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Search Results: 1 - 10 of 2093 matches for " Danielle;Kirsch "
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ANCA-Associated Vasculitides—An Update  [PDF]
Johanna Kegel, Torsten Kirsch
Health (Health) , 2014, DOI: 10.4236/health.2014.614209
Abstract: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are characterized by destruction of small vessels, granulomatous inflammation of the respiratory tract and necrotizing glomerulonephritis. This review describes the clinical diagnosis and therapy as well as the patho-physiology of ANCA-associated vasculitides with a specific focus on the interplay of ANCAs with activated neutrophils and the deleterious pathophysiological consequences of neutrophil-endothelium interaction.
La trasformazione politica del monarca europeo nel XIX secolo
Martin Kirsch
Scienza & Politica : per una Storia delle Dottrine , 2006, DOI: 10.6092/issn.1825-9618/2849
Abstract: La trasformazione politica del monarca europeo nel XIX secolo
An Invitation to Random Schroedinger operators
Werner Kirsch
Physics , 2007,
Abstract: This review is an extended version of my mini course at the Etats de la recherche: Operateurs de Schroedinger aleatoires at the Universite Paris 13 in June 2002, a summer school organized by Frederic Klopp. These lecture notes try to give some of the basics of random Schroedinger operators. They are meant for nonspecialists and require only minor previous knowledge about functional analysis and probability theory. Nevertheless this survey includes complete proofs of Lifshitz tails and Anderson localization.
A Wegner estimate for multi-particle random Hamiltonians
Werner Kirsch
Physics , 2007,
Abstract: We prove a Wegner estimate for a large class of multiparticle Anderson Hamiltonians on the lattice. These estimates will allow us to prove Anderson localization for such systems. A detailed proof of localization will be given in a subsequent paper.
A Higgs Mechanism for Gravity
Ingo Kirsch
Physics , 2005, DOI: 10.1103/PhysRevD.72.024001
Abstract: In this paper we elaborate on the idea of an emergent spacetime which arises due to the dynamical breaking of diffeomorphism invariance in the early universe. In preparation for an explicit symmetry breaking scenario, we consider nonlinear realizations of the group of analytical diffeomorphisms which provide a unified description of spacetime structures. We find that gravitational fields, such as the affine connection, metric and coordinates, can all be interpreted as Goldstone fields of the diffeomorphism group. We then construct a Higgs mechanism for gravity in which an affine spacetime evolves into a Riemannian one by the condensation of a metric. The symmetry breaking potential is identical to that of hybrid inflation but with the non-inflaton scalar extended to a symmetric second rank tensor. This tensor is required for the realization of the metric as a Higgs field. We finally comment on the role of Goldstone coordinates as a dynamical fluid of reference.
On Penrose's square-root law and beyond
Werner Kirsch
Mathematics , 2006,
Abstract: In certain bodies, like the Council of the EU, the member states have a voting weight which depends on the population of the re- spective state. In this article we ask the question which voting weight guarantees a `fair' representation of the citizens in the union. The tra- ditional answer, the square-root law by Penrose, is that the weight of a state (more precisely: the voting power) should be proportional to the square-root of the population of this state. The square root law is based on the assumption that the voters in every state cast their vote inde- pendently of each other. In this paper we concentrate on cases where the independence assumption is not valid.
Recombinant Lysyl Oxidase Propeptide Protein Inhibits Growth and Promotes Apoptosis of Pre-Existing Murine Breast Cancer Xenografts
Manish V. Bais, Matthew A. Nugent, Danielle N. Stephens, S. Selva Sume, Kathrin H. Kirsch, Gail E. Sonenshein, Philip C. Trackman
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031188
Abstract: Lysyl oxidase propeptide (LOX-PP) ectopic overexpression inhibits the growth of cancer xenografts. Here the ability and mode of action of purified recombinant LOX-PP (rLOX-PP) protein to inhibit the growth of pre-existing xenografts was determined. Experimental approaches employed were direct intratumoral injection (i.t.) of rLOX-PP protein into murine breast cancer NF639 xenografts, and application of a slow release formulation of rLOX-PP implanted adjacent to tumors in NCR nu/nu mice (n = 10). Tumors were monitored for growth, and after sacrifice were subjected to immunohistochemical and Western blot analyses for several markers of proliferation, apoptosis, and for rLOX-PP itself. Direct i.t. injection of rLOX-PP significantly reduced tumor volume on days 20, 22 and 25 and tumor weight at harvest on day 25 by 30% compared to control. Implantation of beads preloaded with 35 micrograms rLOX-PP (n = 10) in vivo reduced tumor volume and weight at sacrifice when compared to empty beads (p<0.05). A 30% reduction of tumor volume on days 22 and 25 (p<0.05) and final tumor weight on day 25 (p<0.05) were observed with a reduced tumor growth rate of 60% after implantation. rLOX-PP significantly reduced the expression of proliferation markers and Erk1/2 MAP kinase activation, while prominent increases in apoptosis markers were observed. rLOX-PP was detected by immunohistochemistry in harvested rLOX-PP tumors, but not in controls. Data provide pre-clinical findings that support proof of principle for the therapeutic anti-cancer potential of rLOX-PP protein formulations.
Efeito do priming na redu??o da latência do pipecur?nio, novo bloqueador neuromuscular n?o-despolarizante
Canga, José Carlos;Lehn, Carlos Neutzling;Tonelli, Deoclécio;Sacco, Paula de Camargo Neves;Beltr?o, Danielle;Kirsch, Marcelo;Serralheiro, Fernando César;Cimerman, Gustavo;
Revista Brasileira de Anestesiologia , 2005, DOI: 10.1590/S0034-70942005000400002
Abstract: background and objectives: one of the most important neuromuscular blockers property is short onset, allowing early tracheal intubation. low nondepolarizing blocker dose before the full dose is known to decrease the onset of most neuromuscular blockers. pipecuronium bromide is a long-lasting aminosteroid with major cardiovascular stability, however, with late onset. this study aimed at evaluating pipecuronium priming effect in adult patients submitted to elective surgeries under general anesthesia. methods: participated in this study 33 adult patients of both genders, aged 20 to 65 years, physical status asa i or ii, to be submitted to elective surgeries under general anesthesia. exclusion criteria were patients with kidney or liver failure, neuromuscular diseases, in concurrent use of drugs influencing pipecuronium pharmacokinetics, and patients with family history of malignant hyperthermia. patients were divided in 2 groups: group 1 = priming with 0.01 mg.kg-1 and 3 minutes later the remaining 0.07 mg.kg-1 (total 0.08 mg.kg-1); group 2 = no priming dose (group control). neuromuscular relaxation was controlled by acceleromyography (tof-guard device) and laryngoscopy was accomplished when t1 < 10%. t test for independent samples was used for statistical analysis and shapiro wilks was used to test normality. results: groups were homogeneous. time for t1 < 10% was 161.4 ± 13.7 seconds for group 1 and 217.8 ± 23.4 seconds for group 2, with p < 0.001 and statistically significant differences between groups. conclusions: our results have shown statistically significant differences between groups with and without priming, indicating that pipecuronium also has its onset decreased, similarly to other known neuromuscular blockers.
Applications of Forensic Science in Private Security  [PDF]
Danielle Sapse
Beijing Law Review (BLR) , 2013, DOI: 10.4236/blr.2013.44017
Abstract:

Private security guards are a necessity at the present time, as a complement of the police departments in order to combat crime and terrorism. Both police forces and private security organizations are greatly helped in their work by the methods of forensic science. Forensic science applies scientific methods to the solving of crimes. These methods include fingerprinting, drug analysis, DNA (Deoxyribonucleic Acid) studies, ballistics, arson and explosive investigations, and studies of glass fragments. Fingerprinting and urine, saliva, or hair analysis for the presence of drugs are essential for the hiring of private security guards, in order to establish their suitability for the position.

Chiral magnetic effect and holography
Kirsch, Ingo;Kalaydzhyan, Tigran
High Energy Physics - Phenomenology , 2013,
Abstract: The chiral magnetic effect (CME) is a highly discussed effect in heavy-ion collisions stating that, in the presence of a magnetic field B, an electric current is generated in the background of topologically nontrivial gluon fields. We present a holographic (AdS/CFT) description of the CME in terms of a fluid-gravity model which is dual to a strongly-coupled plasma with multiple anomalous U(1) currents. In the case of two U(1) charges, one axial and one vector, the CME formally appears as a first-order transport coefficient in the vector current. We will holographically compute this coefficient at strong coupling and compare it with the hydrodynamic result. Finally, we will discuss an anisotropic variant of the model and study a possible dependence of the CME on the elliptic flow coefficient v_2.
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