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Search Results: 1 - 10 of 2017 matches for " Derek Martyn "
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N-[5-(3-Phenylpropionyl)-1H-pyrrole-2-carbonyl]-L-proline Methyl Ester
Derek C. Martyn,Andrew D. Abell
Molbank , 2003, DOI: 10.3390/m338
Abstract: No abstract available
(R,S)-Benzyl 5-(1-Hydroxyethyl)-1H-pyrrole-2-carboxylate
Derek C. Martyn,Andrew D. Abell
Molbank , 2003, DOI: 10.3390/m337
Abstract: No abstract available
Citral Sensing by TRANSient Receptor Potential Channels in Dorsal Root Ganglion Neurons
Stephanie C. Stotz, Joris Vriens, Derek Martyn, Jon Clardy, David E. Clapham
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0002082
Abstract: Transient receptor potential (TRP) ion channels mediate key aspects of taste, smell, pain, temperature sensation, and pheromone detection. To deepen our understanding of TRP channel physiology, we require more diverse pharmacological tools. Citral, a bioactive component of lemongrass, is commonly used as a taste enhancer, as an odorant in perfumes, and as an insect repellent. Here we report that citral activates TRP channels found in sensory neurons (TRPV1 and TRPV3, TRPM8, and TRPA1), and produces long-lasting inhibition of TRPV1–3 and TRPM8, while transiently blocking TRPV4 and TRPA1. Sustained citral inhibition is independent of internal calcium concentration, but is state-dependent, developing only after TRP channel opening. Citral's actions as a partial agonist are not due to cysteine modification of the channels nor are they a consequence of citral's stereoisoforms. The isolated aldehyde and alcohol cis and trans enantiomers (neral, nerol, geranial, and geraniol) each reproduce citral's actions. In juvenile rat dorsal root ganglion neurons, prolonged citral inhibition of native TRPV1 channels enabled the separation of TRPV2 and TRPV3 currents. We find that TRPV2 and TRPV3 channels are present in a high proportion of these neurons (94% respond to 2-aminoethyldiphenyl borate), consistent with our immunolabeling experiments and previous in situ hybridization studies. The TRPV1 activation requires residues in transmembrane segments two through four of the voltage-sensor domain, a region previously implicated in capsaicin activation of TRPV1 and analogous menthol activation of TRPM8. Citral's broad spectrum and prolonged sensory inhibition may prove more useful than capsaicin for allodynia, itch, or other types of pain involving superficial sensory nerves and skin.
Matilda Betham-Edwards, Franco-British Cultural Go-between
Martyn Cornick
Synergies Royaume-Uni et Irlande , 2009,
Abstract: Matilda Betham-Edwards was a nineteenth-century writer who represented France to the British public in articles in reviews, magazines and books. After her death in 1919 her work seemed to have disappeared entirely from view until the publication of Joan Rees’s 2006 biography. In 1908, however, a month before the opening of the Franco-British Exhibition at the White City, it was reported that because of her long career and her services to FrancoBritish understanding, Betham-Edwards would have an exhibit devoted to her work. Her work was appreciated during her lifetime, both officially as well as by her readers, as in 1891 she was promoted Officier de l’Instruction publique, a signal French honour believed to be the first such award granted to a British person. This article explores how she explained the French to the British as well as the nature of her contribution to the Entente cordiale.Matilda Betham-Edwards expliquait les Fran ais et la culture, et la société, fran aises au public britannique dans les revues, les magazines et les livres. Après sa mort en 1919, son uvre semblait avoir disparu entièrement, du moins jusqu’à la publication de la biographie de Joan Rees en 2006. En 1908 pourtant, un mois avant l’ouverture de l’Exposition franco-britannique à la White City de Londres, pour marquer sa longue carrière et ses services au rapprochement franco-britannique, il fut annoncé que BethamEdwards serait honorée d’une présentation de ses livres. Son uvre fut appréciée de son vivant tant par les autorités que par son audience, car en 1891 elle fut promue Officier de l’Instruction publique, honneur jamais accordé jusque-là à un citoyen britannique. Cet article étudie comment elle représentait les Fran ais aux Britanniques, ainsi que la nature de sa contribution à l’Entente cordiale.
Historische und vergleichende Anmerkungen zur Beziehung zwischen analytischer Induktion und der Methodologie der Grounded Theory A Historical and Comparative Note on the Relationship Between Analytic Induction and Grounded Theorising Nota histórica y comparativa sobre la relación entre la inducción analítica y la teorización fundamentada
Martyn Hammersley
Forum : Qualitative Social Research , 2010,
Abstract: Analytische Induktion (AI) und die Methodologie der Grounded Theory (GTM) haben lange Zeit die Konzeptbildung und Praxis qualitativer Forschung beeinflusst. Zugleich bleibt deren Beziehung – sowohl hinsichtlich ihrer historischen Entwicklung als auch mit Blick auf ihre konzeptuelle Struktur – weitgehend unklar. In diesem Beitrag besch ftige ich mit einigen Hindernissen, die einem Verst ndnis entgegenstehen: Alfred LINDESMITH, ein Hauptarchitekt der AI und Anselm STRAUSS, Mitbegründer der GTM, studierten zur gleichen Zeit bei Herbert BLUMER und arbeiteten in verschiedenen Projekten zusammen. Aber nur STRAUSS leistete zusammen mit Barney GLASER einen detaillierten Vergleich beider Ans tze. Doch auch dieser Vergleich hinterl sst Verunsicherung über die genaue Art der hnlichkeiten und Differenzen und ihrer Gründe. Die Beziehung von AI und GTM zu BLUMERs methodologischem Erbe erschwert eine Einordnung noch zus tzlich. URN: urn:nbn:de:0114-fqs100243 Analytic induction (AI) and grounded theorising (GT) have long been influential models for conceptualising and guiding particular kinds of qualitative research. However, the relationship between them, in terms of both historical development and conceptual structure, is not always clearly understood. As I show in this article, there are obstacles to understanding these matters. Alfred LINDESMITH, one of the major architects and champions of AI, and Anselm STRAUSS, co-inventor of GT, were students of Herbert BLUMER at the same time, and collaborated on various projects. However, only STRAUSS, with Barney GLASER, provided a detailed comparison between the two approaches. Moreover, even this leaves us with some uncertainties about the precise nature of the similarities and differences, and the reasons for these. The relationship of AI and GT to BLUMER's methodological thinking is even more obscure. URN: urn:nbn:de:0114-fqs100243 La inducción analítica (IA) y la teorización fundamentada (TF) han sido durante mucho tiempo influyentes modelos para conceptualizar y orientar determinados tipos de investigación cualitativa. Sin embargo, la relación entre ellos, tanto en términos de desarrollo histórico como de estructura conceptual, no siempre ha sido claramente comprendida. Como muestro en este artículo, existen obstáculos para la comprensión de estas cuestiones. Alfred LINDERSMITH, uno de los principales arquitectos y campeones de la IA, y Anselm STRAUSS, co-inventor de la teoría fundamentada, fueron estudiantes de Herbert BLUMER al mismo tiempo y colaboraron en varios proyectos. Sin embargo, solamente STRAUSS, junto con
'Oscar Wilde's imprisonment and an early idea of "Banal Evil" ' or 'Two "wasps" in the system. How Reverend W.D. Morrison and Oscar Wilde challenged penal policy in late Victorian England'
Martyn Housden
Forum Historiae Iuris , 2006,
Abstract: In the mid 1890s Oscar Wilde was imprisoned for a homosexual relationship with the son of the Duke of Queensberry. Within weeks there were rumours that conditions within British prisons were so severe that the poet and playwright was showing signs of mental illness. Concerns over Wilde's health helped generate substantial interest in how British penal policy was conducted and contributed to a growing momentum for prison reform. This essay relates Oscar Wilde's experiences to the modernisation of the British prison system. It shows how the issues raised by his imprisonment overlapped with those discussed by the Gladstone Report of April 1895. More importantly, the essay also highlights the little-known critique of the prison system which Wilde published after his release. As he put it: 'Ordinary cruelty is simply stupidity..... Wherever these is centralisation there is stupidity. What is inhuman in modern life is officialism. Authority is as destructive to those who exercise it as to those on whom it is exercised.' In other words, the article shows how Wilde started to develop a discussion of the potential failings of modern bureacracies which more frequently is associated with theorists such as Arendt and Baumann.
Dynamic Maps in Humanities Computing
Martyn Jessop
Human IT: Tidskrift f?r Studier av IT ur ett Humanvetenskapligt Perspektiv , 2006,
Abstract: This paper discusses how and why dynamic maps are better suited to the re-quirements of humanities scholars than conventional cartography or GIS systems. It highlights some of the strengths of dynamic maps and shows their value to humanities computing projects. However, there are also a number of weaknesses with existing technology and techniques. These are discussed and possible ways forward are suggested. It illustrates some of the issues by reference to the experiences of two case study projects that have been conducted at the Centre for Computing in the Humanities at King’s College London.
Making online learning accessible to disabled students: an institutional case study
Martyn Copper
Research in Learning Technology , 2006, DOI: 10.3402/rlt.v14i1.10936
Abstract: Based on the authors' reflections on experience working at the Open University, approaches to making online learning accessible to disabled students are considered. The considerations are applicable to all concerned with online learning and indeed anyone seeking to trade, disseminate information and mediate services online. In reflecting on the Open University experience of making online material accessible, pedagogic, organisational and cultural issues are highlighted and it is argued that it is important to address these issues in order to effect the organisational change needed to ensure that accessibility challenges are effectively met.
New Directions in the History of Written Culture
Lyons, Martyn
Culture & History Digital Journal , 2012, DOI: 10.3989/chdj.2012.007
Abstract: This article reviews some new directions in the history of writing practices, concentrating on Western Europe and the Americas in the nineteenth and early twentieth centuries. I identify some major intellectual influences on the field, deriving from historiography, anthropology and literary studies. I indicate some important archives specialising in popular writings which sustain the study of the writings of ordinary and semi-literate people. A few selected topics in which the history of writing practices makes a contribution are then briefly reviewed. These are, firstly, the history of correspondence and letter-writing instruction manuals, which introduces two important concepts: the ‘epistolary pact’ and ‘epistolary literacy’. Secondly, I introduce three new works on the development of postal services, stressing their role in forging national cohesion. Thirdly, I indicate how the study of emigrants’ writings has contributed to a shift of focus in the study of emigration in general. I conclude that the history of scribal culture can make a significant contribution to socio-cultural history, provided that writing is analysed in its material form, and as a text, not simply as a source of information. Writing practices deserve serious study as a social and cultural phenomenon in their own right. Este artículo revisa algunas tendencias nuevas en la historiografía a propósito de las prácticas de escritura, concentrándose en Europa occidental y las Américas durante en el siglo XIX y principios del XX. Se alo en él algunas de las mayores influencias intelectuales que han incidido en este campo, provenientes de la historiografía, la antropología y los estudios literarios. Indico algunos importantes archivos especializados en escritura popular en los que se basa el estudio de los escritos de la gente corriente y semi-alfabetizada. Después reviso brevemente unos cuantos temas escogidos a los que ha hecho su aportación la historia de las prácticas de escritura: primero, la historia de la correspondencia y de las cartillas de instrucción para escribir cartas, que introducen dos importantes conceptos: el “pacto epistolar” y la “alfabetización epistolar”; en segundo lugar, presento tres nuevos trabajos sobre el desarrollo de los servicios postales, destacando su papel en la forja de la cohesión nacional; y en tercer lugar, indico cómo el estudio de los escritos de emigrantes ha contribuido a cambiar el enfoque en el estudio de la emigración en general. Concluyo que la historia de la cultura escrita puede proporcionar una contribución significativa a la historia soci
Writers into Intellectuals, Culture into Politics: Grappling with History in the NRF, 1920-1940
E-rea : Revue électronique d’études sur le Monde Anglophone , 2006, DOI: 10.4000/erea.214
Abstract: It is now commonplace to view the end of the Great War in 1918 as representing the beginnings of a new world order. The human losses, the vanished empires, the Bolshevik revolution and its lasting consequences, the collapse of the intellectual certainties of the pre-war order, all ensured the irruption of History and Politics into cultural spaces within the European public sphere. The politicisation of cultural spaces was inevitable, given that purveyors of culture—writers and intellectuals—w...
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