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Search Results: 1 - 10 of 215644 matches for " Domingo Martín-Herrera "
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Peripheral Analgesic and Anti-Inflammatory Effects of Smilax canariensis in an Animal Model  [PDF]
Sandra Dévora, Susana Abdala, Domingo Martín-Herrera
Pharmacology & Pharmacy (PP) , 2015, DOI: 10.4236/pp.2015.68040
Abstract: Smilax canariensis Brouss. ex Willd. is an endemic plant of the Canary Islands. Its rhizomes, leaves and stems have been traditionally used in Canary folk medicine to treat a wide variety of conditions including pain. Our objective is to investigate the analgesic and anti-inflammatory activities of different extracts of S. canariensis in Swiss mice, using established biological models for pain and inflammation, such as phenylquinone writhing test, formalin test, tail-flick test and mouse paw edema induced by carrageenan. Oral administration of S. canariensis extracts significantly reduce writhing episodes evoked by phenylquinone injection in a dose-dependent manner; and higher doses result in a reduction of pain similar to or higher than that of the reference drug piroxicam (59.56%; p < 0.01). The extracts also cause a marked dose-dependent inhibition of for-malin-induced pain in the second phase but only minimal inhibition of tail-flick behavior, suggesting that S. canariensis is not a centrally acting analgesic. Finally, in the carrageenan-induced hind paw edema model, the extracts show a moderate anti-inflammatory effect, the most active being the ethyl acetate fraction at 200 mg/kg p.o. (33.33%; p < 0.05). Our results suggest that S. canariensis extracts have clear dose-dependent peripheral analgesic effects, which lends support to the traditional use of this medicinal plant to treat pain associated with inflammatory or other processes.
Hepatocyte growth factor and chronic hepatitis C Factor de crecimiento hepatocitario y hepatitis crónica C
E. Marín-Serrano,C. Rodríguez-Ramos,F. Díaz-García,L. Martín-Herrera
Revista Espa?ola de Enfermedades Digestivas , 2010,
Abstract: Objective: the hepatocyte growth factor (HGF) is a pleiotropic cytokine produced by hepatic stellate cells and implicated in liver regeneration and fibrosis. Serum levels of HGF vary in liver diseases, reflecting hepatic damage and hepatocellular dysfunction. In this study, serum levels of HGF and the relationship between HGF and biochemical, histological and virological data, have been analysed in patients suffering from chronic hepatitis C (CHC). Patients and methods: serum HGF concentration was measured by ELISA in sandwich in 45 patients with CHC. Correlation between HGF levels and histological (necroinflammatory activity and fibrosis score) and biochemical (transaminases, prothrombin activity, albumin, bilirubin), or virological (hepatitis C virus load) parameters was analyzed. Serum HGF concentration was also studied in a subgroup of the original sample treated with interferon and ribavirin. Results: serum HGF concentrations of patients with CHC were significantly higher than those detected in healthy controls. Patients with significant fibrosis (F ≥ 2) had a significantly older age, lower count of platelets and higher values of AST, GGT and HGF, than those patients with a fibrosis score F < 2. HGF concentration was identified by multivariate analysis as the only independent factor associated with significant fibrosis. Moreover, area under receiver operating curve, using HCG levels, showed similar values to those of previously validated non-invasive indexes of fibrosis. However, levels of HGF did not show a significant decrease in patients with a sustained response to anti-virus C therapy. Conclusion: serum HGF concentration correlates with fibrosis score in patients with CHC, but is insensitive to monitor changes induced by anti-virus C therapy. Objetivo: el factor de crecimiento hepatocitario (HGF) es una citocina pleiotrópica producida por las células estrelladas hepáticas, que está implicada en la regeneración y la fibrosis hepática. La concentración sérica del HGF en las enfermedades hepáticas es variable, reflejando da o hepático y disfunción hepatocelular. En este estudio se ha analizado la concentración sérica del HGF en pacientes con hepatitis crónica por virus de la hepatitis C (VHC) y su relación con los datos bioquímicos, histológicos y virológicos. Pacientes y métodos: se determinó la concentración sérica de HGF mediante ELISA en sándwich y se analizó la correlación entre los niveles del HGF y los datos histológicos (actividad necroinflamatoria, estadio de fibrosis), bioquímicos (transaminasas, actividad de protrombina, albúmina, bilir
Hepatocyte growth factor and chronic hepatitis C
Marín-Serrano,E.; Rodríguez-Ramos,C.; Díaz-García,F.; Martín-Herrera,L.; Fernández-Gutiérrez-del-álamo,C.; Girón-González,J. A.;
Revista Espa?ola de Enfermedades Digestivas , 2010, DOI: 10.4321/S1130-01082010000600004
Abstract: objective: the hepatocyte growth factor (hgf) is a pleiotropic cytokine produced by hepatic stellate cells and implicated in liver regeneration and fibrosis. serum levels of hgf vary in liver diseases, reflecting hepatic damage and hepatocellular dysfunction. in this study, serum levels of hgf and the relationship between hgf and biochemical, histological and virological data, have been analysed in patients suffering from chronic hepatitis c (chc). patients and methods: serum hgf concentration was measured by elisa in sandwich in 45 patients with chc. correlation between hgf levels and histological (necroinflammatory activity and fibrosis score) and biochemical (transaminases, prothrombin activity, albumin, bilirubin), or virological (hepatitis c virus load) parameters was analyzed. serum hgf concentration was also studied in a subgroup of the original sample treated with interferon and ribavirin. results: serum hgf concentrations of patients with chc were significantly higher than those detected in healthy controls. patients with significant fibrosis (f ≥ 2) had a significantly older age, lower count of platelets and higher values of ast, ggt and hgf, than those patients with a fibrosis score f < 2. hgf concentration was identified by multivariate analysis as the only independent factor associated with significant fibrosis. moreover, area under receiver operating curve, using hcg levels, showed similar values to those of previously validated non-invasive indexes of fibrosis. however, levels of hgf did not show a significant decrease in patients with a sustained response to anti-virus c therapy. conclusion: serum hgf concentration correlates with fibrosis score in patients with chc, but is insensitive to monitor changes induced by anti-virus c therapy.
Functional Change of Brain Serotonergic Activity and Free Tryptophan in the Plasma of Depressed Women  [PDF]
Felipe Vázquez-Estupi?an, Rocío Herrera-Márquez, José Antonio Mondragón-Herrera, Guillermina Lara-Pérez, Gabriel Manjarrez-Gutiérrez
Open Journal of Depression (OJD) , 2019, DOI: 10.4236/ojd.2019.81002
Abstract: The main objective was to show the decrement of serotoninergic brain activity in depressed women, through the analyses of the slope amplitude of N1/P2 components of the auditory-evoked potentials (AEP), and the measurement of the L-tryptophan free fraction in plasma (FFT). This cross-sectional study was carried out in 60 women, 30 depressed and 30 normal controls. Both groups were measured FFT, glucose, and neutral amino acids (NAA) levels; besides performing AEP to analyses the N1/P2 slope amplitude. It was found a lengthening in the slope amplitude of N1/P2 components of AEP in the group of depressed women, and despite that the level of FFT was low, there were no changes between bound fraction and the total L-Trp. The former suggests a decrease in serotonergic brain activity in the group of depressed women. Otherwise, since the auditory cortex response to sound is regulated by serotonergic innervation, it was expected a change in the behavior of AEP in the group of depressed patients. Thus, the slope amplitude of N1/P2 components of the AEP and the measurement of FFT have proved to be a good clinical indicators of the serotonergic neurotransmission state in the brain of depressed patients, and in another clinical conditions where brain serotonin is involved.
Effect upon hospital activity of the application of a continued care model centered on patients with inflammatory bowel disease
Casellas-Jordá,Francesc; Borruel-Sainz,Natalia; Torrejón-Herrera,Antonio; Castells,Isabel;
Revista Espa?ola de Enfermedades Digestivas , 2012, DOI: 10.4321/S1130-01082012000100004
Abstract: background: since 1999, the crohn-colitis care unit (uacc) has been dedicated to the integral management of patients with crohn's disease (cd) and ulcerative colitis (uc). the working methodology of the uacc is based on personalized, continued, non-physical presence, open access and patient-centered care. from its creation, the uacc has experienced an increase in the number of its users and outpatient services. however, the impact of the activity of the uacc upon patient hospitalization is not known. objectives: to determine the hospital activity related to cd and uc, and correlate it to the activity of the uacc. methods: a retrospective evaluation was made of the physical presence and non-presence activities of the uacc from january 1999 to december 2008, and of the hospital admissions and mean durations of stay due to cd and uc during that same time period. results: the number of attended patients and of presence and non-presence activities of the uacc has gradually increased. this increase contrasts with the number of annual hospital admissions, which has remained stable during the study period, with 200-300 admissions/year. consequently, the hospitalized patients / uacc registered patients ratio has decreased from 0.36 at the start of the study period to 0.14 at the end. the median hospital stay has also decreased, from 11 days at the start of the study period to 8 days at the end. conclusions: the uacc allows effective management of ibd patient care, since it is able to attend the needs of more patients without increasing the number of admissions, and shortening the duration of hospital stay.
Effect upon hospital activity of the application of a continued care model centered on patients with inflammatory bowel disease Efecto de la aplicación de un modelo de asistencia continuada centrada en el paciente con enfermedad inflamatoria intestinal en la actividad hospitalaria
Francesc Casellas-Jordá,Natalia Borruel-Sainz,Antonio Torrejón-Herrera,Isabel Castells
Revista Espa?ola de Enfermedades Digestivas , 2012,
Abstract: Background: since 1999, the Crohn-Colitis Care Unit (UACC) has been dedicated to the integral management of patients with Crohn's disease (CD) and ulcerative colitis (UC). The working methodology of the UACC is based on personalized, continued, non-physical presence, open access and patient-centered care. From its creation, the UACC has experienced an increase in the number of its users and outpatient services. However, the impact of the activity of the UACC upon patient hospitalization is not known. Objectives: to determine the hospital activity related to CD and UC, and correlate it to the activity of the UACC. Methods: a retrospective evaluation was made of the physical presence and non-presence activities of the UACC from January 1999 to December 2008, and of the hospital admissions and mean durations of stay due to CD and UC during that same time period. Results: the number of attended patients and of presence and non-presence activities of the UACC has gradually increased. This increase contrasts with the number of annual hospital admissions, which has remained stable during the study period, with 200-300 admissions/year. Consequently, the hospitalized patients / UACC registered patients ratio has decreased from 0.36 at the start of the study period to 0.14 at the end. The median hospital stay has also decreased, from 11 days at the start of the study period to 8 days at the end. Conclusions: the UACC allows effective management of IBD patient care, since it is able to attend the needs of more patients without increasing the number of admissions, and shortening the duration of hospital stay. Introducción: desde 1999 está en funcionamiento la Unidad de Atención Crohn-Colitis (UACC) para la atención integral a los pacientes con enfermedad de Crohn (EC) y colitis ulcerosa (CU). La UACC sigue un método de trabajo basado en la atención personalizada, continuada, no presencial, de acceso abierto y centrada en el paciente. Desde su implantación, la UACC se ha relacionado con un aumento en el número de usuarios y de actividades. Se desconoce, sin embargo, la repercusión que tiene el funcionamiento UACC sobre la hospitalización de los pacientes. Objetivos: determinar la actividad hospitalaria relacionada con la EC y la CU y su relación con la actividad desarrollada en la UACC. Métodos: revisión de la actividad desarrollada en la UACC desde enero de 1999 a diciembre de 2008, y de los ingresos hospitalarios y estancias medias hospitalarias por EC y CU en el mismo período. Resultados: el número de usuarios y de actividades prestadas en la UACC, ha aumentado d
Enfermedades Autoinflamatorias Autoinflammatory Diseases
édgar Pe?aranda-Parada,Néstor Spinel-Bejarano,José Félix Restrepo,Federico Rondón-Herrera
Revista Colombiana de Reumatología , 2010,
Abstract: Presentamos un artículo de revisión sobre las enfermedades autoinflamatorias, narrando su origen histórico y describiendo la estructura proteica y molecular del Inflamosoma, la clasificación actual de los trastornos autoinflamatorios y una descripción de las características inmunogenéticas y clínicas más sobresalientes de cada enfermedad. We present a review article on the autoinflammatory diseases, narrating its historical origin and describing the protein and molecular structure of the Inflammasome, the current classification of the autoinflammatory diseases and a description of the immunogenetics and clinical characteristics more important of every disease.
Acumulación de mercurio (Hg) por ca?a flecha (Gynerium sagittatum) (Aubl) Beauv. in vitro
Ortega-Ortega,Rafael Esteban; Beltrán-Herrera,, Javier Darío; Marrugo-Negrete,José Luis;
Revista Colombiana de Biotecnología , 2011,
Abstract: in this in vitro study was evaluated the potential for accumulation of mercury (hg) that can hold the cane arrow (gynerium sagittatum) (aubl) beauv. as a viable alternative to be implemented for the rehabilitation of contaminated soils. this study was conducted at the plant biotechnology laboratory, university of sucre (9o 18' n, 75° 23' w). an experimental design was randomized block, an analysis of variance to compare means, tukey test (p ≤ 0.05) to establish significant differences between the treatments, tests of normality (kolmogorov-smirnov) and homogeneity test bartlett variance. the mercury analyses were performed on atomic absorption spectrophotometer thermo electron s4, a cell equipped with quartz windows, by the method of atomic absorption spectrometry with cold steam. the results show that the plant part that presents the greatest accumulation is the root with 55.98 mg g-1 hgt, followed by the stems, leaves 14.84 g g-1 hgt and these values are related to the degree of metal concentration in the culture medium. furthermore, the accumulation of mercury in roots and stems increased with time. in conclusion, in vitro this plant accumulates due to the high hg concentrations in their tissues without affecting the viability of plants.
Acumulación de mercurio (Hg) por ca a flecha (Gynerium sagittatum) (Aubl) Beauv. in vitro
Ortega-Ortega Rafael Esteban,Beltrán-Herrera Javier Darío,Marrugo-Negrete José Luis
Revista Colombiana de Biotecnología , 2011,
Abstract: Accumulation of mercury (Hg) by arrow cane (Gynerium sagittatum) (Aubl) Beauv. in vitro RESUMEN En este estudio se evaluó, in vitro, la capacidad de acumulación de mercurio (Hg) que pueda poseer la ca a flecha (Gynerium sagittatum) (Aubl) Beauv. como una alternativa viable de ser implementada para la rehabilitación de suelos contaminados. Este estudio fue realizado en el laboratorio de Biotecnología Vegetal de la Universidad de Sucre (9o18’ N, 75o23’ O). Se usó un dise o experimental de bloques al azar, un análisis de varianza para comparación de medias, una prueba de Tukey (p≤0,05) para la establecer las diferencias significativas entre los tratamientos, pruebas de normalidad (Kolmogorov-Smirnov) y test de homogeneidad de varianza de Bartlett. Los análisis de mercurio se realizaron en un espectrofotómetro de absorción atómica Thermo Electron S4, provisto de una celda con ventanas de cuarzo, por el método de espectroscopia de absorción atómica con vapor frío. Los resultados muestran que la parte de la planta que presenta mayor acumulación es la raíz con 55,98 μg g-1 HgT, seguida de los tallos-hojas con 14,84 μg g-1 HgT, valores relacionados con el grado de concentración del metal en el medio de cultivo. Además, la acumulación de mercurio en raíces y tallos aumentó con el tiempo. En conclusión, in vitro esta planta acumula Hg debido a las altas concentraciones en sus tejidos sin afectar la viabilidad de las plantas. Palabras clave: fitorremediación, remoción, metales pesados. ABSTRACT In this in vitro study was evaluated the potential for accumulation of mercury (Hg) that can hold the cane arrow (Gynerium sagittatum) (Aubl) Beauv. as a viable alternative to be implemented for the rehabilitation of contaminated soils. This study was conducted at the Plant Biotechnology Laboratory, University of Sucre (9o 18' N, 75° 23' W). An experimental design was randomized block, an analysis of variance to compare means, Tukey test (p ≤ 0.05) to establish significant differences between the treatments, tests of normality (Kolmogorov-Smirnov) and homogeneity test Bartlett variance. The mercury analyses were performed on atomic absorption spectrophotometer Thermo Electron S4, a cell equipped with quartz windows, by the method of atomic absorption spectrometry with cold steam. The results show that the plant part that presents the greatest accumulation is the root with 55.98 mg g-1 HgT, followed by the stems, leaves 14.84 g g-1 HgT and these values are related to the degree of metal concentration in the culture medium. Furthermore, the accumulation of mercury in r
Enfermedades Autoinflamatorias
Pe?aranda-Parada,édgar; Spinel-Bejarano,Néstor; Restrepo,José Félix; Rondón-Herrera,Federico; Millán,Alberto; Iglesias Gamarra,Antonio;
Revista Colombiana de Reumatología , 2010,
Abstract: we present a review article on the autoinflammatory diseases, narrating its historical origin and describing the protein and molecular structure of the inflammasome, the current classification of the autoinflammatory diseases and a description of the immunogenetics and clinical characteristics more important of every disease.
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