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Search Results: 1 - 10 of 444914 matches for " David M. Neyens "
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Simulated Estimates of Pre-Pregnancy and Gestational Diabetes Mellitus in the US: 1980 to 2008
Maria E. Mayorga, Odette S. Reifsnider, David M. Neyens, Mulugeta G. Gebregziabher, Kelly J. Hunt
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073437
Abstract: Purpose To simulate national estimates of prepregnancy and gestational diabetes mellitus (GDM) in non-Hispanic white (NHW) and non-Hispanic black (NHB) women. Methods Prepregnancy diabetes and GDM were estimated as a function of age, race/ethnicity, and body mass index (BMI) using South Carolina live singleton births from 2004–2008. Diabetes risk was applied to a simulated population. Age, natality and BMI were assigned to women according to race- and age-specific US Census, Natality and National Health and Nutrition Examination Surveys (NHANES) data, respectively. Results From 1980–2008, estimated GDM prevalence increased from 4.11% to 6.80% [2.68% (95% CI 2.58%–2.78%)] and from 3.96% to 6.43% [2.47% (95% CI 2.39%–2.55%)] in NHW and NHB women, respectively. In NHW women prepregnancy diabetes prevalence increased 0.90% (95% CI 0.85%–0.95%) from 0.95% in 1980 to 1.85% in 2008. In NHB women from 1980 through 2008 estimated prepregnancy diabetes prevalence increased 1.51% (95% CI 1.44%–1.57%), from 1.66% to 3.16%. Conclusions Racial disparities in diabetes prevalence during pregnancy appear to stem from a higher prevalence of prepregnancy diabetes, but not GDM, in NHB than NHW.
Magnetic Moment of the Fragmentation Aligned 61Fe(9/2)+ Isomer
I. Matea,G. Georgiev,J. M. Daugas,M. Hass,G. Neyens
Physics , 2004, DOI: 10.1103/PhysRevLett.93.142503
Abstract: We report on the g factor measurement of the isomer in $^{61}Fe$ ($E^{*}=861 keV$). The isomer was produced and spin-aligned via a projectile-fragmentation reaction at intermediate energy, the Time Dependent Perturbed Angular Distribution (TDPAD) method being used for the measurement of the g factor. For the first time, due to significant improvements of the experimental technique, an appreciable residual alignment of the isomer has been observed, allowing a precise determination of its g factor: $g=-0.229(2)$. Comparison of the experimental g factor with shell-model and mean field calculations confirms the $9/2^+$ spin and parity assignments and suggests the onset of deformation due to the intrusion of Nilsson orbitals emerging from the $\nu g_{9/2}$.
Precision Measurement of 11Li moments: Influence of Halo Neutrons on the 9Li Core
R. Neugart,D. L. Balabanski,K. Blaum,D. Borremans,P. Himpe,M. Kowalska,P. Lievens,S. Mallion,G. Neyens,N. Vermeulen,D. T. Yordanov
Physics , 2008, DOI: 10.1103/PhysRevLett.101.132502
Abstract: The electric quadrupole moment and the magnetic moment of the 11Li halo nucleus have been measured with more than an order of magnitude higher precision than before, |Q| = 33.3(5)mb and mu=3.6712(3)mu_N, revealing a 8.8(1.5)% increase of the quadrupole moment relative to that of 9Li. This result is compared to various models that aim at describing the halo properties. In the shell model an increased quadrupole moment points to a significant occupation of the 1d orbits, whereas in a simple halo picture this can be explained by relating the quadrupole moments of the proton distribution to the charge radii. Advanced models so far fail to reproduce simultaneously the trends observed in the radii and quadrupole moments of the lithium isotopes.
Molecular Mimicry, the Hygiene Hypothesis, Stealth Infections and Other Examples of Disconnect between Medical Research and the Practice of Clinical Medicine in Autoimmune Disease  [PDF]
David M. Brady
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2013, DOI: 10.4236/ojra.2013.31007

Autoimmune disorders have been on a steep rise in the industrialized countries over the past several decades and while research has been starting to develop a detailed understanding of pathophysiology and many of the underlying mechanisms, any meaningful incorporation of this information into clinical medicine has been painfully slow. Concepts of molecular mimicry, the hygiene hypothesis, intestinal hyper-permeability (leaky gut syndrome) and aggressive use of predictive antibody testing are explored in this article with examples given on how emerging information on these phenomena may aid the clinician in a new, more proactive, approach to management of these conditions.

Modeling overdispersed longitudinal binary data using a combined beta and normal random-effects model
Wondwosen Kassahun, Thomas Neyens, Geert Molenberghs, Christel Faes, Geert Verbeke
Archives of Public Health , 2012, DOI: 10.1186/0778-7367-70-7
Abstract: Two longitudinal binary data sets, collected in south western Ethiopia: the Jimma infant growth study, where the child’s early growth is studied, and the Jimma longitudinal family survey of youth where the adolescent’s school attendance is studied over time, are considered. A new model which combines both overdispersion, and correlation simultaneously, also known as the combined model is applied. In addition, the commonly used methods for binary and binomial data, such as the simple logistic, which accounts neither for the overdispersion nor the correlation, the beta-binomial model, and the logistic-normal model, which accommodate only for the overdispersion, and correlation, respectively, are also considered for comparison purpose. As an alternative estimation technique, a Bayesian implementation of the combined model is also presented.The combined model results in model improvement in fit, and hence the preferred one, based on likelihood comparison, and DIC criterion. Further, the two estimation approaches result in fairly similar parameter estimates and inferences in both of our case studies. Early initiation of breastfeeding has a protective effect against the risk of overweight in late infancy (p?=?0.001), while proportion of overweight seems to be invariant among males and females overtime (p?=?0.66). Gender is significantly associated with school attendance, where girls have a lower rate of attendance (p?=?0.001) as compared to boys.We applied a flexible modeling framework to analyze binary and binomial longitudinal data. Instead of accounting for overdispersion, and correlation separately, both can be accommodated simultaneously, by allowing two separate sets of the beta, and the normal random effects at once.
Self-consistent approach to deformation of intruder states in neutron-deficient Pb and Po
N. A. Smirnova,P. -H. Heenen,G. Neyens
Physics , 2003, DOI: 10.1016/j.physletb.2003.07.042
Abstract: We present systematic calculations of the properties of 11- isomers in neutron-deficient 184-198Pb and 188-200Po. These states are based on the proton (h9/2 i13/2)_{K = 11-} configuration. They are calculated in the framework of the Hartree-Fock-Bogoliubov method with a Skyrme interaction and density-dependent pairing force. The energies and deformations of the 11- states are compared to those of the intruder 0+ states in both Pb and Po isotopes. In the most neutron-deficient Po isotopes, the calculations predict, below a weakly oblate 11- state, another oblate 11- state which is even more deformed than the intruder oblate 11- state in their Pb isotones. The energies and quadrupole moments of the 11- isomers, corresponding to a weakly oblate nuclear shape, are in fair agreement with the available experimental data.
Hemorrhagic Fever Epidemic in Grenada in the 18th Century: A Medical and Historical Analysis  [PDF]
Richard M. Kabuusu, David Lennon
Advances in Anthropology (AA) , 2014, DOI: 10.4236/aa.2014.43015
Abstract: Unlike present times, when the major health concerns for Grenada are chronic diseases, the island’s main health problems in the past were infectious diseases. The aim of this review is to examine whether a hemorrhagic fever epidemic precisely occurred in Grenada in the 1700s, and to identify the mostly likely etiologic agents associated with the outbreak. The methods used to collect information included museum research, interviewing a key informant and reviewing past documents in national archives in London, textbooks, and the internet. This medical and historical analysis reveals that there is sufficient evidence that an outbreak of hemorrhagic fever occurred in Grenada in 1700s and that there are more probable etiologies than previously thought. These include yellow fever, leptospirosis, viral hemorrhagic fever, and dengue hemorrhagic fever.
Nuclear spins, magnetic moments and quadrupole moments of Cu isotopes from N = 28 to N = 46: probes for core polarization effects
P. Vingerhoets,K. T. Flanagan,M. Avgoulea,J. Billowes,M. L. Bissell,K. Blaum,B. A. Brown,B. Cheal,M. De Rydt,D. H. Forest,Ch. Geppert,M. Honma,M. Kowalska,J. Kramer,A. Krieger,E. Mane,R. Neugart,G. Neyens,W. Nortershauser,T. Otsuka,M. Schug,H. H. Stroke,G. Tungate,D. T. Yordanov
Physics , 2010, DOI: 10.1103/PhysRevC.82.064311
Abstract: Measurements of the ground-state nuclear spins, magnetic and quadrupole moments of the copper isotopes from 61Cu up to 75Cu are reported. The experiments were performed at the ISOLDE facility, using the technique of collinear laser spectroscopy. The trend in the magnetic moments between the N=28 and N=50 shell closures is reasonably reproduced by large-scale shell-model calculations starting from a 56Ni core. The quadrupole moments reveal a strong polarization of the underlying Ni core when the neutron shell is opened, which is however strongly reduced at N=40 due to the parity change between the $pf$ and $g$ orbits. No enhanced core polarization is seen beyond N=40. Deviations between measured and calculated moments are attributed to the softness of the 56Ni core and weakening of the Z=28 and N=28 shell gaps.
Nuclear charge radii of potassium isotopes beyond N=28
K. Kreim,M. L. Bissell,J. Papuga,K. Blaum,M. De Rydt,R. F. Garcia Ruiz,S. Goriely,H. Heylen,M. Kowalska,R. Neugart,G. Neyens,W. N?rtersh?user,M. M. Rajabali,R. Sánchez Alarcón,H. H. Stroke,D. T. Yordanov
Physics , 2013, DOI: 10.1016/j.physletb.2014.02.012
Abstract: We report on the measurement of optical isotope shifts for $^{38,39,42,44,46\text{-}51}$K relative to $^{47}$K from which changes in the nuclear mean square charge radii across the N=28 shell closure are deduced. The investigation was carried out by bunched-beam collinear laser spectroscopy at the CERN-ISOLDE radioactive ion-beam facility. Mean square charge radii are now known from $^{37}$K to $^{51}$K, covering all $\nu f_{7/2}$-shell as well as all $\nu p_{3/2}$-shell nuclei. These measurements, in conjunction with those of Ca, Cr, Mn and Fe, provide a first insight into the $Z$ dependence of the evolution of nuclear size above the shell closure at N=28.
Spins and Magnetic Moments of $^{49}$K and $^{51}$K: establishing the 1/2$^+$ and 3/2$^+$ level ordering beyond $N$ = 28
J. Papuga,M. L. Bissell,K. Kreim,K. Blaum,B. A. Brown,M. De Rydt,R. F. Garcia Ruiz,H. Heylen,M. Kowalska,R. Neugart,G. Neyens,W. N?rtersh?user,T. Otsuka,M. M. Rajabali,R. Sánchez,Y. Utsuno,D. T. Yordanov
Physics , 2013, DOI: 10.1103/PhysRevLett.110.172503
Abstract: The ground-state spins and magnetic moments of $^{49,51}$K have been measured using bunched-beam high-resolution collinear laser spectroscopy at ISOLDE-CERN. For $^{49}$K a ground-state spin $I = 1/2$ was firmly established. The observed hyperfine structure of $^{51}$K requires a spin $I > 1/2$ and from its magnetic moment $\mu(^{51}\text{K})= +0.5129(22)\, \mu_N$ a spin/parity $I^\pi=3/2^+$ with a dominant $\pi 1d_{3/2}^{-1}$ hole configuration was deduced. This establishes for the first time the re-inversion of the single-particle levels and illustrates the prominent role of the residual monopole interaction for single-particle levels and shell evolution.
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