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Search Results: 1 - 10 of 238085 matches for " David G. Sterling "
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Symbolic Codes for Rotational Orbits
Holger R. Dullin,James D. Meiss,David G. Sterling
Physics , 2004, DOI: 10.1137/040612877
Abstract: Symbolic codes for rotational orbits and "islands-around-islands" are constructed for the quadratic, area-preserving Henon map. The codes are based upon continuation from an anti-integrable limit, or alternatively from the horseshoe. Given any sequence of rotation numbers we obtain symbolic sequences for the corresponding elliptic and hyperbolic rotational orbits. These are shown to be consistent with numerical evidence. The resulting symbolic partition of the phase space consists of wedges constructed from images of the symmetry lines of the map.
Elucidating Novel Serum Biomarkers Associated with Pulmonary Tuberculosis Treatment
Mary A. De Groote, Payam Nahid, Leah Jarlsberg, John L. Johnson, Marc Weiner, Grace Muzanyi, Nebojsa Janjic, David G. Sterling, Urs A. Ochsner
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061002
Abstract: In an unbiased approach to biomarker discovery, we applied a highly multiplexed proteomic technology (SOMAscan, SomaLogic, Inc, Boulder, CO) to understand changes in proteins from paired serum samples at enrollment and after 8 weeks of TB treatment from 39 patients with pulmonary TB from Kampala, Uganda enrolled in the Center for Disease Control and Prevention’s Tuberculosis Trials Consortium (TBTC) Study 29. This work represents the first large-scale proteomic analysis employing modified DNA aptamers in a study of active tuberculosis (TB). We identified multiple proteins that exhibit significant expression differences during the intensive phase of TB therapy. There was enrichment for proteins in conserved networks of biological processes and function including antimicrobial defense, tissue healing and remodeling, acute phase response, pattern recognition, protease/anti-proteases, complement and coagulation cascade, apoptosis, immunity and inflammation pathways. Members of cytokine pathways such as interferon-gamma, while present, were not as highly represented as might have been predicted. The top proteins that changed between baseline and 8 weeks of therapy were TSP4, TIMP-2, SEPR, MRC-2, Antithrombin III, SAA, CRP, NPS-PLA2, LEAP-1, and LBP. The novel proteins elucidated in this work may provide new insights for understanding TB disease, its treatment and subsequent healing processes that occur in response to effective therapy.
Computing periodic orbits using the anti-integrable limit
D. G. Sterling,J. D. Meiss
Physics , 1998, DOI: 10.1016/S0375-9601(98)00094-2
Abstract: Chaotic dynamics can be effectively studied by continuation from an anti-integrable limit. Using the Henon map as an example, we obtain a simple analytical bound on the domain of existence of the horseshoe that is equivalent to the well-known bound of Devaney and Nitecki. We also reformulate the popular method for finding periodic orbits introduced by Biham and Wenzel. Near an anti-integrable limit, we show that this method is guaranteed to converge. This formulation puts the choice of symbolic dynamics, required for the algorithm, on a firm foundation.
Neuropsychological patterns in systemic lupus erythematosus patients with depression
Elizabeth Kozora, David B Arciniegas, Lening Zhang, Sterling West
Arthritis Research & Therapy , 2007, DOI: 10.1186/ar2203
Abstract: More than 50% of patients with systemic lupus erythematosus (SLE) demonstrate major psychiatric and neurological disorders indicating central nervous system (CNS) involvement [1,2]. Neuropsychiatric manifestations in SLE are diverse and include major manifestations (that is, stroke syndromes, seizures, psychotic episodes, and so on) or less severe abnormalities, including headaches, minor mood disorders, and cognitive difficulties [3]. Depression is the most frequently documented psychiatric problem in patients with SLE [4-7]. However, the role of depression in lupus remains controversial, and it is not known if depression is associated with the effects of a chronic illness or if it represents a manifestation of CNS involvement in this population.There is some discrepancy in the literature regarding the association between psychological factors and cognitive functions in patients with SLE. Although some studies have demonstrated that patients with SLE with overt neuropsychiatric disorders (NPSLE) have strong correlations between psychological and cognitive distress [8-13], other studies have found no relationship between these factors in NPSLE [14-16]. There is consistency in the literature regarding patients with non-NPSLE (SLE with inactive disease without overt neuropsychiatric disorders); few studies have shown a relationship between cognitive and psychological status and depression in these groups [11,14,16-19]. Thus, despite the strong relationships reported between psychological distress and neurobehavioral factors in some patients with SLE, this relationship remains unclear in others. Additionally, the underlying mechanisms are unclear and pose difficult diagnostic and treatment issues.Several studies have demonstrated that patients with NPSLE have stronger correlations between psychological and cognitive distress [8-12,20]. In contrast, a few studies found no relationship between psychiatric histories, psychological status, and cognitive status in NPSLE [14
Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study
Igor Prudovsky,Thallapuranam Krishnaswamy Suresh Kumar,Sarah Sterling,David Neivandt
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14023734
Abstract: Extracellular proteins devoid of signal peptides use nonclassical secretion mechanisms for their export. These mechanisms are independent of the endoplasmic reticulum and Golgi. Some nonclassically released proteins, particularly fibroblast growth factors (FGF) 1 and 2, are exported as a result of their direct translocation through the cell membrane. This process requires specific interactions of released proteins with membrane phospholipids. In this review written by a cell biologist, a structural biologist and two membrane engineers, we discuss the following subjects: (i) Phenomenon of nonclassical protein release and its biological significance; (ii) Composition of the FGF1 multiprotein release complex (MRC); (iii) The relationship between FGF1 export and acidic phospholipid externalization; (iv) Interactions of FGF1 MRC components with acidic phospholipids; (v) Methods to study the transmembrane translocation of proteins; (vi) Membrane models to study nonclassical protein release.
A New Archosauriform (Reptilia: Diapsida) from the Manda Beds (Middle Triassic) of Southwestern Tanzania
Sterling J. Nesbitt, Richard J. Butler, David J. Gower
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072753
Abstract: Background Archosauria and their closest relatives, the non-archosaurian archosauriforms, diversified in the Early and Middle Triassic, soon after the end-Permian extinction. This diversification is poorly documented in most Lower and Middle Triassic rock sequences because fossils of early groups of archosauriforms are relatively rare compared to those of other amniotes. The early Middle Triassic (? late Anisian) Manda beds of southwestern Tanzania form an exception, with early archosaur skeletons being relatively common and preserved as articulated or associated specimens. The Manda archosaur assemblage is exceptionally diverse for the Middle Triassic. However, to date, no non-archosaurian archosauriforms have been reported from these rocks. Methodology/Principal Findings Here, we name a new taxon, Asperoris mnyama gen. et sp. nov., from the Manda beds and thoroughly describe the only known specimen. The specimen consists of a well-preserved partial skull including tooth-bearing elements (premaxilla, maxilla), the nasal, partial skull roof, and several incomplete elements. All skull elements are covered in an autapomorphic highly rugose sculpturing. A unique combination of character states indicates that A. mnyama lies just outside Archosauria as a stem archosaur within Archosauriformes, but more precise relationships of A. mnyama relative to other early archosauriform clades (e.g., Erythrosuchidae) cannot be determined currently. Conclusions/Significance Asperoris mnyama is the first confirmed non-archosaurian archosauriform from the Manda beds and increases the morphological and taxonomic diversity of early archosauriforms known from the Middle Triassic. The direct association of A. mnyama with species referable to Archosauria demonstrates that non-archosaurian archosauriforms were present during the rise and early diversification of Archosauria. Non-archosaurian archosauriforms and archosaurs co-occur in fossil reptile assemblages across Pangaea from the late Early Triassic to the end of the Late Triassic.
Configuring the Mesh Size, Side Taper and Wing Depth of Penaeid Trawls to Reduce Environmental Impacts
Matt K. Broadhurst, David J. Sterling, Russell B. Millar
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099434
Abstract: The effects of reducing mesh size while concomitantly varying the side taper and wing depth of a generic penaeid-trawl body were investigated to improve engineering performance and minimize bycatch. Five trawl bodies (with the same codends) were tested across various environmental (e.g. depth and current) and biological (e.g. species and sizes) conditions. The first trawl body comprised 41-mm mesh and represented conventional designs (termed the ‘41 long deep-wing'), while the remaining trawl bodies were made from 32-mm mesh and differed only in their side tapers, and therefore length (i.e. 1N3B or ‘long’ and ~28o to the tow direction vs 1N5B or ‘short’ and ~35o) and wing depths (‘deep’–97 T vs ‘shallow’–60 T). There were incremental drag reductions (and therefore fuel savings – by up to 18 and 12% per h and ha trawled) associated with reducing twine area via either modification, and subsequently minimizing otter-board area in attempts to standardize spread. Side taper and wing depth had interactive and varied effects on species selectivity, but compared to the conventional 41 long deep-wing trawl, the 32 short shallow-wing trawl (i.e. the least twine area) reduced the total bycatch by 57% (attributed to more fish swimming forward and escaping). In most cases, all small-meshed trawls also caught more smaller school prawns Metapenaeus macleayi but to decrease this effect it should be possible to increase mesh size slightly, while still maintaining the above engineering benefits and species selectivity. The results support precisely optimizing mesh size as a precursor to any other anterior penaeid-trawl modifications designed to improve environmental performance.
Magnetic Untwisting in Solar Jets that Go into the Outer Corona in Polar Coronal Holes
Ronald L. Moore,Alphonse C. Sterling,David A. Falconer
Physics , 2015, DOI: 10.1088/0004-637X/806/1/11
Abstract: We study 14 large solar jets observed in polar coronal holes. In EUV movies from SDO/AIA, each jet appears similar to most X-ray jets and EUV jets that erupt in coronal holes, but each is exceptional in that it goes higher than most, so high that it is observed in the outer corona beyond 2.2 RSun in images from the SOHO/LASCO/C2 coronagraph. From AIA He II 304 {\AA} movies and LASCO/C2 running-difference images of these high-reaching jets, we find: (1) the front of the jet transits the corona below 2.2 RSun at a speed typically several times the sound speed; (2) each jet displays an exceptionally large amount of spin as it erupts; (3) in the outer corona, most of the jets display measureable swaying and bending of a few degrees in amplitude; in three jets the swaying is discernibly oscillatory with a period of order 1 hour. These characteristics suggest that the driver in these jets is a magnetic-untwisting wave that is basically a large-amplitude (i.e., non-linear) torsional Alfven wave that is put into the reconnected open field in the jet by interchange reconnection as the jet erupts. From the measured spinning and swaying we estimate that the magnetic-untwisting wave loses most of its energy in the inner corona below 2.2 RSun. We point out that the torsional waves observed in Type-II spicules might dissipate in the corona in the same way as the magnetic-untwisting waves in our big jets and thereby power much of the coronal heating in coronal holes.
A maximum likelihood estimate of natural mortality for brown tiger prawn (Penaeus esculentus) in Moreton Bay (Australia)
Marco Kienzle,David Sterling,Shijie Zhou,You-Gan Wang
Quantitative Biology , 2015,
Abstract: The delay difference model was implemented to fit 21 years of brown tiger prawn (Penaeus esculentus) catch in Moreton Bay by maximum likelihood to assess the status of this stock. Monte Carlo simulations testing of the stock assessment software coded in C++ showed that the model could estimate simultaneously natural mortality in addition to catchability, recruitment and initial biomasses. Applied to logbooks data collected from 1990 to 2010, this implementation of the delay difference provided for the first time an estimate of natural mortality for brown tiger prawn in Moreton Bay, equal to $0.031 \pm 0.002$ week$^{-1}$. This estimate is approximately 30\% lower than the value of natural mortality (0.045 week$^{-1}$) used in previous stock assessments of this species.
A New Era in Cultural Diplomacy: Promoting the Image of China’s “Belt and Road” Initiative in Asia  [PDF]
Dahlia Patricia Sterling
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.62010
Abstract:
This paper aims to identify and analyze cultural diplomacy as an innovative tool in this new age by promoting the image of China in Asia through the Belt and Road Initiative, by means of the various characteristics of culture as a soft power tool. This paper proposes that through the use of cultural diplomacy as aspects of culture as a soft power tool, it increases cultural awareness about China’s cultural traditions that will in turn, further promote China’s image in Asia and a harmonious society.
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