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Search Results: 1 - 10 of 371257 matches for " David S Seres "
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Nutritional support and brain tissue glucose metabolism in poor-grade SAH: a retrospective observational study
J Michael Schmidt, Jan Claassen, Sang-Bae Ko, Hector Lantigua, Mary Presciutti, Kiwon Lee, E Sander Connolly, Stephan A Mayer, David S Seres, Neeraj Badjatia
Critical Care , 2012, DOI: 10.1186/cc11160
Abstract: We used a retrospective observational cohort study of 50 mechanically ventilated poor-grade (Hunt-Hess 4 or 5) aneurysmal SAH patients who underwent brain microdialysis monitoring for an average of 109 hours. Enteral nutrition was started within 72 hours of admission whenever feasible. Intensive insulin therapy was used to maintain serum glucose levels between 5.5 and 7.8 mmol/l. Serum glucose, insulin and caloric intake from enteral tube feeds, dextrose and propofol were recorded hourly. Cerebral metabolic distress was defined as a lactate to pyruvate ratio (LPR) > 40. Time-series data were analyzed using a general linear model extended by generalized estimation equations (GEE).Daily mean caloric intake received was 13.8 ± 6.9 cal/kg and mean serum glucose was 7.9 ± 1 mmol/l. A total of 32% of hourly recordings indicated a state of metabolic distress and < 1% indicated a state of critical brain hypoglycemia (< 0.2 mmol/l). Calories received from enteral tube feeds were associated with higher serum glucose concentrations (Wald = 6.07, P = 0.048), more insulin administered (Wald = 108, P < 0.001), higher body mass index (Wald = 213.47, P < 0.001), and lower body temperature (Wald = 4.1, P = 0.043). Enteral feeding (Wald = 1.743, P = 0.418) was not related to brain glucose concentrations after accounting for serum glucose concentrations (Wald = 67.41, P < 0.001). In the presence of metabolic distress, increased insulin administration was associated with a relative reduction of interstitial brain glucose concentrations (Wald = 8.26, P = 0.017), independent of serum glucose levels.In the presence of metabolic distress, insulin administration is associated with reductions in brain glucose concentration that are independent of serum glucose levels. Further study is needed to understand how nutritional support and insulin administration can be optimized to minimize secondary injury after subarachnoid hemorrhage.Hyperglycemia, defined as serum glucose > 11 mmol/l after suba
Tumour necrosis factor-α and adenosine in endotoxin shockleading related cardiovascular symptoms
S. Sipka,T. Seres,Z. Dinya,Z. Szekanecz
Mediators of Inflammation , 1995, DOI: 10.1155/s0962935195000731
Abstract:
Avalanche effect and gain saturation in high harmonic generation
Carles Serrat,David Roca,Josep M. Budesca,Jozsef Seres,Enikoe Seres,Bastian Aurand,Andreas Hoffmann,Shinichi Namba,Thomas Kuehl,Christian Spielmann
Physics , 2015,
Abstract: Optical amplifiers in all ranges of the electromagnetic spectrum exhibit two essential characteristics: i) the input signal during the propagation in the medium is multiplied by the avalanche effect of the stimulated emission to produce exponential growth and ii) the amplification saturates at increasing input signal. We demonstrate that the strong-field theory in the frame of high harmonic generation fully supports the appearance of both the avalanche and saturation effects in the amplification of extreme ultraviolet attosecond pulse trains. We confirm that the amplification takes place only if the seed pulses are perfectly synchronized with the driving strong field in the amplifier. We performed an experimental study and subsequent model calculation on He gas driven by intense 30-fs-long laser pulses, which was seeded with an attosecond pulse train at 110 eV generated in a separated Ne gas jet. The comparison of the performed calculations with the measurements clearly demonstrates that the pumped He gas medium acted as an amplifier of the extreme ultraviolet pulse train.
Effects of inosine on reperfusion injury after cardiopulmonary bypass
Gábor Veres, Tamás Radovits, Leila Seres, Ferenc Horkay, Matthias Karck, Gábor Szabó
Journal of Cardiothoracic Surgery , 2010, DOI: 10.1186/1749-8090-5-106
Abstract: Twelve anesthetized dogs underwent hypothermic cardiopulmonary bypass. After 60 minutes of hypothermic cardiac arrest, reperfusion was started after application of either saline vehicle (control, n = 6), or inosine (100 mg/kg, n = 6). Left ventricular end-systolic pressure volume relationship (ESPVR) was measured by a combined pressure-volume-conductance catheter at baseline and after 60 minutes of reperfusion. Left anterior descendent coronary blood flow (CBF), endothelium-dependent vasodilatation to acetylcholine (ACh) and endothelium-independent vasodilatation to sodium nitroprusside (SNP) were also determined.The administration of inosine led to a significantly better recovery (given as percent of baseline) of ESPVR 90 ± 9% vs. 46 ± 6%, p < 0.05. CBF and was also significantly higher in the inosine group (56 ± 8 vs. 23 ± 4, ml/min, p < 0.05). While the vasodilatatory response to SNP was similar in both groups, ACh resulted in a significantly higher increase in CBF (58 ± 6% vs. 25 ± 5%, p < 0.05) in the inosine group.Application of inosine improves myocardial and endothelial function after cardiopulmonary bypass with hypothermic cardiac arrest.Ischemia-reperfusion injury is a well-known phenomenon after cardiac surgery. Independent of the technique of cardioplegia, temporary dysfunction of biventricular contractility can frequently be observed. Even if cardiac dysfunction is not clinically evident, a reduction of myocardial contractility may occur as described in a study in humans using pressure-volume relationships [1]. In addition, coronary endothelial dysfunction may further complicate the postoperative course.Extra-corporal circulation is also known to induce a systemic inflammatory reaction with free radical release leading to secondary organ injury. During ischemia, cellular ATP is degraded into AMP, adenosine, inosine and hypoxanthine. Adenosine and its primary metabolite inosine are ubiquitous nucleosides that can be released from ischemic or reperfused t
Past and possible future of the Lahóca mine, Recsk, Hungary - a historical review
Seres-Hartai éva
Acta Montanistica Slovaca , 1998,
Abstract: Epitermálne zlatonosné zrudnenia sa via u k takym hydrotermálnym systémom, v ktorych sa minerály, obsahujúce zlato, objavujú v h bke 1-2 km pod povrchom. Epitermálne Cu-Au nosné lo isko v Recsku (Ma arsko) sa priestorovo a geneticky via e k recsskému eocénnemu porfyrickému systému. Na tomto území sa dobyvala me s men ím podielom zlata a striebra, v rokoch 1852 - 1979. Vyskum Cu-porfyrového skarnového systému hlb ích obzorov sa za al v roku 1968, bez praktického dobyvania. Vrtny prieskum sa za al v r. 1994 a trvá dodnes. Pod a teraj ích vysledkov a poznania lo iska, je mo né zlato v oblasti Lahóca ekonomicky vyu íva pomocou biooxidaènej technológie.
Coupled-Nonlinear Elastic Structure: An Innovative Parameterization Scheme of the Motion Equations  [PDF]
S. A. David
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.521324
Abstract: In this paper, I applied the Euler-Lagrange equations in order to obtain the coupled-nonlinear motion equations for an elastic structure. The model is composed of six coupled and strongly nonlinear ordinary differential equations. The new contribution of this work arises from the fact that a convenient and innovative parameterization of the motion equations for the elastic system was developed with all mathematical nonlinearities taken into account, without the usage of any simplifying linearization procedure, as found in most of the works presented in the literature. The results can be used as a source for conducting experiments and can be useful for a better understanding and control of such nonlinear elastic systems.
The Human Microbiome and I-Cubed: A Modern Medical Paradigm  [PDF]
David S. Younger
World Journal of Neuroscience (WJNS) , 2016, DOI: 10.4236/wjns.2016.64031
Abstract: Background: Over the past decade, there has been recognition of the importance of the human microbiome. Beyond improved microbial cataloguing through high- throughput genetic sequencing, we have learned that human beings are superorganisms integrating the identity, function and immunity of resident bacterial, while prepared throughout own innate and adaptive immune systems, to deal with invading organisms. Hypothesis: In keeping with the dynamic relation of infection, immunity and inflammation contained in I-Cubed, illness arises when protective immunity becomes the source of autoimmunity, conditioned by environmental and genetic factors. Results: This paradigm explains the etiopathogenesis of diverse medical (type 1 diabetes, spondyloarthropathy), neurologic (Lyme neuroborreliosis), and neuropsychiatric disorders (PANDAS, and autism spectrum disorders). Conclusion: Successful treatments employing immune-modulatory therapy may be employed. Public health officials will be called upon to guide the public’s understanding and mitigate the risk of disorders that result from the interplay of the human microbiome and I-Cubed.
Limbic Encephalitis Associated with Voltage-Gated Potassium Channel-Complex Antibodies: Patient Report and Literature Review  [PDF]
David S. Younger
World Journal of Neuroscience (WJNS) , 2017, DOI: 10.4236/wjns.2017.71002
Abstract: Background: The family of disorders associated with antibodies against neuronal surface antigens is a rapidly expanding category of autoimmune neurologic disease. Methods: Clinical and laboratory findings of a patient with voltage-gated Kv1 potassium channel (VGKC)-complex autoantibodies are reported and the literature is reviewed. Results: New-onset faciobrachial dystonic seizures, distal large and painful small fiber peripheral neuropathy, dysautonomia, cognitive and memory disturbances were associated with hypometabolism of the left temporal lobe without evidence of systemic malignancy in whole-body positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-D-glucose integrated with computed tomography. Brain MRI and cerebrospinal fluid were normal with absent intrathecal VGKC-complex antibodies consistent with extrathecal production. Epidermal nerve fiber studies confirmed small fiber neuropathy in association with abnormal autonomic laboratory testing. Discussion: Neurologic involvement associated with VGKC complex autoimmunity is a precisely delineated disorder involving the central, peripheral, and autonomic nervous system.
Epidemiology of Childhood Mental Illness: A Review of U.S. Surveillance Data and the Literature  [PDF]
David S. Younger
World Journal of Neuroscience (WJNS) , 2017, DOI: 10.4236/wjns.2017.71005
Abstract: Background: Childhood mental illness is a major factor of overall lifespan of children continuing into adulthood. Population based surveys and public health surveillance provide the much needed evidence to understand mental health promotion, prevention, and treatment of mental illness in children in the United States. Objective: To review available current national survey data regarding mental illness in children over the past decade and to review the global implications of childhood mental illness. Results: Altogether, 13% - 20% of children experienced a mental health disorder from 1994 to 2011. The prevalence of depression among children of 3 - 17 years old was 3% and the prevalence of lifetime and past year major depressive episode were 12.8% and 8.1% respectively among adolescents of 12 - 17 years old, with a prevalence of depression in the preceding 2 weeks of 6.7%. 7.1% of children of 12 - 17 years old ever had a diagnosis of depression, 3.5% had current depression and 5.1% had a diagnosis of depression in the past year. Overall, 28.5% of high school students of 14 - 18 years old reported feeling so sad or hopeless every day for two weeks or more in a row that they stopped doing usual activities, higher among girls (35.9%) than boys (21.5%), and greater in Hispanic students (32.6%) than white non-Hispanic (27.2%) or black non-Hispanic students (24.7%). The overall rate of suicide in children in 2010 was 4.5 per 100,000. Conclusions: Mental illness presents serious departures from the expected cognitive, social, and emotional development in children, and an important area for prevention in the U.S. and globally. Mental illness will be managed effectively when there is adequate access to treatment services to reduce its associated morbidity and mortality.
Vaccination: Epidemiological Review  [PDF]
David S. Younger
World Journal of Neuroscience (WJNS) , 2017, DOI: 10.4236/wjns.2017.71006
Abstract: The induction of host protective immunity is an important factor in the immunization against potentially fatal disease and emerging illnesses in the U.S. and global populations especially among immunologically susceptible na?ve hosts. Vaccination programs need to be evaluated as regards their health and economic population benefit among indigenous at risk populations taking into account emerging pathologies defined by the sudden appearance of a pathogen in nature or in a region of the world. Global collaboration is a necessary aspect of vaccine-preventable diseases since even a small number of wild-type cases of eradicated diseases in one region of the world present opportunities for their re-emergence in geographically remote areas. This study is a step in the direction of understanding the epidemiologic aspects of vaccination.
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