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Search Results: 1 - 10 of 5417 matches for " Diana "
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An interview with Diana from Libya
International Journal of Inclusive Democracy , 2011,
Abstract: IJID Note:The interviewer will be referred below as JR and the interviewee as DL. Both the interviewer as well as the interviewee preferred not to reveal publicly their names for security reasons.JR’s Notes:In the 1980s, when Gaddafi’s policies veered to the left and nationalization of the economy became widespread, Diana father’s business was severely affected. So her own background is not what one might expect of someone who now is speaking up passionately against the NATO assault on Libya…Unfortunately, most mainstream western journalists seem interested only in hearing from anti-Gaddafi Libyans. So it is the fact that westerners continue to get a one-sided picture of Libya which helps support the case for NATO bombing. Here’s another side to the story…
Complications of physician misdiagnosis/treatment of rheumatic fever in the United States  [PDF]
Diana C. Peterson
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.41A021

Rheumatic fever is an auto-immune disease caused by exposure to Streptococcus pyogenes. Over the last 50 years, reports of rheumatic fever within the United States have diminished. The decrease was attributed to the advent of penicillin in the treatment of streptococcus infections. We propose that current diagnostic and treatment methodologies may adversely increase the morbidity rate of rheumatic fever within the United States. Publication rates and interest in rheumatic fever has diminished over the last 30 years. Because of this decline, many physicians are only vaguely aware of the disorder. Additionally, the fear of antibiotic resistance has influenced theCenterofDisease Control to suggest a significant decrease in the use of antibiotics by physicians. Although extremely valid for the future health and well-being of the population, such policies must be examined for each individual case carefully. The American Heart Association prescribes long-term antibiotic prophylaxis as the only current treatment; however literature reviews indicate that such therapy is rarely used. Therefore individuals diagnosed with rheumatic fever are not being treated. Additionally, because many physicians are not routinely testing for streptococcus or early signs of endocarditis, it is likely that cases of rheumatic fever will increase in the future, and many individuals may not be diagnosed until sever damage or morbidity occurs. Physician education and clear revised guidelines are necessary to ensure adequate treatment of individuals with rheumatic fever. Mis-understandings of the disease and how it should be treated by first responders (i.e. primary care providers and pediatricians) are discussed.

Monopolar capacitive coupled Radiofrequency (mcRF) and ultrasound-guided Platelet Rich Plasma (PRP) give similar results in the treatment of enthesopathies: 18-Month follow-up  [PDF]
Joseph Cronkey, Diana Villegas
Health (Health) , 2013, DOI: 10.4236/health.2013.56A2011

Introduction: Emergent technologies, i.e., monopolar capacitive coupled Radiofrequency (mcRF) and Platelet Rich Plasma (PRP) are now available to treat conditions characterized by a failed Wound Healing Response. Both mcRF and PRP positively influence the chemical/cellular inflammatory cascade to promote healing. mcRF application results in temperature elevation at the targeted structure up to 50℃ stimulating heat shock proteins, thus inciting the Wound Healing Response. Ultrasound-guided PRP injections results in an inflammatory/reparative reaction through cytokinin release. Methods: Sixty-eight patients who have failed previous conservative treatment for tendinopathies and chronic ligament conditions of the elbow, hip, knee and ankle/foot, were treated either with mcRF or PRP. Treatments were delivered directly by the investigator, and patients were followed prospectively for an average of 19.7 months (range 15 to 24 months). Results: Average age for the mcRF cohort was 53 years (range 17 to 88). Average age for the PRP group was 58 (range 19 to 90). The male to female ratio for both groups was 1/1. 33 of 42 patients treated with mcRF experienced marked improvement (78%), while in the PRP group 19 of 26 patients experienced marked improvement (73%) as self-assessed by study subjects. Discussion/Conclusion: Results of this study are in agreement with reports on the use of both technologies; however, this is the first time that a side-by-side comparison is established. PRP and mcRF represent a new approach to musculoskeletal pathology; both modalities aim at inducing a biological response and are considered at the frontier of regenerative therapeutics. The high safety profile suggests that these, non-invasive (mcRF) and minimally invasive (PRP), office-based alternatives for the management of musculoskeletal conditions are valuable tools and should be used in accordance with a clear understanding of the underlying pathology.

Exploring Factors in the Systematic Use of Outcome Measures: A Multi-Disciplinary Rehabilitation Team Perspective  [PDF]
Diana Zidarov, Lise Poissant
Open Journal of Therapy and Rehabilitation (OJTR) , 2014, DOI: 10.4236/ojtr.2014.22013
Abstract: Purpose: The implementation of routine outcome measurement was initiated as a quality improvement initiative in a unit delivering intensive functional rehabilitation for people with lower limb amputation. Two years post-implementation, completion rates remained low which raised the need to gain an indepth understanding of the factors that might impact the systematic use of Outcome Measures (OMs). Method: A qualitative exploratory study embedded in the ongoing quality improvement initiative was designed. Data were gathered through a focus group with members of a multidisciplinary rehabilitation team. A deductive content analysis was performed using Consolidated Framework for Implementation Research (CFIR) as a guide to explore factors that impact routine outcome measurement. Results: Respondents perceived OMs as valid and offering clear advantages in clinical practice. At the organizational level, lack of fit with clinical practice, loss of project leaders and lack of clear management directives had negative repercussions on the use of OMs. Conclusion: Our results suggest that a dedicated project leader throughout the implementation process and effective communication may contribute to bypassing barriers associated to practice changes leading to a more systematic use of OMs among clinicians.
L-Moments and TL-Moments as an Alternative Tool of Statistical Data Analysis  [PDF]
Diana Bílková
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.210104
Abstract: Moments and cumulants are commonly used to characterize the probability distribution or observed data set. The use of the moment method of parameter estimation is also common in the construction of an appropriate parametric distribution for a certain data set. The moment method does not always produce satisfactory results. It is difficult to determine exactly what information concerning the shape of the distribution is expressed by its moments of the third and higher order. In the case of small samples in particular, numerical values of sample moments can be very different from the corresponding values of theoretical moments of the relevant probability distribution from which the random sample comes. Parameter estimations of the probability distribution made by the moment method are often considerably less accurate than those obtained using other methods, particularly in the case of small samples. The present paper deals with an alternative approach to the construction of an appropriate parametric distribution for the considered data set using order statistics.
Strategies to stabilize compact folding and minimize aggregation of antibody-based fragments  [PDF]
Diana Gil, Adam G. Schrum
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.44A011

Monoclonal antibodies (mAbs) have proven to be useful for development of new therapeutic drugs and diagnostic techniques. To overcome the difficulties posed by their complex structure and folding, reduce undesired immunogenicity, and improve pharmacoki- netic properties, a plethora of different Ab fragments have been developed. These include recombinant Fab and Fv segments that can display improved properties over those of the original mAbs upon which they are based. Antibody (Ab) fragments such as Fabs, scFvs, diabodies, and nanobodies, all contain the variable Ig domains responsible for binding to specific antigenic epitopes, allowing for specific targeting of pathological cells and/or molecules. These fragments can be easier to produce, purify and refold than a full Ab, and due to their smaller size they can be well absorbed and distributed into target tissues. However, the physicochemical and structural properties of the immunoglobulin (Ig) domain, upon which the folding and conformation of all these Ab fragments is based, can limit the stability of Ab-based drugs. The Ig domain is fairly sensitive to unfolding and aggregation when produced out of the structural context of an intact Ab molecule. When unfolded, Ab fragments may lose their specificity as well as establish non-native interactions leading to protein aggregation. Aggregated antibody fragments display altered pharmacokinetic and immunogenic properties that can augment their toxicity. Therefore, much effort has been placed in understanding the factors impacting the stability of Ig folding at two different levels: 1) intrinsically, by studying the effects of the amino acid sequence on Ig folding; 2) extrinsically, by determining the environmental conditions that may influence the stability of Ig folding. In this review we will describe the structure of the Ig domain, and the factors that impact its stability, to set the context for the different approaches currently used to achieve stable recombinant Ig domains when pursuing the development of Ab fragment-based biotechnologies.

A Better Understanding of Reasons for the Failure of the Healthcare Reform in Colombia  [PDF]
Oscar Bernal, Diana C. Zamora
Health (Health) , 2014, DOI: 10.4236/health.2014.621330
Abstract: The Colombian healthcare crisis is evidenced by obstacles to health service, diminished working conditions and medical autonomy, financial infeasibility, loss of leadership and legitimacy of the healthcare system. In the year 2013 twelve reform projects were presented to Congress, including a statutory law that defines health as a fundamental right which was approved and another ordinary one which sought a complete reform of the system but was rejected and criticized by different opinion leaders. For this study we have made an adaptation to Q methodology, which assigns quantitative values to the most frequent statement variables obtained from secondary sources (norms, articles, media, forums) giving objective information about the diverse positions in the proposals to healthcare reform. We analyzed from the most objective position and from academic independence the different views of the opinion leaders for a better understanding of the reasons for this failure in healthcare reform. There was a great polarization in the diverse statements which made an agreement with the government unlikely and, when added to a political moment in which the presidential election was being held, made the new reform non-viable. Although there is an agreement about the existence of a crisis, this has not been the case about the analysis of its causes or solutions. At the present time, the government is not presenting a new reform proposal and is focusing on some decree to create a model of healthcare in rural zones, define financial conditions for the EPSes (health providers), update norms for membership in a healthcare system and regulate biotechnological drugs. Even though to date there have been no opinions, plus taking into account the previous analysis, it is very possible there will be much criticism from those who demand a structural change in the system.
Multimodality Imaging of the Peripheral Venous System
Diana Gaitini
International Journal of Biomedical Imaging , 2007, DOI: 10.1155/2007/54616
Abstract: The purpose of this article is to review the spectrum of image-based diagnostic tools used in the investigation of suspected deep vein thrombosis (DVT). Summary of the experience gained by the author as well as relevant publications, regarding vein imaging modalities taken from a computerized database, was reviewed. The imaging modalities reviewed include phlebography, color Doppler duplex ultrasonography (CDDUS), computerized tomography angiography (CTA) and venography (CTV), magnetic resonance venography (MRV), and radionuclide venography (RNV). CDDUS is recommended as the modality of choice for the diagnosis of DVT. A strategy combining clinical score and D-dimer test refines the selection of patients. Phlebography is reserved for discrepant noninvasive studies.
Evolving Towards Mutualism
Diana Gitig
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1000279
El trabajo infanto-juvenil y el estado nutricional de los menores colombianos
Desarrollo y Sociedad , 2007,
Abstract: this paper studies the relationship between child labor and the nutritional status of colombian children. the effect of child labor on the nutrition of children with ages between 6 and 17 years is analyzed using data from the demographic and health survey - dhs 2005. evidence is found about a positive relationship between children labor and their nutrition, which is affected in some cases by school attendance and by belonging to the poorest quintile of wealth. results suggest that child labor has a positive effect on nutrition through the greater income it generates, either by directly contributing to an increase in household income, or by releasing adults from household chores, allowing them to work in other activities. supporting theory and empirical evidence, socioeconomic variables from household are strongly related with the nutritional status of children.
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