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Search Results: 1 - 10 of 34361 matches for " Dong Gu Hur "
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Logistics Cost Management from the Supply Chain Perspective  [PDF]
Yu Gu, Shaojian Dong
Journal of Service Science and Management (JSSM) , 2016, DOI: 10.4236/jssm.2016.93028
Abstract: With the increasingly fierce market competition, China has more sound market economy system. Competition in the market price on the important position of the company is also increasing. It increases its profit source which can provide third-party logistics services business. Third-party logistics enterprises should put the customer requirements on an important position and meet the requirements of customers with the lowest prices. Our third-party logistics companies should know as soon as possible about the process of supply chain operations, and actively involved, starting from its own characteristics. And our third-party logistics companies control the entire supply chain from the perspective of the total cost of logistics companies. To accelerate the development of cost control and improvement, our third-party logistics companies improve their competitiveness, become a very important sector of our economy and the development of new economic growth point, build closer cooperation between the various companies in the supply chain and achieve long-term development.
Molecular and Clinical Characterization of the Variable Phenotype in Korean Families with Hearing Loss Associated with the Mitochondrial A1555G Mutation
Jae Woong Bae, Dong-Bin Kim, Jae Young Choi, Hong-Joon Park, Jong Dae Lee, Dong Gu Hur, Seung-Hyun Bae, Da Jung Jung, Sang Heun Lee, Un-Kyung Kim, Kyu Yup Lee
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042463
Abstract: Hearing loss, which is genetically heterogeneous, can be caused by mutations in the mitochondrial DNA (mtDNA). The A1555G mutation of the 12S ribosomal RNA (rRNA) gene in the mtDNA has been associated with both aminoglycoside-induced and non-syndromic hearing loss in many ethnic populations. Here, we report for the first time the clinical and genetic characterization of nine Korean pedigrees with aminoglycoside-induced and non-syndromic hearing loss. These Korean families carry in the A1555G mutation of 12S rRNA gene and exhibit variable penetrance and expressivity of hearing loss. Specifically, the penetrance of hearing loss in these families ranged between 28.6% and 75%, with an average of 60.8%. These results were higher than the 29.8% penetrance that was previously reported in a Chinese population but similar to the 65.4% and 54.1% penetrance observed in a large Arab-Israeli population and nineteen Spanish pedigrees, respectively. The mutational analysis of the complete mtDNA genome in these families showed that the haplogroups of the Korean population, which belongs to the eastern Asian population, were similar to those of the Chinese population but different from the Spanish population, which belongs to the European-Caucasian population. The mtDNA variants that may act as modifier factors were also found to be similar to the Chinese population. Although the mtDNA haplogroups and variants were similar to the eastern Asian population, we did find some differing phenotypes, although some subjects had the same variants. This result suggests that both the ethnic background and environmental factors lead to a variable phenotype of the A1555G mutation.
TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3β pathway and activation of caspases
Suk-Bin Seo, Jung-Gu Hur, Mi-Ju Kim, Jae-Won Lee, Hak-Bong Kim, Jae-Ho Bae, Dong-Wan Kim, Chi-Dug Kang, Sun-Hee Kim
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-199
Abstract: MDR variants, CEM/VLB10-2, CEM/VLB55-8 and CEM/VLB100 cells, with gradually increased levels of P-gp derived from human lymphoblastic leukemia CEM cells, were gradually more susceptible to TRAIL-induced apoptosis and cytotoxicity than parental CEM cells. The P-gp level of MDR variants was positively correlated with the levels of DNA-PKcs, pAkt, pGSK-3β and c-Myc as well as DR5 and negatively correlated with the level of c-FLIPs. Hypersensitivity of CEM/VLB100 cells to TRAIL was accompanied by the activation of mitochondrial apoptotic pathway as well as the activation of initiator caspases. In addition, TRAIL-induced down-regulation of DNA-PKcs/Akt/GSK-3β pathway and c-FLIP and up-regulation of cell surface expression of death receptors were associated with the increased susceptibility to TRAIL of MDR cells. Moreover, TRAIL inhibited P-gp efflux function via caspase-3-dependent degradation of P-gp as well as DNA-PKcs and subsequently sensitized MDR cells to MDR-related drugs such as vinblastine and doxorubicin. We also found that suppression of DNA-PKcs by siRNA enhanced the susceptibility of MDR cells to vincristine as well as TRAIL via down-regulation of c-FLIP and P-gp expression and up-regulation of DR5.This study showed for the first time that the MDR variant of CEM cells was hypersensitive to TRAIL due to up-regulation of DR5 and concomitant down-regulation of c-FLIP, and degradation of P-gp and DNA-PKcs by activation of caspase-3 might be important determinants of TRAIL-induced sensitization of MDR cells to MDR-related drugs. Therefore, combination of TRAIL and chemotherapeutic drugs may be a good strategy for treatment of cancer with multidrug resistance.Acquired resistance to chemotherapeutic agents remains a major obstacle for the effective treatment of many advanced and metastatic cancers. Several mechanisms are thought to be involved in the development of multidrug resistance (MDR), defined by simultaneous cross-resistance to a variety of anticancer drugs
On the Empirical Estimation of Utility Distribution Damping Parameters Using Power Quality Waveform Data
Hur Kyeon,Santoso Surya,Gu Irene YH
EURASIP Journal on Advances in Signal Processing , 2007,
Abstract: This paper describes an efficient yet accurate methodology for estimating system damping. The proposed technique is based on linear dynamic system theory and the Hilbert damping analysis. The proposed technique requires capacitor switching waveforms only. The detected envelope of the intrinsic transient portion of the voltage waveform after capacitor bank energizing and its decay rate along with the damped resonant frequency are used to quantify effective X/R ratio of a system. Thus, the proposed method provides complete knowledge of system impedance characteristics. The estimated system damping can also be used to evaluate the system vulnerability to various PQ disturbances, particularly resonance phenomena, so that a utility may take preventive measures and improve PQ of the system.
On the Empirical Estimation of Utility Distribution Damping Parameters Using Power Quality Waveform Data
Kyeon Hur,Surya Santoso,Irene Y. H. Gu
EURASIP Journal on Advances in Signal Processing , 2007, DOI: 10.1155/2007/95328
Abstract: This paper describes an efficient yet accurate methodology for estimating system damping. The proposed technique is based on linear dynamic system theory and the Hilbert damping analysis. The proposed technique requires capacitor switching waveforms only. The detected envelope of the intrinsic transient portion of the voltage waveform after capacitor bank energizing and its decay rate along with the damped resonant frequency are used to quantify effective X/R ratio of a system. Thus, the proposed method provides complete knowledge of system impedance characteristics. The estimated system damping can also be used to evaluate the system vulnerability to various PQ disturbances, particularly resonance phenomena, so that a utility may take preventive measures and improve PQ of the system.
Boundary partial regularity for the high dimensional Navier-Stokes equations
Hongjie Dong,Xumin Gu
Mathematics , 2013, DOI: 10.1016/j.jfa.2014.08.001
Abstract: We consider suitable weak solutions of the incompressible Navier--Stokes equations in two cases: the 4D time-dependent case and the 6D stationary case. We prove that up to the boundary, the two-dimensional Hausdorff measure of the set of singular points is equal to zero in both cases.
Partial Regularity of solutions to the Four-Dimensional Navier-Stokes Equations
Hongjie Dong,Xumin Gu
Mathematics , 2013,
Abstract: In this paper, we consider suitable weak solutions of incompressible Navier--Stokes equations in four spatial dimensions. We prove that the two-dimensional time-space Hausdorff measure of the set of singular points is equal to zero.
Impact of the Barents Sea SST in Autumn on the Winter Climate in Northeast China  [PDF]
Xiaomeng Shi, Yu Gu, Jilin Sun, Jingshu Dong, Min Geng
Journal of Geoscience and Environment Protection (GEP) , 2017, DOI: 10.4236/gep.2017.57009
Abstract: We studied effects of sea surface temperature anomaly (SSTA) in the Barents Sea in autumn on the atmospheric circulation in northeast China in winter, using the NCEP reanalysis data and sea surface temperature (SST) data of the Hadley Center. The results show that the ocean thermal conditions in the Barents Sea in autumn can be used as an important reference factor for predicting the cold air activity in China. When the sea surface temperature anomaly of the Barents Sea elevated in the autumn, the sea-level pressure anomaly elevated in eastern China on December, northeast China and southeastern Russia on January and February. In the years when the SSTA of the Barents Sea elevated in the autumn, the abnormal high-pressure ridge developed over Europe, and the geopotential height in western China appeared negative anomaly at 500 hPa. At 1000 hPa, the Mongolia high-pressure increased and the northerly airflow strengthened the cold high-latitude air broke out to the south, which was easy to affect northeast and north of China. In negative SSTA years, the high-pressure ridge was west to the north Atlantic, and the geopotential height in central and northern Siberia appeared negative anomaly at 500 hPa; the Mongolia high-pressure was weakened at 1000 hPa.
Electroweak symmetry breaking and cold dark matter from strongly interacting hidden sector
Hur, Taeil;Jung, Dong-Won;Ko, P.;Lee, Jae Yong
High Energy Physics - Phenomenology , 2007, DOI: 10.1016/j.physletb.2010.12.047
Abstract: We consider a hidden sector with a vectorlike confining gauge theory like QCD with $N_{h,c}$ colors and $N_{h,f}$ light quarks ${\cal Q}_h$ in the hidden sector. Then a scale $\Lambda_H$ would be generated by dimensional transmutation, and chiral symmetry breaking occurs in the hidden sector. This scale $\Lambda_H$ can play a role of the SM Higgs mass parameter, triggering electroweak symmetry breaking (EWSB). Furthermore the lightest mesons in the hidden sector is stable by flavor conservation of the hidden sector strong interaction, and could be a good cold dark matter (CDM). We study collider phenomenology, and relic density and direct detection rates of the CDM of this model.
Effect of Dietary Cholesterol and Cholesterol Oxides on Blood Cholesterol, Lipids, and the Development of Atherosclerosis in Rabbits
Sun Jin Hur,Byungrok Min,Ki Chang Nam,Eun Joo Lee,Dong Uk Ahn
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140612593
Abstract: Two studies were conducted to determine the effects of dietary cholesterol (CHO) and cholesterol oxides (COPs) on the development of atherosclerosis and the changes in fatty acid and blood characteristics in rabbits. In the first study, forty male New Zealand white rabbits were divided into 5 groups and fed commercial rabbit chow with no added CHO or COPs, 1 g CHO, 0.9 g CHO + 0.1 g COPs, 0.8 g CHO + 0.2 g COPs, or 0.5 g CHO + 0.5 g COPs per kg diet. In the second study, 24 male New Zealand White rabbits were divided into 3 groups and fed a diet containing 2 g CHO, 1.6 g CHO + 0.4 g COPs, or 1.2 g CHO + 0.8 g COPs per kg diet. All diets induced atherosclerotic lesions in the rabbits’ ascending thoracic aorta. The serum CHO and triglyceride levels ( p < 0.05) increased significantly with the increased levels of CHO in the diets. Dietary CHO or COPs did not influence high-density lipoprotein CHO levels. The ratio of saturated fatty acid to unsaturated fatty acid increased as the level of dietary CHO and COPs increased.
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