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Search Results: 1 - 10 of 1497 matches for " Domenico Serino "
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Attention deficit hyperactivity disorder secondary to lesion of the basal ganglia  [PDF]
Giovanni Mazzotta, Lucia Lucia Cirulli, Marco Sposato, Domenico Serino
World Journal of Neuroscience (WJNS) , 2012, DOI: 10.4236/wjns.2012.21007
Abstract: Attention Deficit Hyperactivity Disorder (ADHD) is a childhood onset autoregulation disorder characterized by attention deficit, hyperactivity and/or impul- siveness, which results in social and academic functional impairment. ADHD has a complex aetiology: along with genetic factors, anomalies in several cere-bral districts have been reported. We describe the case of a 9 year old boy with glucose-6-phosphate dehydrogenase deficiency in association with memory, behavioural and attentive disabilities. The patient’s clinical history is characterized by cerebral stroke at 3 years of age during a febrile episode, resulted in slight hemiparesis. Neuroimaging revealed a cystic lesion in the anterior portion of the right lenticular nucleus. Neuropsychological and psychiatric assess- ment evidenced alterations of executive functions. Diagnosis of ADHD secondary to lesion of the basal ganglia was made. We report the patient’s clinical profile in the light of current evidence pointing towards dysfunction of the basal ganglia as a crucial aetiological factor in memory and executive function impairment.
Pearson Walk with Shrinking Steps in Two Dimensions
C. A. Serino,S. Redner
Physics , 2009, DOI: 10.1088/1742-5468/2010/01/P01006
Abstract: We study the shrinking Pearson random walk in two dimensions and greater, in which the direction of the Nth is random and its length equals lambda^{N-1}, with lambda<1. As lambda increases past a critical value lambda_c, the endpoint distribution in two dimensions, P(r), changes from having a global maximum away from the origin to being peaked at the origin. The probability distribution for a single coordinate, P(x), undergoes a similar transition, but exhibits multiple maxima on a fine length scale for lambda close to lambda_c. We numerically determine P(r) and P(x) by applying a known algorithm that accurately inverts the exact Bessel function product form of the Fourier transform for the probability distributions.
Agro-Biodiversity Spatial Assessment and Genetic Reserve Delineation for the Pollino National Park (Italy)  [PDF]
Giovanni Figliuolo, Domenico Cerbino
Natural Resources (NR) , 2014, DOI: 10.4236/nr.2014.57029

Ancient fruit trees, grape vines, traditional crop and garden cultivars have been inventoried in Pollino National Park by adopting a spatial sampling grid which covers 23 different municipalities (~1500 Km2) and 190 surveyed sites. Each site is a circle with a visible radius of 200 - 250 m. The spatial analysis of the diversity of plant genetic resources has been conducted with pre-fixed landscape units (size: 4 Km × 4 Km). Overall, 49 different woody long cycle (455 ancient cultivars) and 53 short cycle species (102 ancient cultivars) have been scored. Long cycle species exhibit higher cultivar richness than short cycle species. The analysis has recognized that pre-Columbian indigenous cultivars had not been displaced by the American species introduced after the 16th century. In addition, it is confirmed that small-scale poly-production, under conditions of spatial niche variation, is associated to high species and cultivar richness. The mapped realized niche, for both pre- and post-Columbian genetic resources, includes the actual genetic reserve suitable for in situ conservation of plant agro-biodiversity. Agro-biodiversity models, drivers of genetic erosion, and realistic responses to genetic erosion are outlined.

The Open Access Model, Trends and Opportunities in Accounting Research  [PDF]
Simone Domenico Scagnelli
Open Journal of Accounting (OJAcct) , 2014, DOI: 10.4236/ojacct.2014.31001
Abstract: The Open Access Model, Trends and Opportunities in Accounting Research
Neuropathological Changes in Hydrocephalus—A Comprehensive Review  [PDF]
Domenico L. Di Curzio
Open Journal of Modern Neurosurgery (OJMN) , 2018, DOI: 10.4236/ojmn.2018.81001
Abstract: Hydrocephalus is a heterogeneous, neurological condition characterized by altered flow of cerebrospinal fluid (CSF) that can occur at any age. Neuropathological changes associated with hydrocephalus are dependent on the age of onset, rate of ventricular enlargement, and the etiology. Hydrocephalic brain damage is also influenced by contributions from both mechanical forces and metabolic changes, which increases the heterogeneity of the condition. However, as ventriculomegaly progresses, the surrounding brain tissue is compressed within the cranial vault, elevating intracranial pressure and eventually leading to severe brain damage. From this perspective, it makes sense that periventricular brain regions are the initial sites of damage as ventricular dilatation occurs. The following review of neuropathological changes in hydrocephalus will first discuss cellular and region specific damage from the ventricles and outward towards the cortex and brainstem. This will be followed by vascular and hypoxic changes associated with the condition. Both types of brain impairments are dependent on the severity of the condition, and they will be described accordingly.
Animal Models of Hydrocephalus  [PDF]
Domenico L. Di Curzio
Open Journal of Modern Neurosurgery (OJMN) , 2018, DOI: 10.4236/ojmn.2018.81004

Hydrocephalus is a neurological condition characterized by altered cerebrospinal fluid (CSF) flow leading to an accumulation of CSF inside the cranial vault. Neuropathogenesis associated with hydrocephalus has been elucidated by pathological studies of human brains and through experimental and genetic animal models. Experimental animal models have been developed in numerous species using a variety of methods and agents to induce hydrocephalus or through genetic mutations in rodents. Each of these animal models has been described briefly in this review, along with the basic strengths and weaknesses of each model. Although none of these models can fully mimic the human condition, they each provide fundamental knowledge contributing to understanding more about the pathogenesis of hydrocephalus and its underlying causes.

Dynamic Sounds Capture the Boundaries of Peripersonal Space Representation in Humans
Elisa Canzoneri, Elisa Magosso, Andrea Serino
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044306
Abstract: Background We physically interact with external stimuli when they occur within a limited space immediately surrounding the body, i.e., Peripersonal Space (PPS). In the primate brain, specific fronto-parietal areas are responsible for the multisensory representation of PPS, by integrating tactile, visual and auditory information occurring on and near the body. Dynamic stimuli are particularly relevant for PPS representation, as they might refer to potential harms approaching the body. However, behavioural tasks for studying PPS representation with moving stimuli are lacking. Here we propose a new dynamic audio-tactile interaction task in order to assess the extension of PPS in a more functionally and ecologically valid condition. Methodology/Principal Findings Participants vocally responded to a tactile stimulus administered at the hand at different delays from the onset of task-irrelevant dynamic sounds which gave the impression of a sound source either approaching or receding from the subject’s hand. Results showed that a moving auditory stimulus speeded up the processing of a tactile stimulus at the hand as long as it was perceived at a limited distance from the hand, that is within the boundaries of PPS representation. The audio-tactile interaction effect was stronger when sounds were approaching compared to when sounds were receding. Conclusion/Significance This study provides a new method to dynamically assess PPS representation: The function describing the relationship between tactile processing and the position of sounds in space can be used to estimate the location of PPS boundaries, along a spatial continuum between far and near space, in a valuable and ecologically significant way.
Motor Properties of Peripersonal Space in Humans
Andrea Serino, Laura Annella, Alessio Avenanti
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0006582
Abstract: Background A stimulus approaching the body requires fast processing and appropriate motor reactions. In monkeys, fronto-parietal networks are involved both in integrating multisensory information within a limited space surrounding the body (i.e. peripersonal space, PPS) and in action planning and execution, suggesting an overlap between sensory representations of space and motor representations of action. In the present study we investigate whether these overlapping representations also exist in the human brain. Methodology/Principal Findings We recorded from hand muscles motor-evoked potentials (MEPs) induced by single-pulse of transcranial magnetic stimulation (TMS) after presenting an auditory stimulus either near the hand or in far space. MEPs recorded 50 ms after the near-sound onset were enhanced compared to MEPs evoked after far sounds. This near-far modulation faded at longer inter-stimulus intervals, and reversed completely for MEPs recorded 300 ms after the sound onset. At that time point, higher motor excitability was associated with far sounds. Such auditory modulation of hand motor representation was specific to a hand-centred, and not a body-centred reference frame. Conclusions/Significance This pattern of corticospinal modulation highlights the relation between space and time in the PPS representation: an early facilitation for near stimuli may reflect immediate motor preparation, whereas, at later time intervals, motor preparation relates to distant stimuli potentially approaching the body.
I Feel what You Feel if You Are Similar to Me
Andrea Serino, Giulia Giovagnoli, Elisabetta Làdavas
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004930
Abstract: Social interactions are influenced by the perception of others as similar or dissimilar to the self. Such judgements could depend on physical and semantic characteristics, such as membership in an ethnic or political group. In the present study we tested whether social representations of the self and of others could affect the perception of touch. To this aim, we assessed tactile perception on the face when subjects observed a face being touched by fingers. In different conditions we manipulated the identity of the shown face. In a first experiment, Caucasian and Maghrebian participants viewed a face belonging either to their own or to a different ethnic group; in a second experiment, Liberal and Conservative politically active participants viewed faces of politicians belonging to their own or to the opposite political party. The results showed that viewing a touched face most strongly enhanced the perception of touch on the observer's face when the observed face belonged to his/her own ethnic or political group.
Effect of Dilution on Spinodals and Pseudospinodals
K. Liu,W. Klein,C. A. Serino
Physics , 2013,
Abstract: We investigate the effect of quenched dilution on the critical and spinodal points in the infinite range (mean-field) and long-range (near-mean-field) Ising model. We find that unlike the short-range Ising model, the effect of the dilution is not simply related to the divergence of the specific heat, i.e., the Harris criterion. We also find the mean-field behavior differs from that of $d=4$ (upper critical dimension) nearest neighbor model at the critical point. These results are an important first step for understanding the effect of the spinodal on the nucleation process as well as the properties of the metastable state in systems of considerable interest in material science, geophysics, and econophysics which in general have defects.
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