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Search Results: 1 - 10 of 2653 matches for " Doaa Abdel-Aleem "
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The Impact of Neutrophil to Lymphocytic Ratio (NLR) as a Predictor of Treatment Outcomes in Rectal Carcinomas: A Retrospective Cohort Study  [PDF]
Samir Eid, Hoda Hasan, Doaa Abdel-Aleem, Amal Rayan
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.109064
Abstract: Background and aim: The prognostic role of neutrophil to lymphocyte ratio (NLR) has been shown in many solid tumors included in a recent meta-analysis of one hundred studies. We aimed to evaluate the prognostic value of neutrophil to lymphocyte ratio in treatment outcomes; response and survival of patients with different stages of rectal cancers. Patients and methods: All patients with pathologically confirmed cancer rectum presented to our department during the period from January 2012 to the end of 2014 were included in this retrospective study, these recruited patients were evaluated through their files to determine different objectives of our study. Results: The median overall survival was 31 ± 4.676 months while disease free survival was 40 ± 2.346 for the whole study group; neutrophil to lymphocyte ratio was negatively correlated with overall survival with r = 0.743, P < 0.001, also with disease free survival with r = 0.717, P < 0.0001. Neutrophil to lymphocyte ratio was positively correlated with the number of positive lymph nodes dissected to total number of lymph nodes dissected ratio with r = +0.254, P =
Reconstruction of Humeral Head Defect in Locked Posterior Dislocation Shoulder. A Case Series of Nine Patients  [PDF]
Said K. Abdel-Hameed, Abdel-Khalek A. Ibrahem Alzalabany, Mohamed A. Abdel-Aal, Abdel-Aleem Soltan
Open Journal of Orthopedics (OJO) , 2015, DOI: 10.4236/ojo.2015.52004
Abstract: Locked posterior dislocation shoulder is uncommon and frequently missed injury. It account for 2% - 4% of all shoulder dislocations. It is commonly associated with osseous defects in humeral head articular surface known as reverse Hill-Sachs lesion. Numerous surgical procedures invented to repair this defect with variable outcomes but evidence based management strategies are lacking. Among these procedures are: transfer of lesser tuberosity or subscapularis tendon, rotational osteotomy of humerus, osteochondral grafts. Salvage procedure as hemiarthroplasty or total shoulder arthroplasty used in huge non-constructable defect or very old neglected dislocation. In our case series, we treated 9 cases (2 females) of locked posterior shoulder dislocation with antero-medial humeral head defects ranging between 30% - 50% of head size. Open reduction of dislocation followed by transfer of the lesser tuberosity together with subscapularis tendon for reconstruction of the humeral head defect. The transfer was fixed with Ethibond suture size 5-0 (Ethicon, Inc. Somerville, New Jersy). The mean follow-up period was 14.5 months (range, 12 - 25 months). Seven cases had no pain or restriction of activities of daily living. No patient had symptoms of instability of the shoulder. According to UCLA Shoulder rating scale, there were 3 cases rated excellent, 4 cases rated good, one case rated fair and one case rated poor. It is concluded that reconstruction of the humeral head defect provides good pain relief, stability and function for patients with a locked posterior dislocation where the defect involves between 30% - 50% of the articular surface circumference. Our technique is simple, cheap and there is no need for second operation for hardware removal.
Green Synthesis of Novel 5-Arylazo-2-[(2S, 3S, 4R, 5R)-3, 4, 5-Trihydroxy-6-(Hydroxymethyl) Tetrahydro-2H-Pyran-2-Yloxy]-4, 6-Dimethyl 3-Nicotinonitrile  [PDF]
Magda H. Abdellattif, Mohamed Mohamed Helmy Arief, Adel A. H. Abdel-Rahman, Abdel-Aleem H. Abdel Aleem, Abdel Moneam Farag Eissa
International Journal of Organic Chemistry (IJOC) , 2017, DOI: 10.4236/ijoc.2017.74031
Abstract: Introduction: Pyridone derivatives played important roles in the last decade to approach many and different functionalities, especially as antitumor, antibacterial, anti-fungal, and many of pharmacological activities. Methodology: Novel compounds of 5-Arylazo-2-[(substituted)-3, 4, 5-trihydroxy-6-(hydroxymethyl) tetrahydro-2H-pyran-2-yloxy]-4, 6-dimethylnicotinonitrile, (3a-e), generally called (fluroarylazopyridine glucosides) were synthesised via green protocol, microwave. Results: The compounds were investigated by (IR, 1HNMR, 13CNMR and mass spectrometry). Where some of pharmacological activities like antibacterial and antifungal studies had been investigated and characterized. It was found that 3a-d had characterized by high activities as antibacterial and antifungal. Where microwave synthetic methods were more efficient, gave higher products quantity, and more saving for time requirement and for using of much more solvents.
Clinical, anthropometric, radiological and molecular characteristics of Egyptian achondroplasia patients
MS Aglan, AK Abdel-Aleem, A IS EL-Katoury, MH Hafez, SN Saleem, GA Otaify, SA Temtamy
Egyptian Journal of Medical Human Genetics , 2009,
Abstract: Background: Achondroplasia is the most common form of non lethal skeletal dysplasia. It is a fully penetrant autosomal dominant disorder and the majority of cases are sporadic resulting from de novo mutations associated with advanced paternal age. The phenotype of achondroplasia is related to disturbance in endochondral bone formation due to mutations in the fi broblast growth factor receptor-3 (FGFR3) gene. Aim of the Work: Evaluation of the cardinal phenotypic features in achondroplasia, the body physique using anthropometric measurements, the characteristic radiological signs in the patients as a main tool for diagnosis and detection of the most common mutations in achondroplasia patients in the studied sample. Subjects and Methods: From 42 cases referred to us as achondroplasia, we selected 20 cases where clinical manifestations were consistent with achondroplasia. Cases were subjected to full clinical examination, detailed anthropometric measurements, whole body skeletal survey and molecular studies of the most common mutations of the FGFR3 gene using PCR amplifi cation technique. Results: Nineteen cases were sporadic (95%) and one case had an affected father (5%). A paternal age above 35 years at the time of child’s birth was present in 7 cases (35%). Paternal exposure to occupational heat was noted in 6 cases (30%) and parental exposure to chemicals in 3 cases (15%). All cases showed typical clinical and radiological manifestations of achondroplasia. Anthropometric measurements quantitatively confi rmed the body physique in the studied cases. G380R common mutations of the FGFR3 gene were detected in 15/18 cases (83%) with the G to A transition at nucleotide 1138 in 14 cases (77%). Agenesis of corpus callosum, not previously reported in association with achondroplasia, was present in the only case with the G-C transversio nmutation at nucleotide 1138 (5%). Conclusions: Awareness of the cardinal features of achondroplasia, proper anthropometric measurements and detailed skeletal survey are the key for accurate diagnosis, genetic counseling and avoidance of over diagnosis. The majority of studied Egyptian achondroplasia patients have the same common mutation that has been most often defi ned in patients with achondroplasia from other countries.
Making stillbirths count, making numbers talk - Issues in data collection for stillbirths
J Frederik Fr?en, Sanne J Gordijn, Hany Abdel-Aleem, Per Bergsj?, Ana Betran, Charles W Duke, Vincent Fauveau, Vicki Flenady, Sven Hinderaker, G Justus Hofmeyr, Abdul Jokhio, Joy Lawn, Pisake Lumbiganon, Mario Merialdi, Robert Pattinson, Anuraj Shankar
BMC Pregnancy and Childbirth , 2009, DOI: 10.1186/1471-2393-9-58
Abstract: In this report, we assess how different definitions and limits in registration affect data capture, and we discuss the specific challenges of stillbirth registration, with emphasis on implementation. We identify what data need to be captured, we suggest a dataset to cover core needs in registration and analysis of the different categories of stillbirths with causes and quality indicators, and we illustrate the experience in stillbirth registration from different cultural settings. Finally, we point out gaps that need attention in the International Classification of Diseases and review the qualities of alternative systems that have been tested in low- and middle-income settings.Obtaining high-quality data will require consistent definitions for stillbirths, systematic population-based registration, better tools for surveys and verbal autopsies, capacity building and training in procedures to identify causes of death, locally adapted quality indicators, improved classification systems, and effective registration and reporting systems.The vast majority of stillbirths are preventable, and simple interventions could lead to healthy infants as a rich reward for the resources invested [1-6]. Mothers and families could be spared the emotional burden accompanying pregnancy loss, and societies could gain by reducing a major public health problem.Being counted is essential. Stillbirths are estimated to account for more than half of the world's perinatal deaths, but only a fraction are registered in any health information system [7]. Stillbirths have been invisible in the World Health Organization (WHO) reports on the global burden of disease [8] and in the United Nations (UN) Millennium Development Goals and Targets. According to the most recent WHO reports on perinatal mortality, 90 countries worldwide lacked any kind of data on stillbirths [7,9]. Improvements in basic registrations of stillbirths are both possible and urgently needed [10]. The "Who Counts?" series in The Lan
Active management of the third stage of labour without controlled cord traction: a randomized non-inferiority controlled trial
A Metin Gülmezoglu, Mariana Widmer, Mario Merialdi, Zahida Qureshi, Gilda Piaggio, Diana Elbourne, Hany Abdel-Aleem, Guillermo Carroli, G Justus Hofmeyr, Pisake Lumbiganon, Richard Derman, Pius Okong, Shivaprasad Goudar, Mario Festin, Fernando Althabe, Deborah Armbruster
Reproductive Health , 2009, DOI: 10.1186/1742-4755-6-2
Abstract: The primary objective is to determine whether the simplified package of oxytocin 10 IU IM/IV is not less effective than the full AMTSL package.A hospital-based, multicentre, individually randomized controlled trial is proposed. The hypothesis tested will be a non-inferiority hypothesis. The aim will be to determine whether the simplified package without CCT, with the advantage of not requiring training to acquire the manual skill to perform this task, is not less effective than the full AMTSL package with regard to reducing blood loss in the third stage of labour.The simplified package will include uterotonic (oxytocin 10 IU IM) injection after delivery of the baby and cord clamping and cutting at approximately 3 minutes after birth. The full package will include the uterotonic injection (oxytocin 10 IU IM), controlled cord traction following observation of uterine contraction and cord clamping and cutting at approximately 3 minutes after birth. The primary outcome measure is blood loss of 1000 ml or more at one hour and up to two hours for women who continue to bleed after one hour. The secondary outcomes are blood transfusion, the use of additional uterotonics and measure of severe morbidity and maternal death.We aim to recruit 25,000 women delivering vaginally in health facilities in eight countries within a 12 month recruitment period.Overall trial management will be from HRP/RHR in Geneva. There will be eight centres located in Argentina, Egypt, India, Kenya, Philippines, South Africa, Thailand and Uganda. There will be an online data entry system managed from HRP/RHR. The trial protocol was developed following a technical consultation with international organizations and leading researchers in the field.The main objective of this trial is to investigate whether a simplified package of third stage management can be recommended without increasing the risk of PPH. By avoiding the need for a manual procedure that requires training, the third stage management can b
Causes of stillbirths and early neonatal deaths: data from 7993 pregnancies in six developing countries
Ngoc,Nhu Thi Nguyen; Merialdi,Mario; Abdel-Aleem,Hany; Carroli,Guillermo; Purwar,Manorama; Zavaleta,Nelly; Campódonico,Liana; Ali,Mohamed M; Hofmeyr,G Justus; Mathai,Matthews; Lincetto,Ornella; Villar,José;
Bulletin of the World Health Organization , 2006, DOI: 10.1590/S0042-96862006000900012
Abstract: objective: to report stillbirth and early neonatal mortality and to quantify the relative importance of different primary obstetric causes of perinatal mortality in 171 perinatal deaths from 7993 pregnancies that ended after 28 weeks in nulliparous women. methods: a review of all stillbirths and early newborn deaths reported in the who calcium supplementation trial for the prevention of pre-eclampsia conducted at seven who collaborating centres in argentina, egypt, india, peru, south africa and viet nam. we used the baird-pattinson system to assign primary obstetric causes of death and classified causes of early neonatal death using the international classification of diseases and related health problems, tenth revision (icd-10). findings: stillbirth rate was 12.5 per 1000 births and early neonatal mortality rate was 9.0 per 1000 live births. spontaneous preterm delivery and hypertensive disorders were the most common obstetric events leading to perinatal deaths (28.7% and 23.6%, respectively). prematurity was the main cause of early neonatal deaths (62%). conclusions: advancements in the care of premature infants and prevention of spontaneous preterm labour and hypertensive disorders of pregnancy could lead to a substantial decrease in perinatal mortality in hospital settings in developing countries.
Evaluation of Serum and Aqueous Humor Vascular Endothelial Growth Factor in Neovascular Glaucoma  [PDF]
Waled Mahdy Nada, Doaa Attia Abdel-Moety
Open Journal of Ophthalmology (OJOph) , 2017, DOI: 10.4236/ojoph.2017.72012
Abstract: Purpose: The study aimed to evaluate and correlate between the levels of vascular endothelial growth factor (VEGF) in serum and aqueous humor in cases of neovascular glaucoma (NVG) to stand up on if it can be used as a marker for early detection of such cases. Methods: This observational case control study included 60 eyes, divided into 3 groups, group A of 30 eyes presented by cataract of different causes (not diabetic patients and no signs of NVG) as a control group and group B of 30 eyes with NVG due to different causes, group C of the same eyes in group B but after one month of treatment by intravitreal bevacizumab and laser treatment by pan retinal photocoagulation (PRP). Serum VEGF was estimated in all groups, also aqueous humor VEGF was estimated in group A and B only. In addition glycosylated hemoglobin (HbA1c) was estimated in group B; statistical analysis of the results was performed. Results: The study revealed that the commonest cause of NVG was proliferative diabetic retinopathy (PDR) in 26 cases (86.7%), HbA1c in group B revealed mean value 7.68% ± 2.75%. Serum VEFG level in the group B of cases of NVG was significantly higher than the control group A (P < 0.001), and moderate significantly lower than group C of treated NVG by intravitreal bevacizumab injection and PRP (P < 0.05). Also aqueous VEGF level in group B was increased significantly from control group A (P < 0.001). In group B, the study reported a positive correlation between serum VEGF (S-VEGF) and aqueous humor VEGF (A-VEGF) levels (r = 0.638) with a high significant result (P < 0.001). Also, there was positive correlation between HbA1c and VEGF in serum (r = 0.409) with a moderate significant result (P < 0.05) But there was no correlation between HbA1c and VEGF in aqueous humor (r = 0.327) with an insignificant result (P > 0.05). Conclusions: VEGF is considered a good marker for the NVG either in serum or aqueous humor, laser treatment and the use of anti-VEGF are crucial treatment for such cases, and also glycemic control is a must for regulation of the vascular process in diabetic patients for prevention of such ocular neovascularization.
A Novel Spectrophotometric Method for Determination of Gabapentin in Pharmaceutical Formulations Using 2,5-Dihydroxybenzaldehyde  [PDF]
Magda S. Saleh, Ahmed K. Youssef, Elham Y. Hashem, Doaa A. Abdel-Kader
Computational Chemistry (CC) , 2014, DOI: 10.4236/cc.2014.22004
Abstract: A highly simple, rapid, sensitive and selective method is developed for spectrophotometric determination of gabapentin in pure form as well as in pharmaceutical formulations. The method is based on the formation of a yellow Schiff base derived from the condensation of gabapentin drug (1-amino methyl) cyclo hexane acetic acid and 2,5-dihydroxybenzaldehyde (DHBA) exhibiting a maximum absorbance at 445 nm. The composition, molar absorptivity and effect of different excipient have been determined spectrophotometrically. Under optimized experimental conditions, Beer’s law is obeyed in the concentration range 2.57 - 37.25 μg/ml. The method is validated with respect to accuracy, precision, limit of detection and limit of quantification. The Sandell sensitivity, correlation coefficient and regression equation are calculated. The equilibrium constant and free energy change using Benesi-Hildebrand plot are also determined. The Schiff base derived from condensation of gabapentin with DHBA is also synthesized and characterized. The condensation reaction mechanism has been proposed.
Synthesis, Reactions and Antimicrobial Activity of Some New 3-Substituted Indole Derivatives  [PDF]
Asmaa S. Salman, Naema A. Mahmoud, Anhar Abdel-Aziem, Mona A. Mohamed, Doaa M. Elsisi
International Journal of Organic Chemistry (IJOC) , 2015, DOI: 10.4236/ijoc.2015.52010
Abstract: Reaction of indole-3-carboxaldehydes 4 with hydrazine derivatives and different substituted acid hydrazides afforded the corresponding hydrazine derivatives 5a-c and acid hydrazide derivatives 7-11 respectively. Condensation of indole-3-carboxaldehydes 4 with phenacyl bromide and thiourea gives 1,3-thiazol-2-amine derivative 18. On the other hand, reaction 4 with 3-acetylchromene-2-one afforded chalcone derivative 19. Compound 4 undergoing Knoevenagel condensation with cyanoacetamide, ethyl cyanoacetate, benzimidazol-2-ylacetonitrile, rhodanine-3-acetic acid, 2,3-dihydropyrimidin-4-one derivative and 2,4-dihydropyrazol-3-one afforded the compounds 20a,b, 22, 23, 27 and 28 respectively. The structure of the newly synthesized compounds has been confirmed by elemental analysis and spectra data. The antimicrobial activities of the some newly synthesized compounds were measured and showed that most of them have high activities
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