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Search Results: 1 - 10 of 86031 matches for " Derek W; "
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Entropy and Uncertainty
Derek W. Robinson
Entropy , 2008, DOI: 10.3390/e10040493
Abstract: We give a survey of the basic statistical ideas underlying the definition of entropy in information theory and their connections with the entropy in the theory of dynamical systems and in statistical mechanics.
New insights into the anti-inflammatory actions of aspirin- induction of nitric oxide through the generation of epi-lipoxins
Gilroy, Derek W;
Memórias do Instituto Oswaldo Cruz , 2005, DOI: 10.1590/S0074-02762005000900009
Abstract: aspirin has always remained an enigmatic drug. not only does it present with new benefits for treating an ever-expanding list of apparently unrelated diseases at an astounding rate but also because aspirin enhances our understanding of the nature of these diseases processe. originally, the beneficial effects of aspirin were shown to stem from its inhibition of cyclooxygenase-derived prostaglandins, fatty acid metabolites that modulate host defense. however, in addition to inhibiting cyclooxygenase activity aspirin can also inhibit pro-inflammatory signaling pathways, gene expression and other factors distinct from eicosanoid biosynthesis that drive inflammation as well as enhance the synthesis of endogenous protective anti-inflammatory factors. its true mechanism of action in anti-inflammation remains unclear. here the data from a series of recent experiments proposing that one of aspirin's predominant roles in inflammation is the induction of nitric oxide, which potently inhibits leukocyte/endothelium interaction during acute inflammation, will be discussed. it will be argued that this nitric oxide-inducing effects are exclusive to aspirin due to its unique ability, among the family of traditional anti-inflammatory drugs, to acetylate the active site of inducible cyclooxygenase and generate a family of lipid mediators called the epi-lipoxins that are increasingly being shown to have profound roles in a range of host defense responses.
Avian history is written by the winners
Derek W. Yalden
Frontiers of Biogeography , 2012,
Uniqueness of diffusion operators and capacity estimates
Derek W Robinson
Mathematics , 2013,
Abstract: Let $\Omega$ be a connected open subset of $\Ri^d$. We analyze $L_1$-uniqueness of real second-order partial differential operators $H=-\sum^d_{k,l=1}\partial_k\,c_{kl}\,\partial_l$ and $K=H+\sum^d_{k=1}c_k\,\partial_k+c_0$ on $\Omega$ where $c_{kl}=c_{lk}\in W^{1,\infty}_{\rm loc}( \Omega), c_k\in L_{\infty,{\rm loc}}(\Omega)$, $c_0\in L_{2,{\rm loc}}(\Omega)$ and $C(x)=(c_{kl}(x))>0$ for all $x\in\Omega$. Boundedness properties of the coefficients are expressed indirectly in terms of the balls $B(r)$ associated with the Riemannian metric $C^{-1}$ and their Lebesgue measure $|B(r)|$. \noindent\hspace{10mm}First we establish that if the balls $B(r)$ are bounded, the T\"acklind condition $\int^\infty_Rdr\,r(\log|B(r)|)^{-1}=\infty$ is satisfied for all large $R$ and $H$ is Markov unique then $H$ is $L_1$-unique. If, in addition, $C(x)\geq \kappa\, (c^{T}\!\otimes\, c)(x)$ for some $\kappa>0$ and almost all $x\in\Omega$, $\divv c\in L_{\infty,{\rm loc}}(\Omega)$ is upper semi-bounded and $c_0$ is lower semi-bounded then $K$ is also $L_1$-unique. \noindent\hspace{10mm}Secondly, if the $c_{kl}$ extend continuously to functions which are locally bounded on $\partial\Omega$ and if the balls $B(r)$ are bounded we characterize Markov uniqueness of $H$ in terms of local capacity estimates and boundary capacity estimates. For example, $H$ is Markov unique if and only if for each bounded subset $A$ of $\overline\Omega$ there exist $\eta_n \in C_c^\infty(\Omega)$ satisfying $\lim_{n\to\infty} \|\one_A\Gamma(\eta_n)\|_1 = 0$, where $\Gamma(\eta_n)=\sum^d_{k,l=1}c_{kl}\,(\partial_k\eta_n)\,(\partial_l\eta_n)$, and $\lim_{n\to\infty}\|\one_A (\one_\Omega-\eta_n )\, \varphi\|_2 = 0$ for each $\varphi \in L_2(\Omega)$ or if and only if $\capp(\partial\Omega)=0$.
Gaussian bounds, strong ellipticity and uniqueness criteria
Derek W. Robinson
Mathematics , 2014,
Abstract: Let $h$ be a quadratic form with domain $W_0^{1,2}(\Ri^d)$ given by \[ h(\varphi)=\sum^d_{i,j=1}(\partial_i\varphi,c_{ij}\,\partial_j\varphi) \] where $c_{ij}=c_{ji}$ are real-valued, locally bounded, measurable functions and $C=(c_{ij})\geq 0 $. If $C$ is strongly elliptic, i.e.\ if there exist $\lambda, \mu>0$ such that $\lambda\,I\geq C\geq \mu \,I>0$, then $h$ is closable, the closure determines a positive self-adjoint operator $H$ on $L_2(\Ri^d)$ which generates a submarkovian semigroup $S$ with a positive distributional kernel~$K$ and the kernel satisfies Gaussian upper and lower bounds. Moreover, $S$ is conservative, i.e.\ $S_t\one=\one$ for all $t>0$. Our aim is to examine converse statements. First we establish that $C$ is strongly elliptic if and only if $h$ is closable, the semigroup $S$ is conservative and $K$ satisfies Gaussian bounds. Secondly, we prove that if the coefficients are such that a Tikhonov growth condition is satisfied then $S$ is conservative. Thus in this case strong ellipticity of $C$ is equivalent to closability of $h$ together with Gaussian bounds on $K$. Finally we consider coefficients $c_{ij}\in W^{1,\infty}_{\rm loc}(\Ri^d)$. It follows that $h$ is closable and a growth condition of the T\"acklind type is sufficient to establish the equivalence of strong ellipticity of $C$ and Gaussian bounds on $K$.
Markov uniqueness of degenerate elliptic operators
Derek W. Robinson,Adam Sikora
Mathematics , 2009,
Abstract: Let $\Omega$ be an open subset of $\Ri^d$ and $H_\Omega=-\sum^d_{i,j=1}\partial_i c_{ij} \partial_j$ a second-order partial differential operator on $L_2(\Omega)$ with domain $C_c^\infty(\Omega)$ where the coefficients $c_{ij}\in W^{1,\infty}(\Omega)$ are real symmetric and $C=(c_{ij})$ is a strictly positive-definite matrix over $\Omega$. In particular, $H_\Omega$ is locally strongly elliptic. We analyze the submarkovian extensions of $H_\Omega$, i.e. the self-adjoint extensions which generate submarkovian semigroups. Our main result establishes that $H_\Omega$ is Markov unique, i.e. it has a unique submarkovian extension, if and only if $\capp_\Omega(\partial\Omega)=0$ where $\capp_\Omega(\partial\Omega)$ is the capacity of the boundary of $\Omega$ measured with respect to $H_\Omega$. The second main result establishes that Markov uniqueness of $H_\Omega$ is equivalent to the semigroup generated by the Friedrichs extension of $H_\Omega$ being conservative.
$L_1$-uniqueness of degenerate elliptic operators
Derek W. Robinson,Adam Sikora
Mathematics , 2010,
Abstract: Let $\Omega$ be an open subset of $\Ri^d$ with $0\in \Omega$. Further let $H_\Omega=-\sum^d_{i,j=1}\partial_i\,c_{ij}\,\partial_j$ be a second-order partial differential operator with domain $C_c^\infty(\Omega)$ where the coefficients $c_{ij}\in W^{1,\infty}_{\rm loc}(\bar\Omega)$ are real, $c_{ij}=c_{ji}$ and the coefficient matrix $C=(c_{ij})$ satisfies bounds $00$ where $\mu(s)=\int^s_0dt\,c(t)^{-1/2}$ then we establish that $H_\Omega$ is $L_1$-unique, i.e.\ it has a unique $L_1$-extension which generates a continuous semigroup, if and only if it is Markov unique, i.e.\ it has a unique $L_2$-extension which generates a submarkovian semigroup. Moreover these uniqueness conditions are equivalent with the capacity of the boundary of $\Omega$, measured with respect to $H_\Omega$, being zero. We also demonstrate that the capacity depends on two gross features, the Hausdorff dimension of subsets $A$ of the boundary the set and the order of degeneracy of $H_\Omega$ at $A$.
Ellipticity and Ergodicity
Derek W. Robinson,Adam Sikora
Mathematics , 2008,
Abstract: Let $S=\{S_t\}_{t\geq0}$ be the submarkovian semigroup on $L_2(\Ri^d)$ generated by a self-adjoint, second-order, divergence-form, elliptic operator $H$ with Lipschitz continuous coefficients $c_{ij}$. Further let $\Omega$ be an open subset of $\Ri^d$. Under the assumption that $C_c^\infty(\Ri^d)$ is a core for $H$ we prove that $S$ leaves $L_2(\Omega)$ invariant if, and only if, it is invariant under the flows generated by the vector fields $Y_i=\sum^d_{j=1}c_{ij}\partial_j$.
Degenerate elliptic operators in one dimension
Derek W. Robinson,Adam Sikora
Mathematics , 2009,
Abstract: Let $H$ be the symmetric second-order differential operator on $L_2(\Ri)$ with domain $C_c^\infty(\Ri)$ and action $H\varphi=-(c \varphi')'$ where $ c\in W^{1,2}_{\rm loc}(\Ri)$ is a real function which is strictly positive on $\Ri\backslash\{0\}$ but with $c(0)=0$. We give a complete characterization of the self-adjoint extensions and the submarkovian extensions of $H$. In particular if $\nu=\nu_+\vee\nu_-$ where $\nu_\pm(x)=\pm\int^{\pm 1}_{\pm x} c^{-1}$ then $H$ has a unique self-adjoint extension if and only if $\nu\not\in L_2(0,1)$ and a unique submarkovian extension if and only if $\nu\not\in L_\infty(0,1)$. In both cases the corresponding semigroup leaves $L_2(0,\infty)$ and $L_2(-\infty,0)$ invariant. In addition we prove that for a general non-negative $ c\in W^{1,\infty}_{\rm loc}(\Ri)$ the corresponding operator $H$ has a unique submarkovian extension.
Analysis of degenerate elliptic operators of Grushin type
Derek W. Robinson,Adam Sikora
Mathematics , 2006,
Abstract: We analyze degenerate, second-order, elliptic operators $H$ in divergence form on $L_2({\bf R}^{n}\times{\bf R}^{m})$. We assume the coefficients are real symmetric and $a_1H_\delta\geq H\geq a_2H_\delta$ for some $a_1,a_2>0$ where \[ H_\delta=-\nabla_{x_1} c_{\delta_1, \delta'_1}(x_1) \nabla_{x_1}-c_{\delta_2, \delta'_2}(x_1) \nabla_{x_2}^2 . \] Here $x_1\in{\bf R}^n$, $x_2\in{\bf R}^m$ and $c_{\delta_i, \delta'_i}$ are positive measurable functions such that $c_{\delta_i, \delta'_i}(x)$ behaves like $|x|^{\delta_i}$ as $x\to0$ and $|x|^{\delta_i'}$ as $x\to\infty$ with $\delta_1,\delta_1'\in[0,1>$ and $\delta_2,\delta_2'\geq0$. Our principal results state that the submarkovian semigroup $S_t=e^{-tH}$ is conservative and its kernel $K_t$ satisfies bounds \[ 0\leq K_t(x ;y)\leq a (|B(x ;t^{1/2})| |B(y ;t^{1/2})|)^{-1/2} \] where $|B(x ;r)|$ denotes the volume of the ball $B(x ;r)$ centred at $x$ with radius $r$ measured with respect to the Riemannian distance associated with $H$. The proofs depend on detailed subelliptic estimations on $H$, a precise characterization of the Riemannian distance and the corresponding volumes and wave equation techniques which exploit the finite speed of propagation. We discuss further implications of these bounds and give explicit examples that show the kernel is not necessarily strictly positive, nor continuous.
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