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Search Results: 1 - 10 of 415 matches for " DelVecchio MT "
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Utility of adjunctive macrolide therapy in treatment of children with asthma: a systematic review and meta-analysis
Mikailov A, Kane I, Aronoff SC, Luck R, DelVecchio MT
Journal of Asthma and Allergy , 2013, DOI: http://dx.doi.org/10.2147/JAA.S38652
Abstract: ility of adjunctive macrolide therapy in treatment of children with asthma: a systematic review and meta-analysis Review (1533) Total Article Views Authors: Mikailov A, Kane I, Aronoff SC, Luck R, DelVecchio MT Published Date January 2013 Volume 2013:6 Pages 23 - 29 DOI: http://dx.doi.org/10.2147/JAA.S38652 Received: 29 September 2012 Accepted: 06 November 2012 Published: 16 January 2013 Anar Mikailov,1 Ilona Kane,2 Stephen C Aronoff,3 Raemma Luck,3, Michael T DelVecchio3 1Beth Israel Deaconess Medical Center, Boston, MA, 2St Christopher's Hospital for Children, Philadelphia, PA, 3Department of Pediatrics, Temple University School of Medicine, Philadelphia, PA, USA Raemma Luck is now deceased Background: The purpose of this study was to investigate macrolides as an adjunct to an asthma controller regimen in children with asthma. Methods: Prospective clinical trials of macrolide therapy in children with asthma using outcome measures of change in forced expiratory volume in one second (FEV1) and/or oral corticosteroid requirement were searched for in PubMed up to December 2009. The reference lists of studies were also included in the analysis, as well as those listed in published meta-analyses. Results: The literature search yielded 116 studies, six of which were included in this meta-analysis. The change in FEV1 from baseline with adjunctive use of macrolide therapy in all children was not significant (0.25% predicted; 95% confidence interval [CI] 0.37, 0.86 predicted, P = 0.43); however, the change in FEV1 among children receiving daily oral corticosteroids was significant (3.89% predicted; 95% CI 0.01, 7.79, P = 0.05). Addition of macrolide therapy to the treatment of children with oral corticosteroid-dependent asthma resulted in a statistically significant decrease in daily corticosteroid dosage ( 3.45 mg/day; 95% CI 5.79, 1.09 mg/day, P = 0.004). This reduction in daily corticosteroid dosage was directly proportional to the duration of macrolide therapy ( 0.17 mg methylprednisolone per week of macrolide therapy; 95% CI 0.33, 0.021, P = 0.025). Conclusion: Addition of macrolides to the treatment regimen of children with oral corticosteroid-dependent asthma improves FEV1 and decreases the daily dosage of corticosteroids required for control in these children. The degree of dose reduction is directly related to the duration of macrolide therapy. Additional large, randomized, placebo-controlled trials of adjunctive macrolide use in children with oral corticosteroid-dependent asthma are required to verify this observation.
Using magnetic resonance to diagnose breast cancer and predict therapeutic response
MT Nelson
Breast Cancer Research , 2004, DOI: 10.1186/bcr834
Abstract: Women scheduled for a breast biopsy or scheduled to CT were recruited for our study. All studies were done with a 4 T MRI/MRS scanner. A baseline scan was done prior to the start of CT and 24 hours after CT. Suspicious lesions were identified and measured with a fat-suppressed high-resolution 3D FLASH image (Gd-TPA, 0.1 mmol/kg). Concentrations of tCho were quantified [3]. Each scan was interpreted by evaluation of lesion size, architecture, signal intensity, and tCho.Twenty-six out of 69 patients had infiltrative ductal carcinoma, 10/69 patients had infiltrative lobular carcinoma, 3/69 patients had ductal carcinoma in situ, 1/69 patients had lobular carcinoma in situ, and 29/69 patients were found to have benign breast lesions. Eight patients have been through CT. Tumor response was seen in six patients. MRS could detect decreased [tCho] within 24 hours after CT. In the six patients with decreased [tCho] at 24 hours, 100% showed diminished tumor size measured by MRI after 9 weeks of CT. However, the two patients with sustained or elevated [tCho] at 24 hours failed to have response to CT.Based on these results, we expect that the addition of MRS to MRI will provide a noninvasive technique for determining whether a breast abnormality is benign or malignant. Furthermore, the [tCho] measured at 24 hours appears to predict response to CT.
The methylenetetrahydrofolate reductase gene variant (C677T) in risk mothers with Down syndrome among Saudi population
MT Tayeb
Egyptian Journal of Medical Human Genetics , 2012,
Abstract: This unreeled study aimed to examine the relationship between the genetic polymorphisms C677T in MTHFR gene and mapped this figure with other ethnic populations. The present study examined 70 Saudi females (30 mothers with DS children plus 40 healthy mothers who gave birth only to healthy children) for C677T genotypes using restriction fragment length polymorphism (RFLP) of the amplified genomic DNA. The frequencies of the combined mutant genotypes CT and TT in the MTHFR gene were modestly represented in the case mothers compared to that in controls (33% vs. 35% and 13% vs. 10%) with no significance (OR 1.1, 95% CI, 0.41–2.77, p= 0.91). The frequency of the mutant 677T allele was 28% in the case mothers and plotted as a moderate value with different ethnic populations. The present study concluded that there was a null association between the common C677T polymorphism and the increased risk of Down syndrome, but the T allele slightly supported the increase of this maternal risk. The intermediacy to previous reports may probably be due to the small sample size, gene-nutritional-environmental factors, or the consequences of much social intermarriage between some Asian, Arab peoples and the Saudi community.
Association of the UCP2 –866G/A polymorphism with type 2 diabetes and obesity in Saudi population
MT Tayeb
Egyptian Journal of Medical Human Genetics , 2009,
Abstract: Background: Diabetes mellitus is emerging as a major public health problem allover the world particularly Saudi Arabia. Recent studies reported that Uncoupling Protein 2 (UCP2) was associated with obesity and type 2 diabetes (T2D). Aim of the Study: This study was conducted to clarify the contribution of polymorphism in UCP2 in obesity and T2D in the Saudi population. Subjects and Methods: The distribution of the –866G/A polymorphism was examined in a case-control study including samples from 110 obese patients, 81 T2D patients, 96 obese-T2D patients and 100 healthy unrelated Saudi subjects. The –866G/A polymorphism were determined by using PCR/RFLP (polymerase chain reaction/restriction fragment length polymorphism) techniques. Results: The results of this study showed that the frequency of the GG genotype was significantly higher in both obese and T2D patients (p-value= 0.0001, p-value= 0.014, respectively) compared with healthy control. The G allele was significantly associated with increase risk of obesity (odd ratio, OR: 3.3; 95% confidence interval, CI: 1.37-7.98), but not with T2D (OR, 1.97; Cl, 0.80-4.87). In obese-T2D patients group, no significant correlation with –866G/A polymorphism (p= 0.067; OR, 1.21; Cl, 0.25-2.80). This unreeled study suggested that the G allele of UCP2 –866G/A polymorphism was related to obesity, which indicated the possible role of this polymorphism in causing metabolic syndrome. Conclusion: This study concluded that the G allele of UCP2 –866G/A polymorphism might be related to obesity and T2D which might be used as a predictive marker for obesity and T2D. Key Words: T2D, Obesity, Uncoupling protein 2 (UCP2) gene, –866G/A polymorphism, Saudi population.
Evaluation of the Protection against Infectious Bursal Disease (IBD) Challenge in Progeny Born to Parents Having Received a Vaccination Program Using a Herpesvirus of Turkey-Infectious Bursal Disease (HVT-IBD) Vector Vaccine  [PDF]
Stephane Lemiere, Jean-Claude Gauthier, Angeli Kodjo, Laure Vinit, Andrea Delvecchio, Francesco Prandini
World Journal of Vaccines (WJV) , 2013, DOI: 10.4236/wjv.2013.32008

Broiler breeder vaccination against IBD is usually based on the injection of at least one inactivated vaccine in oil adjuvant, typically included in a combined vaccine. Priming using one or several IBD vaccine (s) has been the most common way to immunize the breeders so far. In summary, protection against vvIBD challenge in chicks of one commercial genetic line vaccinated in ovo with the HVT-IBD vector vaccine was demonstrated. The parents’ IBD vaccination program, using the HVT-IBD vector vaccine alone, the HVT-IBD vector vaccine plus IBD inactivated vaccine, and inactivated IBD vaccine alone, did not impair their progeny’s in ovo HVT-IBD vector vaccine take and subsequent protection against vvIBD virus challenge. An advantage in terms of immunization of the progeny against vvIBD was shown in the chicks born to breeders vaccinated with the HVT-IBD vaccine as a primer, as compared to breeders vaccinated with the inactivated vaccine alone. High level of IBD maternally-derived antibodies transmitted to the progeny by their parents induces together with an early onset of immunity by in ovo injection of a HVT-IBD vector vaccine clinical protection, as monitored on bursas, after vvIBD virus challenge.

Murni Rachmawati, MT,Andy Mappajaya, MT
Academic Research International , 2012,
Abstract: The 21st century architecture is faced with three major issues: nature, technology and humanity. Java architecture which derived from the philosophy of Java was known by its local wisdom. However, it is not known whether the wisdom is related with the issues of the 21st century or not. For that conducted the study which obtains the position of Java’s wisdom when viewed from the three issues: the handling of nature, technology and humanity in architecture. The data was derived from literatures and field study. The method used is criticism and logical argumentation. The final result is the suitability and unsuitability of Java’s wisdom with the issue of the 21st century. Java’s wisdom actually suits the three issues because they already had their own wisdom which able to handle these issues, but not all writes on literatures.
Starter dietary lysine level and strain cross effects on performance and carcass traits of broiler females
Corzo, A;Kidd, MT;
Revista Brasileira de Ciência Avícola , 2004, DOI: 10.1590/S1516-635X2004000200004
Abstract: dietary lysine has been shown to impact the performance of broilers, particularly with aspect of breast meat accretion and yield. there have been studies that suggest that early dietary lysine has an effect on breast meat yield in male broilers. a study was designed to evaluate starter dietary lysine (1.20 vs 1.35% of diet as achieved by the addition of l-lysine at the expense of a filler) effect on performance of female broilers from three different genetic strain crosses, and monitor subsequent effects at 41 and 56 d of age. body weight and feed consumption were higher for birds consuming the high lysine starter diet, but feed conversions were similar when compared to the low lysine diet. body weight and feed conversion were similar among strains. mortality was unaffected by lysine level and strain cross. carcass and breast meat weight, but not yields, were higher in birds fed the high lysine diet. at 56 d differences in carcass yield, abdominal fat, and breast meat yield were seen among strains, such that the strain with highest yield had the least amount of abdominal fat in terms of absolute weight and percentage. no effect on processing yields by dietary lysine was observed at any time regardless of the growing characteristics of the broilers. however, for early slaughter ages, feeding high levels of dietary lysine during the starter phase could prove to be convenient when maximum live performance or breast meat absolute values are desiredin order to maintain the commercial quality of final products.
Preliminary results of the analysis of the population structure of the Nile perch (Lates niloticus linnaeus, 1758) of Lake Victoria using microsatellite markers
MT Mwanja, WW Mwanja
African Journal of Biotechnology , 2008,
Abstract: Preliminary results are provided of a study instituted to analyze the genetic population structure of the Nile perch in Lake Victoria since 2002. 293 individuals from six geographically distinct locations within the lake were analyzed using two polymorphic microsatellite DNA markers. Tests for differentiation with an overall FST = 0.03 (P < 0.05) suggested that populations were genetically differentiated, with the closet population pairs Nyaburu-Rubafu and Mirunda-Maboko as the most differentiated populations. There was an extensive gene flow between the populations (Nm = 20.77). The overall gene diversity (0.17) was low. All the results point to the fact that Nile perch was only recently introduced species in the lake based on a small founder population, which though slow in establishing later exploded to become the most dominant species in the lake. On the whole the two loci indicate some level of differentiation between locations; however, the levels of genetic differentiation shown by the two loci were not enough to define the structure of Nile perch stocks, and assess the level of exchange between locations. Further work is underway using bigger number of microsatellite markers.
Prevalence and Socio-Demographic Correlates for Mental Illness Among Inmates at Lusaka Central Prison, Zambia
MT Nseluke, S Siziya
Medical Journal of Zambia , 2011,
Abstract: Objectives: To determine the prevalence and sociodemographic correlates for mental illness among inmates at Lusaka Central Prison, Zambia. Design: Cross sectional study. Main outcome measure: Mental illness. Results: Of the 206 inmates in Lusaka, 63.1% had current mental illness. Among the factors considered in the study, only marital status was significantly associated with mental illness. Married participants were 40% (OR=0.60; 95% CI [0.36, 0.98]) less likely to have mental illness compared with participants who were who were separated/divorced. Conclusions: A high prevalence of mental health problems was observed among inmates at Lusaka Central prison. Marital status should be considered in designing interventions to reduce the high prevalence of mental illness among inmates in Lusaka, Zambia.
A preliminary study of inflammatory markers in non-alcoholic steatohepatitis patients
MT Priya, DS Sheriff
Libyan Journal of Medicine , 2010,
Abstract: It was reported that C-reactive protein (CRP) levels increase in parallel with the progression of chronic liver diseases, such as chronic hepatitis and liver cirrhosis. Inflammatory markers, such as high sensitive C-reactive protein (hsCRP), ferritin, transferrin, albumin, alpha-1 acid glycoprotein (AAG), alpha-2 macroglobulin (AMG), alpha-1 anti-trypsin (AAT) and lipoprotein a [Lp(a)] were measured in coronary artery disease patients (CAD) and CAD patients with non-alcoholic steatohepatitis (NASH). In the present preliminary study an attempt was made to study whether there is an increase in the levels of CRP in CAD patients associated with NASH. CAD patients showed an increase in CRP and serum ferritin levels. In CAD patients with NASH along with an increase in the levels of serum ferittin (p<0.001), the levels of serum AMG and ceruloplasmin (CP) were also increased (p<0.01). The CAD patients with NASH had a higher proportion of diabetes, hypertension and dyslipidaemia compared to CAD patients. But how this difference contributes to the elevation in acute inflammatory markers particularly AMG and CP levels in CAD patients with NASH cannot be explained. This study shows that a substantial number of CAD patients may be associated with NASH. Non-invasive simple parameters that reflect the degree of inflammation and fibrosis of the liver in patients with NASH would facilitate improved understanding and treatment of the disease. Further studies may be necessary to evaluate the percentage of NASH patients progressing to CAD.
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