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Search Results: 1 - 10 of 131 matches for " Darceny Zanetta;Catai "
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Desenvolvimento de um torquímetro de precis?o para o estudo do desempenho de implantes osseointegrados
Bianchi, Eduardo Carlos;Aguiar, Paulo Roberto de;Santos, Marcelo de Almeida Souza;Gon?alves, Jo?o Roberto;Barbosa, Darceny Zanetta;Catai, Rodrigo Eduardo;
Rem: Revista Escola de Minas , 2003, DOI: 10.1590/S0370-44672003000200008
Abstract: this paper has as objective, to present the project, the construction and the results obtained in the study of the osseointegration with a torque gauge of high precision. the torque gage, especially developed for this research type, was used to improvement of odontological research on osseointegration of dental implant. the implants were done in seven rabbits that were available after 21 and 42 days. in some rabbits were made ultra-sonic stimulations at rabbits' implants. the results showed that the torque to remove the implant of the rabbits is directly proportional at the time of osseointegration and that the ultra-sonic stimulations can also influence the torque in some cases.
Enxerto bovino organico associado ao PRP em calvária de coelhos
Rocha, Flaviana Soares;Ramos, Lara Maria Alencar;Batista, Jonas Dantas;Zanetta-Barbosa, Darceny;Dechichi, Paula;
Arquivos Internacionais de Otorrinolaringologia , 2011, DOI: 10.1590/S1809-48722011000200014
Abstract: introduction: the osseous repairing in big imperfections is a great challenge for the restored surgery in nowadays. objective: the objective of this study was to make an histological evaluation of the osseous restore in rabbit's calvaria after the bovine osseous graft's (gen-ox-organic?) usage associated with plasma rich in platelet (prp). method: it was used 12 rabbits and 02 osseous fragments were removed from bilaterally calvarium. so among 24 surgical sites were randomly, divided in 03 groups: coagulum (group i), organic (group ii) and organic with prp (group iii). after 04 weeks the animals were sacrificied and the grafted area was removed, fixed in formaldehyde at 10% in pbs 0,1m and included in paraffin. results: the histologic parameters analysed were: imperfection area filled up with neoformed, gigantic cells and graft's particles, and osseous neoformation associated with the particles. the group's i imperfections were filled up with fibrous tissue that conditioned the periosteum and presented a small osseous formation in the perimeter. in groups ii and iii, a similar pattern was observed and also with graft's particles and gigantic cell's absence. there was no significative difference in gigantic cells, graft's particles and neoformation's numbers around the particles between the grafted material and the group with prp associated. conclusion: the obtained results show that the isolated organic biomaterial or in association with prp did not improve the osseous regeneration.
Effect of titanium surface on secretion of IL1β and TGFβ1 by mononuclear cells
Moura, Camilla Christian Gomes;Soares, Priscilla Barbosa Ferreira;Souza, Maria Aparecida de;Zanetta-Barbosa, Darceny;
Brazilian Oral Research , 2011, DOI: 10.1590/S1806-83242011000600005
Abstract: mononuclear cells play an important role in the modulation of healing. the characteristics of implant surface topography may alter the production of signaling molecules such as cytokines. the aim of this in vitro study was to evaluate the effects of commercially available titanium surface treatments on both cell viability and the secretion of the antagonist cytokines, il1β and tgfβ1. human mononuclear cells were cultured on 10 mm diameter commercially pure titanium (cpti) disks that were prepared using a turning procedure (control=machined surface) and either acid etched or bio-anodized for 1-7 days. adhered cells were investigated with respect to cell viability using an mtt assay, and cytokine production was verified using an elisa assay. the results indicate that surface characteristics did not alter the cell viability at days 1 and 4, although the machined surface presented the highest absorbance values at day 7 (p = 0.0084). cell viability was reduced throughout the time course for all analyzed surfaces (p < 0.05). on day 4, il1β levels were significantly higher on bio-anodized compared to acid etched surfaces (p = 0.0097). tgfβ1 did not show differences among the surfaces at days 1 and 4. the responses of non-stimulated mononuclear cells to titanium surfaces suggest only modest effects of the surface treatment and roughness on pro-inflammatory cytokine (il1β) release.
Organic Bovine Graft Associated With PRP In Rabbit Calvaria
Rocha, Flaviana Soares,Ramos, Lara Maria Alencar,Batista, Jonas Dantas,Zanetta-Barbosa, Darceny
International Archives of Otorhinolaryngology , 2011,
Abstract: Introduction: Repairing large bone defects is a huge challenge that reconstructive surgery currently faces. Objective: The objective of this study was to perform the histological evaluation of bone repair in rabbit calvaria when using bovine bone graft (Gen-ox-organic ) associated with platelet-rich plasma (PRP). Method: 12 rabbits were used and two bone fragments were bilaterally removed from calvaria. Then, 24 surgical sites were randomly divided into 3 groups: coagulum (group I), organic (group II) and PRP-included organic (group III). After four weeks, the animals were sacrificed and the grafted area removed, fixed in 10% formalin with PBS 0.1 M, and embedded in paraffin. Study method:The analyzed histological parameters were: defective area filled with the newly-formed bone, graft's giant cells and particles, as well as the new bone formation associated with the particles. Group I's defects were filled with fibrous tissue attaching the periosteum and revealed a little bone formation peripherally. In both groups II and III, a similar standard was noticed in addition to the absence of graft particles and giant cells. There was no significant difference in the number of giant cells, graft particles and new bone formation around the particles between the grafted material and the PRP-related group. Conclusion: The results achieved indicate that the organic biomaterial neither separately nor jointly with PRP improves bone regeneration.
Enxerto Bovino Organico Associado ao PRP em Calvária de Coelhos
Rocha, Flaviana Soares,Ramos, Lara Maria Alencar,Batista, Jonas Dantas,Zanetta-Barbosa, Darceny
Arquivos Internacionais de Otorrinolaringologia , 2011,
Abstract: Introdu o: O reparo ósseo de grandes defeitos é um grande desafio para a cirurgia reconstrutora atualmente. Objetivo: O objetivo desse estudo foi realizar avalia o histológica do reparo ósseo em calvária de coelhos depois do uso de enxerto ósseo bovino (Gen-ox-organic ) associado a plasma rico em plaquetas (PRP). Método: Foram utilizados 12 coelhos, e dois fragmentos ósseos foram removidos da calvária bilateralmente. Ent o 24 sítios cirúrgicos foram aleatoriamente separados em 3 grupos: coágulo (grupo I), organico (grupo II) e organico com PRP (grupo III). Depois de quatro semanas, os animais foram sacrificados e a área enxertada foi removida, fixada em formol a 10%, em PBS 0,1M e incluídas em parafina. Resultados: Os parametros histológicos analisados foram: área do defeito preenchida com osso neoformado, presen a de células gigantes e partículas do enxerto, e neoforma o óssea associada com as partículas. Os defeitos do grupo I foram preenchidos com tecido fibroso que condicionou o periósteo e apresentou uma pequena forma o óssea na periferia. Nos grupos II e III, um padr o semelhante foi observado e também ausência de partículas do enxerto e células gigantes. N o houve diferen a significativa no número de células gigantes, partículas do enxerto e neoforma o óssea em volta das partículas entre o material enxertado e o grupo com PRP associado. Conclus o: Os resultados obtidos indicam que o biomaterial organico isolado ou em associa o com o PRP n o melhoraram a regenera o óssea.
Plasma Treatment Maintains Surface Energy of the Implant Surface and Enhances Osseointegration
Fernando P. S. Guastaldi,Daniel Yoo,Charles Marin,Ryo Jimbo,Nick Tovar,Darceny Zanetta-Barbosa,Paulo G. Coelho
International Journal of Biomaterials , 2013, DOI: 10.1155/2013/354125
Abstract: The surface energy of the implant surface has an impact on osseointegration. In this study, 2 surfaces: nonwashed resorbable blasting media (NWRBM; control) and Ar-based nonthermal plasma 30 days (Plasma 30 days; experimental), were investigated with a focus on the surface energy. The surface energy was characterized by the Owens-Wendt-Rabel-Kaelble method and the chemistry by X-ray photoelectron spectroscopy (XPS). Five adult beagle dogs received 8 implants ( per surface, per tibia). After 2 weeks, the animals were euthanized, and half of the implants ( ) were removal torqued and the other half were histologically processed ( ). The bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO) were evaluated on the histologic sections. The XPS analysis showed peaks of C, Ca, O, and P for the control and experimental surfaces. While no significant difference was observed for BIC parameter ( ), a higher level for torque ( ) and BAFO parameter ( ) was observed for the experimental group. The surface elemental chemistry was modified by the plasma and lasted for 30 days after treatment resulting in improved biomechanical fixation and bone formation at 2 weeks compared to the control group. 1. Introduction The interaction between the implant surface and the living body begins soon after the placement of the biomaterial in the body, and it has always been a challenge to determine the optimal modification to accelerate the biologic events which lead to faster osseointegration [1–3]. Since it has been proven that moderately rough surfaces outperform the turned surfaces [4–8], recent research has focused on further modifications that could possibly increase the bioactivity of the implant [9]. Thus, some of the state-of-the-art research has shifted to chemically modify moderately rough surfaces, which have been indicated to generate synergetic effects [10, 11]. Furthermore, the surface energy is another important factor involved in the regulation of osteogenesis. It has been said that depending on the surface energy, the surface state can either be hydrophilic or hydrophobic [12]. The energy state of the implant depends on the type of biomaterial, the handling during manufacturing, the mode of cleaning, sterilization, and needless to say, the handling of the implant during surgical procedure [13, 14]. In general, when the surface is positively charged, the surface turns hydrophilic and some of the plasma proteins essential for the initial osteogenic interactions adsorb to hydrophilic surfaces [15–17]. It has been suggested that the charge of the implant
Innovations in technology and the online learning environment: A case study of inter-university collaboration
Jansen ZANETTA
Essachess : Journal for Communication Studies , 2010,
Abstract: This paper presents a case study of online learning. It is based on the researcher’s participation in an inter-university collaborative module at two higher education institutions in South Africa and the United States from August to December 2001. The paper addresses the advantages and disadvantages of the online learning environment and learning in a Virtual Classroom. It provides a critical interpretation of the virtual classroom experienced in this collaboration between institutions. It finds that there are benefits from applying this technology in educational practices and programs particularly in the African context where a large majority of school-leaving learners have little or no access to higher education. However, it also expounds the NEPAD (New Partnership for Africa’s Development) initiative to produce ICT in schools throughout Africa to fulfil the Millennium Development Goals on education in developing countries.
Influence of the electrokinetic injection conditions on the separation of DNA fragments in capillary electrophoresis
Catai, Jonatan Ricardo;Carrilho, Emanuel;
Journal of the Brazilian Chemical Society , 2004, DOI: 10.1590/S0103-50532004000300012
Abstract: in genetic analysis by capillary electrophoresis with polymer solutions there are many variables that affect separation of the dna fragments. a very critical one is the sample injection process, which can considerably affect the peak efficiency and the resolution. in this work, we have studied the influence of the dna sample composition and the electrokinetic injection conditions in the separation of dna fragments by capillary electrophoresis using replaceable polymer solutions. the studies were carried out by electrokinetically injecting the dna samples under a variety of conditions, such as sample ionic strength, buffering capacity and the quality of the separation matrix. in all experiments dna was stained with ethidium bromide for laser-induced fluorescence (lif) detection and separated in a poly(vinylalcohol) coated capillary column filled with 0.5% hydroxyethylcellulose solution under a 200 v cm-1 electric field. under such conditions, samples prepared with 1 to 5 mmol l-1 of running buffer have been shown to produce reproducible injections with rsd < 4% for both migration time and peak area.
Influence of the electrokinetic injection conditions on the separation of DNA fragments in capillary electrophoresis
Catai Jonatan Ricardo,Carrilho Emanuel
Journal of the Brazilian Chemical Society , 2004,
Abstract: In genetic analysis by capillary electrophoresis with polymer solutions there are many variables that affect separation of the DNA fragments. A very critical one is the sample injection process, which can considerably affect the peak efficiency and the resolution. In this work, we have studied the influence of the DNA sample composition and the electrokinetic injection conditions in the separation of DNA fragments by capillary electrophoresis using replaceable polymer solutions. The studies were carried out by electrokinetically injecting the DNA samples under a variety of conditions, such as sample ionic strength, buffering capacity and the quality of the separation matrix. In all experiments DNA was stained with ethidium bromide for laser-induced fluorescence (LIF) detection and separated in a poly(vinylalcohol) coated capillary column filled with 0.5% hydroxyethylcellulose solution under a 200 V cm-1 electric field. Under such conditions, samples prepared with 1 to 5 mmol L-1 of running buffer have been shown to produce reproducible injections with RSD < 4% for both migration time and peak area.
Nitridergic Modulation of the Antinociceptive Activity of Rosuvastatin in Mice  [PDF]
Viviana Noriega, Fernando Sierralta, Juan Carlos Prieto, Pilar Zanetta, Hugo F. Miranda
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.51010
Abstract:

Statins, 3-hydroxy-3 methylglutaryl coenzyme A (HMG-CoA) reductase enzyme inhibitors, are lipid-lowering drugs, often used in the treatment of cardiovascular diseases (hyperlipidemia, atherosclerosis). It has been shown that statins have antiinflammatory effects independent of their lipid-lowering effects and these anti-inflammatory effects inhibit the inflammation and pain process. This study evaluated the antinociceptive and anti-inflammatory effects of rosuvastatin using the acetic acid writhing, the formalin hind paw, the orofacial formalin and the hot plate tests. The following experimental group were used: control, acute (1 day) and chronic (3 days) after oral gavage with rosuvastatin (3, 10, 30, 100 and 300 mg/kg). Rosuvastatin produced a dose-dependent antinociception, with different potency, in all the tests. Additionally, nitric oxide synthase inhibitors (Abbreviationsand aminoguanidine) were used to assess the nitric oxide participation on this induced rosuvastatin antinociception. The data demonstrated the antinociceptive and anti-inflammatory activity of rosuvastatin in algesiometer models of tonic or phasic pain. These activities seem to be induced by modulation of iNOS expression, a result that may be relevant in the pharmacological treatment of human pain where rosuvastatin and nitric oxide synthase inhibitors must be used.

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