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Search Results: 1 - 10 of 220 matches for " Demet Gunay "
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The role of mediastinal adipose tissue 11β-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease
Fatmahan Atalar, Selcuk Gormez, Baris Caynak, Gokce Akan, Gamze Tanriverdi, Sema Bilgic-Gazioglu, Demet Gunay, Cihan Duran, Belhhan Akpinar, Ugur Ozbek, Ahmet Buyukdevrim, Zeliha Yazici
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-115
Abstract: Our objective was to evaluate the role of EAT and MAT 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and glucocorticoid receptor (GCR) expression in comparison with subcutaneous adipose tissue (SAT) in the development of coronary atherosclerosis in obese patients with coronary artery disease (CAD), and to assess their correlations with CD68 and fatty acids from these tissues.Expression of 11β-HSD-1 and GCR was measured by qRT-PCR in EAT, MAT and SAT of thirty-one obese patients undergoing coronary artery bypass grafting due to CAD (obese CAD group) and sixteen obese patients without CAD undergoing heart valve surgery (controls). 11β-HSD-1 and GCR expression in MAT were found to be significantly increased in the obese CAD group compared with controls (p?<?0.05). In the obese CAD group, 11β-HSD-1 and GCR mRNA levels were strongly correlated in MAT. Stearidonic acid was significantly increased in EAT and MAT of the obese CAD group and arachidonic acid was significantly expressed in MAT of the obese male CAD group (p?<?0.05).We report for the first time the increased expression of 11β-HSD-1 and GCR in MAT compared with EAT and SAT, and also describe the interrelated effects of stearidonic acid, HOMA-IR, plasma cortisol and GCR mRNA levels, explaining 40.2% of the variance in 11β-HSD-1 mRNA levels in MAT of obese CAD patients. These findings support the hypothesis that MAT contributes locally to the development of coronary atherosclerosis via glucocorticoid action.In obesity, fat depots localized around the heart are reported to contribute to the pathogenesis of coronary artery disease (CAD) [1-3]. Epicardial adipose tissue (EAT) generates various bioactive molecules which significantly affect cardiac function, and their association with the severity of CAD was has also been reported [2,4]. Human and animal studies have demonstrated EAT is located near to the arteries and that segments of an artery surrounded by EAT develop atherosclerosis faster than the intra-m
From the editor
Osman Gunay
Turkish Journal of Public Health , 2012, DOI: 10.5421/10.5421/1304.1086
The Efficacy of Specimen Radiography in Clinically Occult Breast Lesions
Trakya Universitesi Tip Fakultesi Dergisi , 2008,
Abstract: Objectives: The aim of this study was to evaluate the efficacy of specimen radiography for clinically occult breast lesions.Patients and Methods: We retrospectively evaluated specimen radiographs of 215 patients (mean age 48.64±8.4 years; range 28 to 75 years) whose lesions were detected by mammography and/or ultrasonography and localized by wire. Preoperative wire localization was performed under the guidance of ultrasonography in 59 cases (27.4%) and stereotactically in 156 cases (72.6%). The findings of specimen radiography were compared with those of histopathologic examination.Results: Specimen radiographs showed lesions in all but three cases. In these three cases, no breast lesions were found in control mammographies.Conclusion: Breast biopsy specimen radiography is a safe method to ensure complete excision of clinically occult breast lesions.
Matching trees for simplicial complexes and homotopy type of devoid complexes of graphs
Demet Taylan
Mathematics , 2015,
Abstract: We generalize some homotopy calculation techniques such as splittings and matching trees that are introduced for the computations in the case of the independence complexes of graphs to arbitrary simplicial complexes, and exemplify their efficiency on some simplicial complexes, the devoid complexes of graphs, which are simplicial complexes parametrized by graphs. Additionally, we compute the homotopy type of dominance complexes of chordal graphs.
Incidence and Surgical Importance of Zuckerkandl’s Tubercle of the Thyroid and Its Relations with Recurrent Laryngeal Nerve
Emin Gurleyik,Gunay Gurleyik
ISRN Surgery , 2012, DOI: 10.5402/2012/450589
Incidence and Surgical Importance of Zuckerkandl’s Tubercle of the Thyroid and Its Relations with Recurrent Laryngeal Nerve
Emin Gurleyik,Gunay Gurleyik
ISRN Surgery , 2012, DOI: 10.5402/2012/450589
Abstract: Background. Variations of recurrent laryngeal nerve (RLN) and Zuckerkandl’s tubercle (ZT), which is posterior extension of lateral lobes, may affect safety of thyroidectomy. Methods. Total and hemithyroidectomy were surgical procedures in 60 and 40 patients, respectively. Surgical anatomy was studied in 87 right and 73 left lobes. Presence of ZT was noted and its incidence was determined. RLNs were identified and fully isolated. Relationship between ZT and RLN was established. Results. ZTs were identified in 66 (66%) patients and in 81 (51%) lobes. ZT was present in 53 (61%) right and in 28 (38%) left lobes. ZTs were bilateral in 15 (25%) of 60 total thyroidectomy cases. Smaller tubercles show the neurovascular crossing point. RLN was posterior (medial) to ZT in 76 (94%) occurrences. RLN was laying on anterior surface of ZT only in 5 (6%) instances. Conclusions. RLN is unusually laying lateral to ZT which is common structure in the thyroid. Lateral RLN may be more vulnerable to injury. Total thyroidectomy requires dissection of ZT adjacent to RLN. Based on unusual relations and variations, RLN should be fully isolated before excision of adjacent structures. 1. Introduction A thyroid surgeon must have intimate knowledge about all anatomic variations of the gland affecting the safety of surgical operations. Emil Zuckerkandl (1849–1910), an Austrian anatomist has described many anatomical structures in the body [1, 2]. Zuckerkandl’s tubercle (ZT) is defined as posterior extension of the lateral lobes composing of thyroid tissue only [3]. It should be included in the Nomina Anatomica as the “processus posterior glandulae thyroideae” described by Zuckerkandl [4]. It is classified into four groups according to size [5, 6]. The surgical importance of ZT can be summarized as (1) dissection and excision of ZT for total thyroidectomy and (2) close relationship between ZT and recurrent laryngeal nerve (RLN). The completeness of thyroidectomy requires removal of enlarged ZT which is posterolateral extension of thyroid lobes adjacent to RLN. Close relation of two structures urges careful, fine, and very close dissection around the nerve. Due to posterior location of an enlarged ZT, thyroid surgeon must be focused on its relations with inferior laryngeal nerve for safe identification of the nerve and resection of the tubercle. The presence of ZT and close association of RLN to an enlarged tubercle has been documented in many patients [7–10]. We aim to study the presence of ZT, its relations with RLN, and variations of this relationship during surgical dissection of
Journal of Economics Business and Political Researches , 2017, DOI: 10.25204/iktisad.305082
Abstract: When considered economic changes and developments in the world it is seen that the need for professionals with the knowledge and skills to meet the expectations and needs of the job market is constantly increasing. Especially members of the profession who are responsible for the execution of transactions related to money namely it is supply of importance that constantly increase and to be open to innovations necessity of knowledge and skills of professional accountants. Because of these reasons, their employed or willing to be employed workers, have the required qualifications with the professional accountants in the market, are closely related to the institutions that provide education in the field of accounting. Perceptions from accounting education is to reveal the adequacy of the job market accounting education given at universities while expectations from accounting education uncover the situation of what the job market wants to be in accounting education. Perceptions of expectations are expected to increase in parallel with changing conditions and innovations. Accounting education is given in vocational high schools and universities of in some parts. The purpose of this study aims to examine the interaction with the labour market of the accounting education given at universities.
Which Offers the Best? Stent Graft or Bare Metal Stent for Endovascular Treatment of Aortoiliac Disease  [PDF]
Ozcan Gur, Ozkaramanli Gur Demet, Gurkan Selami
World Journal of Cardiovascular Diseases (WJCD) , 2018, DOI: 10.4236/wjcd.2018.811048
Abstract: Background: In the present study, it was aimed to compare the stent grafts and bare-metal stents in terms of post-procedural patency, clinical recovery and complications in the subjects with symptomatic aorto-iliac arterial disease. Methods: A total of 79 subjects with symptomatic aorto-iliac arterial disease treated with endovascular methods were included in the present study. Forty three subjects received self-expendable bare metal stent (ev3 Protégé stent system, Endovascular Inc., Plymouth, Minnesota, USA) and 36 subjects received PTFE-covered stent graft (Fluency Plus Stent Graft, Bard Peripheral Vascular, Tempe, Arizona). The subjects were compared after and at Months 1, 6, and 12 following the procedure in terms of Rutherfords classification, ankle-arm index (AAI), patency rates, and complications. Results: The subjects receiving bare metal stent and stent graft for aorto-iliac arterial disease were followed for averagely 15 months. For the subjects receiving bare metal stent, primary patency rates at months 1, 6, and 12 were 98%, 81%, and 70%, respectively, while secondary patency rate at month 12 was found to be 84%. For the group of stent graft, primary patency rates were found as 97%, 97%, and 92%, respectively and secondary patency rate at month 12 was found to be 94%. Stent grafts were applied at the same time in 2 patients who had metal bare metal because the rupture occurred during the procedure. In the comparison between two groups, the group of stent graft was found to be statistically superior to the other in terms of patency, clinical and post-procedural complications. Conclusion: In conclusion, it was found that the stent grafts were superior to the bare metal stents in terms of patency and complication rates in the subjects with symptomatic aortoiliac disease.
Novel object recognition is not affected by age despite age-related brain changes  [PDF]
Ilay Aktoprak, Pelin Dinc, Gizem Gunay, Michelle M. Adams
World Journal of Neuroscience (WJNS) , 2013, DOI: 10.4236/wjns.2013.34036

Age-related memory impairments show a progressive decline across lifespan. Studies have demonstrated equivocal results in biological and behavioral outcomes of aging. Thus, in the present study we examined the novel object recognition task at a delay period that has been shown to be impaired in aged rats of two different strains. Moreover, we used a strain of rats, Fisher 344XBrown Norway, which have published age-related biological changes in the brain. Young (10 month old) and aged (28 month old) rats were tested on a standard novel object recognition task with a 50-minute delay period. The data showed that young and aged rats in the strain we used performed equally well on the novel object recognition task and that both young and old rats demonstrated a righthanded side preference for the novel object. Our data suggested that novel object recognition is not impaired in aged rats although both young and old rats have a demonstrated side preference. Thus, it may be that genetic differences across strains contribute to the equivocal results in behavior, and genetic variance likely influences the course of cognitive aging.

Vaginal, Cervical and Uterine Bacterial Flora at the Different Stages of the Reproductive Cycle in Ovariohysterectomized Bitches
Ulgen Gunay,Kaan Onat,Aytekin Gunay,Mihriban Ulgen
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2010.478.481
Abstract: The aim of the present study was to determine vaginal, cervical and uterine bacterial flora at the different stages of the reproductive cycle in mixed-bred bitches. Vaginal, cervical and uterine swab specimens were obtained from 55 bitches (Anoestrus = 11, Proestrus = 16, Oestrus = 13, Metoestrus = 9 and Pregnant = 6) at ovariohysterectomy. A total of 61 bacteria were isolated from vagina. These organisms include Yeast (45.4%) and E. coli (30.9%), Proteus sp. (20%), Streptococcus sp. (12.7%) and Enterococcus sp. (1.8%) have been isolated. The mean number of isolates from vagina was 1.2. High bacterial counts in the vagina were found proestrus and oestrus. The results indicated that no bacteria were isolated from the cervix and the uterus and no mycoplasmas were cultured in vagina, cervix and uterus. The uterine microflora did not reflect the vaginal and cervical microflora.
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