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Search Results: 1 - 10 of 215271 matches for " De-Rong Huang "
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Constructing the HBV-human protein interaction network to understand the relationship between HBV and hepatocellular carcinoma
Zhong-Jun Wu, Yu Zhu, De-Rong Huang, Zhi-Qiang Wang
Journal of Experimental & Clinical Cancer Research , 2010, DOI: 10.1186/1756-9966-29-146
Abstract: We catalogued all published interactions between HBV and human proteins, identifying 250 descriptions of HBV and human protein interactions and 146 unique human proteins that interact with HBV proteins by text mining.Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HBV are made up of core proteins that are interconnected with many pathways. A global analysis based on functional annotation highlighted the enrichment of cellular pathways targeted by HBV.By connecting the cellular proteins targeted by HBV, we have constructed a central network of proteins associated with hepatocellular carcinoma, which might be to regard as the basis of a detailed map for tracking new cellular interactions, and guiding future investigations.Hepatitis B virus is one of the most common infectious diseases in the world, and 43 years after its discovery, it still has a great impact on health, particularly in developing countries. More than 350 million people worldwide are known to be chronic carriers of HBV, and each year 15 million people die of hepatitis [1].The HBV viral genome is a relaxed-circular, partially duplex DNA of 3,200 base pairs. It has five genes encoding polymerase, pre-S1/pre-S2/S, X protein, precore/core protein, and the ID2828293 gene which is not well understood without an official gene symbol or description[2]. These proteins can also trans-activate other cellular genes, which may play a role in hepatocarcinogenesis [3].Hepatocellular carcinoma is one of the most common fatal cancers worldwide [4]. HBV is strongly associated with HCC by its presence in the tumor cell and by the striking role of persistent HBV infection as a risk factor for the development of HCC[2]. The incidence of HCC in many countries is increasing in parallel to an increase in chronic HBV infection[1]. It is generally shown that vaccination significantly decreases the incidence of HCC. Moreover, preventing the most severe HBV diseas
Design of the Permanent Magnet Synchronous Motor Speed Control System
VB 在永磁同步电机调速系统中的应用

LUO De-Rong,HUANG Zhen-Hua,SI Zeng-Qin,

计算机系统应用 , 2011,
Abstract: 永磁同步电机的调速系统中,在VB 环境下采用基于modbus 协议的RS-232/RS-485 串口通讯实现PC 机与TMS320F2812 的通信,设计永磁同步电机调速监控系统,详细描述了主机(PC)在VB 环境下与从机(DSP)通信的软件设计。通信的检验方式中采用CRC 校验方式,有效地保证了通信的可靠性,并且充分合理地利用工业现场系统资源的特点,提高了监控的有效性。同时运用了VB 可存储数据的功能,可以方便地查阅电机的历史数据。通过实际的工业现场运行表明,采用VB 开发的监控界面,具有很高的实用价值
No Survival Benefit from Adding Cetuximab or Panitumumab to Oxaliplatin-Based Chemotherapy in the First-Line Treatment of Metastatic Colorectal Cancer in KRAS Wild Type Patients: A Meta-Analysis
Si-wei Zhou, Yuan-yuan Huang, Ying Wei, Zhi-min Jiang, Yuan-dong Zhang, Qiong Yang, De-rong Xie
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0050925
Abstract: Background The efficacy of combined therapies of oxaliplatin-based chemotherapy and anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibodies (MAbs) remains controversial in colorectal cancer (CRC). The aim of this study is to estimate the efficacy and safety of adding cetuximab or panitumumab to oxaliplatin-based chemotherapy in the first line treatment in KRAS wild type patients with metastatic colorectal cancer (mCRC) through meta-analysis. Methods Medline, EMBASE, and Cochrane library, American Society of Clinical Oncology (ASCO) and European Society for Medical Oncology (ESMO) were searched. Eligible studies were randomized controlled trials (RCTs) which evaluated oxaliplatin-based chemotherapy with or without anti-EGFR drugs (cetuximab or panitumumab) in untreated KRAS wild type patients with mCRC. The outcomes included overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and toxicities. Hazard ratios (HR) and risk ratio (RR) were used for the meta-analysis and were expressed with 95% confidence intervals. Results This meta-analysis included four RCTs with 1270 patients, and all of the patients were administered oxaliplatin-based chemotherapy regimens with or without anti-EGFR MAbs. The result of heterogeneity of OS was not significant. Compared with chemotherapy alone, the addition of cetuximab or panitumumab didn’t result in significant improvement in OS (HR = 1.00, 95%CI [0.88, 1.13], P = 0.95) or PFS (HR = 0.86, 95%CI [0.71, 1.04], P = 0.13). The subgroup analysis of cetuximab also revealed no significant benefit in OS (HR = 1.02, 95%CI [0.89, 1.18], P = 0.75) or in PFS (HR = 0.87, 95%CI [0.65, 1.17], P = 0.36). Patients who received combined therapy didn’t have a higher ORR (Risk Ratio = 1.08, 95%CI [0.86, 1.36]). Toxicities slightly increased in anti-EGFR drugs group. Conclusions The addition of cetuximab or panitumumab to oxaliplatin-based chemotherapy in first-line treatment of mCRC in wild type KRAS population did not improve efficacy in survival benefit and response rate. More RCTs are warranted to evaluate the combination of chemotherapy and targeted therapy.
Postoperative Chemoradiotherapy versus Postoperative Chemotherapy for Completely Resected Gastric Cancer with D2 Lymphadenectomy: A Meta-Analysis
Yuan-Yuan Huang, Qiong Yang, Si-Wei Zhou, Ying Wei, Yan-Xian Chen, De-Rong Xie, Bei Zhang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068939
Abstract: Background Both chemoradiotherapy and chemotherapy are used in postoperative adjuvant therapy for resected gastric cancer. However, it is controversial whether chemoradiotherapy or chemotherapy is the optimal strategy for patients with gastric cancer after D2 lymphadenectomy. The present meta-analysis aims to provide more evidence on the relative benefits of adjuvant therapies in this setting. Methods We conducted a systematic review of randomized controlled trials, extracted time-to-event data using Tierney methods (when not reported), and performed meta-analysis to obtain the relative hazards of adjuvant chemoradiotherapy to chemotherapy on efficacy and toxicities. Results A total of 895 patients from 3 randomized controlled trials were identified for this meta-analysis. All patients were from Asian countries. Our results showed that postoperative chemoradiotherapy significantly improved locoregional recurrence-free survival [LRRFS: hazard ratio (HR) = 0.53, 95% CI = 0.32–0.87, p = 0.01] and disease-free survival (DFS: HR = 0.72, 95% CI = 0.59–0.89, p = 0.002); however, the improvement of distant metastasis recurrence-free survival (DMRFS: HR = 0.86; 95% CI = 0.66–1.11, p = 0.25) and overall survival (OS: HR = 0.79, 95% CI = 0.61–1.03, p = 0.08) were non-significant. The main grade 3 or 4 toxicities were equivalent between the two groups. Conclusion In non-selected Asian patients with resected gastric cancer who underwent D2 lymphadenectomy, postoperative chemoradiotherapy improved LRRFS and DFS but might not improve OS compared to postoperative chemotherapy.
Research Progress on Influence of Psychology and Sleep on Temporomandibular Joint Disorders.

管娟娟, 俞律峰, 邹德荣, 黄艺
GUAN Juan-juan
, YU Lv-feng, ZOU De-rong, HUANG Yi

- , 2018, DOI: 10.13701/j.cnki.kqyxyj.2018.03.005
Abstract: 摘要 颞下颌关节紊乱病是口腔临床常见疾病之一,它的病因是多因素的,其中心理因素起着重要的作用,随着现代生活压力的增加,睡眠障碍也越来越多,本文就心理因素和睡眠对颞下颌关节紊乱病影响的研究现状进行综述

FU De-rong,

地球学报 , 1987,
Abstract: According to length of extension, cutting depth, intensity of activity, sequence of formation and different roles in controlling the basins, the faults may be divided into basement faults and syndepositional ones.Basement faults refer to those that control the formation and distribution of the basins, and often make up boundaries of these basins or of the se-condorder structure units within them. They are characterized by early occurrence, prolonged activity, long extension, large throw and, consequently, greater cutting depth.Syndepositional faults refer to some faults in the basin which occurred somewhat later than the basement faults. They are of smaller extension and cutting depth; their downward extension usually fails of reach the basement of the basin, and gradually disappears in the sedimentary cover. It is obvious that they have controlled such sedimentation as lithofacies and variation of thickness in the basin.These two types of faults not only were extensively distributed but also occurred in great quantities in the process of the formation and evolution of the Mesozoic-Ceuozoic basins in east China. As for the characteristics of their forms, the fault surfaces are generally curved upward, and become gentle in dip with depth, possessing the features of normal fault. Therefore, they are called listric faults.Some ideas are put forward in this paper as to the formation mechanism this sort of listric faults as well as their association with the extension of the basins: 1. The formation of the listric basement faults is closely related to the "thermal events". The transmission of thermal energy from the asthenosphe-re to the earth's crust softens the lower part of the crust and makes it ductile, with the ductility dependent on the temperature. As the temperature rises with the depth, it is reasonably presumed that the ductility will increase to some extent at the greater depths of the crust. A preferred interpretation nowadays is that the listric faults formed through extension in the brittle upper crust was actually the products of ductile stretching in the lower crust, while the formation of the basins was controlled by these faults. 2. On the base of the listric basement fault, there may further occur the listric growth fault. Their formation mechanism was remarkably different from the listric basement fault in that they not only were controlled by extension, buy, what is more important, could be formed mainly as a result of gravity or pressure difference of sediments. This sort of faults are rather widespread in Mesozoic-Cenozoic basins in east China. 3. In the large-size basins of east China, the downward extension or the bottom of the listric normal faults is generally in the range of 5-15 km below the surface, as can be examplified by the well-known Cangdong and Shengbei basement faults. 4. Jn the basin controlled by extension and stretching, the original geological boundaries, such as bedding surface, boundary between the cover an
Producing Terahertz Conherent Synchrotron Radiation Based On Hefei Light Source
Xu De-Rong,Xu Hong-Liang,Shao Yan
Physics , 2014,
Abstract: This paper theoretically proves that an electron storage ring can generate coherent radiation in THz region using a quick kicker magnet and an ac sextupole magnet. When the vertical chromaticity is modulated by the ac sextupole magnet, the vertical beam collective motion excited by the kicker produces a wavy spatial structure after a number of longitudinal oscillation periods. We calculate the radiation spectral distribution from the wavy bunch in Hefei Light Source(HLS). If we reduce electron energy to 400MeV, it can produce extremely strong coherent synchrotron radiation(CSR) at 0.115THz.
Landscape patterns and their changes in Sichuan Ruoergai Wetland National Nature Reserve

De-rong Xiao,Bo Tian,Kun Tian,Yang Yang,

生态学报 , 2010,


物理学报 , 2001,
Abstract: Gordon首先采用带有非对称双阱势的氢键链模型研究了氢键铁电体的电导性,给出了扭结解和迁移率的表达式.但是对于电导有贡献的扭结孤子应该对应于质子在两个阱底之间的转移,基于这种考虑,修正了Gordon的结果,重新导出了低能态的扭结解,给出了迁移率的一个新的表达式.当非对称双阱势转化为对称双阱势时,这个表达式恰与以前的研究结果一致.这个表达式表明,相变临界指数是1.


物理学报 , 2001,
Abstract: 阻尼和外电场的作用使得带有非对称双阱势的氢键链存在扭结孤子激发.计算了孤子的迁移率,它包含了φ4链的结果
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