyrosine KRTAP genes have evolved more dynamically, with fewer gene conversion events and thus have a lower GC base content, possibly due to positive selection.Most of the subfamilies emerged early in the evolution of mammals, thus we propose that the mammalian ancestor should have a diverse KRTAP gene repertoire. We propose that hair content characteristics have evolved and diverged rapidly among mammals because of rapid divergent evolution of KRTAPs between species. In contrast, subfamilies of KRTAP genes have been homogenized within each species due to concerted evolution.The availability of the rapidly increasing number of genome sequences provides opportunities for investigators to study evolutionary patterns that potentially account for morphological characteristics, and suggest the genetic basis for variation in phenotypes. In particular, gene families in which duplications, rate variation and pseudogenization occur frequently are likely involved in functional innovation and adaptation [1]. Examples of such gene families are those involved in the perception systems, for example, the odorant receptors [2-4], the vomeronasal receptors [5-8], and the sweet/umami and bitter receptors [9-12]. Furthermore, these studies should facilitate our understanding of the general evolutionary trends in genomic comp
Correction: Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair
Dong-Dong Wu, David M Irwin, Ya-Ping Zhang
BMC Evolutionary Biology , 2009, DOI: 10.1186/1471-2148-9-213
Abstract: In the publication of our work [1], in the table two: Amino acid composition of KRTAPs subfamily genes in mammals, the subfamily 30 should be deleted, and the subfamily 34 should be corrected as 30, 35 should be corrected as 34, and 36 should be corrected as 35. Here, we provide a table 1, which is a corrected version of table two. In the additional file 1, mouse gene repertoire in the table S1, at the line 42, the KRTAP34p1 should be corrected as KRTAP30p1; from the line 177 to 189, the chromosomes should be chr1. We provide a correction of additional file 1. We regret any inconvenience caused to researchers.
PHASE DEPENDENCE OF LUMINESCENT EMISSION OF Eu2+ DOPED SrAl2O4

Jia Dong-dong,Wu Bo-qun,Zhu Jing,

中国物理 B , 2000,
Abstract:
LUMINESCENCE OF Bi3+ and Eu2+ DOUBLE CENTERS DOPED IN CaS HOST

JIA DONG-DONG,WU BO-QUN,ZHU JING,

中国物理 B , 1999,
Abstract: In this work, double-center.doped luminescent material CaS:Bi3+, Eu2+ was made via flux NH4Cl by sintering in excess sulfur environment. The sample had a purplish red net luminescent color. Excitation spectra at both red, 650 nm and blue, 487 nrn were taken. The red emission from Eu2+ center was mainly come from the 4f65d1 absorption in the CaS host. The blue emission from the Bi3+ center on the other hand showed no big difference from the singly doped CaS:Bi3+ materials in excitation spectrum. Emission spectra were obtained at excitaton of 270nm and 300nm. Stokes shift was moved about 20-30nm, under different point excitation. Emission peaks of both Bi3+ and Eu2+ centers appeared at 463nm, 642.5nm by 270nm excitation and 487 nm, 620 nm by 300 nm excitation respectively. After-glow decay cures were also obtained and the shapes of decay curves are similar and it is due to the single hole-trap system by lattice defects.
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