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Search Results: 1 - 10 of 7025 matches for " Daniela Zambonin "
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Vascular Invasion, Satellite Nodules and Absence of Tumor Capsule Strongly Correlate with Disease-Free Survival and Long-Term Outcome in Patients Resected for Hepatocellular Carcinoma  [PDF]
Benedetta Pesi, Luca Moraldi, Daniela Zambonin, Francesco Giudici, Tiziana Cavalli, Rami Addasi, Francesca Leo, Stefano Scaringi, Giacomo Batignani
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.514134
Abstract: Background: Hepatocellular carcinoma (HCC) is one of the most common cancer in the world. Liver resection (LR) is the most used therapy in well compensated liver cirrhosis and maybe used as a first-line treatment. Aim of the study is to evaluate survival rates in patients who underwent LR for HCC and to identify risk factors able to influence the prognosis. Material/Method: A retrospective study was carried out in 115 patients whounderwent LR for HCC. We evaluated overall and disease-free survival rates at 1, 3 and 5years (y) and a series of variables included: type of resection, clamping, blood loss, transfusions, tumor size, presence of capsule, satellite nodules and vascular invasion. Results: The 1-, 3-, 5-y survival rates were 90.2%, 67% and 52.7%, and disease-free survival rates
O léxico do "ribeirinho" amaz nico: um exemplo de sustenta o e expans o de valores
Devino Jo?o Zambonin
Alfa : Revista de Linguística , 2001,
Abstract: A análise do léxico específico do ribeirinho p e-nos em contato n o só com a praxis sócio-cultural que faz desse grupo social um grupo diferenciado de forma marcante, como também nos proporciona o conhecimento de sua dinamica interna num espa o e tempo determinados. O campo Léxico das cren as mostra-nos como o caboclo amaz nico se relaciona com o sobrenatural: encara-o como algo sempre presente em sua vida, é inclinado a lhe atribuir valor prático e se apresenta como indispensável à sua sobrevivência.
Dietary Phenolic Acids Act as Effective Antioxidants in Membrane Models and in Cultured Cells, Exhibiting Proapoptotic Effects in Leukaemia Cells
Laura Zambonin,Cristiana Caliceti,Francesco Vieceli Dalla Sega,Diana Fiorentini,Silvana Hrelia,Laura Landi,Cecilia Prata
Oxidative Medicine and Cellular Longevity , 2012, DOI: 10.1155/2012/839298
Abstract: Caffeic, syringic, and protocatechuic acids are phenolic acids derived directly from food intake or come from the gut metabolism of polyphenols. In this study, the antioxidant activity of these compounds was at first evaluated in membrane models, where caffeic acid behaved as a very effective chain-breaking antioxidant, whereas syringic and protocatechuic acids were only retardants of lipid peroxidation. However, all three compounds acted as good scavengers of reactive species in cultured cells subjected to exogenous oxidative stress produced by low level of H2O2. Many tumour cells are characterised by increased ROS levels compared with their noncancerous counterparts. Therefore, we investigated whether phenolic acids, at low concentrations, comparable to those present in human plasma, were able to decrease basal reactive species. Results show that phenolic acids reduced ROS in a leukaemia cell line (HEL), whereas no effect was observed in normal cells, such as HUVEC. The compounds exhibited no toxicity to normal cells while they decreased proliferation in leukaemia cells, inducing apoptosis. In the debate on optimal ROS-manipulating strategies in cancer therapy, our work in leukaemia cells supports the antioxidant ROS-depleting approach.
Effect of Plasma Membrane Cholesterol Depletion on Glucose Transport Regulation in Leukemia Cells
Cristiana Caliceti, Laura Zambonin, Cecilia Prata, Francesco Vieceli Dalla Sega, Gabriele Hakim, Silvana Hrelia, Diana Fiorentini
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041246
Abstract: GLUT1 is the predominant glucose transporter in leukemia cells, and the modulation of glucose transport activity by cytokines, oncogenes or metabolic stresses is essential for their survival and proliferation. However, the molecular mechanisms allowing to control GLUT1 trafficking and degradation are still under debate. In this study we investigated whether plasma membrane cholesterol depletion plays a role in glucose transport activity in M07e cells, a human megakaryocytic leukemia line. To this purpose, the effect of cholesterol depletion by methyl-β-cyclodextrin (MBCD) on both GLUT1 activity and trafficking was compared to that of the cytokine Stem Cell Factor (SCF). Results show that, like SCF, MBCD led to an increased glucose transport rate and caused a subcellular redistribution of GLUT1, recruiting intracellular transporter molecules to the plasma membrane. Due to the role of caveolae/lipid rafts in GLUT1 stimulation in response to many stimuli, we have also investigated the GLUT1 distribution along the fractions obtained after non ionic detergent treatment and density gradient centrifugation, which was only slightly changed upon MBCD treatment. The data suggest that MBCD exerts its action via a cholesterol-dependent mechanism that ultimately results in augmented GLUT1 translocation. Moreover, cholesterol depletion triggers GLUT1 translocation without the involvement of c-kit signalling pathway, in fact MBCD effect does not involve Akt and PLCγ phosphorylation. These data, together with the observation that the combined MBCD/SCF cell treatment caused an additive effect on glucose uptake, suggest that the action of SCF and MBCD may proceed through two distinct mechanisms, the former following a signalling pathway, and the latter possibly involving a novel cholesterol dependent mechanism.
Aquifer Vulnerability Assessment Methods: The Non-Independence of Parameters Problem  [PDF]
Daniela Ducci
Journal of Water Resource and Protection (JWARP) , 2010, DOI: 10.4236/jwarp.2010.24034
Abstract: This paper investigates the relationship between the two parameters, aquifer media and hydraulic conductiv-ity, and assesses their reliability for aquifer vulnerability assessment. To evaluate the possible non-inde-pendence of the parameters in question, sensitivity analysis procedure was used in a GIS environment. The procedure was tested in three areas where aquifer vulnerability was assessed, corresponding to three different hydrogeological settings. The applications demonstrate that non-independence is confirmed and is more evident in alluvial and volcano-pyroclastic aquifers.
Steviol Glycosides Modulate Glucose Transport in Different Cell Types
Benedetta Rizzo,Laura Zambonin,Cristina Angeloni,Emanuela Leoncini,Francesco Vieceli Dalla Sega,Cecilia Prata,Diana Fiorentini,Silvana Hrelia
Oxidative Medicine and Cellular Longevity , 2013, DOI: 10.1155/2013/348169
Abstract: Extracts from Stevia rebaudiana Bertoni, a plant native to Central and South America, have been used as a sweetener since ancient times. Currently, Stevia extracts are largely used as a noncaloric high-potency biosweetener alternative to sugar, due to the growing incidence of type 2 diabetes mellitus, obesity, and metabolic disorders worldwide. Despite the large number of studies on Stevia and steviol glycosides in vivo, little is reported concerning the cellular and molecular mechanisms underpinning the beneficial effects on human health. The effect of four commercial Stevia extracts on glucose transport activity was evaluated in HL-60 human leukaemia and in SH-SY5Y human neuroblastoma cells. The extracts were able to enhance glucose uptake in both cellular lines, as efficiently as insulin. Our data suggest that steviol glycosides could act by modulating GLUT translocation through the PI3K/Akt pathway since treatments with both insulin and Stevia extracts increased the phosphorylation of PI3K and Akt. Furthermore, Stevia extracts were able to revert the effect of the reduction of glucose uptake caused by methylglyoxal, an inhibitor of the insulin receptor/PI3K/Akt pathway. These results corroborate the hypothesis that Stevia extracts could mimic insulin effects modulating PI3K/Akt pathway. 1. Introduction Stevia rebaudiana Bertoni is a weak perennial shrub belonging to Asteraceae (Compositae) family, native to subtropical regions of Brazil and Paraguay. Its leaves have been used as a sweetener since ancient times and for many other medicinal purposes in Latin America and the Orient for centuries [1, 2]. The “sweet herb” has gained increasing interest from nutritional researchers and commercial area in the last years, due to the growing need to find new natural calorie-free sweeteners alternative to sugar. Indeed, in both industrialized and developing countries, the incidence of type 2 diabetes mellitus and obesity is sharply increasing as a result of dietary behaviours, reduced physical activities, and ageing. These metabolic disorders have become major public health problems worldwide [3, 4]. Glycemic control is fundamental to the management of diabetes since it is associated with significantly decreased rates of retinopathy, nephropathy, neuropathy, and cardiovascular disease, the most common cause of death in diabetic patients. The effort to achieve near-normoglycemia through the key strategy of glycemic control includes recommendations for prevention and control of diabetes, for example, monitoring carbohydrate intake and limiting the consumption
Exploring the Nature of Information Systems Development Methodology: A Synthesized View Based on a Literature Review  [PDF]
Daniela Mihailescu, Marius Mihailescu
Journal of Service Science and Management (JSSM) , 2010, DOI: 10.4236/jssm.2010.32033
Abstract: New Information Systems Development Methodologies (ISDMs) are suggested in the belief that their deployment would be beneficial to consultants in their work. A large number of ISDMs already exist but their value has been questioned and at the same time new methodologies continue to be introduced in an attempt to support and improve the practice of information systems development work. What is not always clear from current studies is that ISDM is a multi-perspective and cross-discipline phenomenon. Although a large amount of knowledge of ISDM is available, different disciplinary interests have resulted in fragmented assessments of it. This paper intends to identify theoretical perspectives applied in the conceptualization of ISDM. A review of the literature on ISDM was conducted and four different theoretical perspectives were identified: 1) system, 2) structure, 3) innovation, and 4) knowledge. While each perspective provides various overarching depictions of ISDM, the synthesized view of ISDM provided in this study reveals the complexities and ambiguities of a multifaceted phenomenon such as ISDM. Suggestions for an alternative conceptualization of ISDM are provided in an attempt to facilitate the investigation of ISDM.
Endoscopic Adenoidectomy Secondary to Druginduced Trismus  [PDF]
Mark Greenberg, Daniela Carvalho
Surgical Science (SS) , 2010, DOI: 10.4236/ss.2010.11006
Abstract: We present the case of a 4 year old girl whose adenoidectomy had to be performed via an endoscopictrans oral approach due to the unexpected inability to fully open the mouth during the procedure. The patient had previously been taking Risperidone for behavioral symptoms associated with her autism. The jaw tone returned to normal following the procedure and there were no complications. An interaction between the Risperidone and the anesthetics were the likely cause of the trismus.
Classification and Selection of Prototyping Activities for Interaction Design  [PDF]
Stefano Filippi, Daniela Barattin
Intelligent Information Management (IIM) , 2012, DOI: 10.4236/iim.2012.44022
Abstract: Because of the evolution of markets and technologies, prototyping concerns should be kept updated almost day by day. Moreover, user centered design moves the focus towards interaction issues. Prototyping activities matching such characteristics are already available, but they are not so diffused in the industrial domain. This is due to many reasons; an important one is that a rigorous classification of them is missing, as well as an effective helping tool for the selection of the best activities, given the design context. The research described in this paper aims at defining a new classification of prototyping activities, as well as at developing a selection algorithm to choose the best ones in an automatic way. These goals are pursued by defining a set of characteristics that allow describing accurately the prototyping activities. The resulting classification is made by five classes, based on eighteen characteristics. This classification is exploited by the first release of an algorithm for the selection of the best activities, chosen in order to satisfy design situations described thanks to a different set of eleven indices. Five experiences in the field have been used up to now as a starting point for validating the research outcomes.
Fighting Against Obesity and Overweight: Approach to Design a New Service in Nutrition Education  [PDF]
Marisela Rodriguez, Daniela Charvel
Journal of Service Science and Management (JSSM) , 2013, DOI: 10.4236/jssm.2013.61011

Overweight and obesity (O&O) are a global public health problem, which many scientists have named as the XXI century epidemic. Since the 80’s decade, the O&O world prevalence has increased both in children and adults, and Mexico is among the highest. Under this context, the main goal of this research is to develop a business model based on a service of nutritional education as a way to fight against O&O. This research proposes a new model founded on a strategic combination of Service Design and Competitive Intelligence methodologies. The aim is to generate a unique and innovative service tailored to customer needs.

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