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Search Results: 1 - 10 of 388 matches for " Deepa Eveleigh "
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Performance evaluation of commercial miRNA expression array platforms
Sachin Sah, Matthew N McCall, Deepa Eveleigh, Michael Wilson, Rafael A Irizarry
BMC Research Notes , 2010, DOI: 10.1186/1756-0500-3-80
Abstract: We compared the performance characteristics of four commercial miRNA array technologies and found that all platforms performed well in separate measures of performance.The Ambion and Agilent platforms were more accurate, whereas the Illumina and Exiqon platforms were more specific. Furthermore, the data analysis approach had a large impact on the performance, predominantly by improving precision.MicroRNAs (miRNAs) are endogenous, non-coding transcripts that regulate a diverse range of functions, including development, differentiation, growth, apoptosis and metabolism. These 17-24 nucleotide RNA molecules confer specific recognition of target mRNAs and modulate gene expression by acting in conjunction with a set of effector proteins of the RNA interference pathway [1,2]. Through this interaction, miRNAs negatively regulate expression of specific target mRNAs by inhibiting translation, sequestering transcripts in P-bodies [3], or by accelerating mRNA decay as a consequence of rapid deadenylation[4]. Moreover, miRNAs have recently been proposed to activate translation of mRNAs under certain conditions [5].The relative abundance of miRNAs in cells is thought to be important for miRNAs to exert their regulatory function. For example, titrated expression of both genomic copies of mouse miR-1 is required for normal heart formation and function during embryogenesis [6]. Aberrant miRNA expression contributes to malignancies, tumor progression and metastasis (reviewed in [7]), and miRNA expression profiles can be correlated with disease pathogenesis and prognosis [8,9]. Thus, the performance characteristics of technologies that measure the relative abundance of miRNAs is important for effectively deciphering their functional roles and their potential utility as diagnostic biomarkers.Microarray technology permits simultaneous expression measurements for hundreds of miRNAs. This technology is already widely used and promises to become a standard tool in the near future. However
Mushrooms for the Millions
Douglas Eveleigh
Journal of Microbiology & Biology Education , 2012, DOI: 10.1128/jmbe.v13i1.407
Abstract: -
Reflections on the United States Military 1941-1987
Mary Mandels, Douglas E Eveleigh
Biotechnology for Biofuels , 2009, DOI: 10.1186/1754-6834-2-20
Abstract: Mary broke the promotional glass ceiling in her own field, all the more remarkable from the perspective that she was born 3 years before women gained the right to vote. Her talents as the family storyteller, enthralling her four siblings while growing up, later reflected her abilities as an outstanding mentor to young scientists. Mary's passions went beyond her career with a love of nature and the outdoors, taking frequent canoe, hiking, skiing, and camping trips. She had a broad fascination for science, foci including her encyclopedic knowledge of plants and wildlife. When not outdoors Mary enjoyed listening to music, from opera to 'Bobby' Dylan, as she called him. Her voracious appetite for books was apparent by the tomes that covered her coffee table. She was never shy to share her political opinions and would send long handwritten letters to politicians who did something to her disapproval. She was strong willed and passionate in everything that she did. In particular was her love of the nation and of the US Army, and this particular article reflects her passion. Mary was an inspiration to all of those who knew her. For me, she was not only my grandmother but also my friend and role model. I will forever miss her wisdom, spirit and passion for life.Susan RocheWhat ails the United States military establishment? Few even in government or military circles would deny that problems exist. Since World War II our only unequivocal military victory was the invasion of Grenada where we defeated a few hundred Cuban construction workers. Since I have enjoyed a fulfilling position in an army research laboratory for more than 30 years, the question troubles me greatly. Here I comment from the perspective of nearly 50 years personal observation, first as the wife of an army officer who later became a civilian employee of the army, and second my own long-term service. Much of what I have to say is personal opinion, anecdotal, and based on observations of one small laboratory (a
Suitable Site Selection of Decentralised Treatment Plants Using Multicriteria Approach in GIS  [PDF]
K. Deepa, M. Krishnaveni
Journal of Geographic Information System (JGIS) , 2012, DOI: 10.4236/jgis.2012.43030
Abstract: Metropolitan cities like Chennai facing rapid urbanisation. This results in informal extension of cities in peri-urban and rural areas. Once the city expands the problem arising is the water supply and sewage treatment system. In the present work an attempt is made in site suitable selection of Decentralised treatment plants (DCTP) with appropriate waste water treatment technologies using GIS techniques. Multicriteria analysis were performed by the combination of Analytical Hierarchy Process (AHP). Six thematic maps were considered such as population density map, landuse map, slope map, soil map, cost map and technology. Different classes were identified for each thematic maps. Using Analytical Hierarchy Principle (AHP) [1] (Saaty, 2000), a paired comparison matrix was prepared for criteria classes and individual class weights and map scores were worked out. These weights were applied in linear summation equation to obtain a unified weight map containing due weights of all input variables. Finally all the weighted maps were reclassified to arrive the best suitable site location of decentralised treatment plants.
Analyzing the Impact of Different Factors on Software Cost Estimation in Today’s Scenario  [PDF]
Deepa Gangwani, Saurabh Mukherjee
Journal of Software Engineering and Applications (JSEA) , 2015, DOI: 10.4236/jsea.2015.85025
Abstract: Software cost estimation is a main concern of the software industry. However, the fact is also that in today’s scenario, software industries are more interested in other issues like new technologies in the market, shorter development time, skill shortage etc. They are actually deviating from critical issues to routine issues. Today, people expect high quality products at very low costs and same is the goal of software engineering. An accuracy in software cost estimation has a direct impact on company’s reputation and also affects the software investment decisions. Accurate cost estimation can minimize the unnecessary costs and increase the productivity and efficiency of the company. The objective of this paper is to identify the existing methods of software cost estimation prevailing in the market and analyzing some of the important factors impacting the software cost estimation process. In order to achieve the objective, a survey was conducted to find out:

Nature of projects that companies prefer.

Impact of training on employees in software cost estimation.

How many people review the estimated cost?

How much risk buffer the company keeps for future prospects?

Gesondheidsorg vir Kinders: Voldoen Suid-Afrikaanse Wetgewing Aan die Land se Verpligtinge Ingevolge die Konvensie Oor die Regte van die Kind en die Grondwet?
M Büchner-Eveleigh, A Nienaber
Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese Regsblad , 2012,
Abstract: Included in the Convention on the Rights of the Child, 1989 (UN Children's Convention) is the right of children to the highest attainable standard of health. In terms of article 4 of the UN Children's Convention, in implementing the UN Children's Convention state parties must "undertake all appropriate legislative, administrative, and other measures for the implementation of the rights recognised in the present Convention". South Africa showed its commitment to protecting and promoting children's health when it ratified the UN Children's Convention and subsequently adopted the Constitution of the Republic of South Africa, 1996, which includes provisions guaranteeing the health rights of children. South Africa also showed commitment to giving legislative effect to the protection and promotion of children's health by promulgating the National Health Act 61 of 2003, the Children's Act 38 of 2005 and the Mental Health Care Act 17 of 2002. The article evaluates existing policy and legislation affecting child health in order to assess how well South African legislation addresses the issue of children's healthcare rights and whether or not it complies with its international law and constitutional obligations in this regard. The article concludes that although much legislation exists, none provides comprehensively for children's healthcare rights, and there are many gaps in existing legislation. Most importantly, there is no reference to the core minimum requirements for the state in providing for the health of children, particularly in the way of healthcare services and nutrition. Further, there is a complete lack of legislation which protects the health needs of children with disabilities. In order to ensure that the health rights of children are protected and promoted, we propose more comprehensive legislative protection. KEYWORDS: Children; basic healthcare; UN Children's Convention; Convention on the Rights of the Child; South African legislation; responsibilities; socio-economic rights; section 28 of the Constitution
Gesondheidsorg vir Kinders: Voldoen Suid-Afrikaanse Wetgewing Aan die Land se Verpligtinge Ingevolge die Konvensie Oor die Regte van die Kind en die Grondwet?
M Büchner-Eveleigh,A Nienaber
Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese Regsblad , 2012,
Abstract: Included in the Convention on the Rights of the Child, 1989 (UN Children's Convention) is the right of children to the highest attainable standard of health. In terms of article 4 of the UN Children's Convention, in implementing the UN Children's Convention state parties must "undertake all appropriate legislative, administrative, and other measures for the implementation of the rights recognised in the present Convention". South Africa showed its commitment to protecting and promoting children's health when it ratified the UN Children's Convention and subsequently adopted the Constitution of the Republic of South Africa, 1996, which includes provisions guaranteeing the health rights of children. South Africa also showed commitment to giving legislative effect to the protection and promotion of children's health by promulgating the National Health Act 61 of 2003, the Children's Act 38 of 2005 and the Mental Health Care Act 17 of 2002.The article evaluates existing policy and legislation affecting child health in order to assess how well South African legislation addresses the issue of children's healthcare rights and whether or not it complies with its international law and constitutional obligations in this regard. The article concludes that although much legislation exists, none provides comprehensively for children's healthcare rights, and there are many gaps in existing legislation. Most importantly, there is no reference to the core minimum requirements for the state in providing for the health of children, particularly in the way of healthcare services and nutrition. Further, there is a complete lack of legislation which protects the health needs of children with disabilities. In order to ensure that the health rights of children are protected and promoted, we propose more comprehensive legislative protection.
ELMAN Neural Network with Modified Grey Wolf Optimizer for Enhanced Wind Speed Forecasting  [PDF]
M. Madhiarasan, S. N. Deepa
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.710255
Abstract: The scope of this paper is to forecast wind speed. Wind speed, temperature, wind direction, relative humidity, precipitation of water content and air pressure are the main factors make the wind speed forecasting as a complex problem and neural network performance is mainly influenced by proper hidden layer neuron units. This paper proposes new criteria for appropriate hidden layer neuron unit’s determination and attempts a novel hybrid method in order to achieve enhanced wind speed forecasting. This paper proposes the following two main innovative contributions 1) both either over fitting or under fitting issues are avoided by means of the proposed new criteria based hidden layer neuron unit’s estimation. 2) ELMAN neural network is optimized through Modified Grey Wolf Optimizer (MGWO). The proposed hybrid method (ELMAN-MGWO) performance, effectiveness is confirmed by means of the comparison between Grey Wolf Optimizer (GWO), Adaptive Gbest-guided Gravitational Search Algorithm (GGSA), Artificial Bee Colony (ABC), Ant Colony Optimization (ACO), Cuckoo Search (CS), Particle Swarm Optimization (PSO), Evolution Strategy (ES), Genetic Algorithm (GA) algorithms, meanwhile proposed new criteria effectiveness and precise are verified comparison with other existing selection criteria. Three real-time wind data sets are utilized in order to analysis the performance of the proposed approach. Simulation results demonstrate that the proposed hybrid method (ELMAN-MGWO) achieve the mean square error AVG ± STD of 4.1379e-11 ± 1.0567e-15, 6.3073e-11 ± 3.5708e-15 and 7.5840e-11 ± 1.1613e-14 respectively for evaluation on three real-time data sets. Hence, the proposed hybrid method is superior, precise, enhance wind speed forecasting than that of other existing methods and robust.
Political Solution As Garnered By The National Dailies During The Ethnic Crisis In Srilanka- Frame Analysis
Deepa Viswam
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: Tamil United Liberation front Chief V.Anadasangaree vehemently opposed the unitary label within unitedSrilanka. He expressed concern over media reports about the possibility of the All Parties Representative conferences(APRC) coming forward with package of proposals with unitary label. He warned that such a proposal would onlystrengthen the LTTE's call for separation and give oxygen to the dying organization and kill hopes of those who haveplaced their faith in (APRC).A political solution with the unitary label where the state is not willing to recognize the othercommunities as those with legitimate grounds of power sharing is a defeat for people like who have been changing theTamil community to forget separation and come into path of a united srilanka. Any solution under unitary constitution willbe half baked one. It will give room for further agitation in the future fuelled by the remnants of the LTTE. The resultwould be a disruption of the hard earned peace and the country back square back one, into another cycle of violence. “Nopolitical solution will be acceptable to the LTTE, other than a kingdom for Prabhakaran………….fair and just politicalsolution will convince the Tamil people not only in the country but around the world that there is no need for tyranny andterror of LTTE”. He advocated the Indian Model as an ideal solution for the ethnic crisis, the Indian constitution does notsay federal or unitary but has managed to hold the country together for 60 years.(sep,13,07,The Hindu).The editor –inchiefof the Hindu N.Ram during the annual meeting of the srilanka –India friendship society said democratic governancewas the need of the hour in the east and went on to ask if the government was ready to demonstrate the political will andtake reasonable risks in its quest to resolve the ethnic question.“There are huge gaps in the development status of provinces. For instance, while the western province accountsfor 50% of the country's GDP the share of the eastern province is more 2.5 percent. That is why we say the issue is notfederalism but democracy and equality. President, Tamil United Liberation Front (TULF), V.Anandasangree also wantedthe Srilankan government to find out possible solution to ethnic problems the weakening of the Liberation Tigers of TamilEelam National party(UNP) openly acknowledged federalism as the option to solve the problem and the leftists alwayssupported it. Mr.anandasangree said though the people had been liberated from LTTE control they were going throughenormous is possible hardship. He also urged leaders and people of Tamilnadu
Feature Extraction for Collaborative Filtering: A Genetic Programming Approach
Deepa Anand
International Journal of Computer Science Issues , 2012,
Abstract: Collaborative filtering systems offer customized recommendations to users by exploiting the interrelationships between users and items. Users are assessed for their similarity in tastes and items preferred by similar users are offered as recommendations. However scalability and scarcity of data are the two major bottlenecks to effective recommendations. With web based RS typically having users in order of millions, timely recommendations pose a major challenge. Sparsity of ratings data also affects the quality of suggestions. To alleviate these problems we propose a genetic programming approach to feature extraction by employing GP to convert from user-item space to user-feature preference space where the feature space is much smaller than the item space. The advantage of this approach lies in the reduction of sparse high dimensional preference information into a compact and dense low dimensional preference data. The features are constructed using GP and the individuals are evolved to generate the most discriminative set of features. We compare our approach to content based feature extraction approach and demonstrate the effectiveness of the GP approach in generating the optimal feature set.
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