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Search Results: 1 - 10 of 1506 matches for " Dolores Corella "
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Diet-gene interactions between dietary fat intake and common polymorphisms in determining lipid metabolism
Corella, Dolores
Grasas y Aceites , 2009,
Abstract: Current dietary guidelines for fat intake have not taken into consideration the possible genetic differences underlying the individual variability in responsiveness to dietary components. Genetic variability has been identified in humans for all the known lipid metabolim-related genes resulting in a plethora of candidate genes and genetic variants to examine in diet-gene interaction studies focused on fat consumption. Some examples of fat-gene interaction are reviewed. These include: the interaction between total intake and the 514C/T in the hepatic lipase gene promoter in determining high-density lipoprotein cholesterol (HDL-C) metabolism; the interaction between polyunsaturated fatty acids (PUFA) and the 75G/A polymorphism in the APOA1 gene plasma HDL-C concentrations; the interaction between PUFA and the L162V polymorphism in the PPARA gene in determining triglycerides and APOC3 concentrations; and the interaction between PUFA intake and the 1131TC in the APOA5 gene in determining triglyceride metabolism. Although hundreds of diet-gene interaction studies in lipid metabolism have been published, the level of evidence to make specific nutritional recommendations to the population is still low and more research in nutrigenetics has to be undertaken. Las recomendaciones dietéticas actuales referentes al consumo de grasas en la dieta han sido realizadas sin tener en cuenta las posibles diferencias genéticas de las personas que podrían ser las responsables de las diferentes respuestas interindividuales que frecuentemente se observan ante la misma dieta. La presencia de variabilidad genética ha sido puesta de manifiesto para todos los genes relacionados con el metabolismo lipídico, por lo que existe un ingente número de genes y de variantes genéticas para ser incluidas en los estudios sobre interacciones dieta-genotipo en el ámbito específico del consumo de grasas y aceites. Se revisarán algunos ejemplos sobre interacciones grasa-genotipo. Estas interacciones incluyen: la interacción entre el consumo de grasa total y el polimorfismo 514C/T en el promotor del gen de la lipasa hepática determinando las concentraciones de colesterol ligado a lipoproteínas de alta densidad (c-HDL); la interacción entre el consumo de ácidos grasos poliinsaturados y el polimorfismo 75G/A en el promotor del gen APOA1 en las concentraciones plasmáticas de c-HDL; la interacción entre los ácidos grasos poliinsaturados y el polimorfismo L162V en el gen PPARA determinando las concentraciones plasmáticas de triglicéridos y de apolipoproteína C-III; la interacción entre el polimorfismo
Impacto de la apolipoproteína A5 en el riesgo cardiovascular: Modulaciones genéticas y ambientales
SOTOS-PRIETO,MERCEDES; FRANCéS,FRANCESC; CORELLA,DOLORES;
Revista médica de Chile , 2010, DOI: 10.4067/S0034-98872010000700013
Abstract: triglyceride concentrations are an independent risk factor for coronary heart disease. apolipoprotein a5 gene (apoa5) has an important role determining triglyceride metabolism and it is a potential cardiovascular risk. however the mechanisms for these actions are not well-known. despite the different allelic frequency of its major polymorphisms in different populations, multiple studies have shown consistent associations between these variants and fasting triglycerides. variations in the apoa5 gene have also been associated with postprandial triglycerides, as well as with different sizes of lipoproteins and other markers. moreover, some of the apoa5 gene variants have been associated with ischemic heart disease, stroke, and carotid intima media thickness, although the references on this issue are scanty and contradictory. this may be due to the presence of gene-environment interactions that have been poorly studied until now. among the few studies that have examined the infuence of environmental factors on possible genetic variations, the most important are those that contemplate possible gene-diet interactions. however, the evidence is still scarce and more research is required in the feld of nutrigenomics. to understand the impact of this gene on cardiovascular disease, we review the genetic functionality and variability of apoa5, its associations with intermediate and fnal phenotypes and gene-environment interactions detected.
Comparación de las frecuencias de los alelos factor V Leiden (G1691A) y protrombina-G20210A entre pacientes con trombosis venosa profunda y población general mediterránea espa ola Factor V Leiden (G1691A) and prothrombin-G20210A alleles among patients with deep venous thrombosis and in the general population from Spain
Francesc Francès,Olga Portolès,Francisco Gabriel,Dolores Corella
Revista médica de Chile , 2006,
Abstract: Background: Factor V leiden and the -G20210A variant of prothrombin gene are associated to a higher risk of deep venous thrombosis. Aim: To assess the frequency of factor V Leiden (G1691A) and prothrombin -G20210A alleles in patients with deep venous thrombosis (DVT) and in the general population from Spain. Material and methods: Factor V Leiden (g1691a) and prothrombin-g20210a alleles were genotyped in 493 individuals from the Spanish general populations and in 131 patients with DVT. The presence of DVT was confirmed by phlebography. Allelic frequencies and the DVT risk associated with these variants were estimated. Results: Allelic frequencies for the factor V Leiden (G1691A) allele were 0.019 in patients with DVT and 0.010 in the general population (p=0.235). The frequencies for the prothrombin-G20210A allele were 0.027 and 0.026 (p=0.975). After adjustment for age and gender, the odds ratio for DVT, associated with the presence of G1691A allele was 2.41, but not statistically significant (95% confidence intervals 0.63-9.19). Conclusions: Prothrombin-G20210A allele was more prevelant than factor V Leiden (G1691A) allele in the Spanish population. However, the magnitude of the association between the G20210A and DVT risk is very low. On the contrary, the G1691A allele is associated by itself with a two fold increase in DVT risk in this population although without reaching statistical significance due to its low frequency
Impacto de la apolipoproteína A5 en el riesgo cardiovascular: Modulaciones genéticas y ambientales Impact of apolipoprotein A5 on cardiovascular risk: Genetic and environmental modulation
MERCEDES SOTOS-PRIETO,FRANCESC FRANCéS,DOLORES CORELLA
Revista médica de Chile , 2010,
Abstract: Triglyceride concentrations are an independent risk factor for coronary heart disease. Apolipoprotein A5 gene (APOA5) has an important role determining triglyceride metabolism and it is a potential cardiovascular risk. However the mechanisms for these actions are not well-known. Despite the different allelic frequency of its major polymorphisms in different populations, multiple studies have shown consistent associations between these variants and fasting triglycerides. Variations in the APOA5 gene have also been associated with postprandial triglycerides, as well as with different sizes of lipoproteins and other markers. Moreover, some of the APOA5 gene variants have been associated with ischemic heart disease, stroke, and carotid intima media thickness, although the references on this issue are scanty and contradictory. This may be due to the presence of gene-environment interactions that have been poorly studied until now. Among the few studies that have examined the infuence of environmental factors on possible genetic variations, the most important are those that contemplate possible gene-diet interactions. However, the evidence is still scarce and more research is required in the feld of nutrigenomics. To understand the impact of this gene on cardiovascular disease, we review the genetic functionality and variability of APOA5, its associations with intermediate and fnal phenotypes and gene-environment interactions detected.
Modulación de la expresión fenotípica del paciente con cistinuria: influencia de la intervención terapéutica y de la dieta
Francés,Francesc; Corella,Dolores; Carrasco,Paula; Sáiz,Carmen; Guillén,Marisa;
Archivos Espa?oles de Urología (Ed. impresa) , 2007, DOI: 10.4321/S0004-06142007000200002
Abstract: objectives: the final phenotype of patients with cystinuria depends on the absence or molecular defect, more o less acute, of the transport of cystine and dibasic aminoacids, and, also on environmental factors. the objective of this work is to study the effect of the modulation of some environmental factors (urinary ph, intake of liquids, pharmacological treatment and, specially, diet) on the final phenotype of the patient with cystinuria. methods: we study 45 patients with cystinuria (25 men and 20 women), 42 relatives (15 men and 27 women) and 90 unrelated controls. anthropometric, clinical (personal and familiar history of urinary infections, colics and calculi expulsion), biochemical (microscopy analysis of urine and urinary aminoacids cuantification) and life style (diet and medical treatment) variables were obtained. statistical analysis was performed using tests to compare means and frequencies and, also, logistic regression and multivariate analysis. results: of the 45 patients with cystinuria, only 20% showed cystine cristalls in urine, the rest of the phenotypical manifestations of cystinuria were found with the same prevalence as in relatives and in the control group. 50% of the patients did not undergo any therapeutic intervention; of these, only 50% were effective. in patients with cystinuria, the presence of cystine cristalls was associated with a diet rich in meats and poor in milk products (p<0.05). meat consumption also tend to associate with a higher risk of urinary infections, meanwhile the stone expulsion showed a negative tendance with a diet rich in phytate. the elevate consumption of oranges and mandarins was the variable of the diet which was more associated with urinary aminoacids concentrations, specially with lower levels of lysine and arginine (p<0,05). conclusions: some components of the diet, in addition to standard treatment, modulate the phenotypical manifestations of cystinuria.
Vaccines and recommendations for their use in inflammatory bowel disease
María Dolores Sánchez-Tembleque,Carmen Corella,Jose L Pérez-Calle
World Journal of Gastroenterology , 2013, DOI: 10.3748/wjg.v19.i9.1354
Abstract: The patient with inflammatory bowel disease will be predisposed to numerous infections due their immune status. It is therefore important to understand the immune and serologic status at diagnosis and to put the patient into an adapted vaccination program. This program would be applied differently according to two patient groups: the immunocompromised and the non-immunocom-promised. In general, the first group would avoid the use of live-virus vaccines, and in all cases, inflammatory bowel disease treatment would take precedence over vaccine risk. It is important to individualize vaccination schedules according to the type of patient, the treatment used and the disease pattern.In addition, patient with inflammatory bowel disease should be considered for the following vaccines: varicella vaccine, human papilloma virus, influenza, pneumococcal polysaccharide vaccine and hepatitis B vaccine.
Análisis edad-periodo-cohorte de la mortalidad por accidentes de tráfico en Espa a
Saiz-Sánchez Carmen,Bautista-Rentero Daniel,Corella-Piquer Dolores,Cortina-Birlanga Silvia
Salud Pública de México , 1999,
Abstract: OBJETIVO. Estudiar la evolución de la mortalidad por accidentes de tráfico en Espa a y su posible aplicación a un modelo edad-periodo-cohorte, así como el efecto que pueden tener algunas medidas de seguridad vial seleccionadas. MATERIAL Y MéTODOS. Se obtuvieron las tasas de mortalidad por accidentes de tráfico y las tasas en intervalos quinquenales de edad para cada sexo, lo que permite su estudio como tasas específicas de edad por cohortes de nacimiento. Para determinar la asociación entre las medidas de seguridad vial seleccionadas y la mortalidad se han construido modelos de regresión de Poisson. RESULTADOS. Se observaron dos ondas evolutivas en la mortalidad por accidentes de tráfico. Respecto a la edad, no podemos hablar de un efecto claro; tampoco se encontró un efecto cohorte ni para varones ni para mujeres. En relación con las medidas de seguridad vial, se discutió la consistencia que guardaban los modelos seleccionados con los resultados gráficos, y se obtuvo que el uso obligatorio del casco y de las luces de cruce en motocicletas se ha asociado significativamente a la reducción de la mortalidad (RR 0.73, p< 0.05). CONCLUSIONES. La mortalidad por accidentes de tráfico en Espa a muestra un ligero incremento en el periodo estudiado. Este comportamiento de las tasas no puede ser explicado suficientemente por los efectos de la edad, el periodo de diagnóstico de la muerte y la cohorte de nacimiento; en cambio las medidas de seguridad vial introducidas se valoraron positivamente.
Heterogeneity of the Stearoyl-CoA desaturase-1 (SCD1) Gene and Metabolic Risk Factors in the EPIC-Potsdam Study
Maria Arregui, Brian Buijsse, Norbert Stefan, Dolores Corella, Eva Fisher, Romina di Giuseppe, Oscar Coltell, Sven Knüppel, Krasimira Aleksandrova, Hans-Georg Joost, Heiner Boeing, Cornelia Weikert
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048338
Abstract: Background Stearoyl-CoA desaturase-1 (SCD1) is an enzyme involved in lipid metabolism. In mice and humans its activity has been associated with traits of the metabolic syndrome, but also with the prevention of saturated fatty acids accumulation and subsequent inflammation, whereas for liver fat content inconsistent results have been reported. Thus, variants of the gene encoding SCD1 (SCD1) could potentially modify metabolic risk factors, but few human studies have addressed this question. Methods In a sample of 2157 middle-aged men and women randomly drawn from the Potsdam cohort of the European Prospective Investigation into Cancer and Nutrition, we investigated the impact of 7 SCD1 tagging-single nucleotide polymorphisms (rs1502593, rs522951, rs11190480, rs3071, rs3793767, rs10883463 and rs508384) and 5 inferred haplotypes with frequency >5% describing 90.9% of the genotype combinations in our population, on triglycerides, body mass index (BMI), waist circumference (WC), glycated haemoglobin (HbA1c), high-sensitivity C-reactive protein (hs-CRP), gamma-glutamyltransferase (GGT), alanine aminotransferase (ALT) and fetuin-A. Results No significant associations between any of the SNPs or haplotypes and BMI, WC, fetuin-A and hs-CRP were observed. Associations of rs10883463 with triglycerides, GGT and HbA1c as well as of rs11190480 with ALT activity, were weak and became non-significant after multiple-testing correction. Also associations of the haplotype harbouring the minor allele of rs1502593 with HbA1c levels, the haplotype harbouring the minor alleles of rs11190480 and rs508384 with activity of ALT, and the haplotype harbouring the minor alleles of rs522951, rs10883463 and rs508384 with triglyceride and HbA1C levels and GGT activities did not withstand multiple-testing correction. Conclusion These findings suggest that there are no associations between common variants of SCD1 or its inferred haplotypes and the investigated metabolic risk factors. However, given the results from animal models, heterogeneity of human SCD1 warrants further investigation, in particular with regard to rare variants.
Análisis edad-periodo-cohorte de la mortalidad por accidentes de tráfico en Espa?a
Saiz-Sánchez,Carmen; Bautista-Rentero,Daniel; Corella-Piquer,Dolores; Cortina-Birlanga,Silvia; González-Arraez,José Ignacio;
Salud Pública de México , 1999, DOI: 10.1590/S0036-36341999000300005
Abstract: objective. to study the evolution of traffic accidents mortality in spain and its possible application to an age-period-cohort analysis, as well as the effect of selected road safety measures. material and methods. road accidents rates of mortality were obtained, and five-year interval age rates for each sex, which allows the study of specific rates of age by birth cohorts. to determine the association between the selected road safety measures and mortality, poisson regression models were adjusted. results. two waves emerge in the evolution of traffic accidents. there was no clear effect with respect to age, nor was there a cohort effect for men or women. as to the road safety measures, we discuss the consistency between the selected models and graphic results. the compulsory use of helmet and of crossing lights is significantly associated to a reduction in mortality (rr 0.73, p< 0.05). conclusions. road accidents mortality shows a slight increase in the studies period. this rate performance cannot be sufficiently explained by age effects, diagnostic period nor birth cohort, however, road safety measures are considered positive.
Comparación de las frecuencias de los alelos factor V Leiden (G1691A) y protrombina-G20210A entre pacientes con trombosis venosa profunda y población general mediterránea espa?ola
Francès,Francesc; Portolès,Olga; Gabriel,Francisco; Corella,Dolores; Sorlí,José Vicente; Sabater,Antonio; Alfonso,José L; Guillén,Marisa;
Revista médica de Chile , 2006, DOI: 10.4067/S0034-98872006000100002
Abstract: background: factor v leiden and the -g20210a variant of prothrombin gene are associated to a higher risk of deep venous thrombosis. aim: to assess the frequency of factor v leiden (g1691a) and prothrombin -g20210a alleles in patients with deep venous thrombosis (dvt) and in the general population from spain. material and methods: factor v leiden (g1691a) and prothrombin-g20210a alleles were genotyped in 493 individuals from the spanish general populations and in 131 patients with dvt. the presence of dvt was confirmed by phlebography. allelic frequencies and the dvt risk associated with these variants were estimated. results: allelic frequencies for the factor v leiden (g1691a) allele were 0.019 in patients with dvt and 0.010 in the general population (p=0.235). the frequencies for the prothrombin-g20210a allele were 0.027 and 0.026 (p=0.975). after adjustment for age and gender, the odds ratio for dvt, associated with the presence of g1691a allele was 2.41, but not statistically significant (95% confidence intervals 0.63-9.19). conclusions: prothrombin-g20210a allele was more prevelant than factor v leiden (g1691a) allele in the spanish population. however, the magnitude of the association between the g20210a and dvt risk is very low. on the contrary, the g1691a allele is associated by itself with a two fold increase in dvt risk in this population although without reaching statistical significance due to its low frequency
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