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Search Results: 1 - 10 of 7023 matches for " Daniela Giannessi "
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A remark on infinite-dimensional variational inequalities
Franco Giannessi
Le Matematiche , 1994,
Abstract: An infinite-dimensional Quasi-Variational Inequality is considered, whose domain in expressed as intersection of the level sets of functionals having infinite-dimensional image. A proposal is made to handle it by means of Lagrange multipliers.
Embedding variational inequalities and their generalizations into a separation scheme
Giannessi F
Journal of Inequalities and Applications , 1997,
Abstract: When the domain of a variational inequality is given as intersection of level sets of functionals, then it is useful to introduce a separation scheme. Starting from this it is possible to carry out, in a uniform way, several topics, as penalization, regularization, gap functions, duality.
Embedding variational inequalities and their generalizations into a separation scheme
F. Giannessi
Journal of Inequalities and Applications , 1997, DOI: 10.1155/s102558349700009x
Abstract: When the domain of a variational inequality is given as intersection of level sets of functionals, then it is useful to introduce a separation scheme. Starting from this it is possible to carry out, in a uniform way, several topics, as penalization, regularization, gap functions, duality.
Regional evidence of modulation of cardiac adiponectin level in dilated cardiomyopathy: pilot study in a porcine animal model
Chiara Caselli, Vincenzo Lionetti, Manuela Cabiati, Tommaso Prescimone, Giovanni D Aquaro, Virginia Ottaviano, Fabio Bernini, Letizia Mattii, Silvia Del Ry, Daniela Giannessi
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-143
Abstract: Cardiac tissue was collected from seven instrumented adult male minipigs by pacing the left ventricular (LV) free wall (180 beats/min, 3 weeks), both from pacing (PS) and opposite sites (OS), and from five controls. Circulating ADN levels were inversely related to global and regional cardiac function. Myocardial ADN in PS was down-regulated compared to control (p < 0.05), yet ADN receptor 1 was significantly up-regulated (p < 0.05). No modifications of AMPK were observed in either region of the failing heart. Similarly, myocardial mRNA levels of PPARγ, PPARα, TNFα, iNOS were unchanged compared to controls.Paradoxically, circulating ADN did not show any cardioprotective effect, confirming its role as negative prognostic biomarker of heart failure. Myocardial ADN was reduced in PS compared to control in an AMPK-independent fashion, suggesting the occurrence of novel mechanisms by which reduced cardiac ADN levels may regionally mediate the decline of cardiac function.Adiponectin (ADN) is an adipocyte-derived protein that is abundantly present in plasma [1] and is also expressed in cardiomyocytes [2] and endothelial cells [3]. Two ADN receptors, AdipoR1 and AdipoR2, have been characterized: AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver [4]. T-cadherin, an additional ADN receptor, is expressed in cardiomyocytes and is involved in ADN-mediated cardioprotection [5]. The remodeling of the failing heart has induced a number of investigators to test the hypothesis that modulation of myocardial metabolism might prove therapeutically advantageous [6].Potential downstream effectors of ADN receptors include AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-α (PPAR-α). AMPK is considered an energy-sensing enzyme that on stimulation enhances glucose use and fatty acid oxidation, whereas PPAR-α is a key nuclear transcription factor, regulating expression of genes involved in fatty acid upt
Impact of Obesity on the Expression Profile of Natriuretic Peptide System in a Rat Experimental Model
Manuela Cabiati, Serena Raucci, Tiziana Liistro, Eugenia Belcastro, Tommaso Prescimone, Chiara Caselli, Marco Matteucci, Patricia Iozzo, Letizia Mattii, Daniela Giannessi, Silvia Del Ry
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072959
Abstract: Natriuretic peptides (NPs) play an important role in obesity and aim of this study was to evaluate, in cardiac tissue of obese Zucker rats (O, n = 29) their transcriptomic profile compared to controls (CO, n = 24) by Real-Time PCR study; CNP protein expression was evaluated by immunostaining and immunometric tests. Myocardial histology was performed, confirming no alteration of organ structure. While ANP and BNP are cardiac peptides, CNP is mainly an endothelial hormone; thus its expression, as well as that of NPR-B and NPR-C, was also evaluated in kidney and lung of an animal subgroup (n = 20). In heart, lower BNP mRNA levels in O vs CO (p = 0.02) as well as ANP and CNP (p = ns), were detected. NPR-B/NPR-A mRNA was similar in O and CO, while NPR-C was numerically lower (p = ns) in O than in CO. In kidney, CNP/NPR-B/NPR-C mRNA was similar in O and CO, while in lung CNP/NPR-C expression decreased and NPR-B increased (p = ns) in O vs CO. Subdividing into fasting and hyperglycemic rats, the pattern of mRNA expression for each gene analyzed remained unchanged. The trend observed in heart, kidney and lung for CNP protein concentrations and immunohistochemistry reflected the mRNA expression. TNF-α and IL-6 mRNA were measured in each tissue and no significant genotype effect was detected in any tissue. The main NP variations were observed at the cardiac level, suggesting a reduced release by cardiac cells. The understanding of mechanisms involved in the modulation of the NP system in obesity could be a useful starting point for future clinical study devoted to identifying new obesity treatment strategies.
Effects of systemic glucocorticosteroids on peripheral neutrophil functions in asthmatic subjects: an ex vivo study
P. L. Paggiaro,L. Bancalari,D. Giannessi,W. Bernini
Mediators of Inflammation , 1995, DOI: 10.1155/s0962935195000408
Energy Phase Correlation and Pulse Dynamics in Short Bunch High Gain FELs
G. Dattoli,L. Giannessi,P. L. Ottaviani,S. Pagnutti
Physics , 2010,
Abstract: We analyze the dynamics of Free Electron Laser (FEL) devices, operating with a bunched beam exhibiting a longitudinal phase space correlation. We show that the presence of an energy-position correlation term is responsible for very interesting effects like an enhancement of the peak output power, a shortening of the laser pulses and an increase of the non linearly generated harmonic intensities. We conjecture that the mechanism is due to a kind of energy tapering effect associated with the correlation. We discuss the difference of the dynamics with respect to an ordinary undulator tapering and the relative advantages.
Aquifer Vulnerability Assessment Methods: The Non-Independence of Parameters Problem  [PDF]
Daniela Ducci
Journal of Water Resource and Protection (JWARP) , 2010, DOI: 10.4236/jwarp.2010.24034
Abstract: This paper investigates the relationship between the two parameters, aquifer media and hydraulic conductiv-ity, and assesses their reliability for aquifer vulnerability assessment. To evaluate the possible non-inde-pendence of the parameters in question, sensitivity analysis procedure was used in a GIS environment. The procedure was tested in three areas where aquifer vulnerability was assessed, corresponding to three different hydrogeological settings. The applications demonstrate that non-independence is confirmed and is more evident in alluvial and volcano-pyroclastic aquifers.
Measurement of the temporal response of ferroelectric cathodes
M. Castellano,M. Ferrario,F. Tazzioli,L. Catani,L. Giannessi,I. Boscolo,S. Cialdi,M. Valentini
Physics , 2000,
Abstract: Ferroelectric ceramics are tested as photocathodes at INFN Frascati Laboratories. In order to characterize them for use in linac injectors it is important to measure the temporal shape of the emitted current. With a duration of the laser pulse of 25 ps, the required resolution is a few ps. An apparatus has been set up for the purpose, consisting of a 30 kV electron gun, a microwave deflecting cavity which translates the temporal distribution of the electron bunch into a spatial one, a fluorescent screen on which the deflected beam traces a sector of a circle and various focusing and charge measuring items. The image on the screen is detected via a CCD camera and a frame grabber. We describe the performance of the apparatus and some preliminary temporal distribution measurements.
Exploring the Nature of Information Systems Development Methodology: A Synthesized View Based on a Literature Review  [PDF]
Daniela Mihailescu, Marius Mihailescu
Journal of Service Science and Management (JSSM) , 2010, DOI: 10.4236/jssm.2010.32033
Abstract: New Information Systems Development Methodologies (ISDMs) are suggested in the belief that their deployment would be beneficial to consultants in their work. A large number of ISDMs already exist but their value has been questioned and at the same time new methodologies continue to be introduced in an attempt to support and improve the practice of information systems development work. What is not always clear from current studies is that ISDM is a multi-perspective and cross-discipline phenomenon. Although a large amount of knowledge of ISDM is available, different disciplinary interests have resulted in fragmented assessments of it. This paper intends to identify theoretical perspectives applied in the conceptualization of ISDM. A review of the literature on ISDM was conducted and four different theoretical perspectives were identified: 1) system, 2) structure, 3) innovation, and 4) knowledge. While each perspective provides various overarching depictions of ISDM, the synthesized view of ISDM provided in this study reveals the complexities and ambiguities of a multifaceted phenomenon such as ISDM. Suggestions for an alternative conceptualization of ISDM are provided in an attempt to facilitate the investigation of ISDM.
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